Israel Structural Proteomics Center (ISPC)

ISPC Homepage at Weizmann

The Israel Structural Proteomics Center (ISPC) at the Weizmann Institute of Science, directed by Prof Gideon Schreiber and Prof Joel L. Sussman, was founded in 2002 with the support of the Israel Ministry of Science and the Divadol Foundation and is now supported by the Dana and Yossie Hollander center from structural proteomics and the Weizmann Institute. It serves as an Israeli Center for protein production, biochemical/biophysical studies and structure determination using state of the art, high throughput infrastructures to fulfill its tasks. The ISPC provides a service for the determination and analsysis of protein structures for scientists both at the Weizmann and at other academic institutions and biotech/pharma companies in Israel and abroad, as well as providing 'in house' training and consultation for students and staff. The ISPC was part of the European Union SPINE2, TeachSG and FESP projects. It is now one of the 6 core partners in the Integrated Structural Biology Infrastructure in Europe (Instruct) project.

The ISPC has developed key new tools for studying protein structure/function:

  • Cloning & expression in bacteria, yeast, Baculovirus and HEK 293 cells
  • Purification & screening of folding conditions
  • High throughput robotic crystallization
  • eMovie: A storyboard-based tool for making molecular movies
  • Visualization of 3D protein structures at the Jean Goldwurm 3D Visualization Theater
  • Proteopedia :The collaborative 3D encyclopedia of proteins and other
    Scientists have an important role in education, particularly of the young generation. We, within this I-CORE, will take this obligation very seriously by holding educational activities involving high-school students. These activities will propagate the knowledge of structure and function of proteins using Proteopedia  - a free, collaborative wiki-like 3D-encyclopedia of proteins and other molecules developed by Sussman (Hodis  et al & Sussman, Genome Biol. 2008;9:R121). Initially, Proteopedia was developed as a data dissemination platform for the scientific community (see for example a Sussman and Ben-Tal collaboration on integrating ConSurf within Proteopedia). As such it will be used to aid in the dissemination of the findings of this I-CORE. However, Proteopedia turned out to also be an excellent educational tool. Sussman and Yael Schwarz (Davidson Institute of Science Education) have been working closely to implement Proteopedia into high schools. Recently, they conducted a week-long workshop on Proteopedia for Israeli high-school teachers interested in introducing it into their classrooms. Sussman and other I-CORE members aim, in collaboration with the Davidson Institute, to build a modular tutorial that will be used both in Israel and internationally, to improve general scientific knowledge about the machines that drive life. Proteopedia pages can be written in any language (e.g., Hebrew and Arabic), which makes them much more accessible than professional tools available only in English, and greatly increases the likelihood that this outreach effort will have a major impact.

 

Two recent papers (just before I-CORE began)

  • Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. & Sussman, J. L. (2013). JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Israel Journal of Chemistry 53, 207-216.
  • Celniker, G., Nimrod, G., Ashkenazy, H., Glaser, F., Martz, E., Mayrose, I., Pupko, T. & Ben-Tal, N. (2013). ConSurf: Using Evolutionary Data to Raise Testable Hypotheses about Protein Function. Israel Journal of Chemistry 53, 199-206.

 

Book Cover

 

For more information please contact

Natasha Gruber

Email: natasha.gruber@weizmann.ac.il