The Smoler Proteomics Center

Proteomics homepage at the Technion

The proteomics center is the Israeli national infrastructure hub for proteome analysis. It was established by the Technion and Israel Ministry of Science to facilitate a direct access to state of the art technologies, instrumentation and knowhow in the fields of proteomics to researchers from universities, research institutes, hospitals, and biotechnology companies, from Israel and worldwide. The center personnel is headed by Prof. Arie Admon from the Department of Biology, managed by Dr. Tamar Ziv and includes six researchers with diverse background and skills; biology, chemistry, biotechnology engineering and mass spectrometry.

Activities in the Center range from identifying and quantifying of just a few proteins to large-scale comparisons of thousands proteins with their posttranslational modifications (such as in healthy and diseased tissues). The center offers direct access to the center’s technology and expertise, including protein and peptide mass spectrometry, nano-capillary chromatography, two-dimensional capillary chromatography and two-dimensional electrophoresis, as well as in analyzing minute amounts of proteins. Four mass spectrometers currently functional in the proteomics center (Orbitrap, Orbitrap XL, Q-Exactive and Q-Exactive-Plus, all produced by Thermo-Fisher). All of them are high resolution and high accuracy instruments enabling advanced high sensitivity proteomics. All mass spectrometers are fitted with nano-capillary HPLC, which enable the perfromance of and very high pressure and high resolution chromatography. 

The Proteomics Center activities are both services on a first comes, first served basis and as research collaborations as needed for more complicated projects.
Services to the biotechnology companies are performed both during the research and development and the quality control phases, and include consultation throughout the projects.
Identification of the full reprtoires of proteins (full proteomes, including many thousands of proteins) present in samples such as cell lines, tissues or mircoorganisms.

  • Quantitative proteomics – definition of the relative amounts of the proteins in different samples and following the changes in the levels in response to treatments or mutations.
  • Analysis of protein complexes – characterization of the interactions between the different cellular proteins and determination of their sub-cellular locations.
  • Modifications – determination of posttranslational modifications patterns (including phosphorylation, ubiquitination, acetylation, etc.) and location of chemical modifications.


For more information please contact

Dr. Tamar Ziv

Smoler Proteomics Center
Emerson Life Science Building Room 219 Technion , Haifa 32000, Israel
Tel:  +972-4-8293446
FAX: +972-4-8295069