Members of the Center

Prof. Gideon Schreiber

Specific protein-protein interactions form a major part of the basic organization of living cells. The structure of a protein complex holds information about the relative mutual organization of two proteins in a frozen state, but not about the kinetic or thermodynamic parameters that are central to their function. For many years I have been interested in understanding the relationships between the structures of transient protein-protein interactions and their binding activity. To address this, I adopted a multidisciplinary approach including: wet biophysical bench work, protein-design and engineering, bioinformatics, and algorithm development and applied the gained knowledge and techniques to address biological questions. As part of this I-CORE I am investigating structure/function aspects of type I interferon-receptor interactions and how these are related to signaling. Through a comprehensive analysis of the structure, energetics and dynamics of IFN recognition by its receptor subunits, and of how these translate into gene induction and activation, we have started to decipher the molecular and structural basis dictating differential signaling initiated by type I interferons, as well as the mechanisms leading from receptor binding to these differential activations. In addition to this, I am also heading the Dana and Yossie Hollander Structural Proteomic Unit at the Weizmann Institute of Science, which is part of this I-CORE. Specific protein-protein interactions form a major part of the basic organization of living cells. The structure of a protein complex holds information about the relative mutual organization of two proteins in a frozen state, but not about the kinetic or thermodynamic parameters that are central to their function. For many years I have been interested in understanding the relationships between the structures of transient protein-protein interactions and their binding activity. To address this, I adopted a multidisciplinary approach including: wet biophysical bench work, protein-design and engineering, bioinformatics, and algorithm development and applied the gained knowledge and techniques to address biological questions. As part of this I-CORE I am investigating structure/function aspects of type I interferon-receptor interactions and how these are related to signaling. Through a comprehensive analysis of the structure, energetics and dynamics of IFN recognition by its receptor subunits, and of how these translate into gene induction and activation, we have started to decipher the molecular and structural basis dictating differential signaling initiated by type I interferons, as well as the mechanisms leading from receptor binding to these differential activations. In addition to this, I am also heading the Dana and Yossie Hollander Structural Proteomic Unit at the Weizmann Institute of Science, which is part of this I-CORE. Names of PhD and Post-Doctoral students in the lab, that are funded by the center: Doron Levin Amir Apelbaum Victoria Urin

Prof. Arie Admon

Faculty of Biology,
Technion – Israel Institute of Technology

Prof. Nir Ben-Tal

Biochemistry and Molecular Biology, Tel Aviv University

Prof. Aaron Ciechanover

The Rappaport Faculty of Medicine and Research Institute Technion-Israel Institute of Technology

Dr. Ron Diskin

Structural Biology, Weizmann Institute of science

Prof. Deborah Fass

Structural Biology,Weizmann Institute of Science

Dr. Sarel Fleishman

Biological Chemistry, Weizmann Institute of Science

Prof. Lucio Frydman

Chemical Physics, Weizmann Institute of Science

Prof. Eyal Gottlieb

Technion Integrated Cancer Centre
Faculty of Medicine, Technion

Dr. Yoni Haitin

Physiology and Pharmacology
Tel Aviv University

Prof. Haim J. Wolfson

School of Computer Science, Tel Aviv University

Prof. Joel L. Sussman

Structural Biology, Weizmann Institute of Science

Assistant Professor Meytal Landau

Faculty of Biology , Technion- Israel Institute of Technology

Dr. Emmanuel Levy

Department of Structural Biology, Weizmann Institute of Science

Dr. Yifat Merbl

Immunology
Weizmann Institute of Science

Prof. Abraham Minsky

Structural Biology, Weizmann Institute of Science

Prof. Nathan Nelson

Biochemistry and Molecular Biology, Tel Aviv University