Specific protein-protein interactions form a major part of the basic organization of living cells. The structure of a protein complex holds information about the relative mutual organization of two proteins in a frozen state, but not about the kinetic or thermodynamic parameters that are central to their function. For many years I have been interested in understanding the relationships between the structures of transient protein-protein interactions and their binding activity. To address this, I adopted a multidisciplinary approach including: wet biophysical bench work, protein-design and engineering, bioinformatics, and algorithm development and applied the gained knowledge and techniques to address biological questions. As part of this I-CORE I am investigating structure/function aspects of type I interferon-receptor interactions and how these are related to signaling. Through a comprehensive analysis of the structure, energetics and dynamics of IFN recognition by its receptor subunits, and of how these translate into gene induction and activation, we have started to decipher the molecular and structural basis dictating differential signaling initiated by type I interferons, as well as the mechanisms leading from receptor binding to these differential activations. In addition to this, I am also heading the Dana and Yossie Hollander Structural Proteomic Unit at the Weizmann Institute of Science, which is part of this I-CORE.
Specific protein-protein interactions form a major part of the basic organization of living cells. The structure of a protein complex holds information about the relative mutual organization of two proteins in a frozen state, but not about the kinetic or thermodynamic parameters that are central to their function. For many years I have been interested in understanding the relationships between the structures of transient protein-protein interactions and their binding activity. To address this, I adopted a multidisciplinary approach including: wet biophysical bench work, protein-design and engineering, bioinformatics, and algorithm development and applied the gained knowledge and techniques to address biological questions. As part of this I-CORE I am investigating structure/function aspects of type I interferon-receptor interactions and how these are related to signaling. Through a comprehensive analysis of the structure, energetics and dynamics of IFN recognition by its receptor subunits, and of how these translate into gene induction and activation, we have started to decipher the molecular and structural basis dictating differential signaling initiated by type I interferons, as well as the mechanisms leading from receptor binding to these differential activations. In addition to this, I am also heading the Dana and Yossie Hollander Structural Proteomic Unit at the Weizmann Institute of Science, which is part of this I-CORE.
Names of PhD and Post-Doctoral students in the lab, that are funded by the center:
Doron Levin
Amir Apelbaum
Victoria Urin
Members of the Center
Prof. Gideon Schreiber |
Prof. Arie Admon
Faculty of Biology,
Technion – Israel Institute of Technology
|
Prof. Nir Ben-Tal
Biochemistry and Molecular Biology, Tel Aviv University
|
Prof. Aaron Ciechanover
The Rappaport Faculty of Medicine and Research Institute Technion-Israel Institute of Technology
|
Dr. Ron Diskin
Structural Biology, Weizmann Institute of science
|
Prof. Deborah Fass
Structural Biology,Weizmann Institute of Science
|
Dr. Sarel Fleishman
Biological Chemistry, Weizmann Institute of Science
|
Prof. Lucio Frydman
Chemical Physics, Weizmann Institute of Science
|
Prof. Eyal Gottlieb
Technion Integrated Cancer Centre
Faculty of Medicine, Technion
|
Dr. Yoni Haitin
Physiology and Pharmacology
Tel Aviv University
|
Prof. Haim J. Wolfson
School of Computer Science, Tel Aviv University
|
Prof. Joel L. Sussman
Structural Biology, Weizmann Institute of Science
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Assistant Professor Meytal Landau
Faculty of Biology , Technion- Israel Institute of Technology
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Dr. Emmanuel Levy
Department of Structural Biology, Weizmann Institute of Science
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Dr. Yifat Merbl
Immunology
Weizmann Institute of Science
|
Prof. Abraham Minsky
Structural Biology, Weizmann Institute of Science
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Prof. Nathan Nelson
Biochemistry and Molecular Biology, Tel Aviv University
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