Research Highlights

  • Modifying the Vicinity of the Isopeptide Bond to Reveal Differential Behavior of Ubiquitin Chains with Interacting Proteins.

    Haj-Yahya, N., Haj-Yahya, M., CastaÇeda, C. A., Spasser, L., Hemantha, H. P., Jbara, M., Penner, M., Ciechanover, A., Fushman, D., and Brik, A. (2013).Angew. Chem. Int. Ed. Engl.  52, 11149-11153

  • Synthetic polyubiquitinated α-Synuclein reveals important insights into the roles of the ubiquitin chain in regulating pathophysiology.

    Haj-Yahyaa, M., Fauvet, B., Herman-Bachinsky, Y., Hejjaoui, M., Bavikar, S. N.,
    Karthikeyan, S. V., Ciechanover, A.*, Lashuel, H. A.*, and Brik, A.* (2013).
    Proc. Natl. Acad. Sci. USA [Epub ahead of print, September 16, 2013].  doi: 10.1073/pnas.1315654110

    *senior corresponding authors

  • Two-dimensional RF Pulses: A New Form of Selectively Exciting J-Coupled Spins in Nuclear Magnetic Resonance

    Lupulescu, H. Aharon and L. Frydman,
    J. Chem. Phys., 139 , 144204 (2013).

  • Single-scan 2D NMR: An Emerging Tool in Analytical Spectroscopy

    P. Giraudeau and L. Frydman,Ann. Rev. Anal. Chem., in press (2014).

  • Computational design of protein-protein interactions.

    Schreiber G, Fleishman SJ.Curr Opin Struct Biol. Volume 23, Issue 6, December 2013, Pages 903–910. 

  • Extracting Insight from Noisy Cellular Networks

    Landry CR*, Levy ED*, Abd Rabbo D, Tarassov K, Michnick SW.Cell 2013 Nov 21; 155(5):983-989

  • The nature and extent of contributions by defective ribosome products to the HLA peptidome

    Dmitry Bourdetsky, Christian E. H. Schmelzer, and Arie Admon.


  • Global view of the protein universe.

    Sergey Nepomnyachiy, Nir Ben-Tal* and Rachel Kolodny*.
    PNAS,vol. 111, August 12, 2014,no. 321 1691–11696

  • Representation of the Protein Universe using Classifications, Maps, and Networks.

    Nir Ben-Tal and Rachel Kolodny
     Israel Journal of Chemistry (in press).

  • Novel activating mutations lacking cysteine in type I cytokine receptors in acute lymphoblastic leukemia

    Chen Shochat, Noa Tal, Vitalina Gryshkova, Yehudit Birger, Obul R. Bandapalli, Giovanni Cazzaniga, Nava Gershman, Andreas E. Kulozik, Andrea Biondi, Marc R. Mansour, Jean-Claude Twizere, Martina U. Muckenthaler, Nir Ben-Tal, Stefan N. Constantinescu, Dani Bercovich, and Shai Izraeli
    BLOOD, 3 JULY 2014, 124: 106-110.

  • High throughput screening for inhibitors of the HECT ubiquitin E3 ligase ITCH identifies antidepressant drugs as regulators of autophagy.

    M Rossi, B Rotblat, K Ansell, I Amelio, M Caraglia, G Misso, F Bernassola, CN Cavasotto, RA Knight, A Ciechanover* ,and G Melino*
    *Corresponding authors
    Cell Death Dis. 2014 [Epub ahead of print: May 1 2014; 5:e1203. doi: 10.1038/cddis.2014.113].

  • Protein Synthesis and Degradation: Multiple Sclerosis Autoantigen Myelin Basic Protein Escapes Control by Ubiquitination during Proteasomal Degradation.

    A Belogurov, A Kudriaeva, E Kuzina, A Smirnov, T Bobik, N Ponomarenko, Y Kravtsova-Ivantsiv, A Ciechanover*, A Gabibov*
    *Corresponding authors
    J Biol Chem. 2014; 289:17758–17766.

  • 13C NMR detection of metabolic mixtures enhanced by Dynamic Nuclear Polarization

    M. Yon, J. Lalande, T. Harris, I. Tea, P. Giraudeau and L. Frydman; Journal of Spectroscopy and Dynamics, 5, 1 (2015).

  • Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression.

    Sandler NG, Bosinger SE, Estes JD, Zhu RT, Tharp GK, Boritz E, Levin D, Wijeyesinghe S, Makamdop KN, del Prete GQ et al.  Nature. 2014 Jul 31;511:601–605. Highlighted: Telenti A. HIV: The mixed blessing of interferon.

  • Multifaceted activities of type I interferon are revealed by a receptor antagonist

    Levin D, Schneider WM, Hoffmann HH, Yarden G, Busetto AG, Manor O, Sharma N, Rice CM, Schreiber G. . Sci Signal. 2014;7:ra50. Highlighted: Made the cover and discussed in STKE podcast.

  • Proteopedia Outreach


  • Detecting objects with electro-sensing
  • Global view of the protein universe
  • חוקרים ישראלים חשפו את האבולוציה החשאית של החלבונים
  • מדעני העתיד של מכון ויצמן
  • The structural mechanism of KCNH-channel regulation by the eag domain
  • Functional evaluation of autism-associated mutations in NHE9
  • Pharmacophores for Amyloid Fibers Involved in Alzheimer's Disease -US Patent