Professor Ruth Arnon The Paul Ehrlich Professor of Immunology E-mail: ruth.arnon@weizmann.ac.il Phone: +972-8-934-4017 Fax: +972-8-947-4141 Location: Wolfson Bldg., Room 431A

 Publications (2004 - 2007)

• A DNA Aptamer prevents influenza infection by blocking the Receptor binding region of the viral haemagglutinin.
  Sung Ho Jeon, Basak Kayhan, Tamar Ben-Yedidia and Ruth Arnon.
  J. Biol. Chem. 279: No 46: pp 48410-48419 (2004).

• Mechanism of action of glatiramer acetate in multiple sclerosis and its potential for the development of new applications.
  Ruth Arnon and Rina Aharoni.
  PNAS 101, (Supplement) (2004).

• Oral Glatiramer Acetate in Experimental Autoimmune Encephalomyelitis. Clinical and Immunological Studies.
  Dvora Teitelbaum, Rina Aharoni, Ety Klinger, Rivka Kreitman, Emanual Raymond, Arthur Malley, Rona Shofti, Michael Sela and Ruth Arnon.
  Ann. N.Y. Acad. Sci. 1029, 239-249 (2004).

• Combined treatment of Glatiramer Acetate and low doses of immunosuppressive drugs is effective in the preventon of graft rejection.
  Rina Aharoni, Alexander Yussim, Michael Sela, Ruth Arnon.
  International Immunopharm. 5: pp 23-32 (2005).

• Regulation of Ecto Kinases in Schistosoma Mansoni by Acetylcholine.
  Rebeca Tarrab-Hazdai, Sung Ho Jeon, Ruth Arnon and Rony Seger.
  Eur. J. Biochem. (Submitted 2005).

• Towards an epitope-based human vaccine for influenza.
  Tamar Ben-Yedidia and Ruth Arnon.
  Human Vaccines Vol 1. 3. 95-101 (2005).

• Therapeutic effect of the immunomodulator glatiramer acetate on trinitrobenzene sullfonic acid-induced experimental colitis.
  Rina Aharoni, Basak Kayhan, Ruth Arnon.
  Inflam. Bowel Disease 11: 106-115 (2005).

• Neurogenesis and Neuroprotection induced by peripheral immunodulatory treatment of experimental autoimmune encephalomyelitis.
  Rina Aharoni and Ruth Arnon
  J. of Neuroscience 25 (36): 8217-8228 (2005).

• Case History of Copaxone® - From the Bench to Bedside.
  Dvora Teitelbaum*, Ruth Arnon and Michael Sela.
  Comprehensive Medicinal Chemistry II. Vol 8: (in press 2005).

• Ecto-and Exo –Protein kinases in Schistosoma mansoni: Regulation of surface phosphorylation by acetylcholine and Identification of the alpha subunit of CKII as a major secreted protein kinase.
  Rebeca Tarrab-Hazdai, Tamar Hanoch, Sung Ho Jeon, Henya Pauli, Daniel Gold, Ruth Arnon and Rony Seger.
  J. of Parasitol. 91, 756-763 (4) (2005).

• The immunomodulator glatiramer acetate augements the expression of neurotrophic factors in brains of experimental autoimmune encephalomyelitis mice.
  Rina Aharoni, Raya Eilam, Hagit Domev, Galya Labunskay, Michael Sela and Ruth Arnon.
  PNAS. 102. 52: 19045-19050 (2005).

• Immunomodulatory Therapeutic Effect of Glatiramer Acetate on Several Murine Models of Inflammatory Bowel Disease.
  Rina Aharoni, Basak Kayhan, Ori Brenner, Hagit Domev, Galya Labunskay and Ruth Arnon
  J. of Pharmacology and Experimental Therapeutics 318: No 1. 68-78 (2006).

• Flagella as a Platform for Epitope-Based Vaccines.
  Tamar Ben-Yedidya and Ruth Arnon.
  IMAJ. 8: 316-317 (2006).

• Does glatiramer acetate indice neurogenesis in experimental autoimmune encephalomyelitis?
  Ruth Arnon.
  Supplement, Barcelona J. Neurol. In press, (2007).

• Copaxone.
  D. Teitelbaum, R. Arnon and M. Sela.
  Comprehensive Medicinal Chemistry II. (Editors-in-Chief John. B. Taylor and David J. Triggle). Vol 8: 173 -185 (2007).

• An epitope based vaccine against influenza.
  T. Ben-Yedidia and R. Arnon. “Expert Review of Vaccines” (ERV). In press, (2007).

• The therapeutic effect of glatiramer acetate in a murine model of inflammatory bowel disease is mediated by anti-inflammatory T- cells.
  Rina Aharoni, Hagar Sonego, Ori Brenner, Raya Eilam and Ruth Arnon.
  Immun. Letts. In press, (2007).

Book Published

• "Copolymer 1 and related peptides as immunomodulsting agents." R. Arnon. Chapter in Martin & Kastin (eds), Handbook of Biologically Active Peptides, 2006.

Review Articles

• A novel approach to vaccine design - Epitope-based vaccines.
  Ruth Arnon.
  Biotech International (Bti), Netherlands 18, 10-13 (2006).

• Neurogenesis and Neuroprotection in the CNS – Fundamental elements in therapeutic immunomodulatory treatment of autoimmune neurological disorders.
  Ruth Aharoni and Ruth Arnon.
  J. of Molecular Neurobiology In press, (2007).