Guy Shakhar, Ph.D. Department of Immunology    Weizmann Institute of Science Wolfson Bldg., Room 402    Rehovot 76100, Israel Tel: +972-8-934-3633    Fax: +972-8-934-2992

My lab studies cellular communication in the immune system with these objectives:

• Keeping biomedical applications in mind
• The lab addresses questions important for optimizing cancer immunotherapy: how tumor antigens are carried to draining lymph nodes, and how tumor cells evade destruction by infiltrating lymphocytes
• The control of autoimmunity by Treg in inflammatory bowel disease
• Observing complicated cellular networks - to be true to the complicated cellular milieu we follow interactions among multiple cell populations by using several channels simultaneously.
• Preserving physiological conditions - we image live mice using the least intrusive microscopic methods to keep blood, lymph and neural connections intact.
• Employing cutting-edge microscopic techniques - we use two-photon fluorescent microscopy and second harmonics generation, which are ideal for in vivo microscopy.