Guy Shakhar, Ph.D.
Department of Immunology Weizmann Institute of Science
Wolfson Bldg., Room 402 Rehovot 76100, Israel
Tel: +972-8-934-3633 Fax: +972-8-934-2992
My lab studies cellular communication in the immune system with these objectives:
- Keeping biomedical applications in mind
- The lab addresses questions important for optimizing cancer immunotherapy: how tumor antigens are carried to draining lymph nodes, and how tumor cells evade destruction by infiltrating lymphocytes
- The control of autoimmunity by Treg in inflammatory bowel disease
- Observing complicated cellular networks - to be true to the complicated cellular milieu we follow interactions among multiple cell populations by using several channels simultaneously.
- Preserving physiological conditions - we image live mice using the least intrusive microscopic methods to keep blood, lymph and neural connections intact.
- Employing cutting-edge microscopic techniques - we use two-photon fluorescent microscopy and second harmonics generation, which are ideal for in vivo microscopy.