We aim to explore the complex mutualistic interactions between the host and its surrounding microbial environment. Using state-of-the-art bioinformatic, molecular, imaging and transgenic technologies we study the innate immune system, the microbiota, and the metabolic system in health and disease. We believe that understanding this intriguing cross-talk is key to creating patient-tailored treatment of complex human disease.
Positions available
We strongly believe in group effort, and in integrating expertise from diverse disciplines. We are currently seeking highly motivated students and postdocs with various backgrounds in immunology, microbiology, molecular biology, genetics and computational biology. If you want to join our journey, contact Eran (see contact details below).
Recent publications
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Metabolic disease may be transmissible by infectious agents. Nature 2012
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Inflammasome-mediated changes in the intestinal microflora lead to transmissible exacerbation of fatty liver disease and obesity, mediated by integration of toll-like receptor (TLR) and NOD-like receptor (NLR) signaling.
Henao-Mejia and Elinav (equal contibutors) et al., Nature 2012
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Inflammasomes in health and disease. Nature 2012
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The complex roles of the known inflammsames in mediating complex infectious, autoimmune and neoplastic disease are reviewed in depth.
Strowig, Henao-Mejia, and Elinav (equal contributors) et al, Nature 2012
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NLRP6 regulates the colonic microflora. Cell 2011
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We identified a novel epithelial protein complex, the NLRP6 inflammasome, that regulates intestinal homeostasis and risk for colitis.
Elinav et al., Cell 2011
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NLR proteins are central in the anti-microbial response. Immunity 2011
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The effects of different NOD-like receptor proteins on the anti-microbial immune response are reviewed.
Elinav et al., Immunity 2011
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The NLRC4 inflammasome regulates inflammation induced tumorogeneis.
PNAS 2010-
We identified a regulatory role for epithelial NLRC4 inflammasome in the pathogenesis of inflammation-induced colorectal cancer.
Hu and Elinav (equal contributors) et al., PNAS 2010
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