Steffen Jung Publications

Publications
Refereed Publications

2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 & Earlier

2009

Landsman L., Bar-On L., Zernecke A. Kim K., Krauthgamer R., Shagdarsuren E., Lira S. A., Weissman I. L., Weber C. and S. Jung. CX3CR1 Mediated Cell Survival in Monocyte Homeostasis and Atherogenesis. (2009) Blood 113(4):963-72.
Gereke M., Jung S., Jan Buer J. and D. Bruder. Alveolar type II epithelial cells present antigen to CD4⁺ T cells and are capable to induce of Foxp3⁺ regulatory T cells. (2009) AJRCCM 179(5):344-55.
Shechter R.*, London A.*, Varol C.*, Cusimano M., Raposo C., Rolls A., Mack, M., Pluchino S., Martino G., Jung S.* and M. Schwartz*. Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice. (2009) PLOS Medicine Jul;6(7):e1000113 Epub 2009. *equal contribution
Varol C., Vallon-Eberhard A., Elinav E., Aychek T., Shapira Y., Luche H., Fehling HJ, Hardt W., Shakhar G. and S. Jung. Intestinal Lamina Propria Dendritic Cell Subsets Have Different Origin and Functions. (2009) Immunity 31:502-12.
Appel, E., Vallon-Eberhard, A., Rabinkov, A., Brenner, O., Shin, I., Sasson, K. , Shadchan, Y., Osherov, O., Jung, S., D. Mirelman. Therapy of pulmonary aspergillosis in infected mice with antibody-alliinase conjugates and alliin. Antimicrob Agents Chemother. 2009.

2008

Hapfelmeier S., Andreas J. Muller AJ., Stecher B., Kaiser P., Barthel M., Endt K., Eberhard M., Robbiani R., Jacobi CA., Heikenwalder M., Kirschning C., Jung S., Stallmach T., Kremer M., and WD Hardt. Microbe sampling by mucosal dendritic cells is a discrete, MyD88-independent step in DinvG S. Typhimurium colitis. (2008). J. Exp. Med. 205(2):437.
Sapoznikov A., Pewzner-Jung, Y. Kalchenko, V., R. Krauthgamer, Shachar, I.* and S. Jung*. Perivascular clusters of dendritic cells provide critical survival signals to B cells in bone marrow niches. (2008) Nat. Immunol. 9(4):388.
* authors contributed equally to work.
Kool M., Soullié T., Van Nimwegen M.,Willart M.A.M, Muskens F., Jung, S., Hoogsteden H.C., Hammad H. and B. N. Lambrecht. Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells. (2008) J. Exp. Med. 205.
Cohen N., Stolarsky-Bennun M., Amir-Kroll H., Margalit R., Nussbaum G., Cohen-Sfady M., Pevsner-Fischer M., Fridkin M., Bercovier H., Eisenbach L., Jung S. and I.R. Cohen. Pneumococcal capsular polysaccharide is immunogenic when present on the surface of macrophages and dendritic cells: TLR4 signaling induced by a conjugate vaccine or by lipopolysaccharide is conducive. (2008) J Immunol. 180(4):2409-18.
Preise D., Oren R., Glinert I., Kalchenko V., Jung S., Scherz A. and Y. Salomon. Systemic antitumor protection by vascular-targeted photodynamic therapy (VTP) involves cellular and humoral immunity. (2008) Cancer Immunol. Immunother. 58(1):71-84.
Vallon-Eberhard A., Makovitzki A., Beauvais A., Latgé J.P., Jung S. and Y. Shai. Efficient clearance of Aspergillus fumigatus by ultrashort anti-microbial lipopeptides in murine lungs. (2008) Antimicrobial Agents and Chemotherapy 52(9):3118-26.
Westendorf A. M., Fleissner D., Groebe L., Jung S., Gruber A. D., Hansen W. and J. Buer. CD4+ Foxp3+ regulatory T cell expansion induced by antigen-driven interaction with intestinal epithelial cells independent of local dendritic cells. (2008) Gut (in press).
del Rio ML., Rodriguez-Barbosa JI., Bölter J., Ballmaier M., Dittrich-Breiholz O., Kracht M., Jung S., Förster R. CX₃CR1+ c-kit+ bone marrow cells give rise to CD103+ and CD103- dendritic cells with distinct functional properties. J. Immunol. 2008 Nov 1;181(9):6178-88.
Landsman L., Bar-On L., Zernecke A. Kim K., Krauthgamer R., Shagdarsuren E., Lira S. A., Weissman I. L., Weber C. and S. Jung. CX₃CR1 Mediated Cell Survival in Monocyte Homeostasis and Atherogenesis. Blood, prepublished online.
Plaks V., Birnberg T., Berkutzki T., Sela S., BenYashar A., Kalchenko V., Mor G., Keshet E., Dekel N., Neeman M. and S. Jung. Uterine Dendritic cells are crucial for Decidua Formation during Embryo Implantation. (2008) J. Clin. Invest..
Birnberg T., Bar-On L., Sapoznikov A., Caton M. L., Cervantes-Barragán L., Makia D., Krauthgamer R., Brenner O., Ludewig B., Brockschnieder D., Riethmacher D., Reizis B. and S. Jung. Lack of conventional Dendritic cells is compatible with normal development and T cell homeostasis, but causes Myeloid Proliferative Syndrome. Immunity.
Ruitenberg MJ., Vukovic J., Blomster L., Hall JM., Jung S., Filgueira L., McMenamin PG., Plant GW. CX3CL1/fractalkine regulates branching and migration of monocyte-derived cells in the mouse olfactory epithelium. J. Neuroimmunol. 2008 Oct 23.

2007

Abe K., Fine S.D., Shen C., Nguyen K.P., Corr M., Jung, S., Lee J., Eckmann L., and E. Raz. Conventional Dendritic Cells Regulate the Outcome of Colonic Inflammation. (2007) PNAS 104:17022.
Loof TG, Rohde M., Chhatwal GS, Jung S., and E. Medina. The contribution of dendritic cells to host defenses against Streptococcus pyogenes. (2007) J. Infect Dis. 196(12):1794-803.
Landsman L., Varol C., and S. Jung. Differential Fate of Blood Monocyte Subsets in the Lung. (2007) J Immunol. 178:2000.
Chinnery HR, Ruitenberg MJ, Plant GW, Pearlman E, Jung S and PG McMenamin. The Chemokine Receptor CX₃CR1 Mediates Homing of MHC class II-Positive Cells to the Normal Mouse Corneal Epithelium (2007). Invest Ophthalmol Vis Sci. 48:1568.
Desai DD, Harbers SO, Flores M, Colonna L, Downie MP, Bergtold A, Jung S, Clynes R. Fcγ Receptor IIB on Dendritic Cells Enforces Peripheral Tolerance by Inhibiting Effector T Cell Responses. (2007) J Immunol. 178:6217.
Harbers SO, Crocker A, Catalano G, D'Agati V, Jung S, Desai DD, Clynes R. Antibody-enhanced cross-presentation of self antigen breaks T cell tolerance (2007). J Clin Invest. 117:1361.
Cleret A., Quesnel-Hellmann A, Vallon-Eberhard A., Verrier, B. Jung S., Vidal D., Mathieu J. and J-N Tournier. Lung Dendritic Cells Rapidly Mediate Anthrax Spore Entry through the Pulmonary Route. (2007) J Immunol. 178:7994.
Butovsky O., Bukshpan S., Kunis G., Jung S., Schwartz M. Microglia can be induced by IFN-γ or IL-4 to express neural or dendritic-like markers.(2007) Mol. Cell Neurosci. 35(3):490-500.
Fraenkel S, Mostoslavsky R, Novobrantseva TI, Pelanda R, Chaudhuri J, Esposito G, Jung S, Alt FW, Rajewsky K, Cedar H, Bergman Y. Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin κ-chain locus. (2007) Nat Immunol. 8(7):715-722.
Gonen E., Vallon-Eberhard A., Harmelin A., Brenner O., Rosenshine I., Jung S. and N. Y. Shpigel. TLR4 is needed to restrict the invasion of Escherichia coli P4 into mammary gland epithelial cells in a murine model of acute mastitis. (2007) Cell. Microbiol. Jun 29
Sapoznikov A., Fischer, J.A.A., Zaft T., Krauthgamer R., Dzionek A. and S. Jung. Organ-dependent In Vivo Priming of Naīve CD4+, but not CD8+ T cells by Plasmacytoid Dendritic cells. (2007) J. Exp. Med. Oct. 2007.
Landsman and S. Jung. Lung Macrophages Serve as Obligatory Intermediate Between Blood Monocytes and Alveolar Macrophages. (2007) J Immunol. 179:3488.

2006

Grunewald M, Avraham I, Dor Y, Bachar-Lustig E, Itin A, Landsman L., Chimenti S., Jung S., Abramovitch R, and Eli Keshet. VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells. (2006) Cell 124:175-89.
Fogg DK, Sibon C., Miled C., Jung S., Aucouturier P., Littman DR, Cumano A. and F. Geissmann. A clonogenic bone marrow progenitor specific for macrophages and dendritic cells. (2006) Science 311(5757):83-7.
Avniel S., Arik Z., Maly A., Sagie A., Bassat HB, Yahana MD, Weiss ID, Pal B, Wald O, Ad-El D., Fujii N., Arenzana-Seisdedos F., Jung S., Galun E., Gur E. and A. Peled. Involvement of the CXCL12/CXCR4 pathway in the recovery of skin following burns. (2006) J Invest Dermatol. 126:468.
Vallon-Eberhard A., Landsman L., Yogev N., Verrier B. and S. Jung. Trans-Epithelial Pathogen Uptake into the Small Intestinal Lamina Propria. J Immunol. 176(4):2465-9.
Vingert B, Adotevi O, Patin D, Jung S, Shrikant P, Freyburger L, Eppolito C, Sapoznikov A, Amessou M, Quintin-Colonna F, Fridman WH, Johannes L, Tartour E. The Shiga toxin B-subunit targets antigen in vivo to dendritic cells and elicits anti-tumor immunity. (2006) Eur J Immunol. 36(5):1124-35.
Butovsky O, Landa G, Kunis G, Ziv Y, Avidan H, Greenberg N, Schwartz A, Smirnov I, Pollack A, Jung S, Schwartz M. Induction and blockage of oligodendrogenesis by differently activated microglia in an animal model of multiple sclerosis. (2006) J. Clin. Invest. 116(4):905-15.
Huang D, Shi FD, Jung S, Pien GC, Wang J, Salazar-Mather TP, He TT, Weaver JT, Ljunggren HG, Biron CA, Littman DR, Ransohoff RM. The neuronal chemokine CX₃CL1/fractalkine selectively recruits NK cells that modify experimental autoimmune encephalomyelitis within the central nervous system. (2006) FASEB J. (7):896.
Cardona AE, Pioro EP, Sasse ME, Kostenko V, Cardona SM, Dijkstra IM, Huang D, Kidd G, Dombrowski S, Dutta R, Lee JC, Cook DN, Jung S, Lira SA, Littman DR and Ransohoff RM. Control of microglial neurotoxicity by the fractalkine receptor. (2006) Nat Neurosci. (7):917-24.
Engel D, Dobrindt U, Tittel A, Peters P, Maurer J, Gutgemann I, Kaissling B, Kuziel W, Jung S, Kurts C. TNFα/ iNOS-producing dendritic cells are rapidly recruited to the bladder in urinary tract infection, but are dispensable for bacterial clearance. (2006) Infect Immun. 74(11):6100-6107.
Neuenhahn M, Kerksiek KM, Nauerth M, Suhre MH, Schiemann M, Gebhardt FE, Stemberger C, Panthel K, Schroder S, Chakraborty T, Jung S., Hochrein H, Russmann H, Brocker T, Busch DH. CD8α⁺ Dendritic Cells Are Required for Efficient Entry of Listeria monocytogenes into the Spleen. (2006) Immunity. 25(4):619-30.
Hebel K., Griewank K., Inamine A., Chang H-D, M?ller-Hilke B., Fillatreau S., Manz R., Radbruch A. and S. Jung. Plasma cell differentiation in T-independent type 2 immune responses is independent of CD11c^high Dendritic Cells. (2006) Eur J Immunol. 36(11):2912-2919.
KleinJan A., Willart M., van Rijt L. S., Braunstahl G.-J., Leman K., Jung S., Henk C. Hoogsteden H. C. and Bart N. Lambrecht. An essential role for dendritic cells in human and experimental allergic rhinitis. (2006) J Allergy Clin Immunol. Nov;118(5):1117-25.
Varol C., Landsman, L., Fogg, D.K., Greenshtein, L., Gildor, B., Margalit, R., Kalchenko, V., Geissmann, F. and S. Jung. Monocytes give rise to mucosal, but not splenic conventional dendritic cells. (2006) J. Exp. Med. 204(1):171.

2005

Niess, J.H., Brand, S., Gu, X., Landsman, L. Jung, S., McCormick, B., Vyas, J.M., Boes, M., Ploegh, H.L., Fox, J.G., Littman, D.R. and H,-C. Reinecker. CX₃CR1-Mediated Dendritic Cell Access to the Intestinal Lumen and Bacterial Clearance. (2005) Science 307:254.
Van Rijt, L., Jung, S., KleinJan, A., Vos, N., Willart, M., Duez, C., Henk C., Hoogsteden,H.C. and Bart N. Lambrecht. In vivo depletion of lung CD11c⁺ dendritic cells during allergen challenge abrogates the cardinal features of asthma. (2005) J. Exp. Med. 201(6):981.
Muraille, E., Giannino, R., Guirnalda, P., Leiner, I., Jung, S., Eric G. Pamer, E.G. And Gregoire Lauvau. Distinct in vivo dendritic cell activation by live versus killed Listeria monocytogenes. (2005) Eur J Immunol 35(5):1463.
Buch, T., Heinen, T., Kremer, M., Wunderlich, T., Jung, S. and Arie Waisman. A Cre-inducible Toxin Receptor Mediates Cell Lineage Ablation Following Diphtheria Toxin Administration. (2005) Nat Methods. 2:419.
Bennett, C.L., van Rijn, E., Jung, S., Inaba, K., Steinman, R.M., Martien L. Kapsenberg, M.L. and B.E. Clausen. Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity. (2005) J Cell Biol. 169(4):569.
Davalos D., Grutzendler J., Yang G., Kim J.V., Zuo Y, Jung S., Littman DR, Dustin ML and WB. Gan. ATP mediates rapid microglial response to local brain injury in vivo. (2005) Nat Neurosci. 8(6):752.
Bertrand J.Y., Jalil A., Klaine M., Jung S., Cumano A. and I. Godin. Three pathways to mature macrophages in the early Mouse Yolk Sac. (2005) Blood 106(9):3004.
Srivastava, M., Jung S., Wilhelm J., Fink L., Buhling F., Welte T., Bohle R.M., Seeger W., Lohmeyer J. and U. A. Maus. The Inflammatory versus Constitutive Trafficking of Mononuclear Phagocytes into the Alveolar Space of Mice Is Associated with Drastic Changes in Their Gene Expression Profiles. (2005) J Immunol. 175(3):1884.
Zaft, T., Sapoznikov, A., Krauthgamer, R., Littman, D.R. and S. Jung. CD11c^high dendritic cell ablation impairs Lymphopenia-driven proliferation of naive and memory CD8⁺ T cells. (2005) J Immunol. 175(10):6428.

2004

Fainaru, O., Woolf, E., Lotem, J. Brenner, O., Goldenberg, D., Negreanu, V., Bernstein, Y., Levanon, D., Jung S. and Y. Groner. Runx³ regulates mouse TGF-β-mediated dendritic cell function and its absence results in airway inflammation. EMBO J. 2004 Feb 5.
Qu C, Edwards EW, Tacke F, Angeli V, Llodra J, Sanchez-Schmitz G, Garin A, Haque NS, Peters W, van Rooijen N, Sanchez-Torres C, Bromberg J, Charo IF, Jung S, Lira SA,Randolph GJ. Role of CCR8 and other chemokine pathways in the migration of monocyte-derived dendritic cells to lymph nodes. (2004) J Exp Med. 200(10):123.
Goldmit M, Ji Y, Skok J, Roldan E, Jung S, Cedar H. and Yehudit Bergman. Epigenetic ontogeny of the Igk locus during B cell development. (2004) Nat Immunol. 6(2):198.
2003

Geissmann, F. *, Jung, S. * and D.R. Littman. Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties. (2003) Immunity, 19:71.
* authors contributed equally to work.
2002

Jung S., Unutmaz, D, Wong, P., Sano, G., De los Santos, K., Sparwasser, T., Wu, S., Vuthoori, S., Ko, K., Zavala, F., Pamer, E.G., Littman D.R. and R. A. Lang. In Vivo Depletion of CD11c⁺ Dendritic Cells Abrogates Priming of CD8⁺ T Cells by exogenous cell-associated antigens. (2002) Immunity, 17:211.
Huo Y., Schober, A., Forlow S.B., Hyman, M.C., Smith, D.F., Jung S., Littman D. R., Weber C. and K. Ley. Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E. (2002) Nature Medicine, Dec 16.
2001

Vyas, Y.M., Mehta, K., Morgan, M., Maniar, H., Butros, L., Jung, S., Burkhardt, J.K. and B. Dupont. Spatial organization of signal transduction molecules in the NK cell immune synapses during MHC class I-regulated non-cytolytic and cytolytic interactions. (2001) J. Immunol. 167(8):4358-4367.
Huo Y., Weber C., Forlow S.B., Sperandio M., Thatte, J., Mack, M., Jung S., Littman D. R. and K. Ley. The chemokine KC, but not MCP-1, triggers monocyte arrest on early atherosclerotic endothelium. (2001) J. Clin. Invest. 108(9):1307-1314.
Palframan R.T., Jung, S., Cheng, G., Weninger, W., Luo, Y., Dorf, M., Littman, D, Rollins, B., H. Zweerink, H., Rot, A. and U. H. von Andrian. Inflammatory Chemokine Transport and Presentation in HEV: a Remote Control Mechanism for Monocyte Recruitment to Lymph Nodes in Inflamed Tissues. (2001) J. Exp. Med. 194(9):1361.
2000

Lavon I, Goldberg I, Amit S, Landsman L, Jung S., Tsuberi BZ, Barshack I, Kopolovic J, Galun E, Bujard H. and Y. Ben-Neriah. High susceptibility to bacterial infection, but no liver dysfunction, in mice compromised for hepatocyte NF-κB activation. (2000) Nature Med. May;6(5):573-7.
Jung, S., Aliberti, J., Graemmel, P., Sunshine, MJ., Kreutzberg, G. W., Sher, A. and Littman, DR. Analysis of fractalkine receptor CX3CR1 function by targeted deletion and GFP reporter gene insertion. (2000) Mol. Cell.Biol.Jun;20(11):4106-14.
Kim, D., Mebius, R.E., MacMicking, J.D., Jung, S., Cupedo, T., Castellanos, Y., Josien, R., Kim, N., Rennert. P.D. and Y. Choi. Regulation of peripheral lymph node genesis by a TNF family member, TRANCE. (2000) J. Exp. Med. 192:1467-1478.
Ellmeier, W., Jung, S., Sunshine, MJ., Hatam, F., Xu, Y., Baltimore , D., Mano, H. and D.R. Littman. Severe B cell deficiency in mice lacking the Tec kinase family members Tec and Btk. (2000). J. Exp. Med. 192:1611-1624.

1999 & Earlier

Jung, S., Rajewsky, K. and A. Radbruch. (1993) Shutdown of Class Switch Recombination by deletion of switch region control element. Science. 259:984-7.
Jung, S., Siebenkotten, G. and A. Radbruch. (1994) Frequency of Immunoglobulin E class switching is autonomously determined and independent of prior switching to other classes. J. Exp. Med. 179:2023-6.
Lorenz,M., Jung, S. and A. Radbruch. (1995) Switch transcripts in immunoglobulin class switching. Science 267:1825-8.
Alkalay, I., Yaron, A., Hatzubai, A., Jung, S., Avraham, A., Gerlitz, O., Pashut-Lavon I. and Y. Ben-Neriah (1995) In vivo Stimulation of IκB phosphorylation is not sufficient to activate NF-κB. Mol. Cell. Biol. 15:1294-9.
Sonoda, E., Pewzner-Jung, Y., Schwers, S., Taki, S., Jung, S., Eilat, D. and K. Rajewsky. (1997) B cell development under the condition of allelic inclusion. Immunity 6(3):225-233.
Yaron, A., Gonen, H., Alkalay, I., Hatzubai, A., Jung, S., Beyth, S., Mercurio, F., Manning, A.M., Ciechanover, A. and Y. Ben-Neriah. (1997) Inhibition of NF-κB cellular function via specific targeting of the IκB-ubiquitin ligase. EMBO J 3;16(21):6486-6494.
Yedidia, Y., Ben-Neriah, Y. and S. Jung. (1998) Primary B cells essentially lack constitutive NF-κB activity. Eur J Immunol 28(1): 30-36.
Avraham, A., Jung, S., Samuels, Y., Seger, R. and Y. Ben-Neriah. Co-stimulation-dependent activation of a JNK-kinase in T lymphocytes. (1998) Eur J Immunol 28(8):2320-2330.
Pewzner-Jung, Y., Friedmann, D., Sonoda, E., Jung, S., Rajewsky, K. and Eilat, D. B cell deletion, anergy and receptor editing in 'knock in' mice targeted with germline-encoded or somatically mutated anti-DNA heavy chain. J Immunol. (1998) Nov 1;161(9):4634-45.

Book Chapters and Reviews

Jung, S. (1992), "Molecular Analysis of Transcriptional Control: the FACS-Galactosidase Assay", in A. Radbruch (ed.) Flow Cytometry and Sorting, Springer, Berlin.
Lorenz,M., Jung, S. and A. Radbruch.(1995) "How cytokines control immunoglobulin class switching." Behring-Inst.-Mitt. 96:97-102.
Jung, S., Yaron, A., Alkalay, I., Hatzubai, A., Avraham, A. and Y. Ben-Neriah. (1995) "Costimulation requirement for AP-1 and NF-kappa B transcription factor activation in T cells." Ann NY Acad Sci 7;766:245-252.
Ben-Neriah, Y., Alkalay, I., Yaron, A., Hatzubai, A. and S. Jung. (1995) "Signalling Intermediates of CD28." Research in Immunology, Institut Pasteur, (61^st Forum in Immunology)
Jung, S. and D.R. Littman. "Chemokine receptors in lymphoid organ homeostasis." Curr Opin Immunol. 1999 Jun;11(3):319-25.
Jung, S. "Good, bad and beautiful - the role of dendritic cells in autoimmunity." (2004) Autoimmunity Reviews 3:54.
Varol, C, Landsman, L. and S. Jung. "Probing In Vivo Origins of Mononuclear Phagocytes by Conditional Ablation and Reconstitution." Methods in Molecular Biology, Humana Press, 2009;531:71-87.
Sapoznikov A. and S. Jung. Probing in vivo dendritic cell functions by conditional cell ablation. Immunol. Cell Biol. 2008 86(5):409-15.
Bar-On L. and S. Jung. Defining in vivo Dendritic cell functions using CD11c-DTR transgenic mice. Methods in Molecular Biology, 2010;595:429-42.
Varol H., Yona, S. and S. Jung. Origins and Tissue-context dependent Fates of Blood Monocytes. Immunol. Cell Biol. 2008 87(1):30-8.
Yona, S. and S. Jung. Monocytes: Subsets, Origins, Fates and Functions. Current Opinion in Hematology 2010 17(1):53-9.