Weizmann Institute of Science Archives
Pioneer Scientists
Prof. Ephraim Katzir-Katchalsky
1916-2009
Prof. Ephraim Katzir was born in Kiev in 1916. His family immigrated to British-ruled Palestine when he was six years old, and he grew up in Jerusalem. Following high school in Jerusalem, he enrolled in the Hebrew University of Jerusalem where he studied botany, zoology and bacteriology before finally concentrating on biochemistry and organic chemistry. In 1941 he completed his Ph.D. thesis on simple synthetic polymers of amino acids, and continued his education at the Polytechnic Institute of Brooklyn, Columbia University and Harvard University.
Like other students at the time, Ephraim Katzir was a member of the Haganah, the underground Jewish defense organization. Later Katzir became deeply involved in the Israel Army's Science Corps, Hemed, founded at the start of the 1948 War of Independence, and for a time commanded it.
Professor Katzir was one of the founding scientists of the Weizmann Institute of Science in 1949, an institution with which he was associated throughout his professional career, both before and after serving as President. As founder and head of the Institute's Biophysics Department, his pioneering studies in proteins contributed to the deciphering of the genetic code, the production of synthetic antigens, and the clarification of the various steps of immune responses.
Katzir also developed a method for binding enzymes, which speed up numerous chemical processes, to a variety of surfaces and molecules. This method laid the foundation for what is now called enzyme engineering, which plays an important part in the food and pharmaceutical industries. His pioneering work on immobilized enzymes used in oral antibiotics, for which he received the Japan Prize in 1985, has revolutionized a number of industries as well as medical research.
Along with his scientific research, Professor Katzir was profoundly involved in the social and educational aspects of science. He headed a governmental committee for the formulation of a national scientific policy, trained a generation of younger scientists, translated important material into Hebrew, and helped to establish a popular science magazine. He served as Chief Scientist of the Israel Defense Ministry, Chairman of the Society for the Advancement of Science in Israel, the Israel Biochemical Society, the National Council for Research and Development, and the Council for the Advancement of Science Education. He headed the National Biotechnology Council, and was President of the World ORT Union - a network of vocational schools.
In 1973 Katzir was elected by the Knesset to serve as fourth President of the State of Israel. His term in office began in May just four months prior to the outbreak of the Yom Kippur War. Additionally, it was exactly a year after the tragic death of his brother, Professor Aharon Katzir, who was murdered in the May 1972 terrorist attack at Ben-Gurion Airport. In November 1977 he hosted President Anwar Sadat of Egypt in the first-ever official visit of an Arab head of state.
Ephraim Katzir retired from the Presidency in May 1978 to return to scientific research at the Weizmann Institute and was named Institute Professor, a prestigious title awarded by Weizmann faculty and administration to outstanding scientists who made significant and meaningful contributions to science or to the State of Israel. He also devoted himself to the promotion of biotechnological research in Israel, and founded the Department of Biotechnology at Tel-Aviv University.
Prof. Katzir was a member of the Israeli Academy of Sciences and Humanities, and of numerous other learned bodies in Israel and abroad, including The Royal Institution of Great Britain, The Royal Society of London, the National Academy of Sciences of the United States, the Academie des sciences in France, the Scientific Academy of Argentina, and the World Academy of Art and Science. He was visiting professor at Harvard University, Rockefeller University, University of California at Los Angeles, and Battelle Seattle Research Center.
Furthermore, Katzir was awarded the Rothschild and Israel Prizes in Natural Sciences, the Weizmann Prize, the Linderstrom Land Gold Medal, the Hans Krebs Medal, the Tchernikhovski Prize for scientific translations, the Alpha Omega Achievement Medal, and the Engineering Foundation's International Award in Enzyme Engineering. He was the first recipient of the Japan Prize, and was appointed to France's Order of Legion of Honor. He received honorary doctorates from more than a dozen institutions of higher learning in Israel and worldwide, including Harvard University, Northwestern University, McGill University, University of Oxford and the Technion-Israel Institute of Technology.Fields of Research
· Physicochemical and biological properties of native proteins
· Methods for binding enzymes, immobilized enzymes
· Factors determining biological recognition by proteins
· Developing fields of molecular biology and biotechnology in Israel
Selected Awards and Honorary Degrees
1950 Weizmann Prize
1959 Israel Prize, Life Sciences
1961 Rothschild Prize
1985 Japan Prize
Selected Publications
Link to Scopus database
Documents Preserved at the WIS Archives
Prof. Katzir’s archive, including documents, letters, protocols, lectures, scientific documentation, newspaper notes, photos and multimedia, is treasured and preserved at the Weizmann Institute Archives.
Selected Archival Documents A letter from Moshe Dayan, 1969 Doctor of Science-Jefferson Medical College, 1981 Selected Bibliography
E. Katchalski-Katzir. My Contributions to Science and Society, JBC Centennial 1905–2005, 100 Years of Biochemistry and Molecular Biology E. Katchalski-Katzir. My life in and beyond the laboratory, Annu. Rev. Biophys. Biomol. Struct., Vol. 24 (1-30), 1995 N. Sharon and I. Silman. Ephraim Katchalski-Katzir – Portrait of an Israeli Scientist. Biotechnological applications of proteins and enzymes, New York : Academic Press, 1977 W. J. Whelan. Scientist and Statesman: Ephraim Katchalski-Katzir at 80, FASEB J., Vol. 10 (1223-1234), 1996