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Adhesion to the extracellular matrix (ECM) or to neighboring cells regulates multiple cellular processes such as cell migration, morphogenesis, proliferation, gene expression and survival. Activation of these responses involves specific interaction of membranebound adhesion receptors with the external surface, sensing its chemical, topographic and mechanical features, activation of specific signaling networks and assembly of multi-protein adhesion complexes at the contact site. Topics addressed by different members of the group include: |
