Selected Publications

• Lev, S., Hernandez, J., Martinez, R., Chen, A., Plowman, G.D., and J. Schlessinger. (1999) Identification of a novel family of targets of PYK2 related to Drosophila Retinal Degeneration B (rdgB) protein. Mol. Cell. Biol., 19, 2278-2288.
• Tian, D., Litvak, V. and Lev, S. (2000) Cerebral ischemia and seizures induce tyrosine phosphorylation of PYK2 in neurons and microglial cells. J. Neurosci., 20, 6478-6487.
• Tian, D., Litvak, V., Toledo-Rodriguez, M., Carmon, S., and Lev, S. (2002) Nir2, a novel regulator of cell morphogenesis. Mol. Cell. Biol., 22, 2650-2288.
• Tian, D., and Lev, S. (2002) Cellular and Developmental Distribution of Human Homologues of the Drosophilia rdgB Protein in the Rat Retina. Invest. Ophthalmol. Vis. Sci., 43(6), 1946-1953.
• Litvak, V., Tian, D., Carmon. S, and Lev, S. (2002) Nir2, a human homolog of the Drosophila rdgB, is essential for cytokinesis. Mol. Cell. Biol., 22, 5064-5075.
• Litvak, V., Shaul, D.Y., Shulewitz, M., Amarilio, R., Carmon, S., and Lev, S. (2002) Targeting of Nir2 to lipid droplets is regulated by a specific threonine residue within its PI-transfer domain. Current Biology, 12 (17), 1513-1518.
• Litvak, V., Argov, R., Dahan, N., Ramachandran, S., Amarilio, R., Shainskaya. A, and Lev, S. (2004) Mitotic phosphorylation of the peripheral Golgi protein Nir2 by Cdk1 provides a docking mechanism for Plk1 and affects cytokinesis completion. Molecular Cell., 14, 319-330.
• Lev, S. (2004) The role of the Nir/rdgB protein family in membrane trafficking and cytoskeleton remodeling. Exper. Cell Res., 297(1), 1-10.
• Amarilio, R., Ramachandran, S., Sabanay, H., and Lev, S. (2005) Differential regulation of ER structure through VAP-Nir protein interaction. J. Biol. Chem., 280(7), 5934-5944.
• Litvak, V., Dahan, N., Ramachandran, S,. Sabanay, H., and Lev, S. (2005) Maintenance of the diacylglycerol level in the Golgi apparatus by the Nir2 protein is critical for Golgi secretory function. Nature Cell Biology, 7(3), 225-234.
• Lev, S. (2006) Lipid Homeostasis and Golgi Secretory Function. Biochem. Soc. Trans., 34(Pt 3):363-366.
• Peretti, D., Dahan, N., Shimoni, E., Hirschberg, K., Lev, S. (2008). Coordinated lipid transfer between the endoplasmic reticulum and the Golgi complex requires the VAP proteins and is essential for Golgi-mediated transport. Mol. Biol. Cell., 19(9):3871-3884.
• Lev, S., Ben Halevy, D., Peretti, D., Dahan, N. (2008) The VAP protein family: from cellular functions to motor-neuron disease. Trends Cell Biology, 18, 282-290.
• Laufman O, Kedan A, Hong W and Lev S. (2009) Direct interaction between the COG complex and the SM protein, Sly1, is required for Golgi SNARE pairing. EMBO J., 28: 2006-2017.
• Kim, S., Leal, S.S., Ben Halevy, D., Gomes, C.M., and Lev, S. (2010) Structural requirements for VAP-B oligomerization and their implication in ALS-associated VAP-B(P56S) neurotoxicity. J. Biol. Chem. In press.
• Kim, S., Leal, S.S., Ben Halevy, D., Gomes, C.M., and Lev, S. (2010) Structural requirements for VAP-B oligomerization and their implication in ALS-associated VAP-B(P56S) neurotoxicity. J. Biol. Chem., 285(18):13839-13849.
• Lev, S., (2010) Non-Vesicular lipid trafficking by lipid-transfer proteins and beyond. Nature Reviews Molecular Cell Biology, 11, 739-750.
• Laufman O, Hong W, Lev S. The COG complex interacts directly with Syntaxin 6 and positively regulates endosome-to-TGN retrograde transport. J Cell Biol., 2011 Aug 8;194(3):459-72.