The main goals of our laboratory are to elucidate the biochemical and biological processes that underlie the ability of p53 to act as a tumor suppressor, and more broadly, to explore the mechanistic links between regulation of gene expression and cancer.
In addition, we are also interested in
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Mdm2 - an oncogene whose protein products inhibit the biochemical activity of p53 and target p53 for rapid degradation
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ARF - a tumor suppressor that can trigger p53 activation in cancer-prone cells
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Lats2 - another tumor suppressor that links p53 activation to oncogenic processes and to regulation of genome stability
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Mutant p53 Gain of Function, by which the mutated protein acquires additional pro-oncogenic functions
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RNF20 - an enzyme responsible for ubiquitination of histone H2B, which acts as a putative tumor suppressor through selective regulation of gene expression
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microRNAs - small non-coding RNAs, whose aberrant expression is broadly involved in cancer