Publications

Blandino G, Deppert W, Hainaut P, Levine A, Lozano G, Olivier M, Rotter V, Wiman K, Oren M,. 2012 Mutant p53 Protein, Master Regulator of Human Malignancies: a Report on the Fifth Mutant p53 Workshop. Cell Death and Differentiation, 19: 180-183
Golomb L, Bublik DR, Wilder S, Nevo R, Kiss V, Grabusic K, Volarevic S, Oren M,. 2012 Importin 7 and Exportin 1 Link c-Myc and p53 to Regulation of Ribosomal Biogenesis. Molecular Cell, 45: 222-232
Zwang Y, Oren M, Yarden Y,. 2012 Consistency Test of the Cell Cycle: Roles For p53 and Egr1. Cancer Research, 72: 1051-1054
Bublik DR, Oren M,. 2012 Get Your Fingers Out of p53's Way!. Embo Reports, 13: 282-283
Hornung G, Oren M, Barkai N. 2012 Nucleosome Organization Affects the Sensitivity of Gene Expression to Promoter Mutations . Molecular Cell, 46: 362-368 Html link to full text
Fuchs G, Shema E, Vesterman R, Kotler E, Wolchinsky Z, Wilder S, Golomb L, Pribluda A, Zhang F, Haj-Yahya M, Feldmesser E, Brik A, YU X, Hanna J, Aberdam D, Domany E, Oren M. 2012 Rnf20 and Usp44 Regulate Stem Cell Differentiation by Modulating H2b Monoubiquitylation. Molecular Cell, 46: 662-673 Html link to full text
Ben-Neriah Y, Pribluda A, Elyada E, Snir-Alkalay I, Pikarsky E, Oren M, Wiener Z, Alitalo K. 2012 Inflammatory Control of Colorectal Cancer Progression. Immunology, 137: 158
Haj-Yahya M, Eltarteer N, Ohayon S, Shema E, Kotler E, Oren M, Brik A,. 2012 N-Methylation of Isopeptide Bond as a Strategy to Resist Deubiquitinases. Angewandte Chemie-International Edition, 51: 11535-11539
Hornung G, Bar-Ziv R, Rosin D, Tokuriki N, Tawfik DS, Oren M, Barkai N,. 2012 Noise-Mean Relationship in Mutated Promoters. Genome Research, 22: 2409-2417
Schmid JO, Dong M, Haubeiss S, Friedel G, Oren M, Murdter T, Aulitzky WE, Van Der Kuip H. 2012 Crosstalk of Cancer Cells and Cancer Associated Fibroblasts in the p53 Response to Cisplatin in Intact Tissues From Nsclc Specimen. Onkologie, 35: 135
Schmid JO, Dong M, Haubeiss S, Friedel G, Bode S, Grabner A, Ott G, Murdter TE, Oren M, Aulitzky WE, Van Der Kuip H,. 2012 Cancer Cells Cue the p53 Response of Cancer-Associated Fibroblasts to Cisplatin. Cancer Research, 72: 5824-5832
Weilbacher A, Gutekunst M, Oren M, Aulitzky W, Van Der Kuip H,. 2012 Differential Effect of the p53 Inducers Nutlin-3 and Rita on Cell Lines With Different p53 Status. Onkologie, 35: 195-196
Bursac S, Brdovcak MC, Pfannkuchen M, Orsolic I, Golomb L, Zhu Y, Katz C, Daftuar L, Grabusic K, Vukelic I, Filic V, Oren M, Prives C, Volarevic S,. 2012 Mutual Protection of Ribosomal Proteins l5 and L11 From Degradation is Essential For p53 Activation Upon Ribosomal Biogenesis Stress. Proceedings of the National Academy of Sciences of the United States of America, 109: 20467-20472
Goldstein I, Marcel V, Olivier M, Oren M, Rotter V, Hainaut P,. 2011 Understanding Wild-Type and Mutant p53 Activities in Human Cancer: New Landmarks on the Way to Targeted Therapies. Cancer Gene Therapy, 18: 2-11
Okada N, Yabuta N, Suzuki H, Aylon Y, Oren M, Nojima H,. 2011 A Novel Chk1/2-Lats2-14-3-3 Signaling Pathway Regulates p-Body Formation in Response to uv Damage. Journal of Cell Science, 124: 57-67
Aylon Y, Oren M,. 2011 New Plays in the p53 Theater. Current Opinion in Genetics & Development, 21: 86-92
Elyada E, Pribluda A, Goldstein RE, Morgenstern Y, Brachya G, Cojocaru G, Snir-Alkalay I, Burstain I, Haffner-Krausz R, Jung S, Wiener Z, Alitalo K, Oren M, Pikarsky E, Ben-Neriah Y,. 2011 Cki Alpha Ablation Highlights a Critical Role For p53 in Invasiveness Control. Nature, 470: 409-U208
Moyal L, Lerenthal Y, Gana-Weisz M, Mass G, SO S, Wang SY, Eppink B, Chung YM, Shalev G, Shema E, Shkedy D, Smorodinsky NI, Van Vliet N, Kuster B, Mann M, Ciechanover A, Dahm-Daphi J, Kanaar R, HU Mct, Chen DJ, Oren M, Shiloh Y,. 2011 Requirement of Atm-Dependent Monoubiquitylation of Histone H2b For Timely Repair of DNA Double-Strand Breaks. Molecular Cell, 41: 529-542
Gutekunst M, Oren M, Weilbacher A, Dengler MA, Markwardt C, Thomale J, Aulitzky WE, Van Der Kuip H. 2011 p53 Hypersensitivity is the Predominant Mechanism of the Unique Responsiveness of Testicular Germ Cell Tumor (Tgct) Cells to Cisplatin. PLoS ONE, 6
Dell'Orso S, Fontemaggi G, Stambolsky P, Goeman F, Voellenkle C, Levrero M, Strano S, Rotter V, Oren M, Blandino G,. 2011 Chip-on-Chip Analysis of in Vivo Mutant p53 Binding to Selected Gene Promoters. Omics-a Journal of Integrative Biology, 15: 305-312
Shema E, Kim J, Roeder RG, Oren M,. 2011 Rnf20 Inhibits Tfiis-Facilitated Transcriptional Elongation to Suppress Pro-Oncogenic Gene Expression. Molecular Cell, 42: 477-488
Zwang YR, Sas-Chen A, Drier Y, Shay T, Avraham R, Lauriola M, Shema E, Lidor-Nili E, Jacob-Hirsch J, Amariglio N, LU YL, Mills GB, Rechavi G, Oren M, Domany E, Yarden Y,. 2011 Two Phases of Mitogenic Signaling Unveil Roles For p53 and Egr1 in Elimination of Inconsistent Growth Signals. Molecular Cell, 42: 524-535
Shema E, Oren M, Minsky N,. 2011 Detection and Characterization of Ubiquitylated H2b in Mammalian Cells. Methods, 54: 326-330
Tarocchi M, Hannivoort R, Hoshida Y, Lee UE, Vetter D, Narla G, Villanueva A, Oren M, Llovet JM, Friedman SL,. 2011 Carcinogen-Induced Hepatic Tumors in Klf6+/- Mice Recapitulate Aggressive Human Hepatocellular Carcinoma Associated With p53 Pathway Deregulation. Hepatology, 54: 522-531
Furth N, Oren M,. 2011 An Aurora a-Lats-Aurora b Axis Ensures Proper Chromosome Segregation. Cell Cycle, 10: 3054-3055
Aylon Y, Oren M,. 2011 p53: Guardian of Ploidy. Molecular Oncology, 5: 315-323
Golomb L, Oren M,. 2011 Depicting p53 Activation: a New Nucleolar Link to Cancer. Cancer Cell, 20: 283-284
Oren M, Aylon Y, Shema E, Fuchs G,. 2011 Tumour Suppressor Networks: Lessons From p53. European Journal of Cancer, 47: S54-S55
Shiloh Y, Shema E, Moyal L, Oren M,. 2011 Rnf20-Rnf40: a Ubiquitin-Driven Link Between Gene Expression and the DNA Damage Response. Febs Letters, 585: 2795-2802
Christoffersen NR, Shalgi R, Frankel LB, Leucci E, Lees M, Klausen M, Pilpel Y, Nielsen FC, Oren M, Lund AH,. 2010 p53-Independent Upregulation of Mir-34a During Oncogene-Induced Senescence Represses Myc. Cell Death and Differentiation, 17: 236-245
Bar J, Moskovits N, Oren M,. 2010 Involvement of Stromal p53 in Tumor-Stroma Interactions. Seminars in Cell & Developmental Biology, 21: 47-54
Oren M, Cooks T,. 2010 Nf Kappa b and p53: a Life and Death Affair. Cell Cycle, 9: 1027
Stambolsky P, Tabach Y, Fontemaggi G, Weisz L, Maor-Aloni R, Sigfried Z, Shiff I, Kogan I, Shay M, Kalo E, Blandino G, Simon I, Oren M, Rotter V,. 2010 Modulation of the Vitamin D3 Response by Cancer-Associated Mutant p53. Cancer Cell, 17: 273-285
Schilling T, Kairat A, Melino G, Krammer PH, Stremmel W, Oren M, Muller M,. 2010 Interference With the p53 Family Network Contributes to the Gain of Oncogenic Function of Mutant p53 in Hepatocellular Carcinoma. Biochemical and Biophysical Research Communications, 394: 817-823
Shalgi R, Pilpel Y, Oren M,. 2010 Repression of Transposable-Elements - a Microrna Anti-Cancer Defense Mechanism?. Trends in Genetics, 26: 253-259
Oren M, Rotter V. 2010 Mutant p53 Gain-of-Function in Cancer. Cold Spring Harbor Perspectives in Biology, 2: 16 pp.
Nili EL, Field Y, Lubling Y, Widom J, Oren M, Segal E,. 2010 p53 Binds Preferentially to Genomic Regions With High DNA-Encoded Nucleosome Occupancy. Genome Research, 20: 1361-1368
Aylon Y, Ofir-Rosenfeld Y, Yabuta N, Lapi E, Nojima H, LU X, Oren M,. 2010 The Lats2 Tumor Suppressor Augments p53-Mediated Apoptosis by Promoting the Nuclear Proapoptotic Function of Aspp1. Genes & Development, 24: 2420-2429
Scherz-Shouval R, Weidberg H, Gonen C, Wilder S, Elazar Z, Oren M,. 2010 p53-Dependent Regulation of Autophagy Protein Lc3 Supports Cancer Cell Survival Under Prolonged Starvation. Proceedings of the National Academy of Sciences of the United States of America, 107: 18511-18516
Addadi Y, Moskovits N, Granot D, Lozano G, Carmi Y, Apte RN, Neeman M, Oren M,. 2010 p53 Status in Stromal Fibroblasts Modulates Tumor Growth in an Sdf1-Dependent Manner. Cancer Research, 70: 9650-9658
Oren M,. 2010 p53 and Cancer: a Complex Affair. Ejc Supplements, 8: 315 -
Bar J, Feniger-Barish R, Lukashchuk N, Shaham H, Moskovits N, Goldfinger N, Simansky D, Perlman M, Papa M, Yosepovich A, Rechavi G, Rotter V, Oren M,. 2009 Cancer Cells Suppress p53 in Adjacent Fibroblasts. Oncogene, 28: 933-936
Galluzzi L, Aaronson SA, Abrams J, Alnemri ES, Andrews DW, Baehrecke EH, Bazan NG, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Castedo M, Cidlowski JA, Ciechanover A, Cohen GM, DE Laurenzi V, DE Maria R, Deshmukh M, Dynlacht BD, EL-Deiry WS, Flavell RA, Fulda S, Garrido C, Golstein P, Gougeon ML, Green DR, Gronemeyer H, Hajnoczky G, Hardwick JM, Hengartner MO, Ichijo H, Jaattela M, Kepp O, Kimchi A, Klionsky DJ, Knight RA, Kornbluth S, Kumar S, Levine B, Lipton SA, Lugli E, Madeo F, Malorni W, Marine Jcw, Martin SJ, Medema JP, Mehlen P, Melino G, Moll UM, Morselli E, Nagata S, Nicholson DW, Nicotera P, Nunez G, Oren M, Penninger J, Pervaiz S, Peter ME, Piacentini M, Prehn Jhm, Puthalakath H, Rabinovich GA, Rizzuto R, Rodrigues Cmp, Rubinsztein DC, Rudel T, Scorrano L, Simon HU, Steller H, Tschopp J, Tsujimoto Y, Vandenabeele P, Vitale I, Vousden KH, Youle RJ, Yuan J, Zhivotovsky B, Kroemer G,. 2009 Guidelines For the Use and Interpretation of Assays For Monitoring Cell Death in Higher Eukaryotes. Cell Death and Differentiation, 16: 1093-1107
Pirngruber J, Shchebet A, Schreiber L, Shema E, Minsky N, Chapman RD, Eick D, Aylon Y, Oren M, Johnsen SA,. 2009 Cdk9 Directs H2b Monoubiquitination and Controls Replication-Dependent Histone Mrna 3 '-End Processing. Embo Reports, 10: 894-900
Schilling T, Schleithoff ES, Kairat A, Melino G, Stremmel W, Oren M, Krammer PH, Muller M,. 2009 Active Transcription of the Human Fas/Cd95/Tnfrsf6 Gene Involves the p53 Family. Biochemical and Biophysical Research Communications, 387: 399-404
Bar J, Feniger-Barish R, Moskovits N, Lukashchuk N, Goldfinger N, Rotter V, Goss G, Oren M,. 2009 Cancer Cells Suppress p53 in Adjacent Fibroblasts. Journal of Thoracic Oncology, 4: S605
Levine AJ, Oren M,. 2009 The First 30 Years of p53: Growing Ever More Complex. Nature Reviews Cancer, 9: 749-758
Aylon Y, Yabuta N, Besserglick H, Buganim Y, Rotter V, Nojima H, Oren M,. 2009 Silencing of the Lats2 Tumor Suppressor Overrides a p53-Dependent Oncogenic Stress Checkpoint and Enables Mutant h-Ras-Driven Cell Transformation. Oncogene, 28: 4469-4479
Skorta I, Oren M, Markwardt C, Gutekunst M, Aulitzky WE, Van Der Kuip H,. 2009 Imatinib Mesylate Induces Cisplatin Hypersensitivity in Bcr-Abl(+) Cells by Differential Modulation of p53 Transcriptional and Proapoptotic Activity. Cancer Research, 69: 9337-9345
Shalgi R, Brosh R, Oren M, Pilpel Y, Rotter V,. 2009 Coupling Transcriptional and Post-Transcriptional miRNA Regulation in the Control of Cell Fate. Aging-us, 1: 762-770
Lavelin I, Beer A, Kam Z, Boner V, Oren M, Navon A, Geiger B. 2009 Discovery of Novel Proteasome Inhibitors Using a High-Content Cell-Based Screening System. PLoS ONE, 4: 8 pp.
Minsky N, Shema E, Field Y, Schuster M, Segal E, Oren M,. 2008 Monoubiquitinated H2b is Associated With the Transcribed Region of Highly Expressed Genes in Human Cells. Nature Cell Biology, 10: 483-490
Abe Y, Oda-Sato E, Tobiume K, Kawauchi K, Taya Y, Okamoto K, Oren M, Tanaka N,. 2008 Hedgehog Signaling Overrides p53-Mediated Tumor Suppression by Activating Mdm2. Proceedings of the National Academy of Sciences of the United States of America, 105: 4838-4843
Bossi G, Marampon F, Maor-Aloni R, Zani B, Rotter V, Oren M, Strano S, Blandino G, Sacchi A,. 2008 Conditional RNA Interference in Vivo to Study Mutant p53 Oncogenic Gain of Function on Tumor Malignancy. Cell Cycle, 7: 1870-1879
Finkin S, Aylon Y, Anzi S, Oren M, Shaulian E,. 2008 Fbw7 Regulates the Activity of Endoreduplication Mediators and the p53 Pathway to Prevent Drug-Induced Polyploidy. Oncogene, 27: 4411-4421
Shema E, Tirosh I, Aylon Y, Huang J, YE CY, Moskovits N, Raver-Shapira N, Minsky N, Pirngruber J, Tarcic G, Hublarova P, Moyal L, Gana-Weisz M, Shiloh Y, Yarden Y, Johnsen SA, Vojtesek B, Berger SL, Oren M,. 2008 The Histone H2b-Specific Ubiquitin Ligase Rnf20/Hbre1 Acts as a Putative Tumor Suppressor Through Selective Regulation of Gene Expression. Genes & Development, 22: 2664-2676
Ofir-Rosenfeld Y, Boggs K, Michael D, Kastan MB, Oren M,. 2008 Mdm2 Regulates p53 Mrna Translation Through Inhibitory Interactions With Ribosomal Protein L26. Molecular Cell, 32: 180-189
Brosh R, Shalgi R, Liran A, Landan G, Korotayev K, Nguyen GH, Enerly E, Johnsen H, Buganim Y, Solomon H, Goldstein I, Madar S, Goldfinger N, Brresen-Dale AL, Ginsberg D, Harris CC, Pilpel Y, Oren M, Rotter V,. 2008 p53-Repressed Mirnas Are Involved With E2f in a Feed-Forward Loop Promoting Proliferation. Molecular Systems Biology, 4
Weisz L, Damalas A, Liontos M, Karakaidos P, Fontemaggi G, Maor-Aloni R, Kalis M, Levrero M, Strano S, Gorgoulis VG, Rotter V, Blandino G, Oren M,. 2007 Mutant p53 Enhances Nuclear Factor Kappa b Activation by Tumor Necrosis Factor Alpha in Cancer Cells. Cancer Research, 67: 2396-2401
Oren M, Bartek J,. 2007 The Sunny Side of p53. Cell, 128: 826-828
Shmueli A, Oren M,. 2007 Mdm2: p53's Lifesaver?. Molecular Cell, 25: 794-796
Weisz L, Oren M, Rotter V,. 2007 Transcription Regulation by Mutant p53. Oncogene, 26: 2202-2211
Raver-Shapira N, Marciano E, Meiri E, Spector Y, Rosenfeld N, Moskovits N, Bentwich Z, Oren M,. 2007 Transcriptional Activation of Mir-34a Contributes to p53-Mediated Apoptosis. Molecular Cell, 26: 731-743
Aylon Y, Oren M,. 2007 Living With p53, Dying of p53. Cell, 130: 597-600
Germann M, Rentsch CA, Wetterwald A, Schwaninger R, Voller M, Rotter V, Oren M, Schalken J, Thalmann GN, Cecchini MG,. 2007 Differential Expression of the Tsc22 Domain Family of Transcription Factors in Normal Prostate and Prostate Cancer. Bju International, 100: 26
Shalgi R, Lieber D, Oren M, Pilpel Y. 2007 Global and Local Architecture of the Mammalian Microrna-Transcription Factor Regulatory Network. Plos Computational Biology, 3: 1291-1304
LU XB, MA O, Nguyen TA, Joness SN, Oren M, Donehower LA. 2007 The Wip1 Phosphatase Acts as a Gatekeeper in the p53-Mdm2 Autoregulatory Loop. Cancer Cell, 12: 342-354
Reef S, Shifman O, Oren M, Kimchi A,. 2007 The Autophagic Inducer smARF Interacts With and is Stabilized Bythe Mitochondrial p32 Protein. Oncogene, 26: 6677-6683
Lantner F, Starlets D, Gore Y, Flaishon L, Yamit-Hezi A, Dikstein R, Leng L, Bucala R, Machluf Y, Oren M, Shachar I,. 2007 Cd74 Induces Tap63 Expression Leading to B-Cell Survival. Blood, 110: 4303-4311
Raver-Shapira N, Oren M,. 2007 Tiny Actors, Great Roles - Micrornas in p53's Service. Cell Cycle, 6: 2656-2661
Skorta I, Van Der Kuip H, Henkes M, Oren M, Aulitzky WE,. 2007 Combination of Imatinib With Cisplatin and Nutlin-3: Functional and Molecular Effects on Bcr-Abl Positive Cells. Blood, 110: 868A
Margalit O, Amram H, Amariglio N, Simon AJ, Shaklai S, Granot G, Minsky N, Shimoni A, Harmelin A, Givol D, Shohat M, Oren M, Rechavi G,. 2006 Bcl6 is Regulated by p53 Through a Response Element Frequently Disrupted in B-Cell Non-Hodgkin Lymphoma. Blood, 107: 1599-1607
Zalcenstein A, Weisz L, Stambolsky P, Bar J, Rotter V, Oren M. 2006 Repression of the Msp/Mst-1 Gene Contributes to the Antiapoptotic Gain of Function of Mutant p53. Oncogene, 25: 359-369
Kogan I, Goldfinger N, Milyavsky M, Cohen M, Shats I, Dobler G, Klocker H, Wasylyk B, Voller M, Aalders T, Schalken JA, Oren M, Rotter V. 2006 Htert-Immortalized Prostate Epithelial and Stromal-Derived Cells: an Authentic in Vitro Model For Differentiation and Carcinogenesis. Cancer Research, 66: 3531-3540
Reef S, Zalckvar E, Shifman O, Bialik S, Sabanay H, Oren M, Kimchi A,. 2006 A Short Mitochondrial Form of p19(Arf) Induces Autophagy and Caspase-Independent Cell Death. Molecular Cell, 22: 463-475
Avkin S, Sevilya Z, Toube L, Geacintov N, Chaney SG, Oren M, Livneh Z,. 2006 p53 and p21 Regulate Error-Prone DNA Repair to Yield a Lower Mutation Load. Molecular Cell, 22: 407-413
Scherz Z, Oren M,. 2006 How to Change Students' Images of Science and Technology. Science Education, 90: 965-985
Stambolsky P, Weisz L, Shats I, Klein Y, Goldfinger N, Oren M, Rotter V,. 2006 Regulation of Aif Expression by p53. Cell Death and Differentiation, 13: 2140-2149
Rentsch CA, Germann M, Wetterwald A, Schwaninger R, Voller M, Rotter V, Oren M, Schalken JA, Studer UE, Thalmann GN, Cecchini MG,. 2006 Transforming Growth Factor Stimulated Clone 22 (Tsc-22): Potential Tumor Suppressive Role in Prostate Cancer and Novel Prostate Basal Cell Marker. European Urology Supplements, 5: 790
Aylon Y, Michael D, Shmueli A, Yabuta N, Nojima H, Oren M,. 2006 A Positive Feedback Loop Between the p53 and Lats2 Tumor Suppressors Prevents Tetraploidization. Genes & Development, 20: 2687-2700
Moskovits N, Kalinkovich A, Bar J, Lapidot T, Oren M,. 2006 p53 Attenuates Cancer Cell Migration and Invasion Through Repression of Sdf-1/Cxcl12 Expression in Stromal Fibroblasts. Cancer Research, 66: 10671-10676
Oren M. 2006 Tumor Suppression by p53: Inside and Outside the Cancer Cell. Ejc Supplements, 4: 76
Wohlbold L, Van Der Kuip H, Moehring A, Granot G, Oren M, Vornlocher HP, Aulitzky WE. 2005 All Common p210 and p190 Bcr-Abl Variants Can be Targeted by RNA Interference. Leukemia, 19: 290-292
Hershko T, Chaussepied M, Oren M, Ginsberg D. 2005 Novel Link Between E2f and p53: Proapoptotic Cofactors of p53 Are Transcriptionally Upregulated by E2f. Cell Death and Differentiation, 12: 377-383
Oberst A, Rossi M, Salornoni P, Pandolfi PP, Oren M, Melino G, Bernassola F. 2005 Regulation of the p73 Protein Stability and Degradation. Biochemical and Biophysical Research Communications, 331: 707-712
Shmueli A, Oren M. 2005 Life, Death, and Ubiquitin: Taming the Mule. Cell, 121: 963-965
Gressner O, Schilling T, Lorenz K, Schleithoff ES, Koch A, Schulze-Bergkamen H, Lena AM, Candi E, Terrinoni A, Catani MV, Oren M, Melino G, Krammer PH, Stremmel W, Muller M. 2005 Tap63 Alpha Induces Apoptosis by Activating Signaling Via Death Receptors and Mitochondria. EMBO Journal, 24: 2458-2471
Margalit O, Amram H, Amariglio N, Simon AJ, Granot G, Minsky N, Shaklai S, Shimoni A, Harmelin A, Givol D, Shohat M, Oren M, Rechavi G. 2005 Bcl6 is Regulated by p53 Through a Response Element Frequently Disrupted in B-Cell Non-Hodgkin's Lymphoma.. Blood, 106: 50A-50A
Muller M, Schilling T, Sayan AE, Kairat A, Lorenz K, Schulze-Bergkamen H, Oren M, Koch A, Tannapfel A, Stremmel W, Melino G, Krammer PH. 2005 Tap73/Delta Np73 Influences Apoptotic Response, Chemosensitivity and Prognosis in Hepatocellular Carcinoma. Cell Death and Differentiation, 12: 1564-1577
Bar J, Lukaschuk N, Zalcenstein A, Wilder S, Seger R, Oren M. 2005 The Pi3k Inhibitor Ly294002 Prevents p53 Induction by DNA Damage and Attenuates Chemotherapy-Induced Apoptosis. Cell Death and Differentiation, 12: 1578-1587
Daniely Y, Liao G, Dixon D, Linnoila RI, Lori A, Randell SH, Oren M, Jetten AM. 2004 Critical Role of p63 in the Development of a Normal Esophageal and Tracheobronchial Epithelium. American Journal of Physiology-Cell Physiology, 287: C171-C181
Fiucci G, Beaucourt S, Duflaut D, Lespagnol A, Stumptner-Cuvelette P, Geant A, Buchwalter G, Tuynder M, Susini L, Lassalle JM, Wasylyk C, Wasylyk B, Oren M, Amson R, Telerman A. 2004 Siah-1b is a Direct Transcriptional Target of p53: Identification of the Functional p53 Responsive Element in the Siah-1b Promoter. Proceedings of the National Academy of Sciences of the United States of America, 101: 3510-3515
Wang XJ, Taplick J, Geva N, Oren M. 2004 Inhibition of p53 Degradation by Mdm2 Acetylation. Febs Letters, 561: 195-201
Bar J, Cohen-Noyman E, Geiger B, Oren M. 2004 Attenuation of the p53 Response to DNA Damage by High Cell Density. Oncogene, 23: 2128-2137
Shmueli A, Oren M. 2004 Regulation of p53 by Mdm2: Fate is in the Numbers. Molecular Cell, 13: 4-5
Boese AD, Oren M, Atasoylu O, Martin Jml, Kallay M, Gauss J. 2004 W3 Theory: Robust Computational Thermochemistry in the kj/Mol Accuracy Range. Journal of Chemical Physics, 120: 4129-4141
Levina E, Oren M, Ben-Ze'ev A. 2004 Downregulation of Beta-Catenin by p53 Involves Changes in the Rate of Beta-Catenin Phosphorylation and Axin Dynamics. Oncogene, 23: 4444-4453
Oren M, Lidor E, Minsky N, Stambolsky P, Taplick J, Wang XJ, Weisz L, Zalcenstein A, Rotter V. 2004 The Role of p53 in DNA Damage Response and Apoptosis. Toxicology and Applied Pharmacology, 197: 166-167
Oren M, Iron MA, Burcat A, Martin Jml. 2004 Thermodynamic Properties of c-1 and c-2 Bromo Compounds and Radicals. a Relativistic ab Initio Study. Journal of Physical Chemistry A, 108: 7752-7761
Minsky N, Oren M. 2004 The Ring Domain of Mdm2 Mediates Histone Ubiquitylation and Transcriptional Repression. Molecular Cell, 16: 631-639
Weisz L, Zalcenstein A, Stambolsky P, Cohen Y, Goldfinger N, Oren M, Rotter V. 2004 Transactivation of the Egr1 Gene Contributes to Mutant p53 Gain of Function. Cancer Research, 64: 8318-8327
Wohlbold L, Van Der Kuip H, Moehring A, Granot G, Oren M, Vornlocher HP, Aulitzky WE. 2004 Repeated Application of Sequence-Specific siRNA Molecules Leads to an Effective Downmodulation of All Clinically Relevant Bcr-Abl Gene Variants.. Blood, 104: 165B-165B
Oren M, Lidor E, Minsky N, Stambolsky P, Taplick J, Wang XJ, Weisz L, Zalcenstein A, Rotter V. 2004 The Role of p53 in DNA Damage Response and Apoptosis. Toxicology and Applied Pharmacology, 197: 166-167
Lavon I, Pikarsky E, Gutkovich E, Goldberg I, Bar J, Oren M, Ben-Neriah Y. 2003 Nuclear factor-kappa B Protects the Liver Against Genotoxic Stress and Functions Independently of p53. Cancer Research, 63: 25-30
Michael D, Oren M. 2003 The p53-Mdm2 Module and the Ubiquitin System. Seminars in Cancer Biology, 13: 49-58
Passer BJ, Nancy-Portebois V, Amzallag N, Prieur S, Cans C, DE Climens AR, Fiucci G, Bouvard V, Tuynder M, Susini L, Morchoisne S, Crible V, Lespagnol A, Dausset J, Oren M, Amson R, Telerman A. 2003 The p53-Inducible Tsap6 Gene Product Regulates Apoptosis and the Cell Cycle and Interacts With Nix and the Myt1 Kinase. Proceedings of the National Academy of Sciences of the United States of America, 100: 2284-2289
Ofek P, Ben-Meir D, Kariv-Inbal Z, Oren M, Lavi S. 2003 Cell Cycle Regulation and p53 Activation by Protein Phosphatase 2c Alpha. Journal of Biological Chemistry, 278: 14299-14305
Oren M. 2003 Decision Making by p53: Life, Death and Cancer. Cell Death and Differentiation, 10: 431-442
Wang X, Zalcenstein A, Oren M. 2003 Nitric Oxide Promotes p53 Nuclear Retention and Sensitizes Neuroblastoma Cells to Apoptosis by Ionizing Radiation. Cell Death and Differentiation, 10: 468-476
Iron MA, Oren M, Martin Jml. 2003 Alkali and Alkaline Earth Metal Compounds: Core-Valence Basis Sets and Importance of Subvalence Correlation. Molecular Physics, 101: 1345-1361
Zalcenstein A, Stambolsky P, Weisz L, Muller M, Wallach D, Goncharov TM, Krammer PH, Rotter V, Oren M. 2003 Mutant p53 Gain of Function: Repression of Cd95(Fas/Apo-1) Gene Expression by Tumor-Associated p53 Mutants. Oncogene, 22: 5667-5676
Balass M, Kalef E, Maya R, Wilder S, Oren M, Katchalski-Katzir E. 2002 Characterization of Two Peptide Epitopes on Mdm2 Oncoprotein That Affect p53 Degradation.. Peptides, 23: 1719-25
Blander Gil, Zalle Noa, Daniely Yaron, Taplick Jan, Gray Matthew D, Oren Moshe. 2002 DNA Damage-Induced Translocation of the Werner Helicase is Regulated by Acetylation.. Journal of Biological Chemistry, 277: 50934-40
Shtutman Michael, Zhurinsky Jacob, Oren Moshe, Levina Elina, Ben-Ze'ev Avri, ET AL. 2002 Pml is a Target Gene of Beta-Catenin and Plakoglobin, and Coactivates Beta-Catenin-Mediated Transcription.. Cancer Research, 62: 5947-54
Folberg-Blum Adriana, Sapir Amir, Shilo Ben-Zion, Oren Moshe. 2002 Overexpression of Mouse Mdm2 Induces Developmental Phenotypes in Drosophila.. Oncogene, 21: 2413-7
Michael Dan, Oren Moshe. 2002 The p53 and Mdm2 Families in Cancer.. Current Opinion in Genetics & Development, 12: 53-9
Wang XJ, Michael D, DE Murcia G, Oren M. 2002 p53 Activation by Nitric Oxide Involves Down-Regulation of Mdm2. J Biol Chem , 277: 15697-15702
Gottlieb TM, Leal Jfm, Seger R, Taya Y, Oren M. 2002 Cross-Talk Between Akt, p53 and Mdm2: Possible Implications For the Regulation of Apoptosis. Oncogene, 21: 1299-1303
Kairat A, Lorenz K, Oren M, Stremmel W, Krammer P, Muller M. 2002 Differential Regulation of the Cd95 Gene by Wild Type and Mutant p53: Implications For Tumorigenesis and Therapy Resistance.. Hepatology, 36: 321A-321A
Shtutman M, Zhurinsky J, Oren M, Levina E, Ben-Ze'ev A. 2002 Pml is a Target Gene of Beta-Catenin and Plakoglobin and Coactivates Beta-Catenin-Mediated Transcription. Molecular Biology of the Cell, 13: 433A-433A
Michael D, Oren M. 2002 The p53 and Mdm2 Families in Cancer. Current Opinion in Genetics & Development, 12: 53-59
Blander G, Zalle N, Daniely Y, Taplick J, Gray MD, Oren M. 2002 DNA Damage-Induced Translocation of the Werner Helicase is Regulated by Acetylation. Journal of Biological Chemistry, 277: 50934-50940
Oren M, Damalas A, Gottlieb T, Michael D, Taplick J, Leal JF, Maya R, Moas M, Seger R, Taya Y, Ben-Ze'ev A. 2002 Regulation of p53 - Intricate Loops and Delicate Balances. Annals of the New York Academy of Sciences, 973: 374-383
Oren M, Damalas A, Gottlieb T, Michael D, Taplick J, Leal Jfm, Maya R, Moas M, Seger R, Taya Y, Ben-Ze'ev A,. 2002 Regulation of p53: Intricate Loops and Delicate Balances. Biochemical Pharmacology, 64: 865-871
Strano S, Munarriz E, Rossi M, Castagnoli L, Shaul Y, Sacchi A, Oren M, Sudol M, Cesareni G, Blandino G. 2001 Physical Interaction With Yes-Associated Protein Enhances p73 Transcriptional Activity. Journal of Biological Chemistry, 276: 15164-15173
Maya R, Balass M, Kim ST, Shkedy D, Leal Jfm, Shifman O, Moas M, Buschmann T, Ronai Z, Shiloh Y, Kastan MB, Katzir E, Oren M. 2001 Atm-Dependent Phosphorylation of Mdm2 on Serine 395: Role in p53 Activation by DNA Damage. Genes & Development, 15: 1067-1077
Goetz AW, Van Der Kuip H, Maya R, Oren M, Aulitzky WE. 2001 Requirement For Mdm2 in the Survival Effects of Bcr-Abl and Interleukin 3 in Hematopoietic Cells. Cancer Research, 61: 7635-7641
Sadot E, Geiger B, Oren M, Ben-Ze'ev A. 2001 Down-Regulation of Beta-Catenin by Activated p53. Molecular and Cellular Biology, 21: 6768-6781
Damalas A, Kahan S, Shtutman M, Ben-Ze'ev A, Oren M. 2001 Deregulated Beta-Catenin Induces a p53-and Arf-Dependent Growth Arrest and Cooperates With Ras in Transformation. EMBO Journal, 20: 4912-4922
Susini L, Passer BJ, Amzallag-Elbaz N, Juven-Gershon T, Prieur S, Privat N, Tuynder M, Gendron MC, Israel A, Amson R, Oren M, Telerman A. 2001 Siah-1 Binds and Regulates the Function of Numb. Proceedings of the National Academy of Sciences of the United States of America, 98: 15067-15072
Goetz AW, Van Der Kuip H, Oren M, Aulitzky WE. 2000 Regulation of Mdm-2 Protein by Physiological Growth Factors or Bcr-Abl in Human and Murine Hematopoietic Cells.. Blood, 96: 79A-79A
Reinstein E, Scheffner M, Oren M, Ciechanover A, Schwartz A. 2000 Degradation of the e7 Human Papillomavirus Oncoprotein by the Ubiquitin-Proteasome System: Targeting Via Ubiquitination of the n-Terminal Residue. Oncogene, 19: 5944-5950
Blander G, Zalle N, Leal Jfm, Bar-OR RL, YU CE, Oren M. 2000 The Warner Syndrome Protein Contributes to Induction of p53 by DNA Damage. Faseb Journal, 14: 2138-2140
Bar-OR RL, Maya R, Segel LA, Alon U, Levine AJ, Oren M. 2000 Generation of Oscillations by the p53-Mdm2 Feedback Loop: a Theoretical and Experimental Study. Proceedings of the National Academy of Sciences of the United States of America, 97: 11250-11255
Ries S, Biederer C, Woods D, Shifman O, Shirasawa S, Sasazuki T, Mcmahon M, Oren M, Mccormick F. 2000 Opposing Effects of Ras on p53: Transcriptional Activation of Mdm2 and Induction of p19(Arf). Cell, 103: 321-330
Strano S, Munarriz E, Rossi M, Cristofanelli B, Shaul Y, Castagnoli L, Levine AJ, Sacchi A, Cesareni G, Oren M, Blandino G. 2000 Physical and Functional Interaction Between p53 Mutants and Different Isoforms of p73. Journal of Biological Chemistry, 275: 29503-29512
Maya R, Oren M. 2000 Unmasking of Phosphorylation-Sensitive Epitopes on p53 and Mdm2 by a Simple Western-Phosphatase Procedure. Oncogene, 19: 3213-3215
Amson R, Lassalle JM, Halley H, Prieur S, Lethrosne F, Roperch JP, Israeli D, Gendron MC, Duyckaerts C, Checler F, Dausset J, Cohen D, Oren M, Telerman A. 2000 Behavioral Alterations Associated With Apoptosis and Down-Regulation of Presenilin 1 in the Brains of p53-Deficient Mice. Proceedings of the National Academy of Sciences of the United States of America, 97: 5346-5350
DE Rozieres S, Maya R, Oren M, Lozano G. 2000 The Loss of Mdm2 Induces p53 Mediated Apoptosis. Oncogene, 19: 1691-1697
Khosravi R, Maya R, Gottlieb T, Oren M, Shiloh Y, Shkedy D. 1999 Rapid Atm-Dependent Phosphorylation of Mdm2 Precedes p53 Accumulation in Response to DNA Damage. Proceedings of the National Academy of Sciences of the United States of America, 96: 14973-14977
Oren M. 1999 Regulation of the p53 Tumor Suppressor Protein. Journal of Biological Chemistry, 274: 36031-36034
Agami R, Blandino G, Oren M, Shaul Y. 1999 Interaction of c-Abl and p73 Alpha and Their Collaboration to Induce Apoptosis. Nature, 399: 809-813
Blander G, Kipnis J, Leal Jfm, YU CE, Schellenberg GD, Oren M. 1999 Physical and Functional Interaction Between p53 and the Werner's Syndrome Protein. Journal of Biological Chemistry, 274: 29463-29469
Blandino G, Levine AJ, Oren M. 1999 Mutant p53 Gain of Function: Differential Effects of Different p53 Mutants on Resistance of Cultured Cells to Chemotherapy. Oncogene, 18: 477-485
Damalas A, Ben-Ze'ev A, Simcha I, Shtutman N, Leal Jfn, Zhurinsky J, Geiger B, Oren M. 1999 Excess Beta-Catenin Promotes Accumulation of Transcriptionally Active p53. EMBO Journal, 18: 3054-3063
Elkeles A, Juven-Gershon T, Israeli D, Wilder S, Zalcenstein A, Oren M. 1999 The c-Fos Proto-Oncogene is a Target For Transactivation by the p53 Tumor Suppressor. Molecular and Cellular Biology, 19: 2594-2600
Juven-Gershon T, Oren M. 1999 Mdm2: the Ups and Downs. Molecular Medicine, 5: 71-83
LU H, Zeng X, Chen L, Jost CA, Maya R, Keller D, Wang X, Kaelin WG, Oren M, Chen J,. 1999 Mdm2 Suppresses p73 Function Without Promoting p73 Degradation. Faseb Journal, 13: A1538
Mueller M, Kairat A, Schulze-Bergkamen H, Friedman SL, Oren M, Krammer PH, Stremmel W,. 1999 An Intact Intronic p53-Binding Site is a Precondition For p53-Dependent Cd95 Gene Expression in Hepatoma Cells.. Hepatology, 30: 1021 -
Oren M, Vousden KH,. 1999 Hot Papers - Cancer Research - Mdm2 Promotes the Rapid Degradation of p53 by y. Haupt, r. Maya, a. Kazaz, m. Oren and Regulation of p53 Stability by Mdm2 by m.h.g. Kubbutat, s.n. Jones, k.h. Vousden - Comments. Scientist, 13: 11
Oren M, Rotter V,. 1999 Introduction: p53 - the First Twenty Years. Cellular and Molecular Life Sciences, 55: 9-11
Roperch JP, Lethrone F, Prieur S, Piouffre L, Israeli D, Tuynder M, Nemani M, Pasturaud P, Gendron MC, Dausset J, Oren M, Amson RB, Telerman A,. 1999 Siah-1 Promotes Apoptosis and Tumor Suppression Through a Network Involving the Regulation of Protein Folding, Unfolding, and Trafficking: Identification of Common Effectors With p53 and p21(Waf1). Proceedings of the National Academy of Sciences of the United States of America, 96: 8070-8073
Sionov RV, Moallem E, Berger M, Kazaz A, Gerlitz O, Ben-Neriah Y, Oren M, Haupt Y,. 1999 C-Abl Neutralizes the Inhibitory Effect of Mdm2 on p53. Journal of Biological Chemistry, 274: 8371-8374
Unger T, Sionov RV, Moallem E, Yee CL, Howley PM, Oren M, Haupt Y,. 1999 Mutations in Serines 15 and 20 of Human p53 Impair Its Apoptotic Activity. Oncogene, 18: 3205-3212
Unger T, Juven-Gershon T, Moallem E, Berger M, Sionov RV, Lozano G, Oren M, Haupt Y,. 1999 Critical Role For Ser20 of Human p53 in the Negative Regulation of p53 by Mdm2. EMBO Journal, 18: 1805-1814
Zeng XY, Chen LH, Jost CA, Maya R, Keller D, Wang XJ, Kaelin WG, Oren M, Chen JD, LU H,. 1999 Mdm2 Suppresses p73 Function Without Promoting p73 Degradation. Molecular and Cellular Biology, 19: 3257-3266
Gottlieb TM, Oren M. 1998 p53 and Apoptosis. Seminars in Cancer Biology, 8: 359-368
Gottlieb E, Oren M,. 1998 p53 Facilitates Prb Cleavage in IL-3-Deprived Cells: Novel Pro-Apoptotic Activity of p53. EMBO Journal, 17: 3587-3596
Hosokawa K, Aharoni D, Dantes A, Shaulian E, Schere-Levy C, Atzmon R, Kotsuji F, Oren M, Vlodavsky I, Amsterdam A,. 1998 Modulation of Mdm2 Expression and p53-Induced Apoptosis in Immortalized Human Ovarian Granulosa Cells. Endocrinology, 139: 4688-4700
Juven-Gershon T, Shifman O, Unger T, Elkeles A, Haupt Y, Oren M,. 1998 The Mdm2 Oncoprotein Interacts With the Cell Fate Regulator Numb. Molecular and Cellular Biology, 18: 3974-3982
Muller M, Wilder S, Bannasch D, Israeli D, Lehlbach K, LI-Weber M, Friedman SL, Galle PR, Stremmel W, Oren M, Krammer PH,. 1998 p53 Activates the Cd95 (Apo-1/Fas) Gene in Response to DNA Damage by Anticancer Drugs. Journal of Experimental Medicine, 188: 2033-2045
Muller M, Wilder S, Israeli D, Friedman SL, Galle PR, Oren M, Stremmel W, Krammer PH,. 1998 The Cd95 (Apo-1/Fas) Gene is a DNA-Damage-Inducible p53 Regulated Death Receptor Gene.. Hepatology, 28: 19 -
Oren M,. 1998 Tumour Suppressors - Teaming up to Restrain Cancer. Nature, 391: 233-234
Ori A, Zauberman A, Doitsh G, Paran N, Oren M, Shaul Y,. 1998 p53 Binds and Represses the Hbv Enhancer: an Adjacent Enhancer Element Can Reverse the Transcription Effect of p53. EMBO Journal, 17: 544-553
Roperch JP, Alvaro V, Prieur S, Tuynder M, Nemani M, Lethrosne F, Piouffre L, Gendron MC, Israeli D, Dausset J, Oren M, Amson R, Telerman A,. 1998 Inhibition of Presenilin 1 Expression is Promoted by p53 and p21(Waf-1) and Results in Apoptosis and Tumor Suppression. Nature Medicine, 4: 835-838
Wang YC, Blandino G, Oren M, Givol D,. 1998 Induced p53 Expression in Lung Cancer Cell Line Promotes Cell Senescence and Differentially Modifies the Cytotoxicity of Anti-Cancer Drugs. Oncogene, 17: 1923-1930
Yardley G, Zauberman A, Oren M, Jackson P,. 1998 Individual Promoter and Intron p53-Binding Motifs From the Rat Cyclin g1 Promoter Region Support Transcriptional Activation by p53 But do Not Show co-Operative Activation. Febs Letters, 430: 171-175
Friedman SL, Shaulian E, Littlewood T, Resnitzky D, Oren M,. 1997 Resistance to p53-Mediated Growth Arrest and Apoptosis in Hep 3b Hepatoma Cells. Oncogene, 15: 63-70
Gottlieb E, Haffner R, King A, Asher G, Gruss P, Lonai P, Oren M,. 1997 Transgenic Mouse Model For Studying the Transcriptional Activity of the p53 Protein: Age- and Tissue-Dependent Changes in Radiation-Induced Activation During Embryogenesis. EMBO Journal, 16: 1381-1390
Hansen R, Oren M,. 1997 p53; From Inductive Signal to Cellular Effect. Current Opinion in Genetics & Development, 7: 46-51
Haupt Y, Maya R, Kazaz A, Oren M,. 1997 Mdm2 Promotes the Rapid Degradation of p53. Nature, 387: 296-299
Israeli D, Tessler E, Haupt Y, Elkeles A, Wilder S, Amson R, Telerman A, Oren M,. 1997 A Novel p53-Inducible Gene, Pag608, Encodes a Nuclear Zinc Finger Protein Whose Overexpression Promotes Apoptosis. EMBO Journal, 16: 4384-4392
Oren M,. 1997 Lonely no More: p53 Finds Its Kin in a Tumor Suppressor Haven. Cell, 90: 829-832
Ruaro EM, Collavin L, Delsal G, Haffner R, Oren M, Levine AJ, Schneider C,. 1997 A Proline-Rich Motif in p53 is Required For Transactivation-Independent Growth Arrest as Induced by Gas1. Proceedings of the National Academy of Sciences of the United States of America, 94: 4675-4680
Ruaro ME, Collavin L, Delsal G, Haffner R, Oren M, Levine A, Schneider C,. 1997 A Proline Rich Domain in Mp53 is Required to Mediate Gas1 Growth Inhibitory Effect. European Journal of Cell Biology, 72: 31
Shaulian E, Resnitzky D, Shifman O, Blandino G, Amsterdam A, Yayon A, Oren M,. 1997 Induction of Mdm2 and Enhancement of Cell Survival by Bfgf. Oncogene, 15: 2717-2725
SO PL, Saliba RS, Ginsburg D, Gruss P, Oren M, Stuart ET,. 1997 Down-Regulation of p53 by Pax5 in Lung Cancer. Developmental Biology, 186: A138
Zauberman A, Oren M, Zipori D,. 1997 Involvement of p21(Waf1/Cip1), Cdk4 and rb in Activin a Mediated Signaling Leading to Hepatoma Cell Growth Inhibition. Oncogene, 15: 1705-1711
Oren M, Prives C,. 1996 p53: Upstream, Downstream and Off Stream - Review of the 8th p53 Workshop (Dundee, July 5-9, 1996). Biochimica et Biophysica Acta-Reviews on Cancer, 1288: R13-R19
Friedman SL, Shaulian E, Oren M,. 1996 Does p53 Regulate Hepatocellular Differentiation?. Hepatology, 24: 928
Friedlander P, Haupt Y, Prives C, Oren M,. 1996 A Mutant p53 That Discriminates Between p53-Responsive Genes Cannot Induce Apoptosis. Molecular and Cellular Biology, 16: 4961-4971
Eizenberg O, Faberelman A, Gottlieb E, Oren M, Rotter V, Schwartz M,. 1996 p53 Plays a Regulatory Role in Differentiation and Apoptosis of Central Nervous System-Associated Cells. Molecular and Cellular Biology, 16: 5178-5185
Bacus SS, Yarden Y, Oren M, Chin DM, Lyass L, Zelnick CR, Kazarov A, Toyofuku W, Graybablin J, Beerli RR, Hynes NE, Nikiforov M, Haffner R, Gudkov A, Keyomarsi K,. 1996 Neu Differentiation Factor (Heregulin) Activates a p53-Dependent Pathway in Cancer Cells. Oncogene, 12: 2535-2547
Gottlieb TM, Oren M,. 1996 p53 in Growth Control and Neoplasia. Biochimica et Biophysica Acta-Reviews on Cancer, 1287: 77-102
Amson RB, Nemani M, Roperch JP, Israeli D, Bougueleret L, Legall I, Medhioub M, Linarescruz G, Lethrosne F, Pasturaud P, Piouffre L, Prieur S, Susini L, Alvaro V, Millasseau P, Guidicelli C, Bui H, Massart C, Cazes L, Dufour F, Bruzzonigiovanelli H, Owadi H, Hennion C, Charpak G, Dausset J, Calvo F, Oren M, Cohen D, Telerman A,. 1996 Isolation of 10 Differentially Expressed Cdnas in p53-Induced Apoptosis: Activation of the Vertebrate Homologue of the Drosophila Seven in Absentia Gene. Proceedings of the National Academy of Sciences of the United States of America, 93: 3953-3957
Haupt Y, Barak Y, Oren M,. 1996 Cell Type-Specific Inhibition of p53-Mediated Apoptosis by Mdm2. EMBO Journal, 15: 1596-1606
Gottlieb E, Lindner S, Oren M,. 1996 Relationship of Sequence-Specific Transactivation and p53-Regulated Apoptosis in Interleukin 3-Dependent Hematopoietic Cells. Cell Growth & Differentiation, 7: 301-310
Bowman T, Symonds H, GU LY, Yin CY, Oren M, Vandyke T,. 1996 Tissue-Specific Inactivation of p53 Tumor Suppression in the Mouse. Genes & Development, 10: 826-835
Knippschild U, Oren M, Deppert W,. 1996 Abrogation of Wild-Type p53 Mediated Growth-Inhibition by Nuclear Exclusion. Oncogene, 12: 1755-1765
Nemani M, Linarescruz G, Bruzzonigiovanelli H, Roperch JP, Tuynder M, Bougueleret L, Cherif D, Medhioub M, Pasturaud P, Alvaro V, Dersarkissan H, Cazes L, Lepaslier D, Legall I, Israeli D, Dausset J, Sigaux F, Chumakov I, Oren M, Calvo F, Amson RB, Cohen D, Telerman A,. 1996 Activation of the Human Homologue of the Drosophila Sina Gene in Apoptosis and Tumor Suppression. Proceedings of the National Academy of Sciences of the United States of America, 93: 9039-9042
Rowan S, Ludwig RL, Haupt Y, Bates S, LU X, Oren M, Vousden KH,. 1996 Specific Loss of Apoptotic But Not Cell-Cycle Arrest Function in a Human Tumor Derived p53 Mutant. EMBO Journal, 15: 827-838
Tanaka N, Ishihara M, Lamphier MS, Nozawa H, Matsuyama T, Mak TW, Aizawa S, Tokino T, Oren M, Taniguchi T,. 1996 Cooperation of the Tumour Suppressors Irf-1 and p53 in Response to DNA Damage. Nature, 382: 816-818
Harlow E, Tlsty T, Courtneidge S, Mccormick F, Tocque B, Yaniv M, Woude GV, Herlich P, Bohmann D, Howley P, Levine A, Prives C, Lane D, Oren M, Kimchi A, Thomas G, Feuteun J,. 1995 Cancer: the Translation of Advances in Basic Science to Human Therapy. 22-27 July, 1995 - la Fondation Des Treilles, Tourtour, France - Discussion. Comptes Rendus de l Academie Des Sciences Serie III-Sciences de la Vie-Life Sciences, 318: 1173-1179
Haupt Y, Gottlieb E, Rowan S, Shaulian E, Oren M,. 1995 The Role of p53 in the Control of Cell Death. European Journal of Cancer, 31A: 767
Aharoni D, Dantes A, Oren M, Amsterdam A,. 1995 cAMP-Mediated Signals as Determinants For Apoptosis in Primary Granulosa-Cells. Experimental Cell Research, 218: 271-282
Corvi R, Savelyeva L, Breit S, Wenzel A, Handgretinger R, Barak J, Oren M, Amler L, Schwab M,. 1995 Non-Syntenic Amplification of Mdm2 and Mycn in Human Neuroblastoma. Oncogene, 10: 1081-1086
Eizenberg O, Faberelman A, Gottlieb E, Oren M, Rotter V, Schwartz M,. 1995 Direct Involvement of p53 in Programmed Cell-Death of Oligodendrocytes. EMBO Journal, 14: 1136-1144
Haupt Y, Rowan S, Shaulian E, Vousden KH, Oren M,. 1995 Induction of Apoptosis in Hela-Cells by Trans-Activation-Deficient p53. Genes & Development, 9: 2170-2183
Haupt Y, Rowan S, Oren M,. 1995 p53-Mediated Apoptosis in Hela-Cells Can be Overcome by Excess Prb. Oncogene, 10: 1563-1571
Hiebert SW, Packham G, Strom DK, Haffner R, Oren M, Zambetti G, Cleveland JL,. 1995 E2f-1/dp-1 Induces p53 and Overrides Survival Factors to Trigger Apoptosis. Molecular and Cellular Biology, 15: 6864-6874
Kerental I, Suh BS, Dantes A, Lindner S, Oren M, Amsterdam A,. 1995 Involvement of p53 Expression in cAMP-Mediated Apoptosis in Immortalized Granulosa-Cells. Experimental Cell Research, 218: 283-295
Malcomson Rdg, Oren M, Wyllie AH, Harrison DJ,. 1995 p53-Independent Death and p53-Induced Protection Against Apoptosis in Fibroblasts Treated With Chemotherapeutic Drugs. British Journal of Cancer, 72: 952-957
Shaulian E, Haviv I, Shaul Y, Oren M,. 1995 Transcriptional Repression by the c-Terminal Domain of p53. Oncogene, 10: 671-680
Stuart ET, Haffner R, Oren M, Gruss P,. 1995 Loss of p53 Function Through Pax-Mediated Transcriptional Repression. EMBO Journal, 14: 5638-5645
Zauberman A, Flusberg D, Haupt Y, Barak Y, Oren M,. 1995 A Functional p53-Responsive Intronic Promoter is Contained Within the Human Mdm2 Gene. Nucleic Acids Research, 23: 2584-2592
Zauberman A, Lupo A, Oren M,. 1995 Identification of p53 Target Genes Through Immune Selection of Genomic DNA - the Cyclin-g Gene Contains 2 Distinct p53 Binding-Sites. Oncogene, 10: 2361-2366
Barak Y, Lupo A, Zauberman A, Juven T, Alonigrinstein R, Gottlieb E, Rotter V, Oren M,. 1994 Targets For Transcriptional Activation by Wild-Type p53 - Endogenous Retroviral Ltr, Immunoglobulin-Like Promoter, and an Internal Promoter of the Mdm2 Gene. Cold Spring Harbor Symposia on Quantitative Biology, 59: 225-235
Barak Y, Gottlieb E, Juvengershon T, Oren M,. 1994 Regulation of Mdm2 Expression by p53 - Alternative Promoters Produce Transcripts With Nonidentical Translation Potential. Genes & Development, 8: 1739-1749
Ciechanover A, Shkedy D, Oren M, Bercovich B,. 1994 Degradation of the Tumor-Suppressor Protein-p53 by the Ubiquitin-Mediated Proteolytic System Requires a Novel Species of Ubiquitin-Carrier Protein, e2. Journal of Biological Chemistry, 269: 9582-9589
Gottlieb E, Haffner R, Vonruden T, Wagner EF, Oren M,. 1994 Down-Regulation of Wild-Type p53 Activity Interferes With Apoptosis of IL-3-Dependent Hematopoietic-Cells Following IL-3 Withdrawal. EMBO Journal, 13: 1368-1374
Oren M,. 1994 Relationship of p53 to the Control of Apoptotic Cell-Death. Seminars in Cancer Biology, 5: 221-227
Zauberman A, Lupo A, Juven T, Haffner R, Gottlieb E, Barak Y, Oren M,. 1994 Targets of p53. Journal of Cellular Biochemistry: 165
Barak Y, Juven T, Haffner R, Oren M,. 1993 Mdm2 Expression is Induced by Wild Type-p53 Activity. EMBO Journal, 12: 461-468
Juven T, Barak Y, Zauberman A, George DL, Oren M,. 1993 Wild-Type p53 Can Mediate Sequence-Specific Transactivation of an Internal Promoter Within the Mdm2 Gene. Oncogene, 8: 3411-3416
Levy N, Yonishrouach E, Oren M, Kimchi A,. 1993 Complementation by Wild-Type p53 of Interleukin-6 Effects on m1 Cells - Induction of Cell-Cycle Exit and Cooperativity With c-Myc Suppression. Molecular and Cellular Biology, 13: 7942-7952
Oren M,. 1993 Aloni,Yosef - (1936-1993) - Obituary. Oncogene, 8: 1405
Ragimov N, Krauskopf A, Navot N, Rotter V, Oren M, Aloni Y,. 1993 Wild-Type But Not Mutant-p53 Can Repress Transcription Initiation Invitro by Interfering With the Binding of Basal Transcription Factors to the Tata Motif. Oncogene, 8: 1183-1193
Shaulian E, Zauberman A, Milner J, Davies EA, Oren M,. 1993 Tight DNA-Binding and Oligomerization Are Dispensable For the Ability of p53 to Transactivate Target Genes and Suppress Transformation. EMBO Journal, 12: 2789-2797
Telerman A, Tuynder M, Dupressoir T, Robaye B, Sigaux F, Shaulian E, Oren M, Rommelaere J, Amson R,. 1993 A Model For Tumor Suppression Using ¹H Parvovirus. Proceedings of the National Academy of Sciences of the United States of America, 90: 8702-8706
Yonishrouach E, Grunwald D, Wilder S, Kimchi A, May E, Lawrence JJ, May P, Oren M,. 1993 p53-Mediated Cell-Death - Relationship to Cell-Cycle Control. Molecular and Cellular Biology, 13: 1415-1423
Zauberman A, Barak Y, Ragimov N, Levy N, Oren M,. 1993 Sequence-Specific DNA-Binding by p53 - Identification of Target Sites and Lack of Binding to P53mdm2 Complexes. EMBO Journal, 12: 2799-2808
Barak Y, Oren M,. 1992 Enhanced Binding of a 95-Kda Protein to p53 in Cells Undergoing p53-Mediated Growth Arrest. EMBO Journal, 11: 2115-2121
Oren M,. 1992 p53 - the Ultimate Tumor Suppressor Gene. Faseb Journal, 6: 3169-3176
Oren M,. 1992 The Involvement of Oncogenes and Tumor Suppressor Genes in the Control of Apoptosis. Cancer and Metastasis Reviews, 11: 141-148
Shaulian E, Zauberman A, Ginsberg D, Oren M,. 1992 Identification of a Minimal Transforming Domain of p53 - Negative Dominance Through Abrogation of Sequence-Specific DNA-Binding. Molecular and Cellular Biology, 12: 5581-5592
Yehiely F, Oren M,. 1992 The Gene For the Rat Heat-Shock Cognate, Hsc70, Can Suppress Oncogene-Mediated Transformation. Cell Growth & Differentiation, 3: 803-809
Eizenberg O, Oren M,. 1991 Reduced Levels of Alpha-1 (i) Collagen Messenger-RNA in Cells Immortalized by Mutant p53 or Transformed by Ras. Biochimica et Biophysica Acta, 1129: 34-42
Halevy O, Rodel J, Peled A, Oren M,. 1991 Frequent p53 Mutations in Chemically-Induced Murine Fibrosarcoma. Oncogene, 6: 1593-1600
Ginsberg D, Mechta F, Yaniv M, Oren M,. 1991 Wild-Type p53 Can Down-Modulate the Activity of Various Promoters. Proceedings of the National Academy of Sciences of the United States of America, 88: 9979-9983
Ginsberg D, Hirai S, Pinhasikimhi O, Yaniv M, Oren M,. 1991 Transfected Mouse c-Jun Can Inhibit Transformation of Primary Rat Embryo Fibroblasts. Oncogene, 6: 669-672
Ginsberg D, Michaelmichalovitz D, Ginsberg D, Oren M,. 1991 Induction of Growth Arrest by a Temperature-Sensitive p53 Mutant is Correlated With Increased Nuclear-Localization and Decreased Stability of the Protein. Molecular and Cellular Biology, 11: 582-585
Michaelmichalovitz D, Yehiely F, Gottlieb E, Oren M,. 1991 Simian Virus-40 Can Overcome the Antiproliferative Effect of Wild-Type-p53 in the Absence of Stable Large t-Antigen-p53 Binding. Journal of Virology, 65: 4160-4168
Michalovitz D, Halevy O, Oren M,. 1991 p53 Mutations - Gains or Losses. Journal of Cellular Biochemistry, 45: 22-29
Yonishrouach E, Resnitzky D, Lotem J, Sachs L, Kimchi A, Oren M,. 1991 Wild-Type p53 Induces Apoptosis of Myeloid Leukemic-Cells That is Inhibited by Interleukin-6. Nature, 352: 345-347
Ginsberg D, Oren M, Yaniv M, Piette J,. 1990 Protein-Binding Elements in the Promoter Region of the Mouse p53 Gene. Oncogene, 5: 1285-1290
Halevy O, Michalovitz D, Oren M,. 1990 Different Tumor-Derived p53 Mutants Exhibit Distinct Biological-Activities. Science, 250: 113-116
Michalovitz D, Halevy O, Oren M,. 1990 Conditional Inhibition of Transformation and of Cell-Proliferation by a Temperature-Sensitive Mutant of p53. Cell, 62: 671-680
Michalovitz D, Amsterdam A, Oren M,. 1989 Interactions Between SV40 and Cellular Oncogenes in the Transformation of Primary Rat-Cells. Current Topics in Microbiology and Immunology, 144: 63-75
Eliyahu D, Michalovitz D, Eliyahu S, Pinhasikimhi O, Oren M,. 1989 Wild-Type p53 Can Inhibit Oncogene-Mediated Focus Formation. Proceedings of the National Academy of Sciences of the United States of America, 86: 8763-8767
Halevy O, Hall A, Oren M,. 1989 Stabilization of the p53 Transformation-Related Protein in Mouse Fibro-Sarcoma Cell-Lines - Effects of Protein-Sequence and Intracellular Environment. Molecular and Cellular Biology, 9: 3385-3392
Amsterdam A, Zauberman A, Meir G, Pinhasikimhi O, Suh BS, Oren M,. 1988 Cotransfection of Granulosa-Cells With Simian Virus-40 and ha-Ras Oncogene Generates Stable Lines Capable of Induced Steroidogenesis. Proceedings of the National Academy of Sciences of the United States of America, 85: 7582-7586
Eliyahu D, Goldfinger N, Pinhasikimhi O, Shaulsky G, Skurnik Y, Arai N, Rotter V, Oren M,. 1988 Meth-a Fibro-Sarcoma Cells Express 2 Transforming Mutant p53 Species. Oncogene, 3: 313-321
Finlay CA, Hinds PW, Tan TH, Eliyahu D, Oren M, Levine AJ,. 1988 Activating Mutations For Transformation by p53 Produce a Gene-Product That Forms an Hsc70-p53 Complex With an Altered Half-Life. Molecular and Cellular Biology, 8: 531-539
Kraiss S, Quaiser A, Oren M, Montenarh M,. 1988 Oligomerization of Oncoprotein-p53. Journal of Virology, 62: 4737-4744
Michalovitz D, Fischerfantuzzi L, Vesco C, Pipas JM, Oren M,. 1987 Activated ha-Ras Can Cooperate With Defective Simian Virus-40 in the Transformation of Nonestablished Rat Embryo Fibroblasts. Journal of Virology, 61: 2648-2654
Oren M, Michalovitz D, Pinhasikimhi O, Eliyahu D,. 1987 Biological and Molecular-Properties of p53. European Journal of Cancer & Clinical Oncology, 23: 1785
Shohat O, Greenberg M, Reisman D, Oren M, Rotter V,. 1987 Inhibition of Cell-Growth Mediated by Plasmids Encoding p53 Antisense. Oncogene, 1: 277-283
Moav B, Horowitz M, Cohen JB, Rechavi G, Eliyahu E, Oren M, Givol D,. 1986 Structure and Activity of the Translocated c-Myc in Mouse Plasmacytoma Xrpc-24. Gene, 48: 297-300
Kaczmarek L, Oren M, Baserga R,. 1986 Cooperation Between the p53 Protein Tumor-Antigen and Platelet-Poor Plasma in the Induction of Cellular DNA-Synthesis. Experimental Cell Research, 162: 268-272
Michalovitz D, Eliyahu D, Oren M,. 1986 Overproduction of Protein p53 Contributes to Simian-Virus 40-Mediated Transformation. Molecular and Cellular Biology, 6: 3531-3536
Pinhasi-Kimhi O, Michalovitz D, Ben-Ze'ev A, Oren M. 1986 Specific Interaction Between the p53 Cellular Tumor-Antigen and Major Heat-Shock Proteins. Nature, 320: 182-185
Bienztadmor B, Zakuthouri R, Libresco S, Givol D, Oren M,. 1985 The 5' Region of the p53 Gene - Evolutionary Conservation and Evidence For a Negative Regulatory Element. EMBO Journal, 4: 3209-3213
Eliyahu D, Michalovitz D, Oren M,. 1985 Overproduction of p53 Antigen Makes Established Cells Highly Tumorigenic. Nature, 316: 158-160
Lebeau MM, Westbrook CA, Diaz MO, Rowley JD, Oren M,. 1985 Translocation of the p53 Gene in Trans-(15-17) in Acute Promyelocytic Leukemia. Nature, 316: 826-828
Mcbride OW, Merry DE, Oren M, Givol D,. 1985 Human p53 Cellular Tumor-Antigen is on Chromosome 17p13. Cytogenetics and Cell Genetics, 40: 694-695
Oren M,. 1985 The p53 Cellular Tumor-Antigen - Gene Structure, Expression and Protein-Properties. Biochimica et Biophysica Acta, 823: 67-78
Rogel A, Popliker M, Webb CG, Oren M,. 1985 p53 Cellular Tumor-Antigen - Analysis of Messenger-RNA Levels in Normal Adult Tissues, Embryos, and Tumors. Molecular and Cellular Biology, 5: 2851-2855
Zakuthouri R, Bienztadmor B, Givol D, Oren M,. 1985 Human p53 Cellular Tumor-Antigen - CDNA Sequence and Expression in Cos Cells. EMBO Journal, 4: 1251-1255
Bienz B, Zakuthouri R, Givol D, Oren M,. 1984 Analysis of the Gene Coding For the Murine Cellular Tumor-Antigen p53. EMBO Journal, 3: 2179-2183
Czosnek HH, Bienz B, Givol D, Zakuthouri R, Pravtcheva DD, Ruddle FH, Oren M,. 1984 The Gene and the Pseudogene For Mouse p53 Cellular Tumor-Antigen Are Located on Different Chromosomes. Molecular and Cellular Biology, 4: 1638-1640
Eliyahu D, Raz A, Gruss P, Givol D, Oren M,. 1984 Participation of p53 Cellular Tumor-Antigen in Transformation of Normal Embryonic-Cells. Nature, 312: 646-649
Hayner NT, Goyette M, Oren M, Fausto N,. 1984 Modulation of p53 Expression During Liver-Regeneration. Journal of Cell Biology, 99: A450
Pinhasi O, Oren M,. 1984 Expression of the Mouse p53 Cellular Tumor-Antigen in Monkey Cells. Molecular and Cellular Biology, 4: 2180-2186
Wolf D, Admon S, Oren M, Rotter V,. 1984 Abelson Murine Leukemia Virus-Transformed Cells That Lack p53 Protein-Synthesis Express Aberrant p53 Messenger-RNA Species. Molecular and Cellular Biology, 4: 552-558
Oren M, Bienz B, Givol D, Rechavi G, Zakut R,. 1983 Analysis of Recombinant DNA Clones Specific For the Murine-p53 Cellular Tumor-Antigen. EMBO Journal, 2: 1633-1639
Oren M, Levine AJ,. 1983 Molecular-Cloning of a CDNA Specific For the Murine p53 Cellular Tumor-Antigen. Proceedings of the National Academy of Sciences of the United States of America-Biological Sciences, 80: 56-59
Reich NC, Oren M, Levine AJ,. 1983 2 Distinct Mechanisms Regulate the Levels of a Cellular Tumor-Antigen, p53. Molecular and Cellular Biology, 3: 2143-2150
Zakuthouri R, Oren M, Bienz B, Lavie V, Hazum S, Givol D,. 1983 A Single Gene and a Pseudogene For the Cellular Tumor Antigen-p53. Nature, 306: 594-597
Gidoni D, Scheller A, Barnet B, Hantzopoulos P, Oren M, Prives C,. 1982 Different Forms of Simian Virus-40 Large Tumor-Antigen Varying in Their Affinities For DNA. Journal of Virology, 42: 456-466
Oren M, Winocour E, Prives C,. 1980 Differential Affinities of Simian Virus-40 Large Tumor-Antigen For DNA. Proceedings of the National Academy of Sciences of the United States of America-Biological Sciences, 77: 220-224
Prives C, Beck Y, Gidoni D, Oren M, Shure H,. 1979 DNA-Binding and Sedimentation Properties of SV40 t-Antigens Synthesized Invivo and Invitro. Cold Spring Harbor Symposia on Quantitative Biology, 44: 123-130
Prives C, Shure H, Gidoni D, Beck Y, Oren M,. 1979 Comparison of Simian-Virus-40 Big and Little t-Antigens. Israel Journal of Medical Sciences, 15: 100-101
Oren M, Lavi S, Winocour E,. 1978 Structure of a Cloned Substituted SV40-Genome. Virology, 85: 404-421
Gluzman Y, Davison J, Oren M, Winocour E,. 1977 Properties of Permissive Monkey Cells Transformed by uv-Irradiated Simian Virus-40. Journal of Virology, 22: 256-266
Oren M, Kuff EL, Winocour E,. 1976 Presence of Common Host Sequences in Different Populations of Substituted SV40-DNA. Virology, 73: 419-430
Oren M, Kuff EL, Winocour E,. 1976 Common Host Sequences in Substituted Simian Virus-40 DNA. Israel Journal of Medical Sciences, 12: 1390

last update: 20 March, 2013 15:35