Phenotypic and Mechanistic Characterization of Drug Tolerant Persister Cancer Cells

Persister cells are a unique, small sub-population of cancer cells that maintain viability under anti-cancer treatments. These cells do not harbor classic resistance-mediating genetic mutations, and their drug-resistance phenotype is thought to be reversible. This unique capability is believed to be the root of the emergence of drug-resistant tumors; therefore there is a great need to find novel ways to eliminate persisters. We aim to better characterize persisters and their vulnerabilities by applying high throughput techniques, clonal analysis, drug screens and “omics” methods.