Mammalian Cells

  • Farkash-Amar, S; Zimmer, A; Eden, E; Cohen, A; Geva-Zatorsky, N; Cohen, L; Milo, R; Sigal, A; Danon, T; Alon, U
    Noise Genetics: Inferring Protein Function by Correlating Phenotype With Protein Levels and Localization in Individual Human Cells
    Plos Genetics , 10:e1004176 (2014) [PDF]
  • Geva-Zatorsky, N; Issaeva, I; Mayo, A; Cohen, A; Dekel, E; Danon, T; Cohen, L; Liron, Y; Alon, U; Eden, E
    Using Bleach-Chase to Measure Protein Half-Lives in Living Cells
    Nature Protocols , (2012) [PDF]
  • Farkash-Amar, S; Eden, E; Cohen, A; Geva-Zatorsky, N; Cohen, L; Milo, R; Sigal, A; Danon, T; Alon, U
    Dynamic Proteomics of Human Protein Level and Localization Across the Cell Cycle
    PLoS ONE , (2012) [PDF]
  • Eden, E; Geva-Zatorsky, N; Issaeva, I; Cohen, A; Dekel, E; Danon, T; Cohen, L; Mayo, A; Alon, U
    Proteome Half-Life Dynamics in Living Human Cells
    Science , (2011) [PDF] [SOM]
  • Geva-Zatorsky, N; Dekel, E; Cohen, AA; Danon, T; Cohen, L; Alon, U
    Protein Dynamics in Drug Combinations: a Linear Superposition of Individual-Drug Responses
    Cell , (2010) [PDF]

    BioWorld: [PDF]

  • Frenkel-Morgenstern, M; Cohen, AA; Geva-Zatorsky, N; Eden, E; Prilusky, J; Issaeva, I; Sigal, A; Cohen-Saidon, C; Liron, Y; Cohen, L; Danon, T; Perzov, N; Alon, U
    Dynamic Proteomics: a Database For Dynamics and Localizations of Endogenous Fluorescently-Tagged Proteins in Living Human Cells
    Nucleic Acids Research , (2010) [PDF]
  • Geva-Zatorsky, N; Dekel, E; Batchelor, E; Lahav, G; Alon, U
    Fourier Analysis and Systems Identification of the P53 Feedback Loop
    Proceedings of the National Academy of Sciences of the United States of America , (2010) [PDF]
  • Geva-Zatorsky, N; Cohen, AA; Eden, E; Dekel, E; Frenkel-Morgenstern, M; Issaeva, I; Danon, T; Cohen, L; Perzov, N; Milo, R; Sigal, A; Alon, U
    Dynamics Proteomics of Individual Cancer Cells in Response to Drugs
    Febs Journal , (2010)
  • Issaeva, I; Cohen, AA; Eden, E; Cohen-Saidon, C; Danon, T; Cohen, L; Alon, U
    Generation of Double-Labeled Reporter Cell Lines For Studying co-Dynamics of Endogenous Proteins in Individual Human Cells
    PLoS ONE , 5:e13524 (2010) [PDF]
  • Oved, K; Eden, E; Akerman, M; Noy, R; Wolchinsky, R; Izhaki, O; Schallmach, E; Kubi, A; Zabari, N; Schachter, J; Alon, U; Mandel-Gutfreund, Y; Besser, MJ; Reiter, Y
    Predicting and Controlling the Reactivity of Immune Cell Populations Against Cancer
    Molecular Systems Biology , (2009)
  • Cohen-Saidon, C; Cohen, AA; Sigal, A; Alon, U
    Dynamics of Erk2 in Individual Living Human Cells
    Febs Journal , (2009)
  • Cohen, AA; Kalisky, T; Mayo, A; Geva-Zatorsky, N; Danon, T; Issaeva, I; Kopito, RB; Perzov, N; Milo, R; Sigal, A; Alon, U
    Protein Dynamics in Individual Human Cells: Experiment and theory
    PLoS ONE , (2009) [PDF]
  • Cohen-Saidon, C; Cohen, AA; Sigal, A; Liron, Y; Alon, U
    Dynamics and Variability of Erk2 Response to Egf in Individual Living Cells
    Molecular Cell , (2009) [PDF]
  • Cohen, AA; Geva-Zatorsky, N; Eden, E; Frenkel-Morgenstern, M; Issaeva, I; Sigal, A; Milo, R; Cohen-Saidon, C; Liron, Y; Kam, Z; Cohen, L; Danon, T; Perzov, N; Alon, U
    Dynamic Proteomics of Individual Cancer Cells in Response to a Drug
    Science , (2008) [PDF] [SOM]

    See also reviews:

    • Science: [PDF]
    • Nature: [PDF]
    • Nature Reviews Cancer: [PDF]
    • Nature Chemical Biology: [PDF]
    • Nature Biotechnology: [PDF]
    • Chemical Research in Toxicology: [PDF]
    • Journal of Proteome Research: [Link]
    • Chemical & Engineering News: [Link]
  • Sigal, A; Danon, T; Cohen, A; Milo, R; Geva-Zatorsky, N; Lustig, G; Liron, Y; Alon, U; Perzov, N
    Generation of a Fluorescently Labeled Endogenous Protein Library in Living Human Cells
    Nature Protocols , (2007) [PDF]
  • Geva-Zatorsky, N; Rosenfeld, N; Itzkovitz, S; Milo, R; Sigal, A; Dekel, E; Yarnitzky, T; Liron, Y; Polak, P; Lahav, G; Alon, U
    Oscillations and Variability in the P53 System
    Molecular Systems Biology , (2006) [PDF]
  • Sigal, A; Milo, R; Cohen, A; Geva-Zatorsky, N; Klein, Y; Alaluf, I; Swerdlin, N; Perzov, N; Danon, T; Liron, Y; Raveh, T; Carpenter, AE; Lahav, G; Alon, U
    Dynamic Proteomics in Individual Human Cells Uncovers Widespread Cell-Cycle Dependence of Nuclear Proteins
    Nature Methods , (2006) [PDF]
  • Rosenfeld, N; Perkins, TJ; Alon, U; Elowitz, MB; Swain, PS
    A Fluctuation Method to Quantify in Vivo Fluorescence Data
    Biophysical Journal , (2006) [PDF]
  • Sigal, A; Milo, R; Cohen, A; Geva-Zatorsky, N; Klein, Y; Liron, Y; Rosenfeld, N; Danon, T; Perzov, N; Alon, U
    Variability and Memory of Protein Levels in Human Cells
    Nature , (2006) [PDF]
  • Lahav, G; Rosenfeld, N; Sigal, A; Geva-Zatorsky, N; Levine, AJ; Elowitz, MB; Alon, U
    Dynamics of the P53-Mdm2 Feedback Loop in Individual Cells
    Nature Genetics , (2004) [PDF]
  • Bar-Or, RL; Maya, R; Segel, LA; Alon, U; Levine, AJ; Oren, M
    Generation of Oscillations by the P53-Mdm2 Feedback Loop: a theoretical and Experimental Study
    Proceedings of the National Academy of Sciences of the United States of America , (2000)
  • Alon U, Barkai N, Notterman DA, Gish K, Ybarra S, Mack D, Levine AJ.
    Broad Patterns of Gene Expression Revealed by Clustering Analysis of Tumor and Normal Colon Tissues Probed by Oligonucleotide Arrays.
    Proc Natl Acad Sci u s a , (1999) [PDF]