Mammalian Cells

Miri Adler, Avi Mayo, Xu Zhou, Ruth A. Franklin, Jeremy B. Jacox, Ruslan Medzhitov and Uri Alon

Endocytosis as a Stabilizing Mechanism For Tissue Homeostasis

PNAS , (2018) [PDF]
Zhou X, Franklin RA, Adler M, Jacox JB, Bailis W, Shyer JA, Flavell RA, Mayo A, Alon U, Medzhitov R

Circuit Design Features of a Stable Two-Cell System.

Cell , (2018) [PDF]

Preview: Building a Stable Relationship: Ensuring Homeostasis among Cell Types within a Tissue
Farkash-Amar, S; Zimmer, A; Eden, E; Cohen, A; Geva-Zatorsky, N; Cohen, L; Milo, R; Sigal, A; Danon, T; Alon, U

Noise Genetics: Inferring Protein Function by Correlating Phenotype With Protein Levels and Localization in Individual Human Cells

Plos Genetics , 10:e1004176 (2014) [PDF]
Zatorsky, Naama Geva Zatorsky; Irina Issaeva; Avi Mayo; Ariel Cohen; Erez Dekel; Tamar Danon; Lydia Cohen; Yuvalal Liron; Uri Alon; Eran Eden

Using Bleach-Chase to Measure Protein Half-Lives in Living Cells

Nature Protocols , 7:000015208 (2012) [PDF]
Shlomit Farkash-Amar; Eran Eden; Ariel Cohen; Zatorsky, Naama Geva Zatorsky; Lydia Cohen; Ron Milo; Alex Sigal; Tamar Danon; Uri Alon

Dynamic Proteomics of Human Protein Level and Localization Across the Cell Cycle

PLoS ONE , 7:000012765 (2012) [PDF]
Eran Eden; Zatorsky, Naama Geva Zatorsky; Irina Issaeva; Ariel Cohen; Erez Dekel; Tamar Danon; Lydia Cohen; Avi Mayo; Uri Alon

Proteome Half-Life Dynamics in Living Human Cells

Science , 331:000011535 (2011) [PDF] [SOM]
Zatorsky, Naama Geva Zatorsky; Erez Dekel; Ariel Cohen; Tamar Danon; Lydia Cohen; Uri Alon

Protein Dynamics in Drug Combinations: a Linear Superposition of Individual-Drug Responses

Cell , 140:000015207 (2010) [PDF]

BioWorld: [PDF]
Milana Frenkel-Morgenstern; Ariel Cohen; Zatorsky, Naama Geva Zatorsky; Eran Eden; Jaime Prilusky; Irina Issaeva; Alex Sigal; Cellina Cohen-Saidon; Yuvalal Liron; Lydia Cohen; Tamar Danon; Natalie Perzov; Uri Alon

Dynamic Proteomics: a Database For Dynamics and Localizations of Endogenous Fluorescently-Tagged Proteins in Living Human Cells

Nucleic Acids Research , 38:000013795 (2010) [PDF]
Zatorsky, Naama Geva Zatorsky; Erez Dekel; Eric Batchelor; Galit Lahav; Uri Alon

Fourier Analysis and Systems Identification of the P53 Feedback Loop

Proceedings of the National Academy of Sciences of the United States of America , 107:000015206 (2010) [PDF]
Zatorsky, Naama Geva Zatorsky; A. A. Cohen; Eran Eden; Erez Dekel; Milana Frenkel-Morgenstern; Irina Issaeva; Tamar Danon; Liron Cohen; N. Perzov; Ron Milo; A. Sigal; Uri Alon

Dynamics Proteomics of Individual Cancer Cells in Response to Drugs

, :000015205 (2010)
Irina Issaeva; Ariel Cohen; Eran Eden; Cellina Cohen-Saidon; Tamar Danon; Lydia Cohen; Uri Alon

Generation of Double-Labeled Reporter Cell Lines For Studying co-Dynamics of Endogenous Proteins in Individual Human Cells

PLoS ONE , 5:000019668 (2010) [PDF]
Cellina Cohen-Saidon; A. A. Cohen; A. Sigal; Uri Alon

Dynamics of Erk2 in Individual Living Human Cells

, :000009787 (2009)
Ariel Cohen; Tomer Kalisky; Avi Mayo; Zatorsky, Naama Geva Zatorsky; Tamar Danon; Irina Issaeva; Ronen Benjamine Kopito; Natalie Perzov; Ron Milo; Alex Sigal; Uri Alon

Protein Dynamics in Individual Human Cells: Experiment and theory

PLoS ONE , 4:000009444 (2009) [PDF]
Cellina Cohen-Saidon; Ariel Cohen; Alex Sigal; Yuvalal Liron; Uri Alon

Dynamics and Variability of Erk2 Response to Egf in Individual Living Cells

Molecular Cell , 36:000009788 (2009) [PDF]
Kfir Oved; Eran Eden; Martin Akerman; Roy Noy; Ron Wolchinsky; Orit Izhaki; Ester Schallmach; Adva Kubi; Naama Zabari; Jacob Schachter; Uri Alon; Yael Mandel-Gutfreund; Michal J. Besser; Yoram Reiter

Predicting and Controlling the Reactivity of Immune Cell Populations Against Cancer

Molecular Systems Biology , 5:000029491 (2009)
A. A. Cohen; Zatorsky, Naama Geva Zatorsky; Eran Eden; Milana Frenkel-Morgenstern; Irina Issaeva; A. Sigal; Ron Milo; Cellina Cohen-Saidon; Zvi Kam; Liron Cohen; Yuvalal Liron; Tamar Danon; N. Perzov; Uri Alon

Dynamic Proteomics of Individual Cancer Cells in Response to a Drug

Science , 322:000009443 (2008) [PDF] [SOM]
See also reviews:
- Science: [PDF]
- Nature: [PDF]
- Nature Reviews Cancer: [PDF]
- Nature Chemical Biology: [PDF]
- Nature Biotechnology: [PDF]
- Chemical Research in Toxicology: [PDF]
- Journal of Proteome Research: [Link]
- Chemical & Engineering News: [Link]
Alex Sigal; Tamar Danon; Ariel Cohen; Ron Milo; Zatorsky, Naama Geva Zatorsky; Gila Lustig; Yuvalal Liron; Uri Alon; Natalie Perzov

Generation of a Fluorescently Labeled Endogenous Protein Library in Living Human Cells

Nature Protocols , 2:000036441 (2007) [PDF]
Zatorsky, Naama Geva Zatorsky; Nitzan Rosenfeld; Shalev Itzkovitz; Ron Milo; Alex Sigal; Erez Dekel; Talia Yarnitzky; Yuvalal Liron; Paz Polak; Galit Lahav; Uri Alon

Oscillations and Variability in the P53 System

Molecular Systems Biology , 2:000015209 (2006) [PDF]
A Sigal; Ron Milo; Ayala Cohen; Zatorsky, Naama Geva Zatorsky; Yasmin A. Klein; I Alaluf; N Swerdlin; N Perzov; Tamar Danon; Yuvalal Liron; T Raveh; AE Carpenter; G Lahav; Uri Alon

Dynamic Proteomics in Individual Human Cells Uncovers Widespread Cell-Cycle Dependence of Nuclear Proteins

Nature Methods , 3:000036444 (2006) [PDF]
N Rosenfeld; TJ Perkins; Uri Alon; MB Elowitz; PS Swain

A Fluctuation Method to Quantify in Vivo Fluorescence Data

Biophysical Journal , 91:000032804 (2006) [PDF]
Alex Sigal; Ron Milo; Ariel Cohen; Zatorsky, Naama Geva Zatorsky; Yael Klein; Yuvalal Liron; Nitzan Rosenfeld; Tamar Danon; Natalie Perzov; Uri Alon

Variability and Memory of Protein Levels in Human Cells

Nature , 444:000036445 (2006) [PDF]
G Lahav; N Rosenfeld; A Sigal; Zatorsky, Naama Geva Zatorsky; AJ Levine; MB Elowitz; Uri Alon

Dynamics of the P53-Mdm2 Feedback Loop in Individual Cells

Nature Genetics , 36:000023011 (2004) [PDF]
RL Bar-Or; R Maya; LA Segel; Uri Alon; AJ Levine; Moshe Oren

Generation of Oscillations by the P53-Mdm2 Feedback Loop: a theoretical and Experimental Study

Proceedings of the National Academy of Sciences of the United States of America , 97:000005029 (2000)
Alon U, Barkai N, Notterman DA, Gish K, Ybarra S, Mack D, Levine AJ.

Broad Patterns of Gene Expression Revealed by Clustering Analysis of Tumor and Normal Colon Tissues Probed by Oligonucleotide Arrays.

Proc Natl Acad Sci u s a , (1999) [PDF]