Questions? Contact the Feinberg Graduate School at email@example.com
Note: Due to the multidisciplinary nature of scientific research, you may be interested in scanning the entire list of
rotations offered by scientists in all the faculties: chemistry, life sciences, physics, and mathematics/computer
science. There are for example, scientists in life sciences who are interested in rotation students in chemistry, and
scientists in physics who might supervise students in the life sciences. However, before beginning a rotation in an
area that is outside your own field of study, you must obtain the approval of the Head of the Board of Studies.
Research positions available in our department include:
Prof. Valery Krizhanovsky
The impact of senescent cells on stem cells and tissue regeneration in aging and age-related diseases
Cellular senescence, which is a terminal cell cycle arrest, is a potent tumor suppressor mechanism that limits cancer initiation and progression; it also limits tissue damage response. While senescence is protective in the cell autonomous manner, senescent cells secrete a variety of factors that lead to inflammation, tissue destruction and promote tumorigenesis and tissue aging in the sites of their presence. We developed elaborate approaches to eliminate senescent cells from tissues. Our studies show that elimination of senescent cells leads to proliferation of stem cells and tissue regeneration. Now we study the effects of elimination of senescent cells in mouse models of age-related diseases and the molecular mechanisms that mediate these effects.
Prof. Sima Lev
A Postdoctoral position to study the role of exosomes in breast cancer
A Postdoctoral position is available to investigate the role of exosomes in breast cancer progression and metastasis. We investigate the underlying mechanisms of exopsomes biogenesis and secretion, and characterize their protein and RNA/miRNA content. We also explore the role of exosomes as biomarkers and their involvement in tumor-microenvironment crosstalk. We employ multidisciplinary experimental approaches using breast cancer patient samples, in vitro cellular models and in vivo animal models.
Prof. Sima Lev
A Postdoctoral position to study Tumor-Associated Macrophages-TNBC crosstalk
A Postdoctoral position is available to investigate the crosstalk between Tumor-Associated Macrophages (TAMs) and triple negative breast cancer (TNBC) subtypes. In particular, we are interested to define how the crosstalk between these cell types affects signaling reprogramming in the breast cancer cells and modulates the response to treatment. We apply multidisciplinary experimental approaches using in vitro and animal models. Background in immunology is required.
Prof. Sima Lev
Receptor-tyrosine kinases (RTKs)-associated drug Resistance in TNBC subtypes
Drug resistance is a major clinical problem in oncology, and is frequently mediated by upregulation of bypassed mechanisms. Many of the commonly used targeted therapies are associated with upregulation of Receptor-tyrosine kinases (RTKs). For triple-negative breast cancer (TNBC), drug resistance is frequently associated with upregulation of EGFR, cMet and AXL RTKs. We investigate the mechanisms underlying RTKs-associated drug resistance in TNBC subtypes, and plan to develop therapeutic strategies to overcome this resistance.
Dr. Itay Tirosh
Looking for postdocs with computational or experimental background to study tumor biology
Our lab combines computational and experimental approaches to discover sub-populations of human tumor cells, study their biological functions and the therapeutic implications. For more details please see the lab website.
Prof. varda Rotter
A. Involvment of p53 in the life of stem cells:wild type p53 versus mutant p53
B. Development of mutant p53 based cancer therapy.
A. Role of p53 in development, differentiation and stem cells:
Along the years, my laboratory re-examined the role of p53 in cell differentiation and development by using several models of cell differentiation. More recently we focused on understanding the role of p53 in the life of stem cells. In our early studies we showed that p53 is central in regulating cell reprogramming and in agreement with others they found that wild type p53 exerts a negative control on stem cell reprogramming. More recent novel data shows that mutant p53 plays a pivotal role in preventing malignant transformation of induced pluripotent stem cells and that mutant p53 exerts a gain of function activity in inducing cancer stem cells characteristics. These observations are of great relevance for understanding the role of mutant p53 in cancer development, at large and in LI-Fraumeni syndrome, in particular.
B. p53 based therapy:
The understanding that mutant p53 exhibits an oncogenic gain of function activity in tumor cells, prompted the search for ways of altering the mutant p53 protein conformation into a wild type p53 conformation. The idea being that by such an approach may eliminate the oncogenic nature of the cancer cell and concomitantly induce apoptosis by the refolded wild type p53.
By analyzing the p53 protein expressed in embryonic stem cells (ESCs), it was realized that in mutant p53 knocked-in ESCs, in spite of them carrying a mutated p53 gene, they express at high levels a wild type p53 protein. An observation that can explain the phenomenon that mice knocked-in with mutant p53 are born viable and undergo rather normal development. Further analysis indicated that in such ESCs, chaperons bind the mutant p53 protein and refold it into a wild type p53 conformation. Inspired by this observation, a screen of small peptide libraries, revealed a group of peptides that induced refolding the mutant p53 protein and acquiring it with wild type p53 activities, measured by in vitro and in vivo assays. Accordingly, these small peptides can be regarded as potential candidate for mutant-p53-based therapy.
Other positions available at the Weizmann Institute:
>> Undergraduate Summer Programs
>> Postdoctoral Fellowships
>> Visiting Professorships
>> Visiting Scientists
In addition to the above, PhD and postdoctoral positions are available with Igor Ulitsky's group. The Ulitsky lab will start operations in September 2013 and will study the biology of noncoding RNAs and their roles in gene regulation, with a particular focus on the recently emerging class of long intervening noncoding RNAs (lincRNAs). We will study modes of actions and functions of these RNAs, as well as their evolution and their roles in higher-order regulatory networks. To do so, we will use novel and existing techniques in genomics, systems biology, biochemistry and computational sequence analysis.
Candidates with background in computational or molecular biology are sought, and those with a multidisciplinary background, spanning both life sciences and computer sciences, are especially encouraged to apply. Among candidates with background in molecular biology, preference will be given to those with experience in molecular work with RNA, biochemical purifications, and/or studying mammalian stem cells in culture.
The starting date is flexible. Interested and highly motivated applicants should send their CV and brief description of research interests to firstname.lastname@example.org. Informal inquiries are welcome.
For more details and relevant publications see: http://jura.wi.mit.edu/bartel/ulitsky.
Graduate student and postdoctoral benefits are as described at http://www.fgs.org.il/en/.