Publications

Majewska J, Agrawal A, Mayo A, Roitman L, Chatterjee R, Kralova J, Landsberger T, Katzenelenbogen Y, Salame TM, Hagai E, Stanojevic N, Amit I, Alon U, Krizhanovsky V (2023). p16-dependent upregulation of PD-L1 impairs immunosurveillance of senescent cells. biorxiv. 2023, online .

Rachmian N, Medina S, Cherqui U, Akiva H, Deitch D, Edilbi D, Croese T, Salame TM, Peralta Ramos JM, Cahalon L, Krizhanovsky V, Schwartz M. (2023). TREM2-dependent senescent microglia conserved in aging and Alzheimer’s disease. Biorxiv.. 2023, Online .

Levi N, Papismadov N, Majewska J, Roitman L, Wigoda N, Eilam R, Tsoory M, Rotkopf R, Ovadya Y, Akiva H, Regev O, Krizhanovsky V. (2023). p21 facilitates chronic lung inflammation via epithelial and endothelial cells. Aging. 2023, 15 (7):2395-2417.

Rachmian N, Krizhanovsky V. (2023). Senescent cells in the brain and where to find them. FEBS J.. 2023, 290 (5):1256-1266.

Kolodkin-Gal D, Roitman L, Ovadya Y, Azazmeh N, Assouline B, Schlesinger Y, Kalifa R, Horwitz S, Khalatnik Y, Hochner-Ger A, Imam A, Demma JA, Winter E, Benyamini H, Elgavish S, Khatib AA, Meir K, Atlan K, Pikarsky E, Parnas O, Dor Y, Zamir G, Ben-Porath I, Krizhanovsky V (2021). Senolytic elimination of Cox2-expressing senescent cells inhibits the growth of premalignant pancreatic lesions. Gut. 2021, 71 (2):345-355.

Gal H, Majewska J, Krizhanovsky V (2021). The intricate nature of senescence in development and cell plasticity. Semin Cancer Biol. 2021, 87 :214-219.

Di Micco R, Krizhanovsky V, Baker D, d'Adda di Fagagna F. (2021). Cellular senescence in ageing: from mechanisms to therapeutic opportunities. Nat Rev Mol Cell Bio. 2021, 22 (2):75-95.

Papismadov N, Krizhanovsky V. (2021). Natural killers of cognition.. Nat Neurosci. 2021, 24 (1):2-4.

Kinker GS, Greenwald AC, Tal R, Orlova Z, Cuoco MS, McFarland JM, Warren A, Rodman C, Roth JA, Bender SA, Kumar B, Rocco JW, Fernandes PACM, Mader CC, Keren-Shaul H, Plotnikov A, Barr H, Tsherniak A, Rozenblatt-Rosen O, Krizhanovsky V, Puram SV, Regev A, Tirosh I. (2020). Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity. Nat Genet.. 2020, 52 (11):1208-1218.

Shmulevich R, Krizhanovsky V (2020). Cell Senescence, DNA Damage, and Metabolism. Antioxid Redox Signal .. 2020, 34 (4):324-334.

Levi N, Papismadov N, Solomonov I, Sagi I, Krizhanovsky V (2020). The ECM path of senescence in aging: components and modifiers. FEBS J. 2020, 287 (13):2636-2646.

Karin O, Agrawal A, Porat Z, Krizhanovsky V, Alon U (2019). Senescent cell turnover slows with age providing an explanation for the Gompertz law. Nat Commun. 2019, 10 (1):5495.

Gorgoulis V, Adams PD, Alimonti A, Bennett DC, Bischof O, Bishop C, Campisi J, Collado M, Evangelou K, Ferbeyre G, Gil J, Hara E, Krizhanovsky V, Jurk D, Maier AB, Narita M, Niedernhofer L, Passos JF, Robbins PD, Schmitt CA, Sedivy J, Vougas K, von Zglinicki T, Zhou D, Serrano M, Demaria M (2019). Cellular Senescence: Defining a Path Forward. Cell.. 2019, 179 (4):813-827.

Gal H, Lysenko M, Stroganov S, Vadai E, Youssef SA, Tzadikevitch-Geffen K, Rotkopf R, Biron-Shental T, de Bruin A,4, Neeman M, Krizhanovsky V. (2019). Molecular pathways of senescence regulate placental structure and function. EMBO J.. 2019, 38 (18).

Karin O, Agrawal A, Porat Z, Krizhanovsky V, Alon U (2019). Senescent cell turnover slows with age providing an explanation for the Gompertz law. Nat Commun . 2019, 10 (1):5495.

Ovadya Y, Landsberger T, Leins H, Vadai E, Gal H, Biran A, Yosef R, Sagiv A, Agrawal A, Shapira A, Windheim J, Tsoory M, Schirmbeck R, Amit I, Geiger H, Krizhanovsky V. (2018). Impaired immune surveillance accelerates accumulation of senescent cells and aging. Nat Commun . 2018, 9 (1):5435.

Farack L,Golan M, Egozi A, Dezorella N,Bahar Halpern K, Ben-Moshe S, Garzilli I,1 To´ th B, Roitman L, Krizhanovsky V, Shalev Itzkovitz (2018). Transcriptional Heterogeneity of Beta Cells in the Intact Pancreas. Dev Cell. 2018, 48 (1):115-125.

Gal H, Porat Z, Krizhanovsky V (2018). A Multi-Parametric Assay to Evaluate Senescent Cells. Methods Mol Biol. 2018, 1896 :107-117.

Biran A, Porat Z, Krizhanovsky V (2018). Quantitative Identification of Senescent Cells in Cancer. Methods Mol Biol. 2018, 1884 :259-267.

Farladansky-Gershnabel S, Gal H, Kidron D, Krizhanovsky V, Amiel A, Sukenik-Halevy R, Biron-Shental T. (2018). Telomere Homeostasis and Senescence Markers Are Differently Expressed in Placentas From Pregnancies With Early- Versus Late-Onset Preeclampsia. Reprod Sci. 2018, Online .

Ovadya Y, Krizhanovsky V (2018). Strategies targeting cellular senescence. J Clin Invest. 2018, 128 (4):1247-1254.

Sagiv A, Bar-Shai A, Levi N, Hatzav M, Zada L, Ovadya Y, Roitman L, Manella G, Regev O, Majewska J, Vadai E, Eilam R, Feigelson S, Tsoory M, Tauc M, Alon R, Krizhanovsky V (2018). p53 in Bronchial Club Cells Facilitates Chronic Lung Inflammation by Promoting Senescence. Cell Reports. 2018, 22 (13):3468-3479.

Mancini M, Gal H, Gaborit N, Mazzeo L, Romaniello D, Salame T, Lindzen M, Mahlknecht G, Enuka Y, Burton DG, Roth L, Noronha A, Marrocco I, Adreka D, Altstadter RE, Bousquet E, Downward J, Maraver A, Krizhanovsky V, Yarden Y (2017). An oligoclonal antibody durably overcomes resistance of lung cancer to third‐generation EGFR inhibitors. EMBO Mol Med. 2017, Online .

Tzadikevitch-Geffen K, Gal H, Vainer I, Markovitch O, Amiel A, Krizhanovsky V, Biron-Shental T (2017). Senescence and Telomere Homeostasis Might Be Involved in Placenta Percreta—Preliminary Investigation. Reprod Sci. 2017, Online .

Papismadov N, Gal H, Krizhanovsky V (2017). The anti-aging promise of p21. Cell Cycle. 2017, Online :Full text.

Yosef R, Pilpel N, Papismadov N, Gal H, Ovadya Y, Vadai E, Miller S, Porat Z, Ben‐Dor S, Krizhanovsky V (2017). p21 maintains senescent cell viability under persistent DNA damage response by restraining JNK and caspase signaling. EMBO J. 2017, Online .

Biran A, Zada L, Abou-Karam P, Vadai E, Roitman L, Ovadya Y, Porat Z, Krizhanovsky V. (2017). Quantitative identification of senescent cells in aging and disease. Aging Cell. 2017, Online .

Ovadya Y, Krizhanovsky V. (2016). Senescent cell death brings hopes to life. Cell Cycle. 2016, (Online):1-2.

Yosef R, Krizhanovsky V. (2016). mTOR signaling orchestrates the expression of cytoprotective factors during cellular senescence. Oncotarget. 2016, 7 (31):48859.

Yosef R, Pilpel N, Tokarsky-Amiel R, Biran A, Ovadya Y, Cohen S, Vadai E, Dassa L, Shahar E, Condiotti R, Ben-Porath I & Krizhanovsky V. (2016). Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL. Nature Communications . 2016, .

Sagiv A, Burton DG, Moshayev Z, Vadai E, Wensveen F, Ben-Dor S, Golani O, Polic B, Krizhanovsky V. (2016). NKG2D ligands mediate immunosurveillance of senescent cells . Aging. 2016, 8 (2):328-44.

Ovadya Y, Krizhanovsky V. (2015). A new Twist in kidney fibrosis. Nat Med. 2015, 21 (9):975-7.

Biran A, Perelmutter M, Gal H, Burton DG, Ovadya Y, Vadai E, Geiger T, Krizhanovsky V. (2015). Senescent cells communicate via intercellular protein transfer. Genes & Dev. 2015, 29 (8):791-802.

Golomb L, Sagiv A, Pateras IS, Maly A, Krizhanovsky V, Gorgoulis VG, Oren M, Ben-Yehuda A (2015). Age-associated inflammation connects RAS-induced senescence to stem cell dysfunction and epidermal malignancy. Cell Death & Differentiation . 2015, online .

George B, Horn D, Bayo P, Zaoui K, Flechtenmacher C, Grabe N, Plinkert P, Krizhanovsky V, Hess J. (2015). Regulation and function of Myb-binding protein 1A (MYBBP1A) in cellular senescence and pathogenesis of head and neck cancer. Cancer Lett. 2015, 358 (2):191-9.

Burton DG, Krizhanovsky V (2014). Physiological and pathological consequences of cellular senescence. Cell Mol Life Sci. 2014, 71 (22):4373-86.

Ovadya Y, Krizhanovsky V. (2014). Senescent cells: SASPected drivers of age-related pathologies. Biogerontology. 2014, .

Gal H, Krizhanovsky V (2014). Cell fusion induced senescence. Aging. 2014, 6 :353-354.

Abu-Tair L, Axelrod JH, Doron S, Ovadya Y, Krizhanovsky V, Galun E, Amer J, Safadi R (2013). Natural Killer Cell-Dependent Anti-Fibrotic Pathway in Liver Injury via Toll-Like Receptor-9. PLoS ONE. 2013, 8 (12).

Lujambio A, Akkari L, Simon J, Grace D, Tschaharganeh DF, Bolden JE, Zhao Z, Thapar V, Joyce JA, Krizhanovsky V, Lowe SW (2013 ). Non-cell-autonomous tumor suppression by p53. Cell. 2013 , 2 (153):449-60.

Krizhanovsky V (2013). Cellular Senescence Limits the Extent of Fibrosis Following Liver Damage. Tumor Dormancy, Quiescence, and Senescence. 2013, 1 :291-301.

Sagiv A, Krizhanovsky V (2013). Immunosurveillance of senescent cells: the bright side of the senescence program. Biogerontology. 2013, 6 (14):617-628.

Chuprin A, Gal H, Biron-Shental T, Biran A, Amiel A, Rozenblatt S, Krizhanovsky V, (2013). Cell fusion induced by ERVWE1 or measles virus causes cellular senescence. Genes & Development. 2013, 27 (21):2356-2366.

Sagiv A, Biran A, Yon M, Simon J, Lowe SW, Krizhanovsky V, (2013). Granule exocytosis mediates immune surveillance of senescent cells. Oncogene. 2013, 32 (15):1971-1977.

Storer M, Mas A, Robert-Moreno A, Pecoraro M, Ortells MC, Di Giacomo V, Yosef R, Pilpel N, Krizhanovsky V, Sharpe J, Keyes WM, (2013). Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning. Cell. 2013, 155 (5):1119-1130.

Krizhanovsky V, Lowe SW (2009). The promises and perils of p53. Nature. 2009, 460 (7259):1085-6.

Krizhanovsky V, Xue W, Zender L, Yon M, Hernando E, and Lowe SW (2008). Implications of cellular senescence in tumor suppression, tissue damage, and stem cell biology. Cold Spring Harb Symp Quant Biol.. 2008, 73 :513-22.

Krizhanovsky V, Yon M, Dickins RA, Hearn S, Simon J, Miething C, Yee H, Zender L, Lowe SW (2008). Senescence of activated stellate cells limits liver fibrosis. Cell. 2008, 134 (4):657-67.

Xue W, Zender L, Miething C, Dickins RA, Hernando E, Krizhanovsky V, Cordon-Cardo C, Lowe SW (2007). Senescence and tumor clearance is triggered by p53 restoration in murine liver carcinomas. Nature. 2007, 445 (7128):656-60.

Dickins RA, McJunkin K, Hernando E, Premsrirut PK, Krizhanovsky V, Burgess DJ, Kim SY, Cordon-Cardo C, Zender L, Hannon GJ, Lowe SW (2007). Tissue-specific and reversible RNA interference in transgenic mice. Nat Genet.. 2007, 39 (7):914-21.

*Narita M, Narita M, Krizhanovsky V, Nunez S, Chicas A, Hearn SA, Myers MP, Lowe SW (2006). A novel role for High-Mobility Group A proteins in cellular senescence and heterochromatin formation. Cell. 2006, 126 (3):503-14.