Hendricks, W.J., Elson, A., Harroch, S., Pulido, R., Stoker, A. and den Hertog, J. (2013). Protein tyrosine phosphatases in health and disease. FEBS J. 280 (2), 708-730.
Yu, M., Lin, G., Arshadi, N., Kalatskaya, I., Xue, B. Haider, S., Nguyen, F., Boutros, P.C., Elson, A., Muthuswamy, L.B., Tonks, N.K. and Muthuswamy, S.K. (2012).
Expression profiling during mammary epithelial cell 3D morphogenesis identifies PTPRO as a novel regulator of morphogenesis and ErbB2-mediated transformation. Mol. Cell Biol. 32 (19), 3913-3924.
Ebner-Bennatan, S., Patrich, E., Peretz, A., Kornilov, P., Tiran, Z., Elson, A and Attali, B. (2012).
Multi-faceted modulation of K+ channels by protein tyrosine phosphatase epsilon tunes neuronal excitability. J. Biol. Chem., 287 (33), 27614-27628.
Nunes-Xavier CE, Elson A. and Pulido R. (2012).
Epidermal growth factor receptor (EGFR)-mediated positive feedback of protein-tyrosine phosphatase epsilon (PTPepsilon) on ERK1/2 and AKT protein pathways is required for survival of human breast cancer cells. J. Biol Chem. 287 (5), 3433-3444, (2012).
Rousso-Noori L, Knobler H, Levy-Apter E, Kuperman Y, Neufeld-Cohen A, Keshet Y, Akepati VR, Klinghoffer RA, Chen A. and Elson A. (2011).
Protein tyrosine phosphatase epsilon affects body weight by downregulating leptin signaling in a phosphorylation-dependent manner. Cell Metabolism. 13(5), 562-572, (2011).
Granot-Attas, S., Luxenburg, C., Finkelshtein, E. and Elson, A. (2009).
PTP Epsilon regulates integrin-mediated podosome stability in osteoclasts by activating Src. Mol. Biol. Cell 20 (20), 4324-4334, 2009.
Akimoto, M., Mishra, K., Lim, K.T., Tani, N., Hisanaga, S., Katagiri, T., Elson, A., Mizuno, K. and Yakura, H. (2009).
Protein tyrosine phosphatase ε is a negative regulator of FceRI-mediated mast cell responses. Scand. J. Immunol. 69 (5), 401-411, 2009.
De Franceschi, L., Biondani, A., Carta, F., Turrini, F., Laudanna, C., Deana, R., Brunati, A.M., Turretta, L., Iolascon, A., Perrotta, S., Elson, A., Bulato, C. and Brugnara, C. (2008).
PTP Epsilon has a critical role in signaling transduction pathways and phosphoprotein network topology in red cells. Proteomics 8(22), 4695-4708, 2008.
Kraut-Cohen, J., Muller, W.J., and Elson, A. (2008).
Protein tyrosine phosphatase ε regulates Shc signaling in a kinase-specific manner: increasing coherence in tyrosine phosphatase signaling. J. Biol. Chem. 282 (8), 4612-4621, 2008.
Aga-Mizrachi, S., Brutman-Barazani, T., Jacob, A.I., Bak, A., Elson, A. and Sampson, S.R. (2008).
Cytosolic protein tyrosine phosphatase-ε (cytPTPe) is a negative regulator of insulin signaling in skeletal muscle. Endocrinology 149 (2), 605-614, 2008.
Granot-Attas, S. and Elson, A. (2008).
Protein tyrosine phosphatases in osteoclasts: differentiation, adhesion, and bone resorption.
Eur. J. Cell Biol. 87, 470-490, 2008 (invited review).
Hendriks, W.J.A.J., Elson, A., Harroch, S. and Stoker, A.W. (2008).
Protein tyrosine phosphatase functions: Inferences from mouse models and human diseases. FEBS Journal, 275 (5), 816-830, 2008 (Invited review)
Berman-Golan, D., Granot-Attas, S., and Elson, A. (2008).
Protein tyrosine phosphatase Epsilon and Neu-induced mammary tumorigenesis.
Cancer Metastasis Rev. 27, 193-203 (invited review).
Sines, T., Granot-Attas, S., Weisman-Welcher, S. and Elson, A. (2007).
Association of PTPε with microtubules inhibits phosphatase activity and is regulated by the EGF receptor. Mol. Cell. Biol. 27 (20), 7102-7112, 2007.
Berman-Golan, D. and Elson, A. (2007).
Neu-mediated phosphorylation of protein tyrosine phosphatase Epsilon is critical for activation of Src in mammary tumor cells. Oncogene 26 (49), 7028-7037, 2007.
Granot-Attas, S., Knobler, H. and Elson, A. (2007).
Protein tyrosine phosphatases in osteoclasts. Critical Reviews in Eukaryotic Gene Expression, 17 (1), 49-72, 2007 (invited review).
Tiran, Z., Peretz, A., Shinder, V., Sap, J., Attali, B. and Elson, A. (2006).
PTPs ε and α perform specific and overlapping functions in regulation of voltage-gated potassium channels and axon myelination. Mol. Biol. Cell 17 (10), 4330-4342.
Kollet, O., Sztainberg, Y., Samstein, R.M., Dar, A., Lapid, K., Kalinkovich, A., Goichberg, P., Spiegl, A., Shivitel, S., Tesio, M., Elson, A. and Lapidot, T. (2006).
Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells. Nature Medicine 12 (6), 657-664, 2006.
Elson, A. (2005).
Cyt-PTPe. AfCS-Nature Molecule Pages (doi:10.1038/mp.a003816.01)
(Alliance for Cell Signaling-Nature online Molecule Page for cyt-PTPe).
Persson, C., Savenhed, C., Bourdeau, A., Tremblay, M.L., Markova, B., Bohmer, F.D., Haj, F.G., Neel, B.G., Elson, A., Heldin, C.H., Ronnstrand, L., Ostman, A. and Hellberg, C. (2004).
Site-selective regulation of PDGF β receptor tyrosine phosphorylation by TC-PTP. Mol. Cell Biol., 24(5):2190-2201, 2004.
Granot-Attas, S. and Elson, A. (2004).
Protein tyrosine phosphatase epsilon activates Yes and Fyn in Neu-induced mammary tumor cells. Exp. Cell Res. 294 (1), 236-243, 2004.
Chiusaroli, R.*, Knobler, H.*, Luxenburg, C. *, Sanjay, A., Granot-Attas, S., Tiran, Z., Miyazaki, T., Harmelin, A., Baron, R. and Elson, A. (2004).
Tyrosine phosphatase Epsilon is a positive regulator of osteoclast function: increased bone mass in female mice lacking PTPε. Mol. Biol. Cell, 15(1), 234-244, 2004.
Toledano-Katchalski, H., Tiran, Z., Sines, T., Shani, G., Granot-Attas, S. den Hertog, J. and Elson, A. (2003).
Dimerization in vivo and inhibition of the non-receptor form of Protein Tyrosine Phosphatase epsilon. Mol. Cell Biol. 23, 5460-5471, 2003.
Toledano-Katchalski, H., Kraut, J., Sines, T., Granot-Attas, S., Shohat, G., Gil-Henn, H., Yung, Y. and Elson, A. (2003).
Protein tyrosine phosphatase ε inhibits signaling by mitogen-activated protein kinases.
Mol. Cancer Res. 1 (7), 541-550, 2003.
Tiran, Z., Peretz, A., Attali, B. and Elson, A. (2003).
Phosphorylation-dependent regulation of Kv2.1 channel activity at tyrosine 124 by Src and by protein-tyrosine phosphatase ε. J. Biol. Chem. 278 (19), 17509-17514, 2003.
Gil-Henn, H. and Elson, A. (2003).
Tyrosine phosphatase epsilon activates Src and supports the transformed phenotype of Neu-induced mammary tumor cells. J. Biol. Chem. 278 (18), 15579-15586, 2003.
Tiran, Z. and Elson, A. (2003).
Whole mount analysis of mammary gland structure in transgenic mice overexpressing PTPε.
Methods Enzymol. 366, 124-132. (S. Klumpp and J. Krieglstein, eds., Academic Press).
Kraut, J., Volohonski, G., Toledano-Katchalski, H. and Elson, A. (2002).
Nuclear localization of non-receptor protein tyrosine phosphatase ε is regulated by its unique N-terminal domain. Exp. Cell Res. 281 (10), 182-189, 2002.
Waterman, H., Katz, M., Rubin, C., Shtiegman, K., Lavi, S., Elson, A., Jovin, T. and Yarden, Y. (2002).
A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling. EMBO J. 21(3):303-313, 2002.
Gil-Henn, H., Volohonsky, G., and Elson, A. (2001).
Regulation of RPTP α and PTP ε by calpain-mediated proteolytic cleavage.
J. Biol. Chem., 276 (34) 31772-31779, 2001.
Peter, Y., Rotman, G., Lotem, Y., Elson, A., Shiloh, Y. and Groner, Y. (2001).
Elevated Cu/Zn-SOD exacerbates radiation sensitivity and hematopoietic abnormalities of Atm-deficient mice. EMBO J. 20 (7), 1538-1546, 2001.
Andersen, J.N., Elson, A., Lammers, R., Romer, J., Clausen, J.T., Moller, K.B. and Moller, N.P.H. (2001).
Comparative study of PTPε isoforms: membrane localization confers specificity in inhibiting insulin-induced cell rounding and cell detatchment. Biochem. J. 354 (3), 581-590, 2001.
Gil-Henn, H., Peretz, A., Sobko, A., Shinder, V., Attali, B. and Elson, A. (2001).
Regulation of myelination by wild-type and novel forms of PTPε.
In: Protein Modules in Cellular Signaling, Heilmeyer, L.M.G., Jr. (ed.), IOS Press, Amsterdam.
Gil-Henn, H., Volohonsky, G., Toledano-Katchalski, H., Gandre, S. and Elson, A. (2000).
Generation of novel cytoplasmic forms of protein tyrosine phosphatase epsilon by proteolytic processing and translational control. Oncogene 19 (38), 4375-4384, 2000.
Peretz, A*., Gil-Henn, H*., Sobko, A., Shinder, V., Attali, B and Elson, A. (2000).
Hypomyelination and increased activity of voltage-gated potassium channels in mice lacking protein tyrosine phosphatase ε. EMBO J. 19 (15) 4036-4045, 2000.
Elson, A. (1999).
Protein tyrosine phosphatase Epsilon increases the risk of mammary hyperplasia and mammary tumors in transgenic mice. Oncogene 18 (52) 7535-7542, 1999.
Toledano-Katchalski, H. and Elson, A. (1999).
The transmembranal and cytoplasmic forms of protein tyrosine phosphatase epsilon physically interact with the adaptor protein Grb2. Oncogene 18 (36) 5024-5031, 1999.
Eilam, R., Peter, Y., Elson, A., Rotman, G., Shiloh, Y., Groner, Y. and Segal, M. (1998).
Selective loss of dopaminergic nigro-striatal neurons in brains of Atm-deficient mice. Proc. Natl. Acad. Sci. USA 95 (21), 12653-12656, 1998.
Wang, Y.A., Elson, A. and Leder, P. (1997).
Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice. Proc. Natl. Acad. Sci. USA 94, 14950-14595, 1997.
Westphal, C.H., Rowan, S., Schmaltz, C., Elson, A., Fisher, D.E. and Leder, P. (1997).
atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute irradiation toxicity. Nature Genet. 16, 397-401, 1997.
Westphal, C.H., Schmaltz, C., Rowan, S., Elson, A., Fisher, D.E. and Leder, P. (1997).
Genetic interactions between atm and p53 influence cellular proliferation and irradiation-induced cell-cycle checkpoints. Cancer Res. 57 (9), 1664-1667, 1997.
Elson, A., Wang, Y., Daugherty, C., Morton, C.C., Zhou, F., Campos-Torres, J. and Leder, P (1996).
Pleiotropic defects in ataxia-telangiectasia (Atm-deficient) mice. Proc. Natl. Acad. Sci. USA 93, 13084-13089, 1996.
Elson, A., Kozak., C.A., Morton, C.C., Weremowicz, S. and Leder, P. (1996).
The protein-tyrosine phosphatase epsilon gene maps to mouse chromosome 7 and human chromosome 10q26. Genomics 31, 373-375, 1996.
Lane, T.F., Deng, C., Elson, A., Kozak, C.A., Lyu, M.S. & Leder, P. (1995).
Expression of Brca1 is associated with terminal differentiation of ectodermally- and mesodermally-derived tissues in mice. Genes & Development 9, 2712-2722, 1995.
Elson A. and Leder, P. (1995).
Identification of a cytoplasmic, phorbol ester-inducible isoform of the protein tyrosine phosphatase ε. Proc. Natl. Acad. Sci. USA 92 (26), 12235-12239, 1995.
Elson. A. and Leder, P. (1995).
Protein tyrosine phosphatase ε: an isoform specifically expressed in mammary tumors initiated by v-Ha-ras or neu. J. Biol. Chem. 270 (44),26116-26122, 1995.
Elson, A., Deng, C., Campos-Torres, J., Donehower, L.A. and Leder, P. (1995) .
The MMTV/c-myc transgene and p53 null alleles collaborate to induce T-cell lymphomas, but not mammary carcinomas in transgenic mice. Oncogene 11, 181-190, 1995.
Elson, A., Weiss, Y. and Groner, Y. (1994).
Protein kinase C (PKC) level is increased in PC12 cells overexpressing transfected liver-type phosphofructokinase. Biol. Cell. 81 (1), 23-29, 1994.
Elson, A., Levanon, D., Weiss, Y. and Groner, Y. (1994).
Overexpression of liver-type phosphofructokinase (PFKL) in transgenic-PFKL mice: Implication for gene dosage in trisomy 21. Biochem. J. 299 (2), 409-415.
Elson A, Weiss Y, Bernstein Y, Degani H, Levanon D, Ben Hur H, Groner Y. (1993).
Gene dosage effects of PFKL in transfected PC12 cells. Prog. Clin. Biol. Res. 384, 135-156, 1993.
Elson, A., Bernstein, Y., Degani, H., Levanon, D., Ben-Hur, H. and Groner, Y. (1992)
Gene dosage and Down’s syndrome: metabolic and enzymatic changes in PC12 cells overexpressing transfected human liver-type phosphofructokinase. Som. Cell. Mol. Genet. 18 (2), 143-161.
Groner, Y. & Elson, A. (1991).
Down's Syndrome Molecular Genetics.
In: The Encyclopedia of Human Biology, Dulbecco, R., editor. Volume 3, pp. 175-189. Academic Press Inc., San Diego.
Elson, A., Levanon. D., Brandeis, M., Dafni, N., Bernstein, Y., Danciger, E. and Groner, Y. (1990)
The structure of the human liver-type phosphofructokinase gene. Genomics 7, 47-56.
Levanon, D., Danciger, E., Dafni, N., Bernstein, Y., Elson, A., Moens, W., Brandeis, M. and Groner, Y., (1989)
The primary structure of human liver-type phosphofructokinase and it's comparison with other types of PFK. DNA 8 (10), 733-743.
Updated: 29/03/2013 10:46:58 Contact E-mail: Ari.Elson@weizmann.ac.il