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Weizmann Institute of science Weizmann Institute of science Department of molecular genetics
Jeff Gerst's lab mRNA and Protein Trafficking

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  3. Endosomal protein transport in cell growth and disease: Yeast as a model for neurodegenerative disorders

Endosomal protein transport in cell growth and disease: Yeast as a model for neurodegenerative disorders

Endosomal protein transport in cell growth and disease: Yeast as a model for neurodegenerative disorders

Cdc48 and ubiquilins in protein trafficking in health and neurodegenerative disease

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GFP-Yif1 (green) localizes to the Golgi under normal growth conditions, but relocalizes and is degraded in the vacuole (red) upon starvation (STRV) and TOR activation

TOR signaling links Golgi quality control and vacuolar protein sorting

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Btn2 over-production cures yeast from the [URE3] prion (white colonies turn to red), while Btn3 co-expression inhibits curing

Role of endosome-Golgi transport in Batten disease: Btn2 in protein retrieval and inclusion body formation

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Golgi protein, GFP-Yif1, localizes to late endosomes (green) in cells lacking BTN1; note vacuoles are labeled in red

Role of endosome-Golgi transport in Batten disease: Btn1 and SNARE regulation

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[ Last Updated: 28 March 2023 ] [ Contact: EMAIL ] [ site map ]