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Weizmann Institute of science Weizmann Institute of science Department of molecular genetics
Jeff Gerst's lab mRNA and Protein Trafficking

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  3. mRNA trafficking and its role in protein localization, organelle biogenesis, and cell physiology

mRNA trafficking and its role in protein localization, organelle biogenesis, and cell physiology

mRNA trafficking and its role in protein localization, organelle biogenesis, and cell physiology
Model for mRNA multiplexing: Transperon assembly begins by intergenic interactions and is mediated by histone H4. After assembly, the transperon exits the nucleus and transports the mRNAs to a specific sub-cellular destination.

Multiplexed mRNA assembly plays an operon-like role in the control of eukaryotic cell physiology

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A model of the ribosome with labeled ribosomal proteins involved in the translation of specific groups of mRNAs

Ribosome specialization: A means to control the translation of subpopulations of mRNA?

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HER2 mRNA (red) visualized by single-molecule FISH in SKBR3 cells

Cell-cell transfer of mRNA and its role in mammalian cell physiology

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MS2-tagged PEX14 mRNA (green) co-localizes with peroxisomes  (red)

RNA trafficking to peroxisomes and role in peroxisome function and proliferation

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Single-molecule FISH shows that endogenously expressed SUC2 mRNA (red) localizes to cortical and nuclear ER (green) in yeast

How mRNAs traffic to the endoplasmic reticulum and controls protein import

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SRO7 mRNA (green) is polarized along with cortical endoplasmic reticulum (red) to the bud tip of dividing yeast cells

mRNA trafficking and its role in cell polarization, chemotropism, and mating

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mRNA encoding Oxa1 (green), a mitochondrial inner membrane protein, localizes to the mitochondria (red)

mRNA trafficking to the mitochondria and its role in mitochondrial function

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[ Last Updated: 27 March 2023 ] [ Contact: EMAIL ] [ site map ]