Publications
2019
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Tabitha Bucher, Alona Keren-Paz, Jean Hausser, Tsviya Olender, Eddie Cytryn and Ilana Kolodkin-Gal (2019) An active β-lactamase is a part of an orchestrated cell wall stress resistance network of Bacillus subtilis and related rhizosphere species Environmental Microbiology
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Hadas Ganin, Natalie Kemper, Sagit Meir, Ilana Rogachev, Shir Ely, Hassan Massalha, Aviad Mandaby, Abraham Shanzer, Michael M. Meijler, Sergey Malitsky, Asaph Aharoni, and Ilana Kolodkin-Gal
(2019) Indole derivatives maintain the status quo between beneficial biofilms and their plant hosts Molecular Plant Microbe InteractionsIn press -
Ariel Ogran, Eliane Hadas Yardeni, Tabitha Bucher, Rakeshkumar Jain, Omri Gilhar, Alona Keren-Paz, and Ilana Kolodkin-Gal
(2019) The plant host induces antibiotic production in B. subtilis biofilms to increase their competitiveness Applied and Environmental MicrobiologyIn press
2018
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Keith Harris and Ilana Kolodkin-Gal (2018) Applying the handicap principle to biofilms: condition-dependent signaling in Bacillus subtilis microbial communities Environmental Microbiology
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Nitai Steinberg, Shany Doron, Rakeshkumar Jain, Gili Rosenberg, Sven van Teeffelen, and Ilana Kolodkin-Gal (2018) A matrix protein acts as a cue to preserve collective motility of B. subtilis biofilm cells preprint
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Tal Hassanov, Iris Karunker-Hazan, Nitai Steinberg, Ayelet Erez, and Ilana Kolodkin-Gal (2018) Novel antibiofilm chemotherapies target nitrogen from glutamate and glutamine Scientific Reports 8(1):7097
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Nitai Steinberg, Gili Rosenberg, Alona Keren-Paz, and Ilana Kolodkin-Gal (2018) Collective vortex-like movement of Bacillus subtilis facilitates the generation of floating biofilms Frontiers in Microbiology 9: 590
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Alona Keren-Paz, Vlad Brumfeld, Yaara Oppenheimer-Shaanan, and Ilana Kolodkin-Gal (2018) Micro-CT X-ray Imaging Exposes Structured Diffusion Barriers within Biofilms npj Biofilms and Microbiomes 4:8
2017
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Ayelet Erez and Ilana Kolodkin-Gal. (2017) From prokaryotes to cancer: glutamine flux in multicellular units. Trends in Metabolism and Endocrinology 9:637-644
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Martyn Dade-Robertson, Alona Keren-Paz, Meng Zhang and Ilana Kolodkin-Gal (2017) Architects of nature: growing buildings with bacterial biofilms. Microbial Biotechnology 5:1157-1163
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Lianet Noda-García,Maria-Luisa Romero, Liam Longo, Ilana Kolodkin-Gal , and Dan Tawfik (2017) Coevolution of transcriptional and protein regulation underlies the divergence of Bacilli glutamate dehydrogenases. Embo Reports 7:1139-1149
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Ilana Kolodkin-Gal (2017) Beyond the wall: Can D-amino acids and small molecule inhibitors solely used to eliminate infection? Future Medicinal Chemistry 9:843-846
2016
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Zohar Bloom-Ackermann, Nitai Steinberg, Gili Rosenberg, Yaara Oppenheimer-Shaanan, Dan Pollack, Shir Ely, Nimrod Storzi, Asaf Levy and Ilana Kolodkin-Gal. (2016) Toxin-Antitoxin systems eliminate defective cells and preserve symmetry in Bacillus subtilis biofilms. Environmental Microbiology 18:5032–5047
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Eyal Rosen, Igor Tsesis, Shlomo Elbahary, Nimrod Storzi and Ilana Kolodkin-Gal. (2016) Eradication of Enterococcus faecalis biofilms on human dentin. Fronties in Microbiology 7:2055
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Tabitha Bucher, Elena Kartvelishvily and Ilana Kolodkin-Gal. (2016) Methodologies to study Bacillus subtilis biofilms as models for characterizing small molecule biofilm inhibitors. The Journal of Visualized Experiments 116 doi:10.3791/54612
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Gili Rosenberg, Nitai Steinberg, Yaara Oppenheimer-Shaanan, Tsvia Olender, Shany Doron, Julius Ben-Ari, Alexandra Sirota-Madi, Zohar Bloom-Ackermann and Ilana Kolodkin-Gal. (2016) Not so simple, not so subtle: The interspecies competition between Bacillus simplex and Bacillus subtilis and its impact on the evolution of biofilms. npj Biofilms and Microbiomes 15027 doi:10.1038/npjbiofilms.2015.27
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Yaara Oppenheimer-Shaanan, Odelia Sibony-Nevo, Zohar Bloom-Ackermann, Ronit Suissa, Nitai Steinberg, Elena Kartvelishvily, Vlad Brumfeld and Ilana Kolodkin-Gal. (2016) Spatio-temporal Assembly of Functional Mineral Scaffolds within Microbial Biofilms. npj Biofilms and Microbiomes 15031 doi:10.1038/npjbiofilms.2015.31
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Sathish Kumar, Ilana Kolodkin-Gal, Oliver Vesper, Nawsad Alam, Ora Schueler-Furman, Isabella Mol and Hanna Engelberg-Kulka. (2016) The Generation of Escherichia coli Quorum Sensing Peptide EDF: A Novel Multi-distinct Mechanism Regulated by Trans-translation. mBio 7(1):e02034-15
2015
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Tabitha Bucher, Yaara Oppenheimer-Shaanan , Alon Savidor, Zohar Bloom-Ackermann and Ilana Kolodkin-Gal. (2015) Disturbance of the bacterial cell wall specifically interferes with biofilm formation. Enviornmental Microbiology Reports 7: 990–1004
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Zohar Bloom-Ackermann, Hadas Ganin and Ilana Kolodkin-Gal. (2015) Quorum Sensing Cascades Governing Bacterial Multicellular Communities. IJCH 56: 302–309
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Nitai Steinberg and Ilana Kolodkin-Gal. (2015) The Matrix Reloaded: Probing the Extracellular Matrix Synchronizes Bacterial Communities. J Bacteriol. 197:2092-2103
2014
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Hadas Ganin, Eliane Hadas Yardeni, and Ilana Kolodkin-Gal. (2014) Biofilms: Maintenance, Development, and Disassembly of Bacterial Communities Are Determined by QS Cascades. A book chapter in "Quorum sensing Vs Quorum Quenching: A Battle with no end in sight" [Springer]
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Jotham Suez, Tal Korem, David Zeevi, Gili Zilberman-Schapira, Christoph A. Thaiss, Ori Maza, David Israeli, Niv Zmora, Shlomit Gilad, Adina Weinberger, Yael Kuperman, Alon Harmelin, Ilana Kolodkin-Gal, Hagit Shapiro, Zamir Halpern, Eran Segal and Eran Elinav. (2014) Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature 514:181–186
2013
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Yaara Openheimer-Shaanan, Nitai Steinberg and Ilana Kolodkin-Gal. (2013) Small Molecules are Natural Triggers for biofilm Disassembly. Trends in Microbiology 21:594–601
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Sathish Kumar*, Ilana Kolodkin-Gal*, Hanna Engelberg-Kulka. (2013) Quorum Sensing Peptides Mediate Interspecies Bacterial Cell Death. mBio, 4(3):e00314-13*Equal contribution.
IKG Selected Publications
- Thomas Böttcher, Ilana Kolodkin-Gal, Roberto Kolter, John Clardy and Richard Losick. (2013) Synthesis and Activity of biomimetic Biofilm Disruptors. JACS, 135:2927-30.
- Ilana Kolodkin-Gal, Alexander K.W. Elsholz, Christine Muth, Peter R.Girguis, Roberto Kolter, Richard Losick. (2013) Respiration Control of Multicellularity in Bacillus subtilis by a Complex of the Cytochrome Chain with a Membrane-Embedded Histidine Kinase. Genes and Development 27:887-99.
- Ilana Kolodkin-Gal*, S.M. Rubinstein*, Liraz Chai, Roberto Kolter, Richard Losick, David A, Weitz (2012) Osmotic pressure can regulate matrix gene expression in Bacillus subtilis. Mol Microb. 86:426-3.
- *Equal contribution.
- Allon Hochbaum*, Ilana Kolodkin-Gal*, Roberto Kolter, Joanna Aizenberg, Richard Losick (2011) Studying the inhibitory effects of D-amino acids on Staphylococcus aureus biofilm development. J Bacteriol. 193:5616-22
- * Equal contribution
- Anna L. McLoon *, Ilana Kolodkin-Gal *, S.M. Rubinstein, R. Kolter, R. Losick (2011) Spatial Regulation of Histidine Kinases Governing Biofilm Formation in Bacillus subtilis. J Bacteriol. 193:679-85.
- *Equal contribution
- Ilana Kolodkin-Gal, D. Romero, Shugeng Cao, J. Clardy, R. Kolter, R. Losick (2010) D-amino acids trigger biofilm disassembly. Science 328: 627-629.
- Ilana Kolodkin-Gal, R.Verdiger, A. Shlosberg-Fedida, Hanna Engelberg-Kulka (2009) A differential effect of E.coli toxin-antitoxin systems on cell death in liquid media and biofilm formation. PLoS One. 26:e6785.
- Hanna Engelberg-Kulka, Idan Yelin and Ilana Kolodkin-Gal (2009) Activation of a built in bacterial programmed cell death system as a novel mechanism of action of some antibiotics. Communicative & Integrative Biology 2:3, 1-2.
- Ilana Kolodkin-Gal, H. Engelberg-Kulka (2009) The stationary sigma factor S is responsible for the resistance of Escherichia coli stationary cells to mazEF-mediated cell death. J. Bacteriol. 191:3177-82.
- S. Amitai, Ilana Kolodkin-Gal, A. Sacher, H. Engelbeg-Kulka (2009) Escherichia coli MazF leads to simultaneous selective synthesis of both "death proteins" and "survival proteins". PLoS Genetics 5: e1000390.
- Ilana Kolodkin-Gal, B, Sat, A. Keshet, H. Engelberg- Kulka (2009) Communication Factor EDF and mazEF are Determinants in the Mode of Action of Antibiotics in Escherichia coli. PLoS Biology 6:e319.
- Ilana Kolodkin-Gal, H. Engelberg-Kulka (2008) The extracellular death factor: physiological and genetic factors influencing its production and response in Escherichia coli. J. Bacteriol. 190:3169-75.
- Ilana Kolodkin-Gal, R Hazan, A Gaathon, S/ Carmeli, H. Engelberg-Kulka (2007) A linear pentapeptide is a quorum-sensing factor required for mazEF-mediated cell death in Escherichia coli. Science 318:652-5.
- Ilana Kolodkin-Gal, H. Engelberg-Kulka (2006) Induction of Escherichia coli Chromosomal mazEF by stressful conditions causes an irreversible loss of viability. J.Bacteriol. 188:3420-3.
- H. Engelberg-Kulka, S. Amitai, Ilana Kolodkin-Gal, R. Hazan (2006) Bacterial programmed cell death and multicellular behavior in bacteria. PLoS Genet. 2:e135. Review.
Patents
- Kolodkin-Gal I, Engelberg-Kulka H. Antibacterial peptides and methods of treating disease using same. Patent No. PCT/IL2008/000039.
- Kolodkin-Gal I, Engelberg-Kulka H. Identification of Bacillus subtilis and Pseudomonas aeriginosa peptides inducing bacterial cell death. Declaration of invention.
- Richard Losick, Jon Clardy, Roberto G. Kolter, Ilana Kolodkin, Diego Romero, and Shugeng Cao. D -amino acids as anti-biofilm agents. Provisional Patent Application No. 61/293/414
- Richard Losick, Jon Clardy, Roberto G. Kolter, Ilana Kolodkin, Liraz Chai, and Shugeng Cao. Norspermidine act as an antibiofilm agent. Preliminary Assessment of Patentability
- Jon Clardy, Thomas Boettcher, Ilana Kolodkin-Gal, Richard Losick. Methods and copositions for treating biofilms. Patent assignment