Publications

2019

  1. Ariel Ogran, Eliane Hadas Yardeni, Tabitha Bucher, Rakeshkumar Jain, Omri Gilhar, Alona Keren-Paz, and Ilana Kolodkin-Gal

     (2019) The plant host induces antibiotic production in B. subtilis biofilms to increase their competitiveness Applied and Environmental Microbiology   
    In press
  2. Tabitha Bucher, Alona Keren-Paz, Jean Hausser, Tsviya Olender, Eddie Cytryn and Ilana Kolodkin-Gal (2019) An active β-lactamase is a part of an orchestrated cell wall stress resistance network of Bacillus subtilis and related rhizosphere species Environmental Microbiology   

  3. Hadas Ganin, Natalie Kemper, Sagit Meir, Ilana Rogachev, Shir Ely, Hassan Massalha, Aviad Mandaby, Abraham Shanzer, Michael M. Meijler, Sergey Malitsky, Asaph Aharoni, and Ilana Kolodkin-Gal

     (2019) Indole derivatives maintain the status quo between beneficial biofilms and their plant hosts Molecular Plant Microbe Interactions   
    In press

2018

  1. Keith Harris and Ilana Kolodkin-Gal  (2018) Applying the handicap principle to biofilms: condition-dependent signaling in Bacillus subtilis microbial communities Environmental Microbiology   
  2. Nitai Steinberg, Shany Doron, Rakeshkumar Jain, Gili Rosenberg, Sven van Teeffelen, and Ilana Kolodkin-Gal (2018) A matrix protein acts as a cue to preserve collective motility of B. subtilis biofilm cells preprint   
  3. Tal Hassanov, Iris Karunker-Hazan, Nitai Steinberg, Ayelet Erez, and Ilana Kolodkin-Gal (2018) Novel antibiofilm chemotherapies target nitrogen from glutamate and glutamine Scientific Reports 8(1):7097   
  4. Nitai Steinberg, Gili Rosenberg, Alona Keren-Paz, and Ilana Kolodkin-Gal  (2018) Collective vortex-like movement of Bacillus subtilis facilitates the generation of floating biofilms Frontiers in Microbiology 9: 590   
  5. Alona Keren-Paz, Vlad Brumfeld, Yaara Oppenheimer-Shaanan, and Ilana Kolodkin-Gal (2018) Micro-CT X-ray Imaging Exposes Structured Diffusion Barriers within Biofilms npj Biofilms and Microbiomes 4:8   

2017

  1. Ayelet Erez and Ilana Kolodkin-Gal. (2017) From prokaryotes to cancer: glutamine flux in multicellular units. Trends in Metabolism and Endocrinology 9:637-644   
  2. Martyn Dade-Robertson, Alona Keren-Paz, Meng Zhang and Ilana Kolodkin-Gal (2017) Architects of nature: growing buildings with bacterial biofilms. Microbial Biotechnology 5:1157-1163   
  3. Lianet Noda-García,Maria-Luisa Romero, Liam Longo, Ilana Kolodkin-Gal , and Dan Tawfik (2017) Coevolution of transcriptional and protein regulation underlies the divergence of Bacilli glutamate dehydrogenases. Embo Reports 7:1139-1149   
  4. Ilana Kolodkin-Gal  (2017) Beyond the wall: Can D-amino acids and small molecule inhibitors solely used to eliminate infection? Future Medicinal Chemistry 9:843-846   

2016

  1. Zohar Bloom-Ackermann, Nitai Steinberg, Gili Rosenberg, Yaara Oppenheimer-Shaanan, Dan Pollack, Shir Ely, Nimrod Storzi, Asaf Levy and Ilana Kolodkin-Gal. (2016) Toxin-Antitoxin systems eliminate defective cells and preserve symmetry in Bacillus subtilis biofilms. Environmental Microbiology 18:5032–5047   
  2. Eyal Rosen, Igor Tsesis, Shlomo Elbahary, Nimrod Storzi and Ilana Kolodkin-Gal. (2016) Eradication of Enterococcus faecalis biofilms on human dentin. Fronties in Microbiology 7:2055   
  3. Tabitha Bucher, Elena Kartvelishvily and Ilana Kolodkin-Gal. (2016) Methodologies to study Bacillus subtilis biofilms as models for characterizing small molecule biofilm inhibitors. The Journal of Visualized Experiments 116 doi:10.3791/54612   
  4. Gili Rosenberg, Nitai Steinberg, Yaara Oppenheimer-Shaanan, Tsvia Olender, Shany Doron, Julius Ben-Ari, Alexandra Sirota-Madi, Zohar Bloom-Ackermann and Ilana Kolodkin-Gal. (2016) Not so simple, not so subtle: The interspecies competition between Bacillus simplex and Bacillus subtilis and its impact on the evolution of biofilms. npj Biofilms and Microbiomes 15027 doi:10.1038/npjbiofilms.2015.27   
  5. Yaara Oppenheimer-Shaanan, Odelia Sibony-Nevo, Zohar Bloom-Ackermann, Ronit Suissa, Nitai Steinberg, Elena Kartvelishvily, Vlad Brumfeld and Ilana Kolodkin-Gal. (2016) Spatio-temporal Assembly of Functional Mineral Scaffolds within Microbial Biofilms. npj Biofilms and Microbiomes 15031 doi:10.1038/npjbiofilms.2015.31   
  6. Sathish Kumar, Ilana Kolodkin-Gal, Oliver Vesper, Nawsad Alam, Ora Schueler-Furman, Isabella Mol and Hanna Engelberg-Kulka. (2016) The Generation of Escherichia coli Quorum Sensing Peptide EDF: A Novel Multi-distinct Mechanism Regulated by Trans-translation. mBio 7(1):e02034-15   

2015

  1. Tabitha Bucher, Yaara Oppenheimer-Shaanan , Alon Savidor, Zohar Bloom-Ackermann and Ilana Kolodkin-Gal. (2015) Disturbance of the bacterial cell wall specifically interferes with biofilm formation. Enviornmental Microbiology Reports 7: 990–1004   
  2. Zohar Bloom-Ackermann, Hadas Ganin and Ilana Kolodkin-Gal. (2015) Quorum Sensing Cascades Governing Bacterial Multicellular Communities. IJCH 56: 302–309   
  3. Nitai Steinberg and Ilana Kolodkin-Gal. (2015) The Matrix Reloaded: Probing the Extracellular Matrix Synchronizes Bacterial Communities. J Bacteriol. 197:2092-2103   

2014

  1. Hadas Ganin, Eliane Hadas Yardeni, and Ilana Kolodkin-Gal. (2014) Biofilms: Maintenance, Development, and Disassembly of Bacterial Communities Are Determined by QS Cascades. A book chapter in "Quorum sensing Vs Quorum Quenching: A Battle with no end in sight" [Springer]   
  2. Jotham Suez, Tal Korem, David Zeevi, Gili Zilberman-Schapira, Christoph A. Thaiss, Ori Maza, David Israeli, Niv Zmora, Shlomit Gilad, Adina Weinberger, Yael Kuperman, Alon Harmelin, Ilana Kolodkin-Gal, Hagit Shapiro, Zamir Halpern, Eran Segal and Eran Elinav. (2014) Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature 514:181–186   

2013

  1. Yaara Openheimer-Shaanan, Nitai Steinberg and Ilana Kolodkin-Gal. (2013) Small Molecules are Natural Triggers for biofilm Disassembly. Trends in Microbiology 21:594–601   
  2. Sathish Kumar*, Ilana Kolodkin-Gal*, Hanna Engelberg-Kulka. (2013) Quorum Sensing Peptides Mediate Interspecies Bacterial Cell Death. mBio, 4(3):e00314-13   
    *Equal contribution.

IKG Selected Publications

  • Thomas Böttcher, Ilana Kolodkin-Gal, Roberto Kolter, John Clardy and Richard Losick. (2013) Synthesis and Activity of biomimetic Biofilm Disruptors. JACS, 135:2927-30.   
  • Ilana Kolodkin-Gal, Alexander K.W. Elsholz, Christine Muth, Peter R.Girguis, Roberto Kolter, Richard Losick. (2013) Respiration Control of Multicellularity in Bacillus subtilis by a Complex of the Cytochrome Chain with a Membrane-Embedded Histidine Kinase. Genes and Development 27:887-99.  
  • Ilana Kolodkin-Gal*, S.M. Rubinstein*, Liraz Chai, Roberto Kolter, Richard Losick, David A, Weitz (2012) Osmotic pressure can regulate matrix gene expression in Bacillus subtilis. Mol Microb. 86:426-3.    
  • *Equal contribution.
  • Allon Hochbaum*, Ilana Kolodkin-Gal*, Roberto Kolter, Joanna Aizenberg, Richard Losick (2011) Studying the inhibitory effects of D-amino acids on Staphylococcus aureus biofilm development. J Bacteriol. 193:5616-22   
  • * Equal contribution
  • Anna L. McLoon *, Ilana Kolodkin-Gal *, S.M. Rubinstein, R. Kolter, R. Losick (2011) Spatial Regulation of Histidine Kinases Governing Biofilm Formation in Bacillus subtilis. J Bacteriol. 193:679-85.
  • *Equal contribution
  • Ilana Kolodkin-Gal, D. Romero, Shugeng Cao, J. Clardy, R. Kolter, R. Losick (2010) D-amino acids trigger biofilm disassembly. Science 328: 627-629.   
  • Ilana Kolodkin-Gal, R.Verdiger, A. Shlosberg-Fedida, Hanna Engelberg-Kulka (2009) A differential effect of E.coli toxin-antitoxin systems on cell death in liquid media and biofilm formation. PLoS One. 26:e6785.   
  • Hanna Engelberg-Kulka, Idan Yelin and Ilana Kolodkin-Gal (2009) Activation of a built in bacterial programmed cell death system as a novel mechanism of action of some antibiotics. Communicative & Integrative Biology 2:3, 1-2.   
  • Ilana Kolodkin-Gal, H. Engelberg-Kulka (2009) The stationary sigma factor S is responsible for the resistance of Escherichia coli stationary cells to mazEF-mediated cell death. J. Bacteriol. 191:3177-82.   
  • S. Amitai, Ilana Kolodkin-Gal, A. Sacher, H. Engelbeg-Kulka (2009) Escherichia coli MazF leads to simultaneous selective synthesis of both "death proteins" and "survival proteins". PLoS Genetics 5: e1000390.   
  • Ilana Kolodkin-Gal, B, Sat, A. Keshet, H. Engelberg- Kulka (2009) Communication Factor EDF and mazEF are Determinants in the Mode of Action of Antibiotics in Escherichia coli. PLoS Biology 6:e319.   
  • Ilana Kolodkin-Gal, H. Engelberg-Kulka (2008) The extracellular death factor: physiological and genetic factors influencing its production and response in Escherichia coli. J. Bacteriol. 190:3169-75.   
  • Ilana Kolodkin-Gal, R Hazan, A Gaathon, S/ Carmeli, H. Engelberg-Kulka (2007) A linear pentapeptide is a quorum-sensing factor required for mazEF-mediated cell death in Escherichia coli. Science 318:652-5.   
  • Ilana Kolodkin-Gal, H. Engelberg-Kulka (2006) Induction of Escherichia coli Chromosomal mazEF by stressful conditions causes an irreversible loss of viability. J.Bacteriol. 188:3420-3.    
  • H. Engelberg-Kulka, S. Amitai, Ilana Kolodkin-Gal, R. Hazan (2006) Bacterial programmed cell death and multicellular behavior in bacteria. PLoS Genet. 2:e135. Review.  

Patents

  • Kolodkin-Gal I, Engelberg-Kulka H. Antibacterial peptides and methods of treating disease using same. Patent No. PCT/IL2008/000039.
  • Kolodkin-Gal I, Engelberg-Kulka H. Identification of Bacillus subtilis and Pseudomonas aeriginosa peptides inducing bacterial cell death. Declaration of invention.
  • Richard Losick, Jon Clardy, Roberto G. Kolter, Ilana Kolodkin, Diego Romero,  and Shugeng Cao. D -amino acids as anti-biofilm agents. Provisional Patent Application No. 61/293/414
  • Richard Losick, Jon Clardy, Roberto G. Kolter, Ilana Kolodkin, Liraz Chai,  and Shugeng Cao. Norspermidine act as an antibiofilm agent. Preliminary Assessment of Patentability
  • Jon Clardy, Thomas Boettcher, Ilana Kolodkin-Gal, Richard Losick. Methods and copositions for treating biofilms. Patent assignment