Adi Stern

...I am now a post-doctoral fellow in the lab of Dr. Rotem Sorek
in the Department of Molecular Genetics
at the Weizmann institute of Science

Research Interests

My main research interest lies in host-pathogen interactions, particularly the fascinating patterns of co-evolution that hosts and viruses display. In my Ph.D. thesis I focused on developing novel evolutionary models and methodologies, and used these models to study the interactions between HIV and the human host.

Currently, I focus on studying host-phage interactions in the lab of Dr. Rotem Sorek. I am studying the recently discovered CRISPR system, which is an adaptive immune system in prokaryotes. My research interests, among others, include:

  • Studying the evolution of diverse CRISPR systems
  • Exploring co-evolution of CRISPR systems with phages
  • Deciphering the mechanism of action of CRISPR
  • Discovering novel antiviral systems

Publications

Stern A., Sorek R. The phage-host arms race: shaping the evolution of microbes. Bioessays. In press.

Stern A., Keren L., Wurtzel O., Amitai G., Sorek R. Widespread targeting of self-DNA by the prokaryotic CRISPR immune system: gene regulation or autoimmunity? Trends in Genetics. 2010 26(8):335-340.

Stern A., Mayrose I., Shaul S., Gophna U., Pupko T. An Evolutionary Analysis of Lateral Gene Transfer in Thymidylate Synthase Enzymes. Systematic Biology. 59(2): 212-225.

Sela N, Stern, A., Pupko, T., Ast, G. Transduplication resulted in incorporation of a conserved protein domain sequence within the transposable element Harbinger Turmoil-1 in C. elegans. Biology Direct. 2008 Oct 8;3:41

Penn O.*, Stern A.*, Rubinstein N., Dutheil J., Bacharach E., Galtier N., Pupko T. 2008. Evolutionary modeling of rate shifts reveals specificity determinants in HIV-1 subtypes. PLoS Computational Biology. 2008 Nov;4(11):e1000214. *Authors contributed equally.

Cohen, O., Rubinstein, ND., Stern, A., Gophna, U., and Pupko, T. A likelihood framework to analyze phyletic patterns. Proceedings of The Royal Society of London Series B-Biological Sciences. 2008 Dec 27;363(1512):3903-11.

Stern, A., Doron-Faigenboim, A., Erez, E., Martz, E., Bacharach, E., Pupko, T. Selecton 2007: advanced models for detecting positive and purifying selection using a Bayesian inference approach. Nucleic Acids Research. 35: W506-W511.

Stern, A., Privman, E., Rasis, M., Lavi, S., Pupko, T. 2007. Evolution of the metazoan protein phosphatase 2C superfamily. J. Mol. Evol. 64(1):61-70.

Stern, A., Pupko, T. 2006. An Evolutionary Space-Time Model with Varying Among Site Dependencies.
Mol. Biol. Evol. 23: 392-400

Doron-Faigenboim, A.*, Stern, A.*, Mayrose, I., Bacharach, E., and Pupko, T. 2005. Selecton: a server for detecting evolutionary forces at a single amino-acid site. Bioinformatics. 21(9): 2101-2103. *Authors contributed equally.

Software

Contact


E-mail: adi.stern at weizmann.ac.il
Phone: 08-9346350
Lab: Meyer Building, Room 209