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We are looking for two excellent Post-docs for a project involving human genetics and musculoskeletal development and regeneration.

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We walk, run, work and play, paying little attention to our bones, their joints and their muscle connections, because the system works. Evolution has refined robust genetic mechanisms for skeletal development and growth that are able to direct the formation of a complex, yet wonderfully adaptable organ system. How is it done?

The main focus of my lab is skeletogenesis. The skeletal system has made a key contribution to the evolutionary success of numerous species, as it supports the body and protects vital organs while enabling efficient movability. Skeleton development is an important field of research for two main reasons: First, it is a central organ system associated with a large variaty of congenital diseases and malformations. Sheding more light on its embryonic development may improve our ability to treat and prevent these conditions.
Secondly, skeletogenesis involves extensive and intricate interactions with neighboring tissues such as muscles, tendons and blood vessels. This makes the skeleton an excelent model system for studying developmental cooridnation and synchronization, reulatory cross-talk between different types of cells and tissues, the integration of extrinsic physiological signals with cues of the genetic program and tissue patterning.

As aforesaid, skeletogenesis requires a high degree of coordination with neighboring tissues. In order to attain this coordination, proper regulatory mechanisms, with developmental checkpoints installed in them, had to evolve. Our main goal is to identify these developmental checkpoints and to study the molecular mechanisms that underlie their ability to coordinate the development of tissues and organs. To this end, we apply advanced murine genetics research techniques on two aspects of skeleton development: skeletogenesis in the context of the developing musculoskeletal system and the complex interactions between the forming skeleton and the vasculature.