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2022

Special guest seminar, Dr Harry Burgess

Type: Lecture
Date: Aug 15, 2022

Time14:00 - 15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Harry Burgess

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

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Seminar for Thesis Defense of Adi Millman

Type: Lecture
Date: Jul 24, 2022

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAdi Millman

Contactsandra.britton@weizmann.ac.il

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Guest seminar with Prof. Utpal Banerjee

Type: Lecture
Date: Jul 20, 2022

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Utpal Banerjee

Contactsandra.britton@weizmann.ac.il

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Special guest semianr with Dr. Asaf Zviran

Type: Lecture
Date: Jul 17, 2022

Time14:00 - 15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Asaf Zviran

OrganizerCancer Research Club

Contactsandra.britton@weizmann.ac.il

AbstractEarly detection of recurrence and monitoring of Molecular Residual Disease (MRD) post-surgery is critical for clinical decision-making to tailor personalized treatments across solid cancers. C2i Genomics has developed an ultra-sensitive whole-genome ctDNA test, allowing extremely accurate and sensitive monitoring of patients with solid tumors. Here we present results from applying whole-genome sequencing (WGS) and identification of ctDNA across a variety of adult and pediatric solid tumors. We integrate a genome-wide mutation and copy number monitoring approach coupled with advanced signal processing and Artificial Intelligence (AI) for measuring the tumor load from low-input blood samples (~1mL of plasma) with ultra-sensitive detection. The increased sensitivity allowed clinical detection of tumor fraction down to 5*10-5 and recurrence detection sensitivity achieving >65% at the first two months after definitive treatment, enabling earlier clinical intervention for high-risk patients.
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Seminar for PhD thesis defense

Type: Lecture
Date: Jul 12, 2022

Time11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNir Cohen

Contactevi.ben-ami@weizmnn.ac.il

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Special Guest Seminar

Type: Lecture
Date: Jul 11, 2022

Time10:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. David Reich

Contactevi.ben-ami@weizmnn.ac.il

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Seminar for PhD thesis defense

Type: Lecture
Date: May 25, 2022

Time15:00 - 16:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerGal Chaim Nuta

Contactevi.ben-ami@weizmnn.ac.il

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Special guest semianr with Prof. Jin Billy Li

Type: Lecture
Date: May 25, 2022

Time13:15

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerJin Billy Li

Contactsandra.britton@weizmann.ac.il

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Special Guest Seminar with Prof. Hervé Le Hir

Type: Lecture
Date: May 15, 2022

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Hervé Le Hir

Contactsandra.britton@weizmann.ac.il

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Seminar for Thesis Defense

Type: Lecture
Date: May 11, 2022

Time14:00 - 15:00

LecturerKarin Broennimann

Contactevi.ben-ami@weizmnn.ac.il

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Transcription Drive Development Minisymposium

Type: Lecture
Date: May 11, 2022

Time10:30 - 15:00

LocationDolfi and Lola Ebner Auditorium

Contactsandra.britton@weizmann.ac.il

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Molecular Genteics departmental retreat

Type: Lecture
Date: May 09, 2022

Time00:00

Contactsandra.britton@weizmann.ac.il

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Molecular Genetics Departmental seminar

Type: Lecture
Date: May 08, 2022

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerYehuda Danino & Tslil Braun

OrganizerDDP Seminar

ContactSandra.britton@weizmann.ac.il

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Special guest seminar with Prof. Kent Søe

Type: Lecture
Date: Apr 07, 2022

Time13:30 - 14:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Kent Søe

Contactsandra.britton@weizmann.ac.il

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Seminar for PhD thesis defense

Type: Lecture
Date: Mar 10, 2022

Time12:00 - 13:00

LecturerMira Rosenthal

Contactevi.ben-ami@weizmnn.ac.il

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Department of Molecular Genetics departmental seminar

Type: Lecture
Date: Feb 20, 2022

Time13:00 - 14:00

LocationDolfi and Lola Ebner Auditorium

LecturerAssaf Biran

OrganizerDDP Seminar

Contactsandra.britton@weizmann.ac.il

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Special Guest Seminar

Type: Lecture
Date: Feb 15, 2022

Time13:00 - 14:00

LecturerDr. Lilach Sheiner

Contactevi.ben-ami@weizmnn.ac.il

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Department of Molecular Genetics departmental seminar

Type: Lecture
Date: Feb 06, 2022

Time13:00 - 14:00

LecturerYury Bykov and Oldak Bernardo

OrganizerJoint Seminar

Contactsandra.britton@weizmann.ac.il

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Azrieli Institute for Systems Biology, guest seminar with Ahmed H. Badran

Type: Lecture
Date: Jan 18, 2022

Time17:00 - 18:00

LecturerAhmed H. Badran, PhD

OrganizerSystem Biology

Contactsandra.britton@weizmann.ac.il

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Seminar for PhD thesis defense

Type: Lecture
Date: Jan 17, 2022

Time13:30

LecturerSivan Kaminski Strauss

Contactevi.ben-ami@weizmnn.ac.il

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Seminar for PhD thesis defense

Type: Lecture
Date: Jan 05, 2022

Time11:00

LecturerChen Eitan

Contactevi.ben-ami@weizmnn.ac.il

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2021

Guest seminar with Vered Shacham-Silverberg

Type: Lecture
Date: Dec 26, 2021

Time14:00 - 15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Vered Shacham-Silverberg

OrganizerJoint Seminar

Contactsandra.britton@weizmann.ac.il

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Seminar for PhD thesis defense

Type: Lecture
Date: Dec 12, 2021

Time13:15

LecturerTom Shani

Contactevi.ben-ami@weizmnn.ac.il

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MicroEco2 Microbial Ecology Symposium for Young Researchers

Type: conference
Date: Dec 09, 2021

Time08:00

LocationThe David Lopatie Conference Centre

Websitehttps://www.weizmann.ac.il/conferences/MICREC2021/

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Molecular Genetics departmental seminar

Type: Lecture
Date: Nov 28, 2021

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAmit Kahana (lancet lab) Gabriela Lobinska (Pilpel lab)

Contactsandra.britton@weizmann.ac.il

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Special Guest seminar

Type: Lecture
Date: Nov 24, 2021

Time11:00

LecturerProf. Gianni Liti

Contactevi.ben-ami@weizmnn.ac.il

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“Computational Methods for Super-resolution Single Molecule Localization Microscopy”

Type: Lecture
Date: Nov 21, 2021

Time11:30 - 12:30

LecturerDr. Ismail M. Khater

Contactevi.ben-ami@weizmnn.ac.il

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Special Guest Seminar

Type: Lecture
Date: Nov 02, 2021

Time10:00 - 11:00

LecturerDr. Eyal Karzbrun

Contactsandra.britton@weizmann.ac.il

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Seminar for Thesis Defense,

Type: Lecture
Date: Oct 19, 2021

Time09:00 - 10:00

LecturerLia Heinemann Yerushalmi

Contactsandra.britton@weizmann.ac.il

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Seminar for PhD thesis defense

Type: Lecture
Date: Oct 17, 2021

Time10:00

LecturerHagai Marmor - Kollet

Contactevi.ben-ami@weizmann.ac.il

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Special seminar with Dr. Yaara Oren

Type: Lecture
Date: Aug 16, 2021

Time15:00 - 16:00

LecturerDr. Yaara Oren

Contactsandra.britton@weizmann.ac.il

AbstractDespite favorable initial response to therapy, a third of cancer patients will develop recurrent disease and succumb to it within five years of diagnosis. While there has been much progress in characterizing the pathways that contribute to stable genetic drug resistance, the mechanisms underlying early reversible resistance, also known as persisters-driven resistance, remain largely unknown. It has long been believed that persisters represent a subset of cells that happen to be non-proliferating at the time of treatment, and therefore can survive drugs that preferentially kill rapidly proliferating cells. However, in my talk I will describe a rare persister population which, despite not harboring any resistance-conferring mutation, can maintain proliferative capacity in the presence of drug. To study this rare, transiently-resistant, cycling persister population, we developed Watermelon, a high-complexity expressed barcode lentiviral library for simultaneous tracing of each cell’s clonal origin and proliferative and transcriptional states. We combine single cell transcriptomics with imaging and metabolomics to show that cycling and non-cycling persisters arise from different cell lineages with distinct transcriptional and metabolic programs. Finally, I will describe how by studying persister cells we can gain critical insights on cellular memory, fate, and evolution, which can guide the development of better anti-cancer treatments.
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Special guest seminar with Dr. Inna Ricardo-Lax

Type: Lecture
Date: Jul 20, 2021

Time12:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Inna Ricardo-Lax

OrganizerGuest Lecture

Contactsandra.britton@weizmann.ac.il

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Molecular Genetics departmental seminar with Omri Gilhar

Type: Lecture
Date: Jun 27, 2021

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerOmri Gilhar

Contactsandra.britton@weizmann.ac.il

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Molecular Genetics Departmental seminar with Nancy Yacovzada

Type: Lecture
Date: Jun 20, 2021

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNancy Yacovzada

Contactsandra.britton@weizmann.ac.il

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Molecular Genetics Departmental seminar with Daoud Sheiban

Type: Lecture
Date: Jun 13, 2021

Time13:00 - 13:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDaoud Sheiban

Contactsandra.britton@weizmann.ac.il

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Molecular Genetics Departmental seminar with Yotam David

Type: Lecture
Date: Jun 06, 2021

Time13:00 - 13:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerYotam David

Contactsandra.britton@weizmann.ac.il

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Molecular Genetics Departmental seminar with Sveta Markman

Type: Lecture
Date: May 30, 2021

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerSvetlana Markman

OrganizerDDP Seminar

Contactsandra.britton@weizmann.ac.il

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Departmental seminar with Michal Schwartz

Type: Lecture
Date: May 23, 2021

Time13:00 - 13:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Michal Schwartz

Contactsandra.britton@weizmann.ac.il

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Seminar for PhD thesis defense - Aya Shkedy

Type: Lecture
Date: May 13, 2021

Time12:00 - 13:00

LecturerAya Shkedy

ContactEvi.ben-ami@weizmann.ac.il

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Departmental Seminar with Lena Sapoznikov

Type: Lecture
Date: May 09, 2021

Time13:00 - 13:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerLena Sapoznikov

OrganizerStudent and Post-Doc Seminar

Contactsandra.britton@weizmann.ac.il

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Seminar for Thesis defense of Gat Krieger

Type: Lecture
Date: Apr 25, 2021

Time13:30 - 14:30

LecturerGat Krieger

Contactsandra.britton@weizmann.ac.il

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ILASOL 2021 Conference

Type: Lecture
Date: Apr 20, 2021

Time00:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

Contactamit.kahana@weizmann.ac.il

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Seminar for PhD thesis defense - Moran Shalev

Type: Lecture
Date: Apr 18, 2021

Time11:00

LecturerMoran Shalev

ContactEvi.ben-ami@weizmann.ac.il

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Seminar for PhD thesis defense

Type: Lecture
Date: Apr 11, 2021

Time15:00 - 16:00

LecturerGal Ofir

ContactEvi.ben-ami@weizmann.ac.il

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Molecular Genetics Departmental Seminar

Type: Lecture
Date: Apr 11, 2021

Time13:00 - 13:30

LecturerNadav Goldberg

OrganizerStudent and Post-Doc Seminar

Contactsandra.britton@weizmann.ac.il

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Molecular Genetics Departmental Seminar

Type: Lecture
Date: Apr 04, 2021

Time13:00 - 13:30

LecturerSivan Kaminski

OrganizerStudent and Post-Doc Seminar

Contactsandra.britton@weizmann.ac.il

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Seminar for MSc thesis defense - Nadav Goldberg

Type: Lecture
Date: Mar 22, 2021

Time10:00 - 11:00

LecturerNadav Goldberg

ContactEvi.ben-ami@weizmann.ac.il

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Department of Molecular Genetics departmental seminar

Type: Lecture
Date: Mar 21, 2021

Time13:00 - 13:30

LecturerNir Cohen

Contactsandra.britton@weizmann.ac.il

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Department of Molecular Genetics departmental seminar

Type: Lecture
Date: Mar 14, 2021

Time13:00 - 13:30

LecturerSarah Rubin

OrganizerStudent and Post-Doc Seminar

Contactsandra.britton@weizmann.ac.il

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Department of Molecular Genetics department seminar

Type: Lecture
Date: Mar 07, 2021

Time13:00 - 13:30

LecturerJohannes Auth

OrganizerStudent and Post-Doc Seminar

Contactsandra.britton@weizmann.ac.il

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Seminar for PhD thesis defense - Lior Lasman

Type: Lecture
Date: Feb 24, 2021

Time10:00 - 11:00

LecturerLior Lasman

ContactEvi.ben-ami@weizmann.ac.il

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Molecular Genetics Departmental Seminar

Type: Lecture
Date: Feb 14, 2021

Time13:00

LecturerTamar Gera

Contactsandra.britton@weizmann.ac.il

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Seminar for PhD thesis defense - Revital Ravid

Type: Lecture
Date: Feb 07, 2021

Time10:00

LecturerRevital Ravid

ContactEvi.ben-ami@weizmann.ac.il

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PhD Thesis defense - Orel Mizrahi

Type: Lecture
Date: Jan 24, 2021

Time11:00 - 12:00

LecturerOrel Mizrahi

ContactEvi.ben-ami@weizmann.ac.il

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Departmental seminar with Anna Uzonyi

Type: Lecture
Date: Jan 17, 2021

Time13:00 - 13:30

Websitehttps://weizmann.zoom.us/j/98492519654?pwd=a0lNd1ROc0kwTXBaUnI4M0R2aENOdz09

LecturerAnna Uzonyi

OrganizerStudent and Post-Doc Seminar

Contactsandra.britton@weizmann.ac.il

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Departmental seminar with Nelly Frenkel

Type: Lecture
Date: Jan 10, 2021

Time13:00 - 13:30

Websitehttps://weizmann.zoom.us/j/96260232296?pwd=ck16LzU2SjdWNU80eFZRWUNTbXpPUT09

LecturerNelly Frenkel

OrganizerStudent and Post-Doc Seminar

Contactsandra.britton@weizmann.ac.il

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Special zoom joint guest seminar

Type: Lecture
Date: Jan 07, 2021

Time11:00 - 12:00

LecturerDr. Anat Florentin

ContactEvi.ben-ami@weizmann.ac.il

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2020

Special Guest Seminar - David Gokhman

Type: Lecture
Date: Dec 27, 2020

Time10:00

LecturerDr. David Gokhman

ContactEvi.ben-ami@weizmann.ac.il

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Molecular Genetics Departmental Seminar with Yaara Finkel

Type: Lecture
Date: Dec 06, 2020

Time13:00

LecturerYaara Finkel

OrganizerStudent and Post-Doc Seminar

Contactsandra.britton@weizmann.ac.il

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Seminar for thesis definse of Dvir Schirman

Type: Lecture
Date: Dec 03, 2020

Time11:00

LecturerDvir Schirman

OrganizerSeminar

Contactsandra.britton@weizmann.ac.il

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Seminar for thesis defense, Moria Weiss

Type: Lecture
Date: Dec 02, 2020

Time10:00 - 11:00

LecturerMoria Weiss

OrganizerSeminar

Contactsandra.britton@weizmann.ac.il

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Seminar for thesis defense - Shiri Kult

Type: Lecture
Date: Dec 01, 2020

Time16:00

LecturerShiri Kult

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Molecular Genetics departmental seminar with Sharon Ben-Hur

Type: Lecture
Date: Nov 29, 2020

Time13:00

LocationDolfi and Lola Ebner Auditorium

LecturerSharon Ben-Hur

OrganizerSeminar

Contactsandra.britton@weizmann.ac.il

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Molecular Genetics departmental seminar with Orel Mizrahi

Type: Lecture
Date: Nov 22, 2020

Time13:00

LocationDolfi and Lola Ebner Auditorium

LecturerOrel Mizrahi

OrganizerDDP Seminar

Contactsandra.britton@weizmann.ac.il

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Seminar for thesis defense

Type: Lecture
Date: Nov 18, 2020

Time13:00 - 14:00

LecturerNelly Frenkel

ContactEvi.ben-ami@weizmann.ac.il

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seminar for thesis defense with Jonathan Bayerl

Type: Lecture
Date: Nov 17, 2020

Time13:00

LecturerJonathan Bayerl

Contactsandra.britton@weizmann.ac.il

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Special guest seminar with Dr. Yosef Kaplan Dor

Type: Lecture
Date: Nov 16, 2020

Time16:00

LecturerDr. Yosef Dor Kaplan

OrganizerGuest Lecture

Contactsandra.britton@weizmann.ac.il

AbstractSleep is ubiquitous in the animal kingdom, but its function has been a mystery. Besides its importance for the brain, sleep appears to play an essential physiological role, emphasized by the fact that severe sleep loss can be lethal. The cause of this lethality was unknown. We found that extreme sleep deprivation results in high levels of reactive oxygen species (ROS) that trigger oxidative stress specifically in the gut of flies and mice. Using flies, we show that neutralization of intestinal ROS prevents premature death of sleep-deprived animals, suggesting a causal link between ROS accumulation in the gut and lethality upon sleep loss. What may explain the observed phenomena? Could it teach us about the normal, daily function of sleep? In the second part of my talk, I will present our current attempts and preliminary data aiming at answering these questions.
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Seminar for thesis defense with Unnikannan CP

Type: Lecture
Date: Nov 16, 2020

Time10:00

LecturerUnnikannan CP

Contactsandra.britton@weizmann.ac.il

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Molecular Genetics departmental seminar

Type: Lecture
Date: Nov 15, 2020

Time13:00

LecturerNaama Zung

OrganizerStudent and Post-Doc Seminar

Contactsandra.britton@weizmann.ac.il

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Molecular Genetics Departmental seminar

Type: Lecture
Date: Nov 08, 2020

Time13:00

LecturerHagai Marmor

OrganizerStudent and Post-Doc Seminar

Contactsandra.britton@weizmann.ac.il

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Department seminar with Batsheva Rozman

Type: Lecture
Date: Oct 25, 2020

Time13:00 - 14:00

LecturerBatsheva Rozman

OrganizerStudent and Post-Doc Seminar

Contactsandra.britton@weizmann.ac.il

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Braginsky Center for the Interface between Science and the Humanities zoom lecture with Prof. Mario Livio

Type: Lecture
Date: Oct 19, 2020

Time16:00 - 17:00

LecturerProf. Mario Livio

OrganizerSpecial Guest Seminar

Contactsandra.britton@weizmann.ac.il

AbstractA fresh biography of Galileo Galilei which puts his scientific discoveries in context. Disturbed by rampant science denial in America—and around the world—that has only intensified in recent years, I began researching the life, ideas, and actions of this brilliant man who encountered similar pressures centuries ago. The result is a biography filled with lessons relevant for today—whether with respect to trusting the advice given by scientists in relation to COVID-19, the reality of climate change, the efficacy of vaccines, or the teaching of creationist theories in schools. I will discuss these topics in this talk.
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Special zoom Seminar with Dr. Dvir Gur

Type: Lecture
Date: Oct 14, 2020

Time10:00 - 11:00

LecturerDr. Dvir Gur

ContactEvi.ben-ami@weizmann.ac.il

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Special zoom seminar with Dr. Dan Landau

Type: Lecture
Date: Sep 30, 2020

Time16:00 - 17:00

LecturerDr. Dan Landau

OrganizerGuest Lecture

Contactsandra.britton@weizmann.ac.il

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Departmental Seminar by Mira Rosenthal & Lia Yerushalmi

Type: Lecture
Date: Jul 05, 2020

Time13:00 - 14:00

ContactEvi.ben-ami@weizmann.ac.il

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Departmental seminar by Miri Shnayder

Type: Lecture
Date: Jun 28, 2020

Time13:00 - 13:45

ContactEvi.ben-ami@weizmann.ac.il

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Developmental Club Series 2019-20-cancelled

Type: Lecture
Date: Jun 24, 2020

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Ori Avinoam

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

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Departmental Seminar by Romano Strobelt

Type: Lecture
Date: Jun 21, 2020

Time13:00 - 13:45

ContactEvi.ben-ami@weizmann.ac.il

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Departmental Seminar by Aya Shkedy

Type: Lecture
Date: Jun 14, 2020

Time13:00 - 14:00

ContactEvi.ben-ami@weizmann.ac.il

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Developmental Club Series 2019-20 - cancelled

Type: Lecture
Date: Jun 10, 2020

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Eli Arama

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

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Departmental Seminar by Kamalesh Kumari

Type: Lecture
Date: Jun 07, 2020

Time13:00 - 13:45

ContactEvi.ben-ami@weizmann.ac.il

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Departmental seminar by Aude Bernheim

Type: Lecture
Date: May 31, 2020

Time13:00 - 13:45

ContactEvi.ben-ami@weizmann.ac.il

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Developmental Club Series 2019-20

Type: Lecture
Date: May 27, 2020

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Gil Levkowitz

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

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POSTPONED: Braginsky Center for the interface between the Science and the Humanities

Type: Lecture
Date: May 25, 2020

Time14:00 - 15:00

LocationDolfi and Lola Ebner Auditorium

LecturerProf. Menachem Fisch

Contactsandra.britton@weizmann.ac.il

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Departmental Seminar by Daria Amiad-Pavlov

Type: Lecture
Date: May 24, 2020

Time13:00 - 14:00

ContactEvi.ben-ami@weizmann.ac.il

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Developmental Club Series 2019-20

Type: Lecture
Date: May 20, 2020

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Yonatan Stelzer

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

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Developmental Club Series 2019-20

Type: Lecture
Date: May 13, 2020

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Efrat Shema

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

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Developmental Club Series

Type: Lecture
Date: May 06, 2020

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Amir Sapir

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

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Departmental Seminar by Lihi Ben Reuven & Miri Shnayder

Type: Lecture
Date: May 03, 2020

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

ContactEvi.ben-ami@weizmann.ac.il

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Developmental Club Series 2019-20

Type: Lecture
Date: Apr 22, 2020

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Eran Hornstein

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

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Departmental Seminar by Nir Cohen & TBD

Type: Lecture
Date: Apr 19, 2020

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

ContactEvi.ben-ami@weizmann.ac.il

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Decoding transcriptional regulation in Drosophila

Type: Lecture
Date: Apr 07, 2020

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Alexander Stark

OrganizerPhysics distinguished

Contactigor.ulitsky@weizmann.ac.il

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TBA - cancelled

Type: Lecture
Date: Apr 01, 2020

Time12:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerRuth Sperling

ContactEvi.ben-ami@weizmann.ac.il

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POSTPONED: Departmental Seminar by Daria Amiad-Pavlov & Lia Yerushalmi

Type: Lecture
Date: Mar 29, 2020

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

ContactEvi.ben-ami@weizmann.ac.il

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POSTPONED: Developmental Club Series with Elazar Zelzer

Type: Lecture
Date: Mar 25, 2020

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerElazar Zelzer

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

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Seminar for Thesis Defense- Roni Winkler

Type: Lecture
Date: Mar 19, 2020

Time11:30 - 12:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerRoni Winkler

Contactsandra.britton@weizmann.ac.il

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Departmental Seminar by Gat Krieger & Kamalesh Kumari

Type: Lecture
Date: Mar 15, 2020

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

ContactEvi.ben-ami@weizmann.ac.il

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Azrieli Institute for Systems Biology

Type: Lecture
Date: Mar 04, 2020

Time14:00 - 15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Dieter Ebert

OrganizerSystem Biology

Contactsandra.britton@weizmann.ac.il

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Departmental Seminar by Rami Tshuva & Dvir Schirman

Type: Lecture
Date: Mar 01, 2020

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

ContactEvi.ben-ami@weizmann.ac.il

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Molecular Genetics special guest seminar

Type: Lecture
Date: Feb 27, 2020

Time11:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Gilad Barnea

OrganizerSeminar

Contactsandra.britton@weizmann.ac.il

AbstractI will present trans-Tango, a new technique for anterograde transsynaptic circuit tracing and manipulation that we have established in fruit flies. At the core of trans-Tango is a synthetic signaling pathway that is introduced into all neurons in the animal. This pathway converts receptor activation at the cell-surface into reporter expression through site-specific proteolysis. Specific labeling is achieved by presenting a tethered ligand at the synapses of genetically defined neurons, thereby activating the pathway in their postsynaptic partners. Activation of the pathway culminates in expression of a reporter that can be visualized. Because our system is modular, it can be easily adapted to experiments in which the properties of specific circuits are modified and the functional consequences are analyzed. We first validated trans-Tango in the Drosophila olfactory system and then implemented it in the gustatory system, where projections beyond the firstorder receptor neurons are not well characterized. We identified second-order neurons within the sweet and bitter circuits and revealed that they target brain areas involved in neuromodulation with similar but distinct projection patterns. I will also present experiments in which we use trans-Tango in functional analysis of the gustatory circuits. Using our studies in flies as proof of concept, we are currently establishing an equivalent technique for labeling circuits in vertebrate models, such as mice and zebrafish. These experiments establish trans-Tango as a flexible platform for comprehensive transsynaptic analysis of neural circuits.
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Developmental Club Series 2019-20

Type: Lecture
Date: Feb 26, 2020

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Talila Volk

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

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Departmental Seminar by Sagie Brodsky & Noa Novershtern

Type: Lecture
Date: Feb 16, 2020

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

ContactEvi.ben-ami@weizmann.ac.il

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Seminar for thesis defense - Karen Fridman Talmon

Type: Lecture
Date: Feb 13, 2020

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerKaren Fridman Talmon

ContactEvi.ben-ami@weizmann.ac.il

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Special Guest Seminar with Prof. Detlef Wiegel

Type: Lecture
Date: Feb 12, 2020

Time11:30 - 12:30

LocationNella and Leon Benoziyo Building for Biological Sciences

LecturerProf. Detlef Wiegel

OrganizerJoint Seminar

Contactsandra.britton@weizmann.ac.il

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Developmental Club Series 2019-20

Type: Lecture
Date: Feb 12, 2020

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Takashi Kawashima

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

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Special Guest Seminar

Type: Lecture
Date: Feb 05, 2020

Time11:30 - 12:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. David Zeevi

ContactEvi.ben-ami@weizmann.ac.il

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Developmental Club Series 2019-20

Type: Lecture
Date: Feb 05, 2020

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Meital Oren

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

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Departmental Seminar - Molecular Genetics Dept.

Type: Lecture
Date: Feb 02, 2020

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

ContactEvi.ben-ami@weizmann.ac.il

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Next Gen Immunology 2020

Type: conference
Date: Feb 02, 2020

Time08:00

LocationMichael Sela Auditorium

Websitehttps://www.weizmann.ac.il/conferences/NGI2020/

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Developmental Club Series 2019-20

Type: Lecture
Date: Jan 29, 2020

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Oren Schuldiner

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

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Department of Molecular Genetics Special guest seminar

Type: Lecture
Date: Jan 28, 2020

Time14:00 - 15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Francesca Bartolini

OrganizerGuest Lecture

Contactsandra.britton@weizmann.ac.il

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Braginsky Center for the Interface between the Sciences and the Humanities

Type: Lecture
Date: Jan 27, 2020

Time11:00

LocationDolfi and Lola Ebner Auditorium

LecturerProf. Oren Harman

Contactsandra.britton@weizmann.ac.il

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Departmental Seminar - Molecular Genetics Dept.

Type: Lecture
Date: Jan 19, 2020

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

ContactEvi.ben-ami@weizmann.ac.il

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Special Guest Seminar with Dr, Michael E. Ward

Type: Lecture
Date: Jan 16, 2020

Time11:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Michael E. Ward

OrganizerSpecial Guest Seminar

Contactsandra.britton@weizmann.ac.il

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Developmental Club Series 2019-20

Type: Lecture
Date: Jan 15, 2020

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Ido Amit

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

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Departmental Seminar - Molecular Genetics Dept.

Type: Lecture
Date: Jan 05, 2020

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

ContactEvi.ben-ami@weizmann.ac.il

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Special Guest Seminar with Dr. Arbel Harpak

Type: Lecture
Date: Jan 02, 2020

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Arbel Harpak

OrganizerThe Azrieli Institute for Systems Biology

Contactsandra.britton@weizmann.ac.il

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Developmental Club Series 2019-20

Type: Lecture
Date: Jan 01, 2020

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Amnon Sharir, DVM, PhD.

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

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2019

Special Guest Seminar with Dr. Onn Brandman

Type: Lecture
Date: Dec 30, 2019

Time14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Onn Brandman

OrganizerGuest Lecture

Contactsandra.britton@weizmann.ac.il

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The Braginsky Center for the Interface between the Sciences and the Humanities

Type: Lecture
Date: Dec 30, 2019

Time11:00

LocationGerhard M.J. Schmidt Lecture Hall

LecturerProf. Reviel Netz

OrganizerFaculty of Mathematical Sciences Seminar

Contactsandra.britton@weizmann.ac.il

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Seminar for thesis defense, Nofar Mor

Type: Lecture
Date: Dec 29, 2019

Time15:00 - 16:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNofar Mor

ContactEvi.ben-ami@weizmann.ac.il

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Special guest seminar with Moran Dvela-Levitt

Type: Lecture
Date: Dec 22, 2019

Time12:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerMoran Dvela-Levitt

Contactsandra.britton@weizmann.ac.il

AbstractProtein homeostasis is critical for cellular function and survival. Dysregulation of the cellular protein homeostasis can lead to a build-up of misfolded proteins and facilitate the manifestation of a variety of pathological disorders including neurodegeneration, cancer and inflammation. Where and how the misfolded proteins accumulate, however, has remained a mystery. In studying MUC1 kidney disease (a rare kidney disorder), we have found that some of these pathologies may share a single, previously unrecognized cellular mechanism: a jam at a specific step in the secretory pathway involving a cargo receptor called TMED9. A small molecule called BRD4780 can break the jam and restore cells to normal function, providing a promising potential for therapeutic developments.
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Seminar for thesis defense, Maya Voichek

Type: Lecture
Date: Dec 19, 2019

Time15:00 - 16:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerMaya Voichek

Contactsandra.britton@weizmann.ac.il

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Special Guest Seminar

Type: Lecture
Date: Dec 18, 2019

Time12:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Orly Laufman

ContactEvi.ben-ami@weizmann.ac.il

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Developmental Club Series 2019-20

Type: Lecture
Date: Dec 18, 2019

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Yaron Antebi

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

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Departmental Seminar - Molecular Genetics Dept.

Type: Lecture
Date: Dec 15, 2019

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

ContactEvi.ben-ami@weizmann.ac.il

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Developmental Club Series 2019-20

Type: Lecture
Date: Dec 11, 2019

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Avraham Yaron

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

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Seminar for thesis Defense - Zohar Erez

Type: Lecture
Date: Dec 08, 2019

Time15:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerZohar Erez

ContactEvi.ben-ami@weizmann.ac.il

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Special Guest Seminar

Type: Lecture
Date: Dec 02, 2019

Time12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNevan Krogan

OrganizerSystem Biology

ContactEvi.ben-ami@weizmann.ac.il

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Braginsky Center for the Interface between the Sciences and the Humanities, special guest lecture with Daniel Matt

Type: Lecture
Date: Dec 01, 2019

Time16:00 - 17:00

LocationGerhard M.J. Schmidt Lecture Hall

LecturerProf. Daniel Matt

OrganizerGuest Lecture

ContactEvi.ben-ami@weizmann.ac.il

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Departmental Seminar - Molecular Genetics Dept.

Type: Lecture
Date: Dec 01, 2019

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

ContactEvi.ben-ami@weizmann.ac.il

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Seminar for thesis defense Naama Dekel

Type: Lecture
Date: Oct 30, 2019

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNaama Dekel

OrganizerSeminar

Contactsandra.britton@weizmann.ac.il

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Special Guest Seminar

Type: Lecture
Date: Oct 27, 2019

Time12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Peter Tsvetkov

ContactEvi.ben-ami@weizmann.ac.il

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Special Guest Seminar with Anat Zimmer

Type: Lecture
Date: Oct 03, 2019

Time14:00 - 15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAnat Zimmer

OrganizerThe Azrieli Institute for Systems Biology

Contactsandra.britton@weizmann.ac.il

AbstractIt is a challenge to answer questions like: why some people develop a disease, react to a specific treatment and/or develop severe side-effects while others don’t. In order to explain these occurrences, one has to take a holistic approach and study the body physiology from a systems level perspective. Longitudinal multi-omics measurements together with genetics, on a large population, can serve such a purpose and help in predicting, reasoning, and preventing diseases. In partnership with Arivale Inc., we have developed infrastructure to collect longitudinal Personalized Dense Dynamic Data clouds (PD3 clouds) on thousands of individuals, which include genetics and longitudinal measurements of clinical labs, microbiome, metabolome, proteome, and self-reported data. The value of these extremely high-dimensional data clouds is clear; however, it also comprises a challenge in data analysis and interpretation. One way to reduce data dimensionality is called Pareto Task Inference (PARTI, Hart et al. 2015). We used this method to analyze the clinical labs and found that the data falls on a significant tetrahedron. The 4 vertices are archetypes that specialize in a certain task. Using all other datatypes, we identified enriched traits next to every archetype and revealed the underline tradeoffs that shape the data. This distinctive analysis uncovers unexpected relationships between datasets such as metabolomics, proteomics and clinical labs, and helps in interconnecting the different datatypes to characterize different states of human health.
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Special Guest Seminar with Dr. Johnathan Cooper-Knock

Type: Lecture
Date: Sep 05, 2019

Time11:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Johnathan Cooper-Knock

Contactsandra.britton@weizmann.ac.il

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Special Guest Seminar with Ophir Shalem

Type: Lecture
Date: Aug 22, 2019

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerOphir Shalem, Ph.D

OrganizerThe Azrieli Institute for Systems Biology

Contactsandra.britton@weizmann.ac.il

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Developmental Club Series 2018-2019

Type: Lecture
Date: Jul 31, 2019

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Ori Avinoam

OrganizerDevelopmental Club

Contactevi.ben-ami@weizmann.ac.il

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Special Guest Seminar

Type: Lecture
Date: Jul 21, 2019

Time14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerClaire Thomas

ContactEvi.ben-ami@weizmann.ac.il

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Shoulder Injury Seminar Department of Molecular Genetics

Type: Lecture
Date: Jul 18, 2019

Time09:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Louis J. Soslowsky, Ph.D

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

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Special Guest Seminar

Type: Lecture
Date: Jul 16, 2019

Time11:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Yael Weiss

Contactevi.ben-ami@weizmann.ac.il

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Developmental Club Series 2018-2019

Type: Lecture
Date: Jul 03, 2019

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Amrutha Swaminathan

OrganizerDevelopmental Club

ContactEvi.ben-ami@weizmann.ac.il

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Departmental Seminar

Type: Lecture
Date: Jun 30, 2019

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerRuth Barshir

ContactEvi.ben-ami@weizmann.ac.il

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Developmental Club Series 2018-2019

Type: Lecture
Date: Jun 26, 2019

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Nadav Ahituv

OrganizerDevelopmental Club

Contactevi.ben-ami@weizmann.ac.il

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Developmental Club

Type: Lecture
Date: Jun 19, 2019

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerEran Hornstein

ContactEvi.ben-ami@weizmann.ac.il

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Departmental Seminar

Type: Lecture
Date: Jun 16, 2019

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAldema Sas Chen

ContactEvi.ben-ami@weizmann.ac.il

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Developmental Club Series 2018-2019

Type: Lecture
Date: Jun 12, 2019

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerEfrat Shema

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

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Developmental Club Series 2018-2019

Type: Lecture
Date: Jun 12, 2019

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerEfrat Shema

OrganizerDevelopmental Club

ContactEvi.ben-ami@weizmann.ac.il

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Departmental Seminar

Type: Lecture
Date: Jun 02, 2019

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerHarsh Maan

ContactEvi.ben-ami@weizmann.ac.il

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Developmental Club

Type: Lecture
Date: May 29, 2019

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Shalev Itzkovitz

Contactevi.ben-ami@weizmann.ac.il

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Departmental Seminar

Type: Lecture
Date: May 26, 2019

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerYaara Finkel

Contactevi@weizmann.ac.il

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Departmental Seminar

Type: Lecture
Date: May 19, 2019

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerQihui Hou

Contactevi@weizmann.ac.il

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Polymerizing the Fiber Between Bacterial Biofilms and Human Amyloids

Type: Lecture
Date: May 16, 2019

Time10:00 - 11:00

LocationNella and Leon Benoziyo Building for Biological Sciences

LecturerProf. Matthew Chapman

Contactsandra.britton@weizmann.ac.il

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Molecular Genetics Departmental Retreat

Type: Lecture
Date: May 14, 2019

Time00:00

ContactIngrid.lehrer@weizmann.ac.il

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Cross regulation between the apoptotic cascade and the unfolded protein response

Type: Lecture
Date: May 13, 2019

Time11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAvi Ashkenazi

Contactsandra.britton@weizmann.ac.il

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Departmental Seminar

Type: Lecture
Date: May 12, 2019

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerHagai Marmor

OrganizerDDP Seminar

Contactevi@weizmann.ac.il

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Developmental Club Series 2018-2019

Type: Lecture
Date: May 07, 2019

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerOphir Klein

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

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Seminar for thesis defense

Type: Lecture
Date: May 05, 2019

Time11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNeta Felsenthal

Contactevi@weizmann.ac.il

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Developmental Club Series 2018-2019

Type: Lecture
Date: May 01, 2019

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Benny Shilo

OrganizerDevelopmental Club

Contactevi@weizmann.ac.il

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Departmental Seminar

Type: Lecture
Date: Apr 28, 2019

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerInes Castro

OrganizerDDP Seminar

Contactsandra.britton@weizmann.ac.il

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Developmental Club Series 2018-2019

Type: Lecture
Date: Apr 17, 2019

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerYonatan Stelzer

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

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Special Guest Seminar with Dr. Markus Mund

Type: Lecture
Date: Apr 16, 2019

Time12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Markus Mund

OrganizerGuest Lecture

Contactsandra.britton@weizmann.ac.il

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Special Guest Seminar with prof. Johannes Herrmann

Type: Lecture
Date: Apr 11, 2019

Time12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Dr. Johannes Herrmann

OrganizerGuest Lecture

Contactsandra.britton@weizmann.ac.il

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Special guest seminar

Type: Lecture
Date: Apr 04, 2019

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Andrea Pauli

ContactIngrid.lehrer@weizmann.ac.il

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Developmental Club Series 2018-2019

Type: Lecture
Date: Apr 03, 2019

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Andrea Pauli

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

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Department of Molecular Genetics seminar for thesis defense

Type: Lecture
Date: Mar 26, 2019

Time13:00

LecturerYael Cohen Sharir

OrganizerSeminar

Contactsandra.britton@weizmann.ac.il

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Developmental Club Series 2018-2019

Type: Lecture
Date: Mar 20, 2019

Time10:00 - 11:00

LocationCamelia Botnar Building

LecturerHannes Buelow

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

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Developmental Club Series 2018-2019

Type: Lecture
Date: Mar 20, 2019

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerEran Hornstein

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

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Department of Molecular Genetics seminar for thesis defense

Type: Lecture
Date: Mar 19, 2019

Time14:00 - 15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerEyal Metzl Raz

OrganizerSeminar

Contactsandra.britton@weizmann.ac.il

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Department of Molecular Genetics seminar for thesis defense

Type: Lecture
Date: Mar 17, 2019

Time09:00 - 10:00

LecturerMarianna Riutin

OrganizerSeminar

Contactsandra.britton@weizmann.ac.il

Add the event Department of Molecular Genetics seminar for thesis defense to calendar

Developmental Club Series 2018-2019

Type: Lecture
Date: Mar 13, 2019

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Talila Volk

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

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Developmental Club Series 2018-2019

Type: Lecture
Date: Mar 06, 2019

Time09:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerMeital Oren

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

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Molecular Genetics Departmental Seminars 2018-2019

Type: Lecture
Date: Feb 24, 2019

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerEden Yifrach

OrganizerStudent and Post-Doc Seminar

Contactsandra.britton@weizmann.ac.il

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Seminar for thesis defense

Type: Lecture
Date: Feb 20, 2019

Time14:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerTzahi Noiman

Contactsandra.britton@weizmann.ac.il

Add the event Seminar for thesis defense to calendar

Developmental Club Series 2018-2019

Type: Lecture
Date: Feb 06, 2019

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Oren Schuldiner

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

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"Mechanisms of asymmetric cell division"

Type: Lecture
Date: Jan 28, 2019

Time14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Yves Barral

Contactilona.kalderon@weizmann.ac.il

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Molecular Genetics Departmental Seminars 2018-2019

Type: Lecture
Date: Jan 27, 2019

Time00:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerMaayan Barnea

OrganizerDDP Seminar

Contactsandra.britton@weizmann.ac.il

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Special Guest Seminar with Prof. Meytal Landau

Type: Lecture
Date: Jan 22, 2019

Time14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Meytal Landau

OrganizerGuest Lecture

Contactsandra.britton@weizmann.ac.il

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Special Guest Seminar with Dan Bracha

Type: Lecture
Date: Jan 17, 2019

Time12:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDan Bracha

OrganizerSpecial Guest Seminar

Contactsandra.britton@weizmann.ac.il

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Special Guest Seminar with Ariel Schwartz

Type: Lecture
Date: Jan 17, 2019

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Ariel Schwartz

OrganizerGuest Lecture

Contactsandra.britton@weizmann.ac.il

AbstractComputational assignment of function to proteins with no known homologs is still an unsolved problem. We have created a novel, function-based approach to protein annotation and discovery called D-SPACE (Deep Semantic Protein Annotation Classification and Exploration), comprised of a multi-task, multi-label deep neural network trained on over 70 million proteins. Distinct from homology and motif-based methods, D-SPACE encodes proteins in high-dimensional representations (embeddings), allowing the accurate assignment of over 180,000 labels for 13 distinct tasks. The embedding representation enables fast searches for functionally related proteins, including homologs undetectable by traditional approaches. D-SPACE annotates all 109 million proteins in UniProt in under 35 hours on a single computer and searches the entirety of these in seconds. D-SPACE further quantifies the relative functional effect of mutations, facilitating rapid in-silico mutagenesis for protein engineering applications. D-SPACE incorporates protein annotation, search, and other exploratory efforts into a single cohesive model. We have recently extended this work from protein to DNA, enabling assignment of function to whole genomes and metagenomic contigs in seconds. Conserved genomic motifs as well as the functional impact of mutations in coding as well as non-coding genomic regions can be predicted directly from raw DNA sequence without the use of traditional comparative genomics approaches for motif detection, such as multiple sequence alignments, PSSMs, and profile HMMs.
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Special Guest Seminar with Dr. Shai Carmi

Type: Lecture
Date: Jan 16, 2019

Time11:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Shai Carmi

Contactilona.kalderon@weizmann.ac.il

AbstractIn this talk, I will review recent work by myself and others on Jewish population and medical genetics, focusing on Ashkenazi Jews (AJ). I will describe the mixture events of AJ in Europe, the founder event they have experienced in the late Middle Ages, and their connections to ancient populations of the Levant. I will then describe large-scale genomic databases that we have recently generated for AJ, and the opportunities they open in medical genetics given the unique AJ demographic history. I will describe a few medical genetics projects including carrier screening, genome-wide association studies of microbiome composition and other traits, and preimplantation genetic diagnosis.
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Molecular Genetics Departmental Seminars 2018-2019

Type: Lecture
Date: Jan 13, 2019

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerJulie Tai

OrganizerDDP Seminar

Contactsandra.britton@weizmann.ac.il

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Developmental Club Series 2018-2019

Type: Lecture
Date: Jan 09, 2019

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerBruno Lemaitre

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

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“The Foreign within: Drosophilia-Spiroplasma interaction as a model of insect endosymbiosis”

Type: Lecture
Date: Jan 09, 2019

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerBruno Lemaitre

Contactilona.kalderon@weizmann.ac.il

Add the event “The Foreign within: Drosophilia-Spiroplasma interaction as a model of insect endosymbiosis” to calendar

Large-scale genomic investigations of psychiatric and neurodevelopmental disorders and their connection to somatic disease in the Danish population

Type: Lecture
Date: Jan 07, 2019

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerRon Nudel

ContactSimon.Fishilevich@weizmann.ac.il

Add the event Large-scale genomic investigations of psychiatric and neurodevelopmental disorders and their connection to somatic disease in the Danish population to calendar

Molecular Genetics Departmental Seminars 2018-2019

Type: Lecture
Date: Jan 06, 2019

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAdi Millman

OrganizerDDP Seminar

Contactsandra.britton@weizmann.ac.il

Add the event Molecular Genetics Departmental Seminars 2018-2019 to calendar

Molecular Genetics Departmental Seminars 2018-2019

Type: Lecture
Date: Jan 06, 2019

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAdi Millman

OrganizerDDP Seminar

Contactsandra.britton@weizmann.ac.il

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Smaller is better

Type: Lecture
Date: Jan 03, 2019

Time11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Klaus Herick

ContactMoran.Shalev@weizmann.ac.il

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2018

Developmental Club Series 2018-19

Type: Lecture
Date: Dec 26, 2018

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

Lecturer Eldad Tzahor

OrganizerDevelopmental Club

Contactilona.kalderon@weizmann.ac.il

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Molecular Genetics Departmental Seminars 2018-2019

Type: Lecture
Date: Dec 16, 2018

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerInna Averbukh

OrganizerDDP Seminar

Contactsandra.britton@weizmann.ac.il

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Joint mini-symposium

Type: Lecture
Date: Dec 13, 2018

Time11:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Joel Richter

Contactsandra.britton@weizmann.ac.il

Add the event Joint mini-symposium to calendar

Developmental Club Series 2018-19

Type: Lecture
Date: Dec 12, 2018

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Elazar Zelzer

OrganizerDevelopmental Club

Contactilona.kalderon@weizmann.ac.il

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one2many2018 - A System View of Biology

Type: conference
Date: Dec 09, 2018

Time08:00

LocationThe David Lopatie Conference Centre

Websitehttp://www.weizmann.ac.il/conferences/one2many2018/

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Developmental Club Series 2018-2019, special guest seminar

Type: Lecture
Date: Dec 05, 2018

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Naihe Jing

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

AbstractDuring postimplantation development of the mouse embryo, descendants of the inner cell mass cells in the early epiblast transit from the naïve pluripotent state to the primed pluripotent state. Concurrent with the transition of the pluripotency states is the specification of cell lineages and formation of germ layers in the embryos that serves as the blueprint for embryogenesis. Fate mapping and lineage analysis studies have revealed that cells in different regions of the germ layers acquire location-specific cell fates during gastrulation. The regionalization of cell fates heralding the formation of the basic body plan is conserved in vertebrate embryos at a common phylotypic stage of development. Knowledge of the molecular regulation that underpins the lineage specification and tissue patterning is instrumental for understanding embryonic programming and stem cell-based translational study. However, a genome-wide molecular annotation of lineage segregation and tissue architecture of post-implantation embryo has yet to be undertaken. Here, we reported a spatially resolved transcriptome of cell populations at defined positions in the germ layers over the period of pre- to late gastrulation development. This spatio-temporal transcriptome provides high resolution digitized in situ gene expression profiles and defines the molecular attribute of the genealogy of lineages and continuum of pluripotency states in time and space. The transcriptome further identifies the networks of molecular determinants that drive lineage specification and tissue patterning in the early postimplantation mouse embryo.
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Molecular Genetics Departmental Seminars 2018-2019

Type: Lecture
Date: Dec 02, 2018

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerTzahi Gabzi

OrganizerStudent and Post-Doc Seminar

Contactsandra.britton@weizmann.ac.il

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Developmental Club Series 2018-2019

Type: Lecture
Date: Nov 28, 2018

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Nathan Lawson

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

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Department of Molecular Genetics seminar for thesis defense

Type: Lecture
Date: Nov 26, 2018

Time13:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerRivi Halimi

OrganizerSeminar

Contactsandra.britton@weizmann.ac.il

Add the event Department of Molecular Genetics seminar for thesis defense to calendar

Nuclear Genome Nanostructure Imaging at Single Molecule Resolution

Type: Lecture
Date: Nov 20, 2018

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Christoph Cremer

OrganizerDevelopmental Club

ContactIngrid.lehrer@weizmann.ac.il

AbstractSuper-resolution fluorescence microscopy allows quantitative studies of nuclear genome organization on the nanoscale1. Here we report on results obtained by single molecule localization microscopy (SMLM). SMLM has made possible to explore chromatin nanostructure down to the imaging of single histones, of short oligosequences, or single DNA sites; presently, an intranuclear optical resolution down to the 5 nm range has been achieved. Applying a novel SMLM technique (fBALM)2, the DNA distribution across entire nuclei at nanoscale resolution was quantitatively determined, localizing in individual nuclear optical sections up to ~4 million individual DNA bound single fluorophore molecule positions, corresponding to about one position per nucleosome. Intensity profile analyses of the intranuclear DNA distributions indicated sharp transitions between high-density domains and low-density compartments, with differences up to almost two orders of magnitude; compacted regions had a minimum diameter down to ca. 50 nm diameter. In contrast to these results, conventional resolution imaging of the same nuclear sites indicated only small differences in the compaction of different regions, combined with very smooth density transitions. Taken together, the quantitative compaction estimates support models of a nuclear organization based on highly compartmentalized chromatin nanostructures3.
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Special Guest Seminar

Type: Lecture
Date: Nov 19, 2018

Time10:00

LocationNella and Leon Benoziyo Building for Biological Sciences

LecturerDr. Nadav Sharon

OrganizerSpecial Guest Seminar

Contactsandra.britton@weizmann.ac.il

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Molecular Genetics Departmental Seminars 2018-2019

Type: Lecture
Date: Nov 18, 2018

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNeta Rahimi

OrganizerStudent and Post-Doc Seminar

Contactsandra.britton@weizmann.ac.il

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Molecular Genetics Departmental Seminars 2018-2019

Type: Lecture
Date: Nov 18, 2018

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNeta Rahimi

OrganizerStudent and Post-Doc Seminar

Contactsandra.britton@weizmann.ac.il

Add the event Molecular Genetics Departmental Seminars 2018-2019 to calendar

Special Guest Seminar

Type: Lecture
Date: Nov 08, 2018

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Eugene Rosenberg

OrganizerSpecial Guest Seminar

Contactsandra.britton@weizmann.ac.il

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Developmental Club Series 2018-2019

Type: Lecture
Date: Oct 31, 2018

Time10:00

LocationCamelia Botnar Building

LecturerKarina Yaniv

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

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Seminar for thesis defense

Type: Lecture
Date: Oct 11, 2018

Time12:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerUri Weill

OrganizerSeminar

Contactsandra.britton@weizmann.ac.il

Add the event Seminar for thesis defense to calendar

Developmental Club Series 2017-2018

Type: Lecture
Date: Jul 18, 2018

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Eli Arama

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

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Department of Molecular Genetics seminar for thesis defense

Type: Lecture
Date: Jul 04, 2018

Time15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDoreen Ben-Zvi

OrganizerSeminar

Contactsandra.britton@weizmann.ac.il

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Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture
Date: Jul 01, 2018

Time13:15

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerKarin Broennimann

OrganizerStudent and Post-Doc Seminar

Contactsandra.britton@weizmann.ac.il

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Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture
Date: Jun 24, 2018

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerLihi Ben-Reuven

OrganizerStudent and Post-Doc Seminar

Contactsandra.britton@weizmann.ac.il

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Special Guest Seminar

Type: Lecture
Date: Jun 20, 2018

Time14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNava Segev

OrganizerSpecial Guest Seminar

Contactsandra.britton@weizmann.ac.il

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Developmental Club Series 2017-2018

Type: Lecture
Date: Jun 20, 2018

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerOri Avinoam

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

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Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture
Date: Jun 17, 2018

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerRonit Suissa

OrganizerStudent and Post-Doc Seminar

Contactsandra.britton@weizmann.ac.il

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Developmental Club Series 2017-2018

Type: Lecture
Date: Jun 06, 2018

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerCarmine Settembre, PhD

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

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Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture
Date: Jun 03, 2018

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNoa Dahan

OrganizerStudent and Post-Doc Seminar

Contactsandra.britton@weizmann.ac.il

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Contrary to Dogma: Tau is not a stabilizer of microtubules in the axon

Type: Lecture
Date: May 29, 2018

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Peter W. Baas

ContactIngrid.lehrer@weizmann.ac.il

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Building the pathway for motion vision

Type: Lecture
Date: May 27, 2018

Time12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Claude Desplan

OrganizerDevelopmental Club

ContactIngrid.lehrer@weizmann.ac.il

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Developmental Club Series 2017-2018

Type: Lecture
Date: May 23, 2018

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerShalev Itzkovitz

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

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Developmental Club Series 2017-2018

Type: Lecture
Date: May 16, 2018

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Jerome Gros

OrganizerDevelopmental Club

Contactingrid.lehrer@weizmann.ac.il

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Accelerating bio discovery with machine learning

Type: Lecture
Date: May 15, 2018

Time14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerPhilip Nelson

OrganizerThe Azrieli Institute for Systems Biology

ContactIngrid.lehrer@weizmann.ac.il

AbstractGoogle Accelerated Sciences is a translational research team that brings Google's technological expertise to the scientific community. Recent advances in machine learning have delivered incredible results in consumer applications (e.g. photo recognition, language translation), and is now beginning to play an important role in life sciences. Taking examples from active collaborations in the biochemical, biological, and biomedical fields, I will focus on how our team transforms science problems into data problems and applies Google's scaled computation, data-driven engineering, and machine learning to accelerate discovery.
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Leica Biosystems

Type: Lecture
Date: May 15, 2018

Time10:00 - 11:30

LocationRaoul and Graziella de Picciotto Building for Scientific and Technical Support

LecturerDr. Dorothee Lasrich

Contactsandra.britton@weizmann.ac.il

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Cyagen technologies

Type: Lecture
Date: May 14, 2018

Time14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Matthew Wheeler

OrganizerThe Arthur & Rochelle Belfer Institute of Mathematics and Computer Science

Contactsandra.britton@weizmann.ac.il

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Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture
Date: May 13, 2018

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerRoni Winkler

OrganizerStudent and Post-Doc Seminar

Contactsandra.britton@weizmann.ac.il

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Developmental Club Series 2017-2018

Type: Lecture
Date: May 09, 2018

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. James Sharpe

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

AbstractThe vertebrate limb bud is a classical model system for developmental biology – with the advantage of having been studied for many decades. Despite this, and despite its relatively simple shape, a consensus model of its physical morphogenesis has not been reached. I will introduce our own hypothesis on limb bud morphogenesis – convergent-extension coupled with tissue growth – and contrast it to previous ideas. I will introduce a 3D dynamical model which captures this hypothesis (a Cellular Potts Model) and also discuss our ongoing improvements to these simulations.
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Atlases of structure-function relationships in small motifs: the limits of modularity

Type: Lecture
Date: May 08, 2018

Time14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. James Sharpe

OrganizerSystem Biology

ContactIngrid.lehrer@weizmann.ac.il

AbstractAbstract: I will discuss our work on visualizing “topology atlases” which act as a map of possible circuit designs for small 3-node regulatory motifs. These can help in understanding the relationship between a circuit's structure and its function, but how is this relationship affected if the circuit must perform multiple distinct functions within the same organism? In particular, to what extent do multi‐functional circuits contain modules which reflect the different functions? We computationally surveyed a range of bi‐functional circuits which show no simple structural modularity: They can switch between two qualitatively distinct functions, while both functions depend on all genes of the circuit. Our analysis revealed two distinct classes: hybrid circuits which overlay two simpler mono‐functional sub‐circuits within their circuitry, and emergent circuits, which do not. In this second class, the bi‐functionality emerges from more complex designs which are not fully decomposable into distinct modules and are consequently less intuitive to predict or understand. These non‐intuitive emergent circuits are just as robust as their hybrid counterparts, and we therefore suggest that the common bias toward studying modular systems may hinder our understanding of real biological circuits. Relevant papers: 1. A spectrum of modularity in multi-functional gene circuits. Jiménez A, Cotterell J, Munteanu A, Sharpe J. (2017) Mol Syst Biol 13(4):925. doi: 10.15252/msb.20167347 http://msb.embopress.org/content/13/4/925 2. An atlas of gene regulatory networks reveals multiple three-gene mechanisms for interpreting morphogen gradients. Cotterell J, Sharpe J. (2010) Mol Syst Biol 6:425. doi: 10.1038/msb.2010.74 http://msb.embopress.org/content/6/1/425 Bio: James Sharpe was originally captivated by computer programming, but upon learning about the digital nature of the genetic code, chose to study Biology for his undergraduate degree at Oxford University (1988-1991). He then did his PhD on the genetic control of embryo development at NIMR, London (1992-1997) and in parallel started writing computer simulations of multicellular development. During his post-doc in Edinburgh, he began modelling the dynamics of limb development, and also invented a new optical imaging technology called Optical Projection Tomography (OPT), which is dedicated to imaging specimens too large for microscopy - tissues and organs. In 2006 he moved to Barcelona, becoming a senior group leader at the Centre for Genomic Regulation, and focusing on a systems biology approach to modelling limb development – combining experimentation with computer modelling. In this way the group demonstrated that the signalling proteins which pattern the fingers during embryogenesis, act as a Turing reaction-diffusion system. In 2011 he became the coordinator of the Systems Biology Program, and in 2017 was recruited to EMBL as Head of the new Barcelona outstation on Tissue Biology and Disease Modelling.
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Molecular Genetics Departmental Seminar

Type: Lecture
Date: Apr 29, 2018

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAvigail Stokar

OrganizerStudent and Post-Doc Seminar

Contactsandra.britton@weizmann.ac.il

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Developmental Club Series 2017-2018

Type: Lecture
Date: Apr 25, 2018

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Ben-Zion Shilo

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

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Developmental Club Series 2017-2018

Type: Lecture
Date: Apr 25, 2018

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerBenny Shilo

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

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Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture
Date: Apr 22, 2018

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAlona keren-Paz

OrganizerStudent and Post-Doc Seminar

Contactsandra.britton@weizmann.ac.il

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Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture
Date: Apr 15, 2018

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerRivi Halimi

OrganizerStudent and Post-Doc Seminar

Contactsandra.britton@weizmann.ac.il

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Special Guest Seminar

Type: Lecture
Date: Apr 11, 2018

Time11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAvi Ashkenazi, PhD

OrganizerSpecial Guest Seminar

Contactsandra.britton@weizmann.ac.il

AbstractPrecise protein folding by the endoplasmic reticulum (ER) supports homeostasis, while cumulative protein misfolding causes ER stress and promotes disease. The kinases PERK and IRE1 help orchestrate the unfolded protein response (UPR) to alleviate ER stress; however, if stress persists, the UPR activates apoptosis to eliminate the damaged cell. We have previously shown that PERK drives cell death via transcriptional up-regulation of the pro-apoptotic death receptor DR5; we further showed that IRE1—which harbors both kinase and RNase modules—blocks apoptosis through regulated IRE1-dependent mRNA decay (RIDD) of DR5 (Lu et al, Science 2014). Recently, we turned to investigate the paradoxical observation that under irresolvable ER stress PERK activity persists, while IRE1 function attenuates. We discovered that PERK governs the attenuation of IRE1, through a phosphatase called RNA polymerase II-associated protein 2 (RPAP2). RPAP2 reverses IRE1 phosphorylation, inhibiting IRE1 RNase activation. This disrupts IRE1-dependent generation of the cytoprotective transcription factor XBP1s and dampens ER-associated degradation of misfolded proteins. Furthermore, it inhibits RIDD, thereby licensing DR5-mediated caspase activation and apoptotic cell death. Thus, under excessive ER stress, PERK attenuates IRE1 via RPAP2 to abort failed adaptation and trigger an apoptotic cell fate.
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Special Guest Seminar

Type: Lecture
Date: Apr 11, 2018

Time11:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Avi Ashkenazi

OrganizerSpecial Guest Seminar

Contactsandra.britton@weizmann.ac.il

AbstractPrecise protein folding by the endoplasmic reticulum (ER) supports homeostasis, while cumulative protein misfolding causes ER stress and promotes disease. The kinases PERK and IRE1 help orchestrate the unfolded protein response (UPR) to alleviate ER stress; however, if stress persists, the UPR activates apoptosis to eliminate the damaged cell. We have previously shown that PERK drives cell death via transcriptional up-regulation of the pro-apoptotic death receptor DR5; we further showed that IRE1—which harbors both kinase and RNase modules—blocks apoptosis through regulated IRE1-dependent mRNA decay (RIDD) of DR5 (Lu et al, Science 2014). Recently, we turned to investigate the paradoxical observation that under irresolvable ER stress PERK activity persists, while IRE1 function attenuates. We discovered that PERK governs the attenuation of IRE1, through a phosphatase called RNA polymerase II-associated protein 2 (RPAP2). RPAP2 reverses IRE1 phosphorylation, inhibiting IRE1 RNase activation. This disrupts IRE1-dependent generation of the cytoprotective transcription factor XBP1s and dampens ER-associated degradation of misfolded proteins. Furthermore, it inhibits RIDD, thereby licensing DR5-mediated caspase activation and apoptotic cell death. Thus, under excessive ER stress, PERK attenuates IRE1 via RPAP2 to abort failed adaptation and trigger an apoptotic cell fate.
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Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture
Date: Apr 08, 2018

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerMichal Chapal

OrganizerStudent and Post-Doc Seminar

Contactsandra.britton@weizmann.ac.il

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Barcoding evolution

Type: Lecture
Date: Mar 27, 2018

Time13:00

LocationCamelia Botnar Building

LecturerProf. Dmitri Petrov

ContactIngrid.lehrer@weizmann.ac.il

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Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture
Date: Mar 25, 2018

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerRon Weiss

OrganizerStudent and Post-Doc Seminar

Contactsandra.britton@weizmann.ac.il

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Department of Molecular Genetics seminar for thesis defense

Type: Lecture
Date: Mar 25, 2018

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerLiraz Keidar

OrganizerSeminar

Contactsandra.britton@weizmann.ac.il

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Mini-Symposium on Genome, Transcriptome and Proteome

Type: Lecture
Date: Mar 11, 2018

Time14:30 - 16:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

ContactIngrid.lehrer@weizmann.ac.il

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Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture
Date: Mar 11, 2018

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerEyal Metzl-Raz

OrganizerStudent and Post-Doc Seminar

Contactsandra.britton@weizmann.ac.il

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Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture
Date: Mar 11, 2018

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDaoud Sheban

OrganizerStudent and Post-Doc Seminar

Contactsandra.britton@weizmann.ac.il

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Developmental Club Series 2017-2018

Type: Lecture
Date: Mar 07, 2018

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Orly Reiner

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

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Developmental Club Series 2017-2018

Type: Lecture
Date: Mar 07, 2018

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Orly Reiner

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

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Predator-prey interactions of nematophagous fungi and C. elegans

Type: Lecture
Date: Mar 01, 2018

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Yen-Ping Hsueh

OrganizerDevelopmental Club

ContactIngrid.lehrer@weizmann.ac.il

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Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture
Date: Feb 25, 2018

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerLia Yerushalmi

OrganizerStudent and Post-Doc Seminar

Contactsandra.britton@weizmann.ac.il

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Optimizations and trade-offs in cellular growth and survial

Type: conference
Date: Feb 25, 2018

Time08:00

LocationThe David Lopatie Conference Centre

Websitehttp://www.weizmann.ac.il/conferences/OTCGS2018/

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Developmental Club Series 2017-2018

Type: Lecture
Date: Feb 07, 2018

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Eran Hornstein

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

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Noncoding RNA in Health and Disease

Type: Lecture
Date: Jan 30, 2018

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Nikolaus Rajewsky

OrganizerSystem Biology

Contactingrid.lehrer@weizmann.ac.il

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Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture
Date: Jan 28, 2018

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerShiran Maskit

OrganizerStudent and Post-Doc Seminar

Contactsandra.britton@weizmann.ac.il

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Developmental Club Series 2017-2018

Type: Lecture
Date: Jan 24, 2018

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Gil Levkowitz

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

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Functions and regulation of 3D genome organisation in development and disease

Type: Lecture
Date: Jan 23, 2018

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Francois Spitz

OrganizerSystem Biology

Contactingrid.lehrer@weizmann.ac.il

AbstractThe complex hierarchy of three-dimensional patterns that characterize the 3D folding of mammalian chromosomes appears as an important element in controlling gene expression. At the megabase scale, chromosomes are partitioned into domains that define two main compartments, corresponding to transcriptionally active and inactive regions, respectively. Each compartment domain is itself composed of distinct domains characterized by increased self-interactions called topological domains (TADs). Recent high-resolution Hi-C approaches revealed a finer-scale organisation of the genome in smaller “contact domains”, often associated with loops linking specific points. At these different scales, the spatial organisation of the genome shows tight correlation with its chromatin structure and its transcriptional activity. However, while steady progress is being made in describing the 3D folding of the genome at increased resolution, the mechanisms that determine this folding, its dynamic properties and the functional implications of these emerging features are still poorly understood. We use advanced genome tagging and engineering strategies, as well as targeted inactivation of factors involved in chromosomal folding to unravel the elements and mechanisms that drive the folding of large loci in specific yet dynamic conformations and their influence on gene expression. Our recent results show that the complex patterns of vertebrate HiC maps result from the superimposition of two distinct mechanisms: 1) a cohesin-independent mechanism which brings together regions of similar chromatin states 2) a cohesin-dependent folding that associate different small compartments into TADs. Within TADS, we show as well that enhancers are not acting in a homogeneous manner, but that their influence is distributed in complex patterns, partially guided by the underlying structure. I will discuss the different implications of these findings for our views of genome organisation.
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Molecular Genetics Departmental Seminar

Type: Lecture
Date: Jan 21, 2018

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerEran Yanowski

OrganizerStudent and Post-Doc Seminar

Contactsandra.britton@weizmann.ac.il

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Molecular Genetics Special Guest Seminar

Type: Lecture
Date: Jan 21, 2018

Time10:00 - 11:00

LecturerDr. Nicolas Plachta

OrganizerGuest Lecture

Contactsandra.britton@weizmann.ac.il

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Frontiers in Systems Biology: Prof. Anshule Kundaje

Type: Lecture
Date: Jan 16, 2018

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Anshule Kundaje

OrganizerSystem Biology

Contactsandra.britton@weizmann.ac.il

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Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture
Date: Jan 14, 2018

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerIdan Frumkin

OrganizerStudent and Post-Doc Seminar

Contactsandra.britton@weizmann.ac.il

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Molecular Genetics Special Guest Seminar

Type: Lecture
Date: Jan 10, 2018

Time14:00 - 15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Yoav Ram

OrganizerGuest Lecture

Contactsandra.britton@weizmann.ac.il

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Developmental Club Series 2017-2018

Type: Lecture
Date: Jan 10, 2018

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Talila Volk

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

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Perception and computation in cellular signaling pathways

Type: Lecture
Date: Jan 09, 2018

Time13:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Yaron Antebi

OrganizerAdvancing Women in Science Office

ContactIngrid.lehrer@weizmann.ac.il

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Single cell analysis of rare events in cancer

Type: Lecture
Date: Jan 09, 2018

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Arjun Raj

OrganizerSystem Biology

Contactingrid.lehrer@weizmann.ac.il

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Molecular Genetics Departmental Seminar

Type: Lecture
Date: Jan 07, 2018

Time13:15

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDana Lorber

OrganizerSeminar

Contactsandra.britton@weizmann.ac.il

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2017

Special Guest Seminar

Type: Lecture
Date: Dec 28, 2017

Time12:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerRavit Boger, MD

OrganizerGuest Lecture

Contactsandra.britton@weizmann.ac.il

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Developmental Club Series 2017-2018

Type: Lecture
Date: Dec 27, 2017

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerElla Preger-Ben Noon

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

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Revealing the structural basis for membrane transport and GPCR signaling through atomic-level simulation

Type: Lecture
Date: Dec 26, 2017

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Ron Dror

OrganizerSystem Biology

Contactingrid.lehrer@weizmann.ac.il

Add the event Revealing the structural basis for membrane transport and GPCR signaling through atomic-level simulation to calendar

Departmental Seminar

Type: Lecture
Date: Dec 24, 2017

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

Lecturer Gal Nuta

OrganizerStudent and Post-Doc Seminar

Contactsandra.britton@weizmann.ac.il

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Developmental Club Series 2017-2018

Type: Lecture
Date: Dec 20, 2017

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerGil Levkowitz

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

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Frontiers in Systems Biology

Type: Lecture
Date: Dec 19, 2017

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Mihaela Zavolan

OrganizerSystem Biology

Contactsandra.britton@weizmann.ac.il

AbstractIn yeast, the knock out of individual ribosomal protein (RP) genes leads to a wide range of life span phenotypes, some mutants having significantly increased, other significantly decreased life span. In this talk I would like to present our efforts in characterizing the regulation of mRNA translation in relation to cellular states, from yeast to man. I will describe our work on inferring determinants of protein synthesis rates in yeast, where we found that the Gcn4 transcription factor, which is induced in many conditions that enhance yeast lifespan (RP gene knockout, calorie restriction, mTOR inhibition) not only activates transcription of amino acid biosynthesis genes, but also represses protein biosynthesis. How much variation in RP expression is expected in human tissues has been largely unknown, but RP gene mutations have been described in association with hematological disorders. Through a comprehensive analysis of human RP mRNAs expression pattern across 28 tissues, over 300 primary cells and 16 tumor types, we identified many RPs which exhibit tissue-specific expression. In the hematopoietic system, a small number of RP genes, possible regulated by transcription factors with tissue-specific expression, unequivocally discriminate cells of distinct lineages and developmental stages. Different cancer types also show dysregulated expression of individual RPs, some RPs having a relative increase and other decrease in expression. Finally, I will discuss our efforts in mapping sites of snoRNA-guided RNA modifications.
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Unexpected Adventures with Human Endogenous Retroviruses and Centromeres

Type: Lecture
Date: Dec 18, 2017

Time14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. David Markovitz

ContactIngrid.lehrer@weizmann.ac.il

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Accessing the genome: transcription factors as sensors and modifiers of chromatin

Type: Lecture
Date: Dec 12, 2017

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Dirk Schubeler

OrganizerSystem Biology

Contactingrid.lehrer@weizmann.ac.il

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(Re)Constructing the Vertebrate Neural Tube

Type: Lecture
Date: Dec 07, 2017

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. James Briscoe

OrganizerThe Azrieli Institute for Systems Biology

ContactIngrid.lehrer@weizmann.ac.il

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Developmental Club Series 2017-2018

Type: Lecture
Date: Dec 06, 2017

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr.Meital Oren

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

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Frontiers in Systems Biology: Prof. Jörg Vogel

Type: Lecture
Date: Dec 05, 2017

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Jörg Vogel

OrganizerSystem Biology

Contactingrid.lehrer@weizmann.ac.il

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Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture
Date: Dec 03, 2017

Time13:15

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNofar Mor

OrganizerSeminar

Contactsandra.britton@weizmann.ac.il

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Population as Distributed Memory System

Type: Lecture
Date: Nov 29, 2017

Time11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Ehud Lamm

ContactIngrid.lehrer@weizmann.ac.il

AbstractWe show how the distribution of skills or phenotypes in a population acts as collective memory or "distributed information store" serving individual so that individuals with varying innate abilities are able to attain the mature fully skilled phenotype. We show how information moves "in" and "out" of genomes, relative to this memory system, elucidating how evolution determines where best to store information. This question applies to understanding diverse biological systems in which individuals acquire capacities from the population, including immunity, the microbiome, and social learning. Using Agent Based Modeling we investigate how properties of the population and social aspects of the acquisition process affect the behavior of the system. We show that the genetic properties of the population react predictably to changes in population properties that affect selection pressures, without any group level selective processes. Specifically, parameter changes that make acquisition slower lead to skills becoming increasingly innate while changes in parameters that improve the results of acquisition (e.g., making acquisition reliant on abundant left-over tools) lead to an increased reliance on acquisition, all while the average phenotype remains constant. The dynamics we study contribute to understanding how individuals can evolve to become more or less reliant on social learning and cultural information, how this depends on population properties (e.g., group size), and how this manifests demographically. The more information stored externally, the stronger the selection pressure on traits that support acquisition. Finally, we contrast our model and the Baldwin Effect and relate out results to the study of the evolution of human social learning.
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Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture
Date: Nov 26, 2017

Time13:15

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerModi Safra

OrganizerSeminar

Contactsandra.britton@weizmann.ac.il

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Identification of Druggable and Redox vulnerabilities in a genetically defined cancer

Type: Lecture
Date: Nov 26, 2017

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Liron Bar-Peled

OrganizerJoint Seminar

ContactIngrid.lehrer@weizmann.ac.il

Add the event Identification of Druggable and Redox vulnerabilities in a genetically defined cancer to calendar

When enhancers drive the wrong genes: Mechanisms and role in tumorigenesis

Type: Lecture
Date: Nov 22, 2017

Time09:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Yotam Drier

ContactIngrid.lehrer@weizmann.ac.il

Add the event When enhancers drive the wrong genes: Mechanisms and role in tumorigenesis to calendar

"Coordination of microbial metabolism through metabolite-protein interactions”

Type: Lecture
Date: Nov 21, 2017

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Uwe Sauer

OrganizerSystem Biology

Contactingrid.lehrer@weizmann.ac.il

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Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture
Date: Nov 19, 2017

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDagan Segal

OrganizerSeminar

Contactsandra.britton@weizmann.ac.il

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Epistasis, pleiotropy, the ruggedness of fitness landscape, and the Predictability of RNA virus evolution

Type: Lecture
Date: Nov 14, 2017

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Santiago Elena

OrganizerSystem Biology

Contactingrid.lehrer@weizmann.ac.il

Add the event Epistasis, pleiotropy, the ruggedness of fitness landscape, and the Predictability of RNA virus evolution to calendar

Developmental Club Series 2017-2018

Type: Lecture
Date: Nov 08, 2017

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerEfrat Shema

OrganizerSeminar

Contactsandra.britton@weizmann.ac.il

Add the event Developmental Club Series 2017-2018 to calendar

You say tomato, I say potato. Evolution of the genetic code in yeasts

Type: Lecture
Date: Nov 07, 2017

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Ken Wolfe

OrganizerThe Azrieli Institute for Systems Biology

Contactsandra.britton@weizmann.ac.il

Add the event You say tomato, I say potato. Evolution of the genetic code in yeasts to calendar

Specificity and evolution of bacterial signaling proteins

Type: Lecture
Date: Oct 31, 2017

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Michael Laub

OrganizerSystem Biology

Contactingrid.lehrer@weizmann.ac.il

AbstractProtein-protein interactions are critical to the operation and functions of all cells. The specificity of these interactions is often dictated at the level of molecular recognition, meaning proteins have an intrinsic ability to discriminate cognate from non-cognate partners. Understanding precisely how this discrimination is accomplished remains a major problem, particularly for paralogous protein families in which the individual members share high sequence and structural similarity. Our work tackles this problem primarily in the context of two-component signal transduction systems, the predominant form of signaling in bacteria, and more recently with toxin-antitoxin systems, also found throughout the bacterial kingdom. I will describe our work using analyses of amino acid coevolution to pinpoint the molecular basis of specificity in these proteins. This work has enabled the rational rewiring of protein-protein interactions and signal transduction pathways. Additionally, these studies have driven efforts to systematically map sequence spaces and probe the selective pressures and constraints that govern the evolution of protein-protein interactions.
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"A stress-Induced Hidden Secret of the Genetic Code"

Type: Lecture
Date: Oct 22, 2017

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Hanna Engelberg-Kulka

OrganizerGuest Lecture

Contactsandra.britton@weizmann.ac.il

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Systems Biology innovative awards

Type: Lecture
Date: Sep 19, 2017

Time09:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

OrganizerThe Azrieli Institute for Systems Biology

Contactingrid.lehrer@weizmann.ac.il

Add the event Systems Biology innovative awards to calendar

Imaging how cells decide their fate, shape and position in the early mouse embryo

Type: Lecture
Date: Sep 17, 2017

Time11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Nicolas Plachta

ContactIngrid.lehrer@weizmann.ac.il

AbstractABSTRACT During development, each cell must resolve its fate, shape and position. Revealing how these decisions are made is critical to understand how embryos form, yet their real time control in mammals is unknown. Because fixed specimens cannot capture in vivo cell dynamics, we use imaging technologies to study single cells directly in live mouse embryos. We recently combined fluorescence correlation spectroscopy and photoactivation to show how the transcription factors Oct4 and Sox2 bind to DNA to determine the first cell fates of the embryo. We also designed methods to study how cells regulate their mechanical properties, and how they reorganize their actin and microtubule cytoskeletons to establish the first forms of tissue architecture. We discovered a new class of filopodia which helps cells to polarize and achieve embryo compaction, a role for cortical tension in driving the formation of the pluripotent inner mass, and a new type of non-centrosomal microtubule organizing center (MTOC) directing intracellular transport and differentiation in the embryo.
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The surprising expansion of the epigenetic regulatory repertoire in mammals

Type: Lecture
Date: Sep 10, 2017

Time12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Andrew Xiao, PhD

OrganizerThe Azrieli Institute for Systems Biology

Contactsandra.britton@weizmann.ac.il

Add the event The surprising expansion of the epigenetic regulatory repertoire in mammals to calendar

Studying human evolution using DNA methylation maps of Neanderthals

Type: Lecture
Date: Sep 05, 2017

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDavid Gokhman

Contactingrid.lehrer@weizmann.ac.il

Add the event Studying human evolution using DNA methylation maps of Neanderthals to calendar

Virology Club speacial guest seminar

Type: Lecture
Date: Jul 13, 2017

Time12:15

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Osnat Tirosh

OrganizerSeminar

Contactsandra.britton@weizmann.ac.il

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Developmental Club Series 2016-2017

Type: Lecture
Date: Jul 12, 2017

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAlon Greenbaum

OrganizerGuest Lecture

Contactsandra.britton@weizmann.ac.il

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To be announced

Type: Lecture
Date: Jul 02, 2017

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerTzahi Noiman

Contactcherill.banks@weizmann.ac.il

Add the event To be announced to calendar

Microbial Ecology Student's Club

Type: Lecture
Date: Jun 27, 2017

Time13:00 - 15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerArik Ogran; Lianet Noda-Garcia

Contactingrid.lehrer@weizmann.ac.il

Add the event Microbial Ecology Student's Club to calendar

To be announced

Type: Lecture
Date: Jun 25, 2017

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAditya Kshirsagar

Contactcherill.banks@weizmann.ac.il

Add the event To be announced to calendar

Developmental Club Series 2016-2017

Type: Lecture
Date: Jun 21, 2017

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerBenny Shilo

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

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Rapid DNA Re-Identification for Cell Line Authentication and Forensics

Type: Lecture
Date: Jun 20, 2017

Time09:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Sophie Zaaijer

Contactingrid.lehrer@weizmann.ac.il

Add the event Rapid DNA Re-Identification for Cell Line Authentication and Forensics to calendar

To be announced

Type: Lecture
Date: Jun 18, 2017

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerTBD

Contactcherill.banks@weizmann.ac.il

Add the event To be announced to calendar

To be announced

Type: Lecture
Date: Jun 11, 2017

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerEran Yanowski

Contactcherill.banks@weizmann.ac.il

Add the event To be announced to calendar

Developmental Club Series 2016-2017

Type: Lecture
Date: Jun 07, 2017

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerShalev Itzkovitz

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

Add the event Developmental Club Series 2016-2017 to calendar

To be announced

Type: Lecture
Date: Jun 04, 2017

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerInna Averbukh

Contactcherill.banks@weizmann.ac.il

Add the event To be announced to calendar

Through the looking glass: The red queens race and other tales of immunovirology

Type: Lecture
Date: Jun 01, 2017

Time11:15

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Leslie Lobel

Contactingrid.lehrer@weizmann.ac.il

Add the event Through the looking glass: The red queens race and other tales of immunovirology to calendar

To be announced

Type: Lecture
Date: May 28, 2017

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAlina Kolpakova

Contactcherill.banks@weizmann.ac.il

Add the event To be announced to calendar

Mitochondrial DNA transcription regulation - not as simple as once thought

Type: Lecture
Date: May 22, 2017

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDan Mishmar, PhD

Contactingrid.lehrer@weizmann.ac.il

Add the event Mitochondrial DNA transcription regulation - not as simple as once thought to calendar

Understanding HCMV latency by looking at transcription at the single cell level

Type: Lecture
Date: May 21, 2017

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerMiri Shnayder

Contactcherill.banks@weizmann.ac.il

Add the event Understanding HCMV latency by looking at transcription at the single cell level to calendar

The Relation Between Cell Fusion and Aneuploidy

Type: Lecture
Date: May 16, 2017

Time14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Alan Tartakoff

Contactingrid.lehrer@weizmann.ac.il

Add the event The Relation Between Cell Fusion and Aneuploidy to calendar

Directed evolution of high-performance reprogramming factors

Type: Lecture
Date: May 14, 2017

Time10:00

LocationCamelia Botnar Building

Lecturer Ralf Jauch

Contactsandra.britton@weizmann.ac.il

Add the event Directed evolution of high-performance reprogramming factors to calendar

Molecular Genetics retreat

Type: Lecture
Date: May 09, 2017

Time00:00

Contactingrid.lehrer@weizmann.ac.il

Add the event Molecular Genetics retreat to calendar

System level study of the cell death signature in melanoma: a vision towards precision cancer therapy

Type: Lecture
Date: Apr 30, 2017

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNaama Dekel

Contactcherill.banks@weizmann.ac.il

Add the event System level study of the cell death signature in melanoma: a vision towards precision cancer therapy to calendar

Seminar

Type: Lecture
Date: Apr 27, 2017

Time10:00 - 11:00

LocationCamelia Botnar Building

LecturerJoanne Kamens, Ph.D.

Contactsandra.britton@weizmann.ac.il

AbstractTitle; ‘Sharing Speeds Science: Intro to Addgene's Nonprofit Science Model Info; addgene is a nonprofit organization founded to help scientists share materials and useful data across borders around the world. Addgene has distributed over 750,000 plasmids to scientists in 85 countries. This movement of samples has influenced fields from Stem Cells to CRISPR and almost everything in between. Addgene's Executive Director, Joanne Kamens will present on this unique compnay model, what's new with Addgene and about what it is like to be an Addgenie. Dr. Kamens is the Executive Director of Addgene, a mission driven, nonprofit dedicated to helping scientists around the world share useful research reagents and data. Dr. Kamens received her PhD in Genetics from Harvard Medical School then spent 15 years as a researcher and manager in Pharma at BASF/Abbott working on both small molecule and antibody therapies for immune disease. In 2007 she joined RXi Pharmaceuticals as Senior Director of Research Collaborations. Dr. Kamens founded the current Boston chapter of the Association for Women in Science. She has helped start and supports many scientist mentoring programs with training and best practices. In 2010, Dr. Kamens received the Catalyst Award from the Science Club for Girls for longstanding dedication to empowering women in the fields of science, technology, engineering and mathematics and in 2013, she was named one of PharmaVoice's 100 Most Inspiring Commanders & Chiefs. She serves on a number of other non-profit boards and speaks widely on career development and workplace diversity topics in person and via Webinar.
Add the event Seminar to calendar

Mini Symposium on Immune Response to Viral Infections

Type: Lecture
Date: Apr 25, 2017

Time09:00 - 13:30

LocationCamelia Botnar Building

Contactsandra.britton@weizmann.ac.il

Add the event Mini Symposium on Immune Response to Viral Infections to calendar

PTPROt in chronic lymphocytic leukemia: a tumor suppressor or promotor?

Type: Lecture
Date: Apr 23, 2017

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerJean Wakim

Contactcherill.banks@weizmann.ac.il

Add the event PTPROt in chronic lymphocytic leukemia: a tumor suppressor or promotor? to calendar

To be announced

Type: Lecture
Date: Apr 09, 2017

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAnna Gorelick Ashkenazi

Contactcherill.banks@weizmann.ac.il

Add the event To be announced to calendar

"The LINC between nuclear anchoring and coordinated DNA replication in syncytial muscle cells"

Type: Lecture
Date: Apr 02, 2017

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerShuoshuo Wang

Contactcherill.banks@weizmann.ac.il

Add the event "The LINC between nuclear anchoring and coordinated DNA replication in syncytial muscle cells" to calendar

Microbial Ecology Student's Club

Type: Lecture
Date: Mar 28, 2017

Time13:00 - 15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

Contactingrid.lehrer@weizmann.ac.il

Add the event Microbial Ecology Student's Club to calendar

Lissencephaly and Rett syndrome; two disorders, one story

Type: Lecture
Date: Mar 26, 2017

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerLiraz Keidar

Contactcherill.banks@weizmann.ac.il

Add the event Lissencephaly and Rett syndrome; two disorders, one story to calendar

Molecular determinants of a lipid droplet subpopulation at the nucleus vacuole junction

Type: Lecture
Date: Mar 19, 2017

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Maria Bohnert

Contactcherill.banks@weizmann.ac.il

Add the event Molecular determinants of a lipid droplet subpopulation at the nucleus vacuole junction to calendar

Science and Clinical Orthopedics

Type: Lecture
Date: Mar 05, 2017

Time08:30 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Benjamin Alman,Keynote speaker

Contactingrid.lehrer@weizmann.ac.il

Add the event Science and Clinical Orthopedics to calendar

The Impact of Ploidy on Adaptation

Type: Lecture
Date: Mar 02, 2017

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Anna Selmecki

Contactingrid.lehrer@weizmann.ac.il

Add the event The Impact of Ploidy on Adaptation to calendar

RNA Editing in bacteria Recodes Multiple Proteins and Regulates a Toxin-Antitoxin System

Type: Lecture
Date: Feb 26, 2017

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDan Bar-Yaacov

Contactcherill.banks@weizmann.ac.il

Add the event RNA Editing in bacteria Recodes Multiple Proteins and Regulates a Toxin-Antitoxin System to calendar

Growth Plate Anatomy through the lens of cellular architecture

Type: Lecture
Date: Feb 12, 2017

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerSarah Rubin

Contactcherill.banks@weizmann.ac.il

Add the event Growth Plate Anatomy through the lens of cellular architecture to calendar

The role of FABP4 in ER stress-triggered cell death

Type: Lecture
Date: Feb 05, 2017

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerRinat Livne

Contactcherill.banks@weizmann.ac.il

Add the event The role of FABP4 in ER stress-triggered cell death to calendar

Differential mRNA decay re-shapes operon structures in bacteria

Type: Lecture
Date: Jan 29, 2017

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDaniel Dar

Contactcherill.banks@weizmann.ac.il

Add the event Differential mRNA decay re-shapes operon structures in bacteria to calendar

Enhanced Human Naïve Pluripotency Growth Conditions That Endow Tolerance for Loss of Epigenetic Repressors

Type: Lecture
Date: Jan 22, 2017

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerJonathan Bayerl

Contactcherill.banks@weizmann.ac.il

Add the event Enhanced Human Naïve Pluripotency Growth Conditions That Endow Tolerance for Loss of Epigenetic Repressors to calendar

Muscle Mechanosensors Keep Skeletal Morphology on Track

Type: Lecture
Date: Jan 15, 2017

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerRonen Blecher

Contactcherill.banks@weizmann.ac.il

Add the event Muscle Mechanosensors Keep Skeletal Morphology on Track to calendar

GeneHancer: genome-wide integration of enhancers and target genes in GeneCards

Type: Lecture
Date: Jan 08, 2017

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerSimon Fishilevich

Contactcherill.banks@weizmann.ac.il

Add the event GeneHancer: genome-wide integration of enhancers and target genes in GeneCards to calendar

New CRISPR-Cas systems from uncultivated microbes

Type: Lecture
Date: Jan 08, 2017

Time09:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. David Burstein

Contactingrid.lehrer@weizmann.ac.il

Add the event New CRISPR-Cas systems from uncultivated microbes to calendar

2016

Engineering Human T Cell Circuitry

Type: Lecture
Date: Dec 29, 2016

Time14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Alexander Marson

Contactingrid.lehrer@weizmann.ac.il

Add the event Engineering Human T Cell Circuitry to calendar

Building tissues to understand how tissues build themselves

Type: Lecture
Date: Dec 28, 2016

Time11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Zev Gartner

Contactingrid.lehrer@weizmann.ac.il

Add the event Building tissues to understand how tissues build themselves to calendar

Contact inhibition of locomotion drives the even spreading of ECM during Drosophila embryogenesis

Type: Lecture
Date: Dec 27, 2016

Time14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Brian Stramer

Contactcherill.banks@weizmann.ac.il

Add the event Contact inhibition of locomotion drives the even spreading of ECM during Drosophila embryogenesis to calendar

Working successfully with WIS new institutional review board principles and a practical guide to human research at WIS

Type: Lecture
Date: Dec 22, 2016

Time11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Eran Hornstein

Contactingrid.lehrer@weizmann.ac.il

Add the event Working successfully with WIS new institutional review board principles and a practical guide to human research at WIS to calendar

The regulatory role of short structural variants and the implication to neurodegenerative diseases in aging

Type: Lecture
Date: Dec 22, 2016

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Ornit Chiba-Falek

Contactingrid.lehrer@weizmann.ac.il

AbstractIn the post genome-wide association studies (GWAS) era we are shifting gears toward translation of genetic disease loci to molecular mechanisms of pathogenesis and pinpointing the causal genetic factors and their functional effects. It has been suggested that changes, even subtle, in the expression levels of wild-type genes in the brain can, over years, lead to neurodegenerative diseases. Moreover, differences in gene expression profiles between brain tissues from neurodegenerative disease patients compared to healthy controls have been reported. Short structural variants (SSVs) are short genomic variants (<50 bp) other than SNPs. Recently, there has been increased support for the idea that SSVs, which are largely ignored in large-scale genetic studies, may be involved in many complex diseases, and may also contribute significantly to variation in gene expression in human. We have been studying the expression regulation of key genes implicated in Alzheimer’s (AD) and Parkinson’s (PD) diseases and a wide-spectrum of related disorders. In particular, we focus on noncoding SSVs and their cis-regulatory effects on gene expression using a comprehensive strategy that combines multiple-level approaches. (1) in silico: we have developed a new bioinformatics tool for prioritizing candidate functional/causal SSVs. The tool is a searchable, annotated database of SSVs, with associated customizable scoring software that is designed to evaluate and prioritize SSVs that are most likely to have significant biological effects and impact on disease risk. (2) in vitro: we have established induced Pluripotent Stem Cell (iPSC)-derived neurons, dopaminergic and cholinergic, from a normal subject and PD patients. We are currently using this model system to determine how cis-variants modulate expression of disease risk genes via their interactions with the trans-acting factors, by applying CRISPR/Cas9 – mediated genome editing. (3) in vivo: we have quantified cell-type specific gene expression in neurons, astrocytes, and microglia by single-cell gene expression assays using cells isolated from frozen human brain samples via LCM. We have implemented this strategy in studies of genomic loci implicated in Lewy body and AD diseases, specifically SNCA gene and the TOMM40-APOE cluster. Collectively, the innovative approaches we developed represent a cohesive strategy for discovering potentially functional and causal variants within candidate risk-genes associated with AD-PD spectrum disorders.
Add the event The regulatory role of short structural variants and the implication to neurodegenerative diseases in aging to calendar

The natural history of the infant gut microbiome in health and disease

Type: Lecture
Date: Dec 20, 2016

Time09:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Moran Yassour

Contactingrid.lehrer@weizmann.ac.il

Add the event The natural history of the infant gut microbiome in health and disease to calendar

Genetic media

Type: Lecture
Date: Dec 19, 2016

Time14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Yaniv Erlich

Contactcherill.banks@weizmann.ac.il

AbstractAbstract: In the last decade, the human population has produced zettabytes (10^21) of digital data. This creates immense opportunities and challenges for biology research. In this talk, I will present two research directions of my groups on the intersection between genetics and data, which we dub “genetic media”. First, I will speak about crowd sourcing massive genetic data using social media. We collected over 80 million profiles from the largest social-media website driven by genealogy and constructed a single family tree of 13 million people. Using this data, we analyzed the genetic architecture of longevity. I will also speak about our on-going efforts to crowd source genomes and social media phenotypes to this massive pedigree. In the second part of my talk, I will present using synthetic DNA as a medium for long-term data storage. Previous studies in leading journal have presented this concept but failed to show reliable data retrieval. Here, we report a storage strategy, called DNA Fountain, that is highly robust and approaches the Shannon limit. The success of our strategy relies on careful adaptation of coding theory to the domain-specific constraints of DNA molecules. To demonstrate its power, we stored a full computer operating system, movie, and other files in DNA oligos and perfectly retrieved the information. We explored the limit of our architecture in terms of bytes per molecules and obtained a perfect retrieval from a density of 215Petabyte/gram of DNA, orders of magnitudes higher than previous techniques.
Add the event Genetic media to calendar

The non-receptor tyrosine kinase c-Abl controls genomic integrity by coordinating the cell cycle with the DNA damage response

Type: Lecture
Date: Dec 18, 2016

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerVicky Meltzer

Contactcherill.banks@weizmann.ac.il

Add the event The non-receptor tyrosine kinase c-Abl controls genomic integrity by coordinating the cell cycle with the DNA damage response to calendar

Characterization of proteome dynamics in oleate reveals a novel peroxisome targeting receptor

Type: Lecture
Date: Dec 11, 2016

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerEden Yifrach

Contactcherill.banks@weizmann.ac.il

Add the event Characterization of proteome dynamics in oleate reveals a novel peroxisome targeting receptor to calendar

Recruiting the protein interaction map of cell death for studying human genetic disease

Type: Lecture
Date: Dec 04, 2016

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAya Shkedy

Contactcherill.banks@weizmann.ac.il

Add the event Recruiting the protein interaction map of cell death for studying human genetic disease to calendar

Working successfully with WIS new institutional review board principles and a practical guide to human research at WIS

Type: Lecture
Date: Dec 01, 2016

Time11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Eran Hornstein

Contactingrid.lehrer@weizmann.ac.il

Add the event Working successfully with WIS new institutional review board principles and a practical guide to human research at WIS to calendar

Dysregulation of safeguard mechanisms underlies hybrid vigor

Type: Lecture
Date: Nov 27, 2016

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDana Bar-Zvi

Contactcherill.banks@weizmann.ac.il

Add the event Dysregulation of safeguard mechanisms underlies hybrid vigor to calendar

Information processing and decision making in live cells

Type: Lecture
Date: Nov 22, 2016

Time14:00

LocationGerhard M.J. Schmidt Lecture Hall

LecturerProf. Andre Levchenko

OrganizerSystem Biology

Contactingrid.lehrer@weizmann.ac.il

Add the event Information processing and decision making in live cells to calendar

C/EBPβ LIP augments cell death by inducing a novel tumor suppressor gene osteoglycin

Type: Lecture
Date: Nov 20, 2016

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerRina Wassermann-Dozorets

Contactcherill.banks@weizmann.ac.il

Add the event C/EBPβ LIP augments cell death by inducing a novel tumor suppressor gene osteoglycin to calendar

In vivo veritas – Using CRISPR genome editing to model cancer in mice

Type: Lecture
Date: Nov 17, 2016

Time11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Daniel Schramek

Contactingrid.lehrer@weizmann.ac.il

AbstractModern Genetics is revealing virtually all the genetic and epigenetic alterations associated with human malignancies. Mining this information for Precision Medicine is predicated on weeding out ‘bystander’ mutation and identifying the ‘driver’ mutations responsible for tumor initiation, progression and metastasis, as only the latter have diagnostic and therapeutic value. Secondly, we have to elucidate how driver mutations alter the fundamental molecular pathways governing tissue growth and identify actionable nodes within a given cancer gene network that can be exploited therapeutically. The massive quantity of data emerging from cancer genomics therefore demands a corresponding increase in the efficiency and throughput of in vivo models to comprehensively assess all putative cancer genes. We therefore developed a versatile functional genomics toolbox that enables us to generate and analyze thousands of somatic gene knock-out or overexpression clones within a single animal in a matter of weeks. Ultrasound-guided in utero injections allow us to selectively transduce fluorescently-labeled lentiviral CRISPR or ORF libraries into various organs of living mouse embryos. Subsequent mosaic analysis, next-generation sequencing and library barcode deconvolution enables us to identify genes that regulate proliferation, differentiation and survival. Of note, this analysis not only assess the gene function in an physiological and immune-competent microenvironment, but can also be combined with any mouse model and treatment schedule to faithfully model human malignancies. Using this technique, we have completed several proof-of-concept screens and elucidated several novel tumor suppressor genes in Head&Neck. Currently, we are performing several multiplexed in vivo CRISPR screens to uncover context-specific cancer vulnerabilities, novel immune regulators and genes that confer resistance to chemo- or targeted therapies. In this seminar, I will highlight the utility of direct in vivo screening to integrate human cancer genomics and mouse modeling for rapid and systematic discovery of cancer driver mutations and novel cancer vulnerabilities.
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Following Single mRNAs in Living Cells

Type: Lecture
Date: Nov 14, 2016

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Robert Singer

Contactingrid.lehrer@weizmann.ac.il

Add the event Following Single mRNAs in Living Cells to calendar

Host-Bacillus subtilis interaction: using polysaccharides to form new and improved biofilms

Type: Lecture
Date: Nov 13, 2016

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNatalia Kemper

Contactcherill.banks@weizmann.ac.il

Add the event Host-Bacillus subtilis interaction: using polysaccharides to form new and improved biofilms to calendar

Novel Function for Aire During Early Development and Somatic Cell Reprogramming

Type: Lecture
Date: Nov 06, 2016

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerVladik Krupalnik

Contactcherill.banks@weizmann.ac.il

Add the event Novel Function for Aire During Early Development and Somatic Cell Reprogramming to calendar

Experimental evolution in the testube and in the body

Type: conference
Date: Nov 01, 2016

Time00:08 - 00:20

LocationThe David Lopatie Conference Centre

Contactpilpel@weizmann.ac.il

Add the event Experimental evolution in the testube and in the body to calendar

RNA function in germ and stem cell biology

Type: Lecture
Date: Oct 18, 2016

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Dónal O'Carroll

Contactingrid.lehrer@weizmann.ac.il

AbstractThe integrity of the genome transmitted to the next generation intrinsically relies on cells of the germ line. Processes that ensure germ cell development, genomic stability, and reproductive lifespan are essential for the long-term success of a species. Dónal O'Carroll is interested in characterizing spermatogonial stem cell (SSC) populations that support fertility as well the regenerative capacity of the testis throughout adult life. In addition, O'Carroll lab tackles fundamental questions regarding the mammalian male germ line and heredity from an RNA perspective. Specifically, their research explores the contribution of non-coding RNA (miRNA, piRNA and lncRNA) and RNA modification pathways within germ cell development as well as testicular homeostasis/regeneration. The research objectives focus on the contribution of these emerging pathways on the underlying circuitry of self-renewal that underpins the SSC, as well as the coordination of the various cellular/differentiation processes of spermatogenesis.
Add the event RNA function in germ and stem cell biology to calendar