Non-coding RNA tissue functions

Our work explains the principles of miRNA-based commitment to a specific fate in differentiation. We have shown how specific miRNA control the stem cell pool and acquisition of a robust developmental outcomes. We are interested in understanding pancreas tissue dynamics and utilize single-cell transcriptome profiling, single molecule FISH and mouse genetics to understand the source and lineage of the regenerating pancreas.

 

Collaborators: Yuval Dor (HUJ); Iddo Amit, Diego Jaitin, Shalev Itzkovitz (Weizmann); Anthony Gavalas (TU Dresden).