5 6 4
7 8 3
9 2
10 1
Publications
 
 
 

Publications

 

Selected publications 2012 to 1995
   
 
1995   1996   1997   1998   1999   2000   2001
2002-3   2004   2005   2006   2007   2008   2009
2010   2011   2012                
   
 
  2012
  Eisenberg-Lerner, A. and Kimchi, A. (2012) PKD is a Vps34 kinase and a regulator of DAPk-induced autophagy during oxidative stress. Cell Death Differ 19:788–797[PDF]
  Eisenberg-Lerner A, Kimchi A. (2012) PKD at the crossroads of necrosis and autophagy. Autophagy. 8(3) in press[PDF]
  Mor, I., Carlessi, R., Ast, T. and Kimchi, A. (2012) Death associated protein kinase 1 induces increase in glycolytic rate through activation of pyruvate kinase.  Oncogene 31:683-93[PDF]
  Mor, I., Bialik, S. and Kimchi, A. (2012) DAPk and pyruvate kinase: unlikely partners in cancer metabolic regulation. Cell Cycle 11:3-4[PDF]
 

Nakav, S, Cohen, S, Feigelson, SW, Bialik, S, Shoseyov, D, Kimchi, A, and Alon, R (2012) The Tumor Suppressor DAPk Attenuates Inflammatory Responses in the Lung. Am J Respir Cell Mol Biol. 46:313-22.[PDF]

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  2011
  Bialik, S., Pietrokovski, S., and Kimchi, A. (2011) Myosin drives autophagy in a pathway linking Atg1 to Atg9. EMBO J 30:629-30.[PDF]
  Bialik S, Kimchi A. (2011) Pin-pointing a new DAP kinase function: the peptidyl-proly isomerase Pin1 Is Negatively Regulated by DAP kinase-mediated phosphorylation. Mol Cell 42:139-41.[PDF]
  Paz, A., Brownstein, Z., Ber, Y., Bialik, S., David, E., Sagir, D., Ulitsky, I., Elkon, R., Kimchi, A., Avraham, K.B., Shiloh, Y., and Shamir, R. (2011) SPIKE: a database of highly curated human signaling pathways. Nucleic Acids Res 39:D793-9.[PDF]
  Shoval, Y., Berissi, H., Kimchi, A., and Pietrokovski, S. (2011) New Modularity of DAP-Kinases: Alternative Splicing of the DRP-1 Gene Produces a ZIPk-Like Isoform. PLoS One. 6:e17344.[PDF]
  Carlessi, R., Levin-Salomon, V, Ciprut, S, Bialik, S, Berissi, H, Albeck, S, Peleg, Y, and Kimchi, A. (2011) GTP-binding to DAP-kinase’s ROC domain regulates its function via novel intramolecular signaling. EMBO Reports 12:917-23.[PDF]
  Rubinstein, A.D., Eisenstein, M., Ber, Y., Bialik, S., and Kimchi, A. (2011) The Autophagy Protein Atg12 Associates with Anti-Apoptotic Bcl-2 Family Members to Promote Mitochondrial Apoptosis. Mol Cell 44:698-709.[PDF]
  Yosef N, Zalckvar E, Rubinstein AD, Homilius M, Atias N, Vardi L, Berman I, Zur H, Kimchi A, Ruppin E, Sharan R. (2011) ANAT: a tool for constructing and analyzing functional protein networks. Sci Signal. 4:pl1.[PDF]
  Chuang, YT, Lin, YC, Lin, KH, Chou, TF, Kuo WC, Yang, KT, Wu, PR, Chen, RH, Kimchi, A and Lai, MZ (2011) Tumor suppressor death-associated protein kinase is required for full IL-1{beta} production. Blood 117:960-70.[PDF]
 

Wu, PR, Tsai, PI, Chen, GC, Chou, HJ, Huang, YP, Chen, YH, Lin, MY, Kimchi, A, Chien, CT, and Chen, RH. (2011) DAPK activates MARK1/2 to regulate microtubule assembly, neuronal differentiation, and tau toxicity. Cell Death Differ.  18:1507-1520.[PDF]

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  2010
  Guenebeaud, C., Goldschneider, D., Castets, M., Guix, C., Chazot, G., Delloye-Bourgeois, C., Eisenberg-Lerner, A., Shohat, G., Zhang, M., Laudet, V., Kimchi, A., Bernet, A., and Mehlen, P. (2010) The dependence receptor UNC5H2/B triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinase. Mol Cell 40:863-76.[PDF]
  Koren, I., Reem, E., and Kimchi, A. (2010) Autophagy gets a brake: DAP1, a novel mTOR substrate, is activated to suppress the autophagic process. Autophagy 6:1179-80.[PDF]
  Zalckvar, E., Bialik, S., and Kimchi, A. (2010) The road not taken: a systems level strategy for analyzing the cell death network. Autophagy 6:813-5.[PDF]
  Bialik, S., Zalckvar, E., Ber, Y., Rubinstein, A.D., and Kimchi, A. (2010) Systems biology analysis of programmed cell death. Trends Biochem Sci 35:556-64.[PDF]
 

Koren, I., Reem, E., and Kimchi, A. (2010) DAP1, a novel substrate of mTOR, negatively regulates autophagy. Curr Biol 20:1093-8.[PDF]

 

Zalckvar, E., Yosef, N., Reef, S., Sharan, R., Ruppin, E., and Kimchi, A. (2010) RNAi-mediated Perturbations Reveal Multiple Levels of Connectivity Between Apoptosis and Autophagy. Cell Death Differ Cell Death Differ 17:1244-53 [PDF]

  Bialik S., and Kimchi A. (2010) Lethal weapons: DAP-kinase, autophagy and cell death. Curr Opin Cell Biol Cell Death Differ 17:1244-53. [PDF]
 
   
 
  2009
  Zalckvar, E., Berissi, H., Eisenstein, M., and Kimchi, A. (2009) Phosphorylation of Beclin 1 by DAP-kinase promotes autophagy by weakening its interactions with Bcl-2 and Bcl-X(L). Autophagy 5:720-2 [PDF]
  Eisenberg-Lerner, A., Bialik, S., Simon, H.U., and Kimchi, A. (2009) Life and death partners: apoptosis, autophagy and the cross-talk between them. Cell Death Diff 16:966-75. [PDF]
  Yosef, N., Ungar, L., Zalckvar, E., Kimchi, A., Kupiec, M., Ruppin, E., and Sharan, R. (2009) Toward accurate reconstruction of functional protein networks. Mol Syst Biol. 5:248. [PDF]
  Zalckvar, E., Berissi, H., Mizrachy, L., Idelchuk, Y., Koren, I., Eisenstein, M., Sabanay, H., Pinkas-Kramarski, R., and Kimchi, A. (2009) DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-X(L) and induction of autophagy. EMBO Reports 10:285-92 [PDF]
  Eisenberg-Lerner, A. and Kimchi, A. (2009) The paradox of autophagy and its implication in cancer etiology and therapy. Apoptosis 14:376-91 [PDF]
  Liberman, N., Marash, L., and Kimchi, A. (2009) The translation initiation factor DAP5 is a regulator of cell survival during mitosis. Cell Cycle 8:204-9 [PDF]
 
 
  2008
  Gozuacik, D., Bialik, S., Raveh, T., Mitou, G., Shohat, G., Sabanay, H., Mizushima, N., Yoshimori, T., and Kimchi, A. (2008) DAPk is a key mediator of endoplasmic reticulum stress-induced caspase activation and autophagy. Cell Death Diff 15:1875-86 [PDF]
  Liberman, N., Dym, O., Unger, T., Albeck, S., Peleg, Y., Jacobovitch, Y., Branzburg, A., Eisenstein, M., Marash, L., and Kimchi, A. (2008) The crystal structure of the C-terminal DAP5/p97 domain sheds light on the molecular basis for its processing by caspase cleavage. J Mol Biol 383:539-48. [PDF]
  Reef, S. and Kimchi, A. (2008) Nucleolar p19ARF, unlike mitochondrial smARF, is incapable of inducing p53-independent autophagy. Autophagy 4:866-9. [PDF]
  Bialik, S., Berissi, H. and Kimchi, A. (2008) A high-throughput proteomics screen identifies novel substrates of death associated protein kinase. Mol Cell Proteomics 7:1089-98. [PDF]
  Marash, L., Liberman, N., Henis-Korenblit, S., Sivan, G., Reem, E. Stein, O. and Kimchi, A. (2008) DAP5 promotes cap-independent translation of Bcl-2 and CDK1 to facilitate cell survival during mitosis. Mol Cell 30:447-59. [PDF]
  Bialik, S. and Kimchi, A. (2008) Autophagy and tumor suppression: recent advances in understanding the link between autophagic cell death pathways and tumor development. Adv Exp Med Biol 615:177-200. [PDF]
 
 
  2007
 

Eisenberg-Lerner, A. and Kimchi, A. (2007) DAP-kinase regulates JNK signaling by binding and activating protein kinase D under oxidative stress. Cell Death Differ 14:1908-1915. [PDF]

  Reef, S., Shifman, O., Oren, M., and Kimchi, A. (2007) The autophagic inducer smARF interacts with and is stabilized by the mitochondrial p32 protein. Oncogene 26:6677-83. [PDF]
  Gozuacik, D. and Kimchi, A. (2007) Autophagy and cell death. Curr Top Dev Biol 78:217-245. [PDF]
  Kimchi, A. (2007) Programmed Cell Death: from novel gene discovery to studies on   network connectivity and emerging biomedical implications. Cytokine Growth Factor Rev 18:435-440. [PDF]
  Maiuri, C., Zalckvar, E., Kimchi, A. and Kroemer, G. (2007) Self-eating and self-killing:  crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol 8:741-752. [PDF]
  Shoval, Y., Pietrokovski, S. and Kimchi, A. (2007) ZIPk: a unique case of murine specific divergence of a conserved vertebrate gene. PLoS Genetics 3:1884-93. [PDF]
 
   
  2006
  Reef, S., Zalckvar, E., Shifman, O., Bialik, S., Sabanay, I., Oren, M., and Kimchi, A. (2006) A short mitochondrial form of p19ARF induces autophagy and caspase-independent cell death. Mol Cell 22:463-475. [PDF]
  Bialik, S. and Kimchi, A. (2006) The death associated protein kinases: structure, function and beyond. Annu Rev Biochem 75:189-210. [PDF]
  Gozuacik, D. and Kimchi, A. (2006) DAPk protein family and cancer. Autophagy 2:74-79. [PDF]
  Citri, A., Harari, D., Shohat, G., Ramakrishnan, P., Gan, J., Lavi, S., Eisenstein, M., Kimchi, A., Wallach, D., Pietrokovski, S., and Yarden, Y. (2006) Hsp90 recognizes a common surface on client kinases. J Biol Chem 281:14361-9.[PDF]
  Reef, S. and Kimchi, A. (2006) A smARF Way to Die: A Novel Short Isoform of p19ARF is Linked to Autophagic Cell Death. Autophagy 2:328-30. [PDF]
 
   
  2005
  Marash, L. and Kimchi, A. (2005) DAP5 and IRES-mediated translation during programmed cell death.  Cell Death Differ. 12:554-562. [PDF]
  Llambi, F., Lourenco, F.C., Gozuacik, D., Guix, C., Pays, L., Del Rio, G., Kimchi, A. and Mehlen, P. (2005) The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase.  EMBO J 24:1192-1201. [PDF]
 
   
  2004
  Bialik, S., Bresnick, A.R. and Kimchi A. (2004) DAP-kinase-mediated morphological changes are localization dependent and involve myosin-II phosphorylation.  Cell Death Differ 11:631- 644. [PDF]
  Gozuacik, D. and Kimchi, A. (2004) Autophagy as a cell death and tumor suppressor mechanism.  Oncogene 23:2891-906. [PDF]
  Mukamel, Z. and Kimchi, A. (2004) DAP3 localizes to the mitochondria and is involved in the process of mitochondrial fragmentation during cell death.  J Biol Chem 279:36732-36738. [PDF]
  Shani, G., Marash, L., Gozuacik, D., Bialik, S., Teitelbaum, L., Shohat, G. and Kimchi, A. (2004) DAP-kinase phosphorylates ZIP-kinase forming a unique kinase hierarchy to activate its cell death functions. Mol. Cell. Biol. 24:8611-8626. [PDF]
  Bialik, S. and Kimchi, A. (2004) DAP-kinase as a target for drug design in cancer and diseases associated with accelerated cell death. Seminar in Cancer Biol 14:283-294. [PDF]
  Levy, D., Plu-Bureau, G., Decroix, Y., Hugol, D., Rostene, W., Kimchi, A. and Gompel A. (2004) Death-associated protein kinase loss of expression is a new marker for breast cancer prognosis. Clin Cancer Res 10:3124-30. [PDF]
 
   
  2002-2003
  Kimchi, A. (2003) Antisense libraries to isolate tumor suppressor genes.  Methods Mol Biol 222:399-412.
  Pelled, D., Raveh, T., Riebeling, C., Fridkin, M., Berissi, H., Futerman, A.H., and Kimchi, A. (2002) Death Associated protein (DAP)-kinase plays a central role in ceramide-induced apoptosis in cultured hippocampal neurons. J Biol Chem 277:1957-1961. [PDF]
  Inbal, B., Bialik, S., Sabanay, I., Shani, G. and Kimchi, A. (2002) DAP-kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death.  J Cell Biol 157:455-468. [PDF]
  Henis-Korenblit, S., Shani, G., Sines, T., Marash, L., Shohat, G., and Kimchi, A. (2002) The caspase cleaved DAP5 protein supports internal ribosome entry site -mediated translation of death proteins. Proc. Natl. Acad. Sci. USA 99:5400-5405. [PDF]
  Lo Coco, F., Zelent, A., Kimchi, A., Carducci, M., Gore, S.D., and Waxman, S. (2002) Progress in differentiation induction as a treatment for acute promyelocytic leukemia and beyond. Cancer Res. 62:5618-5621.[PDF]
  Schori, H., Yoles, E., Wheeler, L.A., Raveh, T., Kimchi, A., and Schwartz, M.  (2002) Immune-related mechanisms participating in resistance and susceptibility to glutamate toxicity. Eur J Neurosci 16:557-564. [PDF]
  Shohat, G., Shani, G., Eisenstein, M., and Kimchi, A. (2002) The DAP-kinase family of proteins: study of a novel group of calcium-regulated death-promoting kinases. Biochim Biophys Acta. 1600:45-50. [PDF]
  Shohat, G., Spivak-Kroizman, T., Eisenstein, M. and Kimchi, A. (2002) The regulation of death-associated protein (DAP) kinase in apoptosis. Eur Cytokine Network 13:387-395.
 
   
  2001
  Cohen, O. and Kimchi, A. (2001) DAP-kinase: From functional gene cloning to establishment of its role in apoptosis and cancer. Cell Death Diff 8:6-15. [PDF]
  Raveh, T., Droguett, G., Horwitz, M.S., DePinho, R.A., and Kimchi, A. (2001) DAP-kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation.  Nature Cell Biol 3:1-7. [PDF]
  Shani, G., Henis-Korenblit, S., Jona, G., Gileadi, O., Eisenstein, M., Ziv, T., Admon, A., and Kimchi, A. (2001) Autophosphorylation restrains the apoptotic activity of DRP-1 kinase by controlling dimerization and CaM binding.  EMBO J 20:1-15. [PDF]
  Raveh, T. and Kimchi, A. (2001) DAP-kinase- a proapoptotic gene that functions as a tumor suppressor. Exp Cell Res 264:185-192. [PDF]
  Ma, X., Karra, S., Lindner, D.J., Hu, J., Reddy, S.P., Kimchi, A., Yodoi, J., and Kalvakolanu, D.D. (2001) Thioredoxin participates in a cell death pathway induced by interferon and retinoid combination. Oncogene 20:3703-15. [PDF]
  Shohat, G., Spivak, T., Cohen O., Bialik, S., Berissi. H., Eisenstein, M., and Kimchi, A. (2001) The pro-apoptotic function of death-associated protein kinase is controlled by a unique inhibitory autophosphorylation-based mechanism. J Biol Chem 276:47460-47467. [PDF]
  Wittke, I., Madge, B., Wiedemeyer, R., Kimchi, A. and Schwab, M.  (2001) DAP-5 is involved in MycN/IFNgamma-induced apoptosis in human neuroblastoma cells. Cancer Lett 162:237-243. [PDF]
  Kimchi, A. (2001) A cell death-promoting kinase. Nat Struct Biol 8:824-826. [PDF]
 
   
  2000
  Inbal, B., Shani, G., Cohen, O., Kissil, J.L., and Kimchi, A. (2000) DAP-kinase-related protein-1 (DRP-1), a novel serine/threonine kinase involved in apoptosis. Mol. Cell. Biol. 20:1044-1054. [PDF]
  Henis-Korenblit, S., Levy-Strumpf, N. Goldstaub, D., and Kimchi, A. (2000) A novel form of DAP5 accumulates in apoptotic cells as a result of caspase cleavage and IRES-mediated translation. Mol. Cell. Biol. 20:496-506. [PDF]
  Raveh, T., Berissi, H. Eisenstein, M., Spivak, T., and Kimchi, A. (2000) A functional genetic screen identifies regions at the C-terminal tail and death domain of DAP-kinase that are critical for its pro-apoptotic activity. Proc. Natl. Acad. Sci. USA 97:1572-1577. [PDF]
 
   
  1999
  Kissil, J.L., Cohen, O. Raveh, T. and Kimchi, A. (1999) Structure/function analysis of an evolutionary conserved protein, DAP3, which mediates TNF-α and Fas-induced cell death. EMBO J 18:353-362. [PDF]
  Yamamoto, M., Takahashi, H., Hioki, T., Sun, X., Iijima,S., Uchino, S. and Kimchi, A. (1999) Developmental changes in distribution of Death-Associated protein kinase mRNA. J. Neurosci. Res. 58:674-683. [PDF]
  Cohen O., Kissil, J., Raveh, T., Inbal, B., Strumpf, N. Berissi, H., Deiss, L., and Kimchi, A. (1999) Functional Approaches to Gene Isolation in Mammalian Cells. Science 285:299-300. [PDF]
  Cohen, O., Inbal, B., Kissil, J.L., Raveh, T., Berissi, H., Spivak, T., Feinstein H., and Kimchi, A. (1999) DAP-kinase participates in TNF-a and Fas-induced apoptosis and its function requires the death domain. J Cell Biol 146:141-148. [PDF]
 
   
  1998
  Kimchi, A. (1998) DAP genes: novel apoptotic genes isolated by a functional approach to gene cloning. Biochim Biophys Acta 1377:F13-F33. [PDF]
  Kissil, J.L. and Kimchi, A. (1998) Death associated proteins: From gene identification to the analysis of their apoptotic and tumor suppressive functions. Molec. Med. Today 4:268-274. [PDF]
  Levy-Strumpf, N. and Kimchi, A. (1998) Death associated protein (DAPs): from gene identification to the analysis of their apoptotic  functions. Oncogene 17:3331-3340. [PDF]
 
   
  1997
  Cohen, O., Feinstein, E. and Kimchi, A. (1997) DAP-kinase is a Ca2+/ calmodulin-dependent, cytoskeletal associated protein kinase, with cell death-inducing functions that depend on its catalytic activity. EMBO J 16:998-1008. [PDF]
  Levy-Strumpf, N., Deiss, L.P., Berissi, H. and Kimchi, A. (1997) DAP-5, a novel homologue of the translation initiation factor 4g, isolated as a positive modulator of interferon-g-induced programmed cell death. Mol Cell Biol 17:1615-1625. [PDF]
  Kissil, J.L., Feinstein, E., Cohen, O., Jones, P.A., Tsai, Y.C., Knowles, M.A., and Kimchi, A. (1997) DAP-kinase Loss of Expression in various carcinoma and B-cell lymphoma cell Lines: Possible Implications for Role as Tumor Suppressor Gene. Oncogene 15:403-407. [PDF]
  Inbal, B., Cohen, O., Polak-Charcon S., Kopolovic, J., Vadai, E., Eisenbach, L. and Kimchi, A. (1997) DAP-kinase is a tumor suppressor gene that links the control of apoptosis to metastasis. Nature 390:180-184. [PDF]
  Kissil, J.L. and Kimchi, A. (1997) Assignment of human Death Associated Protein-3, DAP3, to Chromosome 1q21. Cytogenet Cell Genet 77:252.
 
   
  1996
  Deiss, L., Galinka,H., Berissi, H., Cohen, O., and Kimchi, A. (1996) Cathepsin D protease mediates programmed cell death induced by interferon-γ, Fas/APO1, and TNF-α. EMBO J 15:3861-3870. [PDF]
  Tiefenbrun, N., Melamed, D., Levy, N. Resnitzky, D., Hoffmann, I., Reed, S.I. and Kimchi, A. (1996) Interferon-a suppresses cyclin D3 and cdc25A genes leading to areversible G0-like arrest. Mol Cell Biol 16:3934-3944. [PDF]
  Raveh, T., Hovanessian, A., Meurs, E., Sonenberg, N., and Kimchi, A. (1996) Double-stranded RNA-dependent protein kinase  mediates c-Myc suppression induced by type I interferons. J Biol Chem 271:25479-25484. [PDF]
 
   
  1995
  Deiss, L., Feinstein, E., Berissi, H., Cohen, O., and Kimchi, A. (1995) Identification of a novel serine/threonine kinase and of a novel 15kDa protein as potential mediators of the interferon-γ-induced cell death. Genes Dev 9:15-30. [PDF]
  Feinstein, E., Druck, T., Kastury, K., Berissi, H., Goodart, S.A., Overhauser, J., Khaspekov, G. Raveh, T., Kimchi,A., and Huebner, K. (1995) Chromosomal assignment of DAP-1 and DAP-kinase-genes that positively mediate programmed cell death triggered by IFN-γ. Genomics 29:305-307. [PDF]
  Kissil, J.L., Deiss, L.P., Bayewitch, M., Raveh, T., Khaspekov, G., and Kimchi, A. (1995) Isolation of DAP-3: a novel mediator of interferon-γ-induced cell death. J Biol Chem 270:27932-27936. [PDF]
  Feinstein, E., Wallach, D., Boldin, M., Varfolomeev, E., and Kimchi, A. (1995) Death Domain - a Module Shared by Proteins with Diverse Cellular Functions. Trends Biochem Sci 20:342-344. [PDF]
 

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