Bio-inspired Intracellular recordings and stimulation of neurons by extracellular multisite noninvasive gold mushroom shaped multi electrode array

The development of Brain Machine Interface (BMI) technologies is driven by the belief that when successful such interfaces could be applied to replace damaged sensory organs (as the retina), replace motor part (limbs), link disrupted neuronal networks (injured spinal cord), generate hybrid neuro-electronic computers and others.

Despite decades of research and development, contemporary approaches fail to provide satisfying scientific concepts and technological solutions to generate efficient and durable interfaces between neurons and electronic devices. In the presentation I will describe a novel biologically inspired approach to enable the generation of efficient bidirectional electrical coupling between cultured neurons and extracellular multi-microelectrode array. The cell biological, molecular and physical principals underlying the novel neuroelectronic configuration will be explained.

The prospective of using our approach for long-term, non-invasive, multisite intracellular recording and stimulation for brain research and clinical BMI applications will be discussed.