Stress-induced psychopathologies

Dysregulation of the behavioral and neuroendocrine responses to stressors can have severe psychological and physiological consequences. There is much evidence suggesting that inappropriate regulation, disproportional intensity, or chronic and/or irreversible activation of the stress response is linked to the etiology and pathophysiology of anxiety disorders and depression. We are employing integrated molecular, biochemical, pharmacological, physiological and behavioral methods, converging on the generation of genetic mouse models as an in vivo tool, in order to study the central pathways and molecular mechanisms mediating the organism‘s stress response and the related psychopathologies. Defining the contributions of known and novel gene products to the maintenance of stress-linked homeostasis may improve our ability to design therapeutic interventions for, and thus manage, stress-related psychiatric disorders.

Relevant Publications

Ramot A, Jiang Z, Tian J.B, Nahum T, Kuperman Y, Justice N, Chen A (2017). Hypothalamic CRFR1 is essential for HPA axis regulation following chronic stress.  Nat. Neurosci. .
Volk N, Pape J.C, Engel M, Zannas A.S, Cattane N, Cattaneo A, Binder E.B, Chen A (2016). Amygdalar MicroRNA-15a Is Essential for Coping with Chronic Stress.  Cell Reports. 17: :1882–91.
Mjag Henckens, Jm Deussing And A Chen (2016). Region-specific roles of the corticotropin-releasing factor– urocortin system in stress.  Nature Reviews. 17: (10):636-651.
Mjag Henckens, Y Printz, U Shamgar, J Dine, M Lebow, Y Drori, C Kuehne, A Kolarz, M Eder, Jm Deussing, Nj Justice, O Yizhar, And A Chen (2016). CRF receptor type 2 neurons in the posterior bed nucleus of the stria terminalis critically contribute to stress recovery.  Molecular Psychiatry. .
Amitai, M., Taler, M., Carmel, M., Michaelovsky, E., Eilat, T., Yablonski, M., Orpaz, N., Chen, A., Apter, A., Weizman, A., Fennig, S. (2016). The Relationship Between Plasma Cytokine Levels and Response to Selective Serotonin Reuptake Inhibitor Treatment in Children and Adolescents with Depression and/or Anxiety Disorders.  J Child Adolesc Psychopharmacol. 26. .
Elliott E, Manashirov S, Zwang R, Gil S, Tsoory M, Shemesh Y, And Chen A (2016). Dnmt3a in the Medial Prefrontal Cortex Regulates Anxiety-Like Behavior in Adult Mice.  Journal of Neuroscience. 36(3): :730-740.
Lebow M, Neufeld-Cohen A, Kuperman Y, Tsoory M, Gil S, Chen A, (2012). Susceptibility to PTSD-Like Behavior Is Mediated by Corticotropin-Releasing Factor Receptor Type 2 Levels in the Bed Nucleus of the Stria Terminalis.  Journal of Neuroscience. 32: (20):6906-6916.
Regev L, Tsoory M, Gil S, Chen A, (2012). Site-Specific Genetic Manipulation of Amygdala Corticotropin-Releasing Factor Reveals Its Imperative Role in Mediating Behavioral Response to Challenge.  Biological Psychiatry. 71: (4):317-326.
Regev L, Neufeld-Cohen A, Tsoory M, Kuperman Y, Getselter D, Gil S, Chen A, (2011). Prolonged and site-specific over-expression of corticotropin-releasing factor reveals differential roles for extended amygdala nuclei in emotional regulation.  Molecular Psychiatry. 16: (7):714-728.
Elliott E, Ezra-Nevo G, Regev L, Neufeld-Cohen A, Chen A, (2010). Resilience to social stress coincides with functional DNA methylation of the Crf gene in adult mice.  Nature Neuroscience. 13: (11):1351-1353.