Stress response regulation and circuitry

The biological response to stressors is concerned with the maintenance of homeostasis in the presence of real or perceived challenges. This process requires numerous adaptive responses involving changes in the central nervous and neuroendocrine systems. When a situation is perceived as stressful, the brain activates many neuronal circuits, linking centers involved in sensory, motor, autonomic, neuroendocrine, cognitive, and emotional functions in order to adapt to the demand. However, the details of the pathways by which the brain translates stressful stimuli into the final, integrated biological response are presently incompletely understood. Understanding the neurobiology of stress by centering on the specific genes and brain circuits, which are associated with, or altered by, the stress response, will provide important insights into the brain mechanisms by which stress affects psychological and physiological disorders.

Relevant Publications

Ramot A, Jiang Z, Tian J.B, Nahum T, Kuperman Y, Justice N, Chen A (2017). Hypothalamic CRFR1 is essential for HPA axis regulation following chronic stress.  Nat. Neurosci. .
Volk N, Pape J.C, Engel M, Zannas A.S, Cattane N, Cattaneo A, Binder E.B, Chen A (2016). Amygdalar MicroRNA-15a Is Essential for Coping with Chronic Stress.  Cell Reports. 17: :1882–91.
Mjag Henckens, Jm Deussing And A Chen (2016). Region-specific roles of the corticotropin-releasing factor– urocortin system in stress.  Nature Reviews. 17: (10):636-651.
Mjag Henckens, Y Printz, U Shamgar, J Dine, M Lebow, Y Drori, C Kuehne, A Kolarz, M Eder, Jm Deussing, Nj Justice, O Yizhar, And A Chen (2016). CRF receptor type 2 neurons in the posterior bed nucleus of the stria terminalis critically contribute to stress recovery.  Molecular Psychiatry. .
Shemesh Y, Forkosh O, Mahn M, Anpilov S, Sztainberg Y, Manashirov S, Shlapobersky T, Elliott E, Tabouy L, Ezra G, Adler Es, Ben-Efraim Yj, Gil S, Kuperman Y, Haramati S, Dine J, Eder M, Deussing Jm, Schneidman E, Yizhar O, Chen A. (2016). Ucn3 and CRF-R2 in the medial amygdala regulate complex social dynamics.  Nat. Neurosci.. 19: (11):1489-1496.
Amitai, M., Taler, M., Carmel, M., Michaelovsky, E., Eilat, T., Yablonski, M., Orpaz, N., Chen, A., Apter, A., Weizman, A., Fennig, S. (2016). The Relationship Between Plasma Cytokine Levels and Response to Selective Serotonin Reuptake Inhibitor Treatment in Children and Adolescents with Depression and/or Anxiety Disorders.  J Child Adolesc Psychopharmacol. 26. .
Lebow M.A., Chen A. (2016). Overshadowed by the amygdala: the bed nucleus of the stria terminalis emerges as key to psychiatric disorders.  Molecular Psychiatry. 21: (4):450-463.
Neufeld-Cohen A, Kelly Pat, Paul Ed, Carter Rn, Skinner E, Olverman Hj, Vaughan Jm, Issler O, Kuperman Y, Lowry Ca, Vale Ww, Seckl Jr, Chen A, Jamieson Pm (2012). Chronic Activation of Corticotropin-Releasing Factor Type 2 Receptors Reveals a Key Role for 5-HT1A Receptor Responsiveness in Mediating Behavioral and Serotonergic Responses to Stressful Challenge.  Biological Psychiatry. 72: (6):437-447.
Lebow M, Neufeld-Cohen A, Kuperman Y, Tsoory M, Gil S, Chen A, (2012). Susceptibility to PTSD-Like Behavior Is Mediated by Corticotropin-Releasing Factor Receptor Type 2 Levels in the Bed Nucleus of the Stria Terminalis.  Journal of Neuroscience. 32: (20):6906-6916.
Regev L, Tsoory M, Gil S, Chen A, (2012). Site-Specific Genetic Manipulation of Amygdala Corticotropin-Releasing Factor Reveals Its Imperative Role in Mediating Behavioral Response to Challenge.  Biological Psychiatry. 71: (4):317-326.