March 02, 2015
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Date:01SundayMarch 2015Lecture
Mixing, stratification, and the spring phytoplankton bloom: Sverdrup’s critical depth revisited
More information Time 11:00Location Sussman Family Building for Environmental Sciences
M. Magaritz Seminar RoomLecturer Amatzia Genin
H. Steinitz Marine Biological Laboratory The Hebrew University of JerusalemOrganizer Department of Earth and Planetary SciencesContact Abstract Show full text abstract about The spring phytoplankton bloom is a major, extensively studi...» The spring phytoplankton bloom is a major, extensively studied phenomenon in temperate and high latitude seas. Much less information isavailable on blooms in subtropical oligotrophic seas, where the water column is usually stratified. Yet, even in temperate seas the processes determining phytoplankton dynamics during the mixed-layer deepening and the factors triggering the initiation of the bloom are controversial. Here we use long-term measurements of chlorophyll concentration, nutrients, mixed-layer depth and grazing rates to examine the validity of three bloom-initiation processes for the Gulf of Aqaba (northern Red Sea): the Critical Depth Hypothesis, the Dilution-Recoupling Hypothesis, and the Critical Turbulence Hypothesis. The Gulf is a unique water body in the subtropics, where convective mixing during winter reaches hundreds of meters in depth, leading to conspicuous spring blooms. Here we show that neither the critical depth mechanism nor the dilution-recoupling hypothesis explain the phytoplankton dynamics during the winter and spring in the Gulf. Instead, our findings indicate that this dynamics is governed by the interplay between three main processes: (1) nutrient-driven primary production in the upper, illuminated layer; (2) physical ‘homogenization’ of phytoplankton by convective mixing; and (3) accumulation of phytoplankton in the upper layer after the termination of sea-surface cooling. The latter mechanism is responsible for the onset and magnitude of the spring bloom.
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Date:01SundayMarch 2015Lecture
Swap-N-Tag: a new tool for systematic characterization of yeast proteins
More information Time 13:00Location Arthur and Rochelle Belfer Building for Biomedical Research
Botnar AuditoriumLecturer Uri Weill
Maya Schuldiner's group, Dept. of Molecular GeneticsOrganizer Life SciencesContact -
Date:02MondayMarch 2015Conference
Computers and Molecules
More information Time 08:30 - 17:00Location David Lopatie Conference Centre
Kimmel AuditoriumChairperson Ehud ShapiroContact -
Date:02MondayMarch 2015Lecture
Preleukemia the normal side of cancer
More information Time 11:00Location Arthur and Rochelle Belfer Building for Biomedical Research
Botnar AuditoriumLecturer Dr. Liran Shlush
Princess Margaret Cancer Center Toronto, CanadaOrganizer Department of Systems ImmunologyContact -
Date:02MondayMarch 2015Colloquia
"Learning from microbes to develop a catalyst for efficient conversion of methane to methanol under ambient conditions"
More information Time 11:00 - 12:30Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Sunney I. Chan
Institute of Chemistry, Academia Sinica, TaiwanOrganizer Faculty of ChemistryContact -
Date:03TuesdayMarch 2015Lecture
Origin and composition of lipid droplets from Dunaliella
More information Time 11:15Location Ullmann Building of Life Sciences
Aharon Katzir HallLecturer Dr. Lital Davidi
Postdoc Fellow at Prof. Edward A. Bayer's lab., PHD at Prof. Uri Pick's lab., Biological Chemistry Dept., WISOrganizer Department of Plant and Environmental SciencesContact -
Date:03TuesdayMarch 2015Lecture
COMT*DYSBINDIN-1 CONCOMITANT REDUCTION PRODUCE SCHIZOPHRENIA-LIKE PHENOTYPES CONVERGING ON DOPAMINE PATHWAYS
More information Time 12:30Location Gerhard M.J. Schmidt Lecture HallLecturer Dr. Francesco Papaleo
Dept of Neuroscience and Brain Technologies,Istituto Italiano di Tecnologia, GenovaOrganizer Department of Brain SciencesContact Abstract Show full text abstract about The etiology of schizophrenia is complex and largely unknown...» The etiology of schizophrenia is complex and largely unknown, but consistent findings report a strong genetic component. While several potential schizophrenia-susceptibility genes have been identified, effect sizes are very small and replication is inconsistent, likely because of the complexity of human polymorphisms, genetic and clinical heterogeneity and the potential uncontrollable impact of gene-gene and gene-environment interactions. In this context, mutant mice bearing targeted mutations of schizophrenia-susceptibility genes are unique tools to elucidate the neurobiological basis of this devastating disorder.
Using COMT*dysbindin-1 double mutant mice, we investigated the COMT*dysbindin-1 gene-gene interacting effects in the expression of rodents’ correlates of schizophrenia-relevant behavioral abnormalities. A major focus of our work is centered on how to dissect higher order cognitive functions in mice with high translational validity to human studies.
In particular, in contrast to single genetic modifications, the combined decreased activity of both COMT and dysbindin-1 produced marked working memory, recency memory and attentional set-shifting deficits, and amphetamine supersensitivity; all abnormalities ascribed as mice’ correlates of schizophrenia-like symptoms. Based on this, we found evidence of the same non-linear genetic interaction in prefrontal cortical function in humans. Finally, to disentangle how COMT*dysbindin-1 interaction might converge in dopaminergic signaling, we measured in these double mutant mice dopamine levels in the PFC and dorsal striatum by in vivo microdialysis. Interestingly, concomitant COMT*dysbindin-1 reduction diminished dopamine levels in PFC and striatum, while amphetamine-evoked dopamine increase was attenuated in the PFC but exacerbated in the striatum. These findings illustrate a clinically relevant experimental animal model based on a predicted epistatic interaction of two schizophrenia-susceptibility genes and unravel interesting genetic mechanisms in the etiology of this mental illness.
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Date:03TuesdayMarch 2015Lecture
"Nucleosome dynamics studied by computer simulation and single molecule spectroscopy"
More information Time 14:00Location Helen and Milton A. Kimmelman Building
Dov Elad RoomLecturer Prof. Jorg Langowski
German Cancer Research Center (DKFZ)Organizer Department of Chemical and Structural BiologyContact -
Date:03TuesdayMarch 2015Lecture
Molecular Neuroscience Forum Seminar
More information Time 15:00 - 16:00Title Interactions between nervous and vascular systems in the CNSLocation Arthur and Rochelle Belfer Building for Biomedical Research
Botnar AuditoriumLecturer Chenghua Gu
Harvard UniversityOrganizer Department of Biomolecular SciencesHomepage Contact -
Date:03TuesdayMarch 2015Lecture
The Interface of Science and Policy
More information Time 15:00 - 16:30Location Edna and K.B. Weissman Building of Physical Sciences
Drory AuditoriumLecturer Dimitri Kusnezov
Chief Scientist, US Department of Energy, National Nuclear Security AdministrationOrganizer Department of Particle Physics and AstrophysicsContact Details Show full text description of 14:45 - Light Refreshments...» 14:45 - Light RefreshmentsAbstract Show full text abstract about Time-urgent policy decisions are increasingly benefiting fro...» Time-urgent policy decisions are increasingly benefiting from the scientific assessments of risks and outcomes. However the ability to inject science into decision processes can be haphazard, requiring awareness of potential tools and involvement in the policy decisions. I hope to provide some insight on how science is drawn into decisions through a series of examples including the Fukushima Daiichi accident and aircraft safety to the Gulf oil spill and Ebola.
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Date:03TuesdayMarch 2015Lecture
The Interface of Science and Policy
More information Time 15:00 - 16:30Location Edna and K.B. Weissman Building of Physical Sciences
Drory AuditoriumLecturer Dimitri Kusnezov
Chief Scientist, US Department of Energy, National Nuclear Security AdministrationOrganizer Department of Particle Physics and AstrophysicsContact Details Show full text description of 14:45 - Light Refreshments...» 14:45 - Light RefreshmentsAbstract Show full text abstract about Time-urgent policy decisions are increasingly benefiting fro...» Time-urgent policy decisions are increasingly benefiting from the scientific assessments of risks and outcomes. However the ability to inject science into decision processes can be haphazard, requiring awareness of potential tools and involvement in the policy decisions. I hope to provide some insight on how science is drawn into decisions through a series of examples including the Fukushima Daiichi accident and aircraft safety to the Gulf oil spill and Ebola.
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Date:03TuesdayMarch 2015Lecture
The Interface of Science and Policy
More information Time 15:00 - 16:30Location Edna and K.B. Weissman Building of Physical Sciences
Drory AuditoriumLecturer Dimitri Kusnezov
Chief Scientist, US Department of Energy, National Nuclear Security AdministrationOrganizer Department of Particle Physics and AstrophysicsContact Details Show full text description of 14:45 - Light Refreshments...» 14:45 - Light RefreshmentsAbstract Show full text abstract about Time-urgent policy decisions are increasingly benefiting fro...» Time-urgent policy decisions are increasingly benefiting from the scientific assessments of risks and outcomes. However the ability to inject science into decision processes can be haphazard, requiring awareness of potential tools and involvement in the policy decisions. I hope to provide some insight on how science is drawn into decisions through a series of examples including the Fukushima Daiichi accident and aircraft safety to the Gulf oil spill and Ebola.
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Date:04WednesdayMarch 2015Lecture
Forum on Mathematical Principles in Biology
More information Time 10:00 - 11:00Title The stem cell challenge: making the right cells at the right timeLocation Arthur and Rochelle Belfer Building for Biomedical Research
Botnar AuditoriumLecturer Shalev Itzkovitz
Dept of Molecular Cell BiologyOrganizer Department of Molecular Cell Biology
System BiologyContact -
Date:04WednesdayMarch 2015Lecture
G-INCPM-Special Seminar - lecture will be in Hebrew - Dr. Ori Inbar, Researcher at Evogene & Chairperson of the Israeli CF Foundation - Kalydeco - breakthrough personalized medicine for Cystic Fibrosis (CF)
More information Time 11:00 - 12:30Location Michael and Anna Wix Auditorium
Small WixOrganizer Department of Biomolecular SciencesContact Abstract Show full text abstract about Cystic Fibrosis (CF) is the most frequent life threatening g...» Cystic Fibrosis (CF) is the most frequent life threatening genetic disorder in the western world. The disease is caused by mutations in the CFTR genes that encode a chloride membrane channel protein that is expressed in epithelial cells. Malfunction of this protein causes a multi system disorder: lungs, pancreas, intestine, liver, bones, sweat glands and male reproductive system. Two years ago the FDA approved Kalydeco, the first personalized drug which is mutation specific: for CF patients that have at least one copy of the mutation G551D. Binding of Kalydeco to the impaired CFTR protein restores its functionality.
The following will be reviewed: CF-genetic basis, prognosis, treatments and genetic tests in Israel and Kalydeco - mode of action, clinical effect on patients, future development and its Israeli angle.
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Date:04WednesdayMarch 2015Lecture
POPULAR LECTURES - IN HEBREW
More information Time 12:00 - 13:00Title על אצות, פוטונים ונוירונים: שיטות חדשות בחקר המוחLocation Dolfi and Lola Ebner AuditoriumLecturer Ofer YizharContact -
Date:05ThursdayMarch 2015Conference
Open Day for M.Sc. Life Science students
More information Time 08:30 - 12:30Location David Lopatie Conference Centre
Kimmel AuditoriumChairperson Ziv ReichContact -
Date:05ThursdayMarch 2015Lecture
Magnetic Resonance Seminar
More information Time 09:00Title How can ultra-high magnetic fields help in preclinical functional MRI studies?Location Gerhard M.J. Schmidt Lecture HallLecturer Dr. Luisa Ciobanu
Neurospin, CEA-Saclay, FranceOrganizer Department of Chemical and Biological PhysicsContact Abstract Show full text abstract about In fMRI studies, contrast-to-noise ratio and spatial resolut...» In fMRI studies, contrast-to-noise ratio and spatial resolution can be improved by using ultra-high magnetic fields. Traditionally, fMRI experiments are performed using the Blood Oxygen Level Dependent (BOLD) technique based on echo planar imaging (EPI) acquisition strategies. When using EPI, certain unwanted effects such as image blurring, distortions and signal voids enhance as the magnetic field strength increases. In the first part of my talk I will present the use of a different acquisition scheme, spatiotemporal encoding (SPEN), which has the potential to improve image quality, offering an attractive alternative to EPI for UHF fMRI.
In the second part of my presentation I will focus on two other approaches to imaging brain function: Diffusion fMRI (DfMRI) and Manganese Enhanced MRI (MEMRI). Specifically, I will present studies which highlight the advantages and disadvantages of each of these techniques with respect to BOLD.
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Date:06FridayMarch 2015Cultural Events
"Michael"
More information Time 21:30Location Michael and Anna Wix AuditoriumContact Details Show full text description of Cult show that appeared throughout Israel for more than 4 Ye...» Cult show that appeared throughout Israel for more than 4 Years.
Ensamble Michael hosting the actress Liat Harlev.