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December 01-31, 2016

  • Date:01ThursdayDecember 2016

    Working successfully with WIS new institutional review board principles and a practical guide to human research at WIS

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    Time
    11:00
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    Botnar Auditorium
    Lecturer
    Prof. Eran Hornstein
    Department of Molecular Genetics, Weizmann Institute of Science
    Organizer
    Department of Molecular Genetics
    Contact
    Lecture
  • Date:01ThursdayDecember 2016

    Do not go gentle into that night: Stars near massive black holes

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    Time
    11:15 - 12:30
    Location
    Edna and K.B. Weissman Building of Physical Sciences
    Auditorium
    Lecturer
    Tal Alexander
    WIS
    Organizer
    Faculty of Physics
    Contact
    DetailsShow full text description of 11:00 – coffee, tea, and more...»
    11:00 – coffee, tea, and more
    AbstractShow full text abstract about I discuss the dynamics that lead stars to interact closely w...»
    I discuss the dynamics that lead stars to interact closely with a massive black hole in a galactic nucleus, and the phenomena that follow. These offer opportunities to study strong gravity and understand the cosmic evolution of black holes. I describe recent progress in the self-consistent modeling of the coupled effects of secular Newtonian and relativistic processes, coherent resonant torques and 2-body relaxation, which govern the orbital evolution of stars near a massive black hole. I present results and predictions that will guide, and be tested by, ongoing and upcoming gravitational waves, radio and IR observations.
    Colloquia
  • Date:01ThursdayDecember 2016

    A circuit architecture for angular integration in Drosophila

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    Time
    12:30
    Location
    Gerhard M.J. Schmidt Lecture Hall
    Lecturer
    Prof. Gaby Maimon
    Laboratory of Integrative Brain Function The Rockefeller University
    Organizer
    Department of Brain Sciences
    Contact
    DetailsShow full text description of Host: Prof. Nachum Ulanovsky nachum.ulanovsky@weizmann.ac.il...»
    Host: Prof. Nachum Ulanovsky nachum.ulanovsky@weizmann.ac.il tel: 6301

    For assistance with accessibility issues, please contact naomi.moses@weizmann.ac.il

    AbstractShow full text abstract about Mammalian brains store and update quantitative internal vari...»
    Mammalian brains store and update quantitative internal variables. Primates and rodents, for example, have an internal sense of whether they are 1 or 10 meters away from a landmark and whether a ripe fruit is twice or four times as appetizing as a less ripe counterpart. Such quantitative internal signals are the basis of cognitive function, however, our understanding of how the brain stores and updates these variables remains fragmentary. In this talk, I will discuss imaging and perturbation experiments in tethered, walking Drosophila. The goal of these experiments is to determine how internal variables are calculated by the tiny Drosophila brain and how these variables influence behavior. Specifically, in the Drosophila central complex a set of heading neurons have been described, whose activity tracks the fly’s orientation, similar to head direction cells in rodents. However, the circuit architecture that gives rise to these orientation tracking properties remains largely unknown in any species. I will describe a set of clockwise- and counterclockwise-shifting neurons whose wiring and calcium dynamics provide a means to rotate the heading system’s angular estimate over time. Shifting neurons are required for the heading system to properly track the fly's movements in the dark, and, their stimulation induces a rotation of the heading signal in the expected direction and by the expected amount. The central features of this circuit are analogous to models proposed for head-direction cells in rodents and may thus inform how neural systems, in general, perform addition.
    Lecture
  • Date:01ThursdayDecember 2016

    microRNAs, “replacement therapy” and cancer – how far have we come?

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    Time
    14:00 - 15:00
    Title
    CANCER RESEARCH CLUB
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    Botnar Auditorium
    Lecturer
    Professor Peter Leedman PhD, FRACP
    Director, Harry Perkins Institute of Medical Research, Professor of Medicine, The University of Western Australia
    Organizer
    Department of Immunology and Regenerative Biology
    Contact
    Lecture
  • Date:01ThursdayDecember 2016

    Immunogenic Sugar Antigens in Cancer and Heart Disease

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    Time
    14:00 - 15:00
    Location
    Wolfson Building for Biological Research
    Auditorium
    Lecturer
    Vered padler-Karavani
    Department of Cell Research and Immunology, Tel Aviv University
    Organizer
    Department of Systems Immunology
    Contact
    Lecture
  • Date:02FridayDecember 2016

    Nathan's friends - From Italy with Love

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    Time
    20:00 - 22:45
    Location
    Michael and Anna Wix Auditorium
    Contact
    Cultural Events
  • Date:03SaturdayDecember 2016

    Drorami & Habubonim in live broadcast- Children's theater

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    Time
    11:00 - 12:00
    Location
    Michael and Anna Wix Auditorium
    Contact
    DetailsShow full text description of Join Drorami & his friends Habubonim to a music comedy. ...»
    Join Drorami & his friends Habubonim to a music comedy.
    Cultural Events
  • Date:04SundayDecember 2016

    Regulation of RNA structure and function by small organic molecules

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    Time
    11:00 - 12:00
    Title
    Cancer Research Club
    Location
    Max and Lillian Candiotty Building
    Seminar Room
    Lecturer
    Prof. Kazuhiko Nakatani
    Director and Professor The Institute of Scientific and Industrial Research Osaka University, Japan
    Organizer
    Department of Immunology and Regenerative Biology
    Contact
    AbstractShow full text abstract about We have studied small molecules binding to and regulating RN...»
    We have studied small molecules binding to and regulating RNA structure and, eventually its function. In the talk, recent our results on the effect of maturation of microRNA by small molecule binding to its precursor pre-microRNA to modulate the Dicer cleavage reaction, and induce the programmed –1 ribosomal frame shift by ligand-induced pseudo knot on mRNA
    Lecture
  • Date:04SundayDecember 2016

    The interplay between terrigenous fluxes and export production in oligotrophic seas: a case study of the modern and late Quaternary Red Sea

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    Time
    11:00
    Location
    Sussman Family Building for Environmental Sciences
    M. Magaritz Seminar Room
    Lecturer
    Adi Torfstein
    IUI Eilat
    Organizer
    Department of Earth and Planetary Sciences
    Contact
    Lecture
  • Date:04SundayDecember 2016

    "Dual Gold Catalysis: Organometallic Steps And Synthetic Benefits"

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    Time
    11:00 - 12:00
    Location
    Helen and Milton A. Kimmelman Building
    Dov Elad Room
    Lecturer
    Prof. Stephen Hashmi
    Ruprecht-Karls-University Heidelberg Germany
    Organizer
    Department of Molecular Chemistry and Materials Science
    Contact
    DetailsShow full text description of Special Seminar...»
    Special Seminar
    Lecture
  • Date:04SundayDecember 2016

    Recruiting the protein interaction map of cell death for studying human genetic disease

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    Time
    13:00
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    Botnar Auditorium
    Lecturer
    Aya Shkedy
    Adi Kimchi's group, Dept. of Molecular Genetics, WIS
    Organizer
    Department of Molecular Genetics
    Contact
    Lecture
  • Date:05MondayDecember 2016

    The 4th Israeli ImageStreamX user meeting Recent advances in Imaging Flow Cytometry

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    Time
    09:00 - 12:00
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    Botnar Auditorium
    Organizer
    Department of Life Sciences Core Facilities
    Contact
    DetailsShow full text description of Schedule: 9:00 Gathering and refreshments 9:15 Recent adva...»
    Schedule:
    9:00 Gathering and refreshments
    9:15 Recent advances in Imaging Flow
    Cytometry Analysis
    Ziv Porat, Weizmann Institute of Science
    9:45 Identification and classification of the
    malaria parasite blood developmental stages
    Elya Dekel, Weizmann Institute of Science
    10:05 High-Throughput Analysis of Golgi structure
    Inbal Wortzel, Weizmann Institute of Science
    10:25 Coffee break
    10:40 Single cell imaging and quantification of
    amyloid intercellular propagation
    Dorin Sade, Tel-Aviv University
    11:00 Elucidating the delivery mechanism of
    quaternized-starch based siRNA
    nanoparticles
    Eliz Amar-Lewis, Ben-Gurion University
    11:20 Folowing extracellular vesicles uptake by
    Imaging Flow Cytometry
    Yifat Ofir-Birin, Weizmann Institute of Science
    11:40 Single cell quantitative analysis of proteinprotein
    interactions and post-translational
    modifications
    Ayelet Avin, Weizmann Institute of
    AbstractShow full text abstract about Imaging Flow Cytometry combines speed, sensitivity, and phen...»
    Imaging Flow Cytometry combines speed, sensitivity, and phenotyping abilities found in flow
    cytometry with the detailed imagery and functional insight of microscopy, for an extensive range
    of novel applications. It allows quantitating cellular morphology and the intensity and location of
    fluorescent probes on, in, or between cells, even in rare sub-populations and highly heterogeneous
    samples.
    The wide range of applications used include studying intracellular localization, shape changes
    and morphology, co-localization, nuclear translocation, cell signaling, T cell – APC interactions,
    DNA damage and repair, cell death and apoptosis, phagocytosis and internalization, FISH, vesicle
    trafficking, and many others.
    Lecture
  • Date:05MondayDecember 201606TuesdayDecember 2016

    ISF-NSFC Joint Workshop on Nanosciencer and Nanophotonics

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    Time
    09:00 - 18:00
    Location
    Edna and K.B. Weissman Building of Physical Sciences
    Drory Auditorium
    Organizer
    Department of Physics of Complex Systems
    Contact
    Lecture
  • Date:05MondayDecember 2016

    "Membrane proteins at the interface of life"

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    Time
    11:00 - 12:15
    Location
    Gerhard M.J. Schmidt Lecture Hall
    Lecturer
    Prof. Tamir Gonen
    Janelia Research Campus, Howard Hughes Medical Institute
    Organizer
    Faculty of Chemistry
    Contact
    Colloquia
  • Date:05MondayDecember 2016

    Pathway Discovery and Metabolic Engineering of Betalains

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    Time
    11:15
    Location
    Ullmann Building of Life Sciences
    Aharon Katzir Hall
    Lecturer
    Guy Polturak
    Prof. Asaph Aharoni's lab., Dept. of Plant & Environmental Sciences
    Organizer
    Department of Plant and Environmental Sciences
    Contact
    Lecture
  • Date:05MondayDecember 2016

    Multipurpose DARPin Binders for Innovative Applications - Identifying Affinity Reagents for Challenging Tasks

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    Time
    13:15 - 14:30
    Location
    Wolfson Building for Biological Research
    Auditorium
    Lecturer
    Dr. Jonas V. Schaefer
    Head, High-Throughput Binder Selection Facility Department of Biochemistry, University of Zurich, Switzerland
    Organizer
    Department of Molecular Cell Biology
    Contact
    AbstractShow full text abstract about Multipurpose DARPin Binders for Innovative Applications - Id...»
    Multipurpose DARPin Binders for Innovative Applications - Identifying Affinity Reagents for Challenging Tasks

    Jonas V. Schaefer, PhD
    Head of High-Throughput Binder Selection Facility
    Department of Biochemistry, University of Zurich, Switzerland


    Obtaining high-quality and reliable affinity reagents remains a major challenge for many scientific projects. Frequently, commercial antibodies fail to behave as advertised or only work for a subset of samples. Therefore, we established a High-Throughput Binder Selection Facility, generating hundreds of high-end binders (so called DARPins) that specifically recognize different, non-overlapping epitopes at their targets with high affinities. Those binders have already been used in a variety of applications both in-house and by numerous international collaboration partners, improving existing and enabling novel, so far unfeasible applications.

    Within my presentation, I will give insights into our streamlined and robust binder generation pipeline and show examples of DARPin applications (amongst others, DARPins have been successfully employed in advanced microscopy, pull-downs, immunohistochemistry, for co-crystallization, as intracellular biosensors, and even have been therapeutically validated).

    Lecture
  • Date:06TuesdayDecember 2016

    The anaerobic shortcut: cytosolic subunit of fumarate reductase modulates the rotation of the flagellar motor

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    Time
    10:00 - 10:30
    Location
    Wolfson Building for Biological Research
    Auditorium
    Lecturer
    Anna Koganitsky
    Members - Dept. of Biomolecul
    Organizer
    Department of Biomolecular Sciences
    Contact
    AbstractShow full text abstract about E. coli is well equipped for living in rapidly changing cond...»
    E. coli is well equipped for living in rapidly changing conditions of its natural ecosystem. For example, it is able to navigate by modulating the rotation of the bidirectional flagellar motor, and it has the ability of switching to anaerobic respiration that involves fumarate reduction, when oxygen is limited. A decade ago it was discovered that there is a crosstalk between the fumarate reduction system and the flagellar motor: fumarate reductase (FRD) was found to be required for flagellar clockwise (CW) rotation, which is essential for the navigation process. Here, by combining biochemical techniques with super resolution microscopy, we found that FRD affects the motor via its cytosolic subunit FrdA, and that this subunit preferentially binds to the CW state of the flagellar rotary unit FliG. This suggests that FrdA stabilizes the CW state of individual FliG subunits, thus increasing the probability of CW-conformational spread over the entire rotor. We further found that a natural increase in FrdA expression levels during microaerophilic growth conditions increases the probability of CW rotation to a level shown earlier to be more efficient for navigation. Thus, FrdA-motor interaction may be a mean of adjusting the navigation efficiency to the microaerophilic conditions found in the mammalian gut.



    Lecture
  • Date:06TuesdayDecember 2016

    Subcellular Roles of mTOR in Sciatic Nerve Injury

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    Time
    10:30 - 11:00
    Location
    Wolfson Building for Biological Research
    Auditorium
    Lecturer
    Dr. Maraco Terenzio
    Members - Dept. of Biomolecular Sciences
    Organizer
    Department of Biomolecular Sciences
    Contact
    AbstractShow full text abstract about mTOR is an atypical Ser/Thr kinase that belongs to the PI3K ...»
    mTOR is an atypical Ser/Thr kinase that belongs to the PI3K family and a key sensor of cellular nutritional state, which regulates a vast array of biological processes. Several lines of evidence have highlighted the importance of mTOR signalling in the regeneration of both the central nervous system (CNS) and the peripheral nervous system (PNS). Though localized changes in mTORC1 activity have been documented in axons and linked to synaptic plasticity, it is still unclear whether mTOR peripheral localization and local activation in the sciatic nerve (SN) plays an important role in retrograde survival signalling after injury. Here we show that mTOR mRNA is present in the sciatic nerve and that its protein levels increase after sciatic nerve crush (SNC) at the site of lesion within 3 hr after injury. Mass-spectrometry analyses of SN axoplasm showed that the axonal pool of mTOR is active and responsible for the local activation of two of its downstream kinases, p70S6K and S6, directly at the site of the lesion. Direct monitoring of protein translation revealed that mTOR activation is responsible for most of the early local translational response in the sciatic nerve after injury. Furthermore, local pharmacological inhibition of mTOR at the SNC site by Torin1 impaired the subsequent conditioning lesion response of dorsal root ganglia (DRG) sensory neurons, and caused a reduction of the survival of large proprioceptor DRG neurons after the injury.


    Lecture
  • Date:06TuesdayDecember 2016

    Spectral sum rules for conformal field theories in arbitrary dimensions

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    Time
    10:30
    Location
    Newe Shalom
    Lecturer
    Justin David
    BANGLORE
    Organizer
    Department of Particle Physics and Astrophysics
    Joint Seminar
    Homepage
    Contact
    DetailsShow full text description of 10:20 Gathering and coffee...»
    10:20 Gathering and coffee
    AbstractShow full text abstract about We derive a spectral sum rule in the shear channel for confo...»
    We derive a spectral sum rule in the shear channel for conformal field theories in general d> 2 dimensions held at finite temperature. The sum rule result from the OPE of the stress tensor at high frequency as well as the hydrodynamic behaviour of the theory at low frequencies. The sum rule states that a weighted integral of the spectral density over frequencies is proportional to the energy density of the theory. We show that the proportionality constant can be written in terms the Maldacena-Hofman variables t_2, t_4 which rely on data which determines the three point function of the stress tensor of the CFT. For theories which admit a two derivative gravity dual this proportionality constant is given by d/2(d+1) . We then use causality constraints and obtain bounds on the sum rule which are valid for any conformal field theory. We illustrate the sum rule by applying it to well studied conformal field theories in d=3, 4, 6. dimensions
    Lecture
  • Date:06TuesdayDecember 2016

    “Visualizing nanoscale assembly and fabrication in solution using in situ TEM”

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    Time
    11:00 - 12:15
    Location
    Helen and Milton A. Kimmelman Building
    Dov Elad Room
    Lecturer
    Prof. Stephen Hashmi
    Department of Biological Sciences & Physics National University of Singapore
    Organizer
    Department of Molecular Chemistry and Materials Science , Department of Molecular Chemistry and Materials Science
    Contact
    DetailsShow full text description of Joint Seminar...»
    Joint Seminar
    Lecture

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