Pages

February 01-28, 2017

  • Date:01WednesdayFebruary 2017

    Cardiovascular Lineage Plasticity During Embryogenesis

    More information
    Time
    10:00
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    Botnar Auditorium
    Lecturer
    Eldad Tzahor
    Dept. of Molecular Cell Biology, WIS
    Organizer
    Life Sciences
    Contact
    Lecture
  • Date:01WednesdayFebruary 2017

    Theory Excellence Center Seminar

    More information
    Time
    11:00 - 12:00
    Title
    Solving the Problem of Anharmonic Densities of States
    Location
    Gerhard M.J. Schmidt Lecture Hall
    Lecturer
    Prof. Julius Jellinek
    Chemical Sciences and Engineering Division Argonne National Laboratory, USA
    Organizer
    Department of Chemical and Biological Physics
    Contact
    AbstractShow full text abstract about Solving the Problem of Anharmonic Densities of States* Ju...»
    Solving the Problem of Anharmonic Densities of States*

    Julius Jellinek

    Chemical Sciences and Engineering Division
    Argonne National Laboratory, Argonne, IL 60439, USA

    Density of states (DOS) is a fundamental characteristic of systems that lies in the very foundation of statistical mechanics and all the theoretical constructs that derive from them (e.g., kinetic rate theories, phase diagrams, etc.). Knowledge of DOS is central for calculation of entropy, partition function, free energy, reaction rate constants, and other important characteristics. The accuracy of all these depends on the accuracy with which the DOS is defined. Even though virtually all real systems are anharmonic, the current practice in the computation of vibrational DOSs is largely based on the harmonic approximation. The reason is that despite major efforts over about eight decades a general and exact, yet practical in applications, solution to the problem of anharmonic DOSs stubbornly resisted resolution. The alternatives introduced are mostly limited to cases of weak anharmonicity and/or suffer from other shortcomings.

    In a recent development, we formulated a general and exact solution to this long-standing problem, which is applicable to arbitrary degree of anharmonicity (i.e., any system) and that is practical and efficient in applications. The solution and its algorithmic implementations are developed within the frameworks of both classical and quantum mechanics. The quantum implementation involves generalization and significant enhancement in the efficiency of the celebrated Beyer-Swinehart counting scheme, which is the fastest to date algorithm used in the computation of the quantum harmonic DOSs. Our solution is based on simulating the actual dynamical behavior of systems on the time scale of interest, short or long, as defined by the experiment and/or the nature of the process or phenomenon at hand. As a consequence, the resulting anharmonic DOSs are fully dynamically informed and, in general, time-dependent. As such, they lay the foundation for formulation of new statistical mechanical frameworks that incorporate time and reproduce exactly the actual time-averaged dynamical behavior of systems on the temporal scale of interest irrespective of whether this behavior is statistical or not in the traditional sense.

    Work has been initiated on extending this development to the general case of rotational(ro)-vibrational DOSs for systems with arbitrary degree of anharmonicity and arbitrarily strong ro-vibrational coupling.
    ----------------
    * This work was supported by the Office of Basic Energy Sciences, Division of Chemical Sciences, Geosciences and Biosciences, U.S. Department of Energy under Contract No. DE-AC02-06CH11357.

    Lecture
  • Date:01WednesdayFebruary 2017

    (β)Arrestin Prostate Cancer Progression

    More information
    Time
    14:00
    Title
    Special Guest Seminar
    Location
    Max and Lillian Candiotty Building
    Seminar Room
    Lecturer
    Prof. Yehia Daaka
    University of Florida
    Organizer
    Department of Immunology and Regenerative Biology
    Contact
    Lecture
  • Date:02ThursdayFebruary 2017

    One day in the life of Anabaena, A one-dimensional developing organism that exhibits Turing-like patterns

    More information
    Time
    11:15 - 12:30
    Location
    Edna and K.B. Weissman Building of Physical Sciences
    Auditorium
    Lecturer
    Joel Stavans
    WIS
    Organizer
    Faculty of Physics
    Contact
    DetailsShow full text description of 11:00 – coffee, tea, and more...»
    11:00 – coffee, tea, and more
    AbstractShow full text abstract about Within the last two decades it has become clear that cells h...»
    Within the last two decades it has become clear that cells having the same genetic information can behave very differently, due to inevitable stochastic fluctuations in gene expression, known as noise. How do cells in multicellular organisms achieve high precision in their developmental fate in the presence of noise, in order to reap the benefits of division of labor? We address this fundamental question from Systems Biology and Statistical Physics perspectives, with Anabaena cyanobacterial filaments as a model system, one of the earliest examples of multicellular organisms in nature. These filaments can form one-dimensional, nearly-regular patterns of cells of two types. The developmental program uses tightly regulated, non-linear processes that include activation, inhibition, and transport, in order to create spatial and temporal patterns of gene expression that we can follow in real time, at the level of individual cells. We study cellular decisions, properties of the genetic network behind pattern formation, and establish the spatial extent to which gene expression is correlated along filaments. Motivated by our experimental results, I will show that pattern formation in Anabaena can be described theoretically by a minimal, three-component model that exhibits a deterministic, diffusion-driven Turing instability. Furthermore, I will discuss how noise can enhance considerably the robustness of the developmental program, by promoting the formation of stochastic patterns in regions of parameter space for which deterministic patterns do not form, suggesting a novel mechanism for pattern formation in this and other systems.

    Colloquia
  • Date:02ThursdayFebruary 2017

    Cellular substrates for network information processing in hippocampal CA1

    More information
    Time
    12:30
    Location
    Gerhard M.J. Schmidt Lecture Hall
    Lecturer
    Dr. Alessio Attardo
    Dept of Stress Neurobiology and Neurogenetics Max Planck Institute of Psychiatry, Munich
    Organizer
    Department of Brain Sciences
    Contact
    DetailsShow full text description of Host: Dr.Yaniv Ziv yaniv.ziv@weizmann.ac.il tel: 4275 For a...»
    Host: Dr.Yaniv Ziv yaniv.ziv@weizmann.ac.il tel: 4275
    For assistance with accessibility issues,
    please contact naomi.moses@weizmann.ac.il
    Lecture
  • Date:02ThursdayFebruary 2017

    Lihi Lapid - New date 2/2/17 instead of 26/1/17

    More information
    Time
    20:30
    Location
    Michael and Anna Wix Auditorium
    Contact
    DetailsShow full text description of Lihi Lapid, who deal with contemporary women's issues. ...»
    Lihi Lapid, who deal with contemporary women's issues.
    In this lecture we will stop a minute and think how can we be good to ourselves
    Cultural Events
  • Date:05SundayFebruary 2017

    Flow Cytometry and Single Cell Heterogeneity in the Mammalian Liver

    More information
    Time
    09:00 - 10:00
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    Botnar Auditorium
    Lecturer
    Dr. Ayala Sharp and Dr. Shalev Itzkovitz
    Organizer
    Department of Life Sciences Core Facilities
    Seminar
    Contact
    Lecture
  • Date:05SundayFebruary 2017

    The elusive nature of Earth magnetic field : paleomagnetic research from nano to global scale

    More information
    Time
    11:00
    Location
    Sussman Family Building for Environmental Sciences
    M. Magaritz Seminar Room
    Lecturer
    Ron Shaar
    Hebrew University of Jerusalem
    Organizer
    Department of Earth and Planetary Sciences
    Contact
    Lecture
  • Date:05SundayFebruary 2017

    The role of FABP4 in ER stress-triggered cell death

    More information
    Time
    13:00
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    Botnar Auditorium
    Lecturer
    Rinat Livne
    Menachem Rubinstein's group, Dept. of Molecular Genetics, WIS
    Organizer
    Department of Molecular Genetics
    Contact
    Lecture
  • Date:06MondayFebruary 2017

    "Imaging wave function of few body systems: He dimers, trimers and the Efimov state of He3"

    More information
    Time
    11:00 - 12:15
    Location
    Gerhard M.J. Schmidt Lecture Hall
    Lecturer
    Prof. Reinhard Doerner
    Institute for Nuclear Physics, Goethe University, Frankfurt
    Organizer
    Faculty of Chemistry
    Contact
    AbstractShow full text abstract about Two and three Helium atoms form very unusual and extreme qua...»
    Two and three Helium atoms form very unusual and extreme quantum systems. Their typical extend is ten to hundred times bigger than radius of the atoms, the wavefunction lives almost completely in the classically forbidden tunneling region and the binding energy of these systems is about 8 orders of magnitude smaller than that of a normal molecule.
    We will show how coincidence detection of charged fragments and super strong laser fields can be used to image the wave functions of these Helium quantum giants and will show the first experimental images of an Efimov state.
    Colloquia
  • Date:06MondayFebruary 2017

    Personalized Cancer Nano-Medicines

    More information
    Time
    14:00 - 15:00
    Title
    Special Guest Seminar
    Location
    Max and Lillian Candiotty Building
    Seminar Room
    Lecturer
    Prof. Avi Schroeder
    Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Chemical Engineering Technion - Israel Institute of Technology, Haifa
    Organizer
    Department of Immunology and Regenerative Biology
    Contact
    AbstractShow full text abstract about The field of medicine is taking its first steps towards pati...»
    The field of medicine is taking its first steps towards patient-specific care. Our research is aimed at tailoring treatments to address each person’s individualized needs and unique disease presentation. Specifically, we are developing nanoparticles that target disease sites, where they perform a programmed therapeutic task. These systems utilize molecular-machines and cellular recognition to improve efficacy and reduce side effects.
    Nanoparticles have many potential benefits for treating cancer, including the ability to transport complex molecular cargoes, as well as targeting to specific cell populations.
    The talk will describe principles for developing lipid nanoparticles that can be remotely triggered to release their payload in disease sites.
    Two examples will be described: the first involves a nanoscale theranostic system for predicting the therapeutic potency of cancer medications. The system provides patient-specific drug activity data with single-cell resolution. The system makes use of barcoded nanoparticles to predict the therapeutic effect different drugs will have on the tumor microenvironment.
    The second system makes use of enzymes, loaded into a biodegradable chip, to perform a programed therapeutic task – surgery with molecular precision. Collagenase is an enzyme that cleaves collagen, but not other tissues. This enzyme was loaded into the biodegradable chip and placed in the periodontal pocket. Once the collagenase releases from the chip, collagen fibers that connect between the teeth and the underlying bone are relaxed, thereby enabling enhanced orthodontic corrective motion and reducing pain. This new field is termed BioSurgery.
    The clinical implications of these approaches will be discussed.
    Lecture
  • Date:06MondayFebruary 2017

    Trofoti - Children's Theater

    More information
    Time
    17:30
    Location
    Michael and Anna Wix Auditorium
    Contact
    Cultural Events
  • Date:07TuesdayFebruary 2017

    Breaking the dimer: NF-kB dimerization emerges as an excellent drug target

    More information
    Time
    10:00 - 10:30
    Location
    Wolfson Building for Biological Research
    Auditorium
    Lecturer
    Shaked Ashkenazi
    Members - Dept. of Biomolecular Sciences-WIS
    Organizer
    Department of Biomolecular Sciences
    Contact
    Lecture
  • Date:07TuesdayFebruary 2017

    QUANTUM FIELD THEORIES OF (N-1)-DIMENSIONAL EXTENDED OBJECTS IN 2N-DIMENSIONAL SPACE-TIME MANIFOLDS AS 2D QUANTUM FIELD THEORIES ON ``QUASI RIEMANN SURFACES'' OF INTEGRAL (N-1)-CURRENTS.

    More information
    Time
    10:00
    Location
    Newe Shalom
    Lecturer
    DANIEL FRIEDAN
    REUTGERS
    Organizer
    Department of Particle Physics and Astrophysics
    Joint Seminar
    Contact
    DetailsShow full text description of 09:50 Gathering and coffee ...»
    09:50 Gathering and coffee

    AbstractShow full text abstract about Abstract: In my talk I will discuss some new features of ...»

    Abstract: In my talk I will discuss some new features of conformal anomaly and entanglement entropy in the presence of boundaries. The talk is based on recent papers.This is a project to develop a wide expanse of new quantum field theories in 2n-dimensional space-time manifolds. For each 2d qft, there is to be a qft of extended objects in every 2n-dimensional space-time manifold M. The quantum fields live on ``quasi Riemann surfaces'', which are certain spaces of integral (n-1)-currents in M. The notion of integral current comes from Geometric Measure Theory. The quasi Riemann surfaces are complete metric spaces with analytic properties strictly analogous to Riemann surfaces. The new qfts are to be constructed on the quasi Riemann surfaces just as 2d qfts are constructed on ordinary Riemann surfaces. Local fields in space-time are obtained by restricting to small extended objects.
    arXiv:1510.04566, arXiv:1601.06418 and arXiv:1604.07571

    Lecture
  • Date:07TuesdayFebruary 2017

    Antimicrobial Peptides: Mechanisms of Bacterial Biofilms Neutralization.

    More information
    Time
    10:30 - 11:00
    Location
    Wolfson Building for Biological Research
    Auditorium
    Lecturer
    Liav Tia Segev Zarko
    Members - Dept. of Biomolecular Sciences-WIS
    Organizer
    Department of Biomolecular Sciences
    Contact
    AbstractShow full text abstract about Multidrug resistant bacteria are a growing phenomenon that c...»
    Multidrug resistant bacteria are a growing phenomenon that concerns the scientific community worldwide. Two extensively studied resistance mechanisms are biofilm colonization and bacterial outer membrane remodeling. An attractive alternative to conventional antibiotics are antimicrobial peptides (AMPs), innate immune system molecules serving as a first line of defense in fighting invading pathogens. We show that AMPs can either inhibit or reduce biofilm formation and degrade established ones via several bactericidal and non- bactericidal mechanisms. Alternatively, AMPs can promote bacterial lipopolysaccharide (LPS) remodeling and potentially affect biofilm colonization. Our findings suggest that bacteria that are unable to remodel LPS compensate for it by adopting a biofilm lifestyle.

    Lecture
  • Date:07TuesdayFebruary 2017

    Controls and functions of non-structural carbon reserves in trees

    More information
    Time
    11:00 - 11:45
    Location
    Ullmann Building of Life Sciences
    Aharon Katzir Hall
    Lecturer
    Dr. Guenter Hoch
    Department of Environmental Sciences - Botany, University of Basel, Switzerland
    Organizer
    Department of Plant and Environmental Sciences
    Contact
    DetailsShow full text description of homepage: https://botanik.unibas.ch/hoch/ ...»
    homepage: https://botanik.unibas.ch/hoch/
    Lecture
  • Date:07TuesdayFebruary 2017

    TACHYONIC ANTIBRANES AND THE LANDSCAPE

    More information
    Time
    11:15
    Location
    Newe Shalom
    Lecturer
    IOSIF BENA
    SACLAY
    Organizer
    Department of Particle Physics and Astrophysics
    High Energy Theory Joint Seminar
    Contact
    AbstractShow full text abstract about Abstract:: ntibranes in backgrounds that have charge dissolv...»
    Abstract:: ntibranes in backgrounds that have charge dissolved in fluxes are a key ingredient in constructing a landscape (Multiverse) of deSitter vacua in String Theory, and also of constructing microstate solutions corresponding to non-supersymmetric near-extremal black holes. There are several regimes of parameters in which one can study the physics of these antibranes, and I will show that in the regime of parameters where their gravitational backreaction is important, antibranes have a naked singularity that cannot be resolved either by brane polarization or by cloaking with a black hole horizon, and that signals a tachyonic instability. I will also present recent evidence that the theory on the wordvolume of anti-D3 branes is finite to all loops. I will conclude by discussing the implications of these results for the Multiverse paradigm and for the Fuzzball proposal.
    Lecture
  • Date:07TuesdayFebruary 2017

    Store it, use it or lose it; Carbon reserve dynamics in stressed trees

    More information
    Time
    12:15 - 13:00
    Location
    Ullmann Building of Life Sciences
    Aharon Katzir Hall
    Lecturer
    Prof. Simon Landhausser
    Department of Renewable Resources, University of Alberta, Edmonton, Canada
    Organizer
    Department of Plant and Environmental Sciences
    Contact
    DetailsShow full text description of Website: http://www.rr.ualberta.ca/ and http://landhausser.u...»
    Website: http://www.rr.ualberta.ca/ and http://landhausser.ualberta.ca/
    Lecture
  • Date:07TuesdayFebruary 2017

    S-DUALITY IN MATHCAL{N} = 1 ORIENTIFOLD SCFTS

    More information
    Time
    12:30
    Location
    Newe Shalom
    Lecturer
    INAKI GARCIA-ETXEBARRIA
    MPI
    Organizer
    Department of Particle Physics and Astrophysics
    High Energy Theory Joint Seminar
    Contact
    AbstractShow full text abstract about Abstract: I will present a general solution to the problem o...»
    Abstract: I will present a general solution to the problem of determining all S-dual descriptions for a specific (but very rich) class of N=1 SCFTs. These SCFTs are indexed by decorated toric diagrams, and can be engineered in string theory by probing orientifolds of isolated toric singularities with D3 branes. The S-dual phases are described by quiver gauge theories coupled to specific types of conformal matter which I will describe explicitly.
    Lecture
  • Date:07TuesdayFebruary 2017

    Why Sensory Deprivation and High Plasticity may lead to Hallucinations and Synaesthesia:A Computational Perspective

    More information
    Time
    12:30
    Location
    Gerhard M.J. Schmidt Lecture Hall
    Lecturer
    Dr. Oren Shriki
    Dept of Cognitive and Brain Sciences Ben-Gurion University
    Organizer
    Department of Brain Sciences
    Contact
    DetailsShow full text description of Host: Dr.Yaniv Ziv yaniv.ziv@weizmann.ac.il tel: 4275 For a...»
    Host: Dr.Yaniv Ziv yaniv.ziv@weizmann.ac.il tel: 4275
    For assistance with accessibility issues, please contact naomi.moses@weizmann.ac.il
    AbstractShow full text abstract about Recurrent connections are abundant in cortical circuitry but...»
    Recurrent connections are abundant in cortical circuitry but their functional role has been the subject of intense debates. The talk will present a computational approach to investigate the role of recurrent connections in the context of sensory processing. Specifically, I will describe a neural network model in which the recurrent connections evolve according to concrete learning rules that optimize the information representation of the network. Interestingly, these networks tend to operate near a "critical" point in their dynamics, namely close to a phase of "hallucinations", in which non-trivial spontaneous patterns of activity evolve even without structured input. Various scenarios, such as attenuation of the external inputs or increased plasticity, can lead the network to cross the border into the hallucinatory phase. The theory will be illustrated through applications to a model of a visual hypercolumn, a model of tinnitus and a model of synaesthesia.

    References:
    Shriki O. and Yellin D., Optimal Information Representation and Criticality in an Adaptive Sensory Recurrent Neural Network. PLoS Computational Biology 12(2): e1004698. doi:10.1371/journal.pcbi.1004698, 2016

    Shriki O., Sadeh Y. and Ward J., The Emergence of Synaesthesia in a Neuronal Network Model via Changes in Perceptual Sensitivity and Plasticity. PLoS Computational Biology 12(7): e1004959. doi:10.1371/journal.pcbi.1004959, 2016.
    Lecture

Pages