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March 01-31, 2017

  • Date:01WednesdayMarch 2017

    Ubiquitin and proteolytic pathways: from molecular mechanisms to human diseases

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    Time
    08:00 - 17:30
    Location
    David Lopatie Conference Centre
    Kimmel Auditorium
    Chairperson
    Michal Sharon
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    Conference
  • Date:01WednesdayMarch 2017

    AMO Special Seminar

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    Time
    13:15 - 14:15
    Title
    Attosecond charge transport in atoms and condensed matter
    Location
    Edna and K.B. Weissman Building of Physical Sciences
    Auditorium
    Lecturer
    Prof. Ursula Keller
    ETH
    Organizer
    Department of Physics of Complex Systems
    Optics and Atomic Physics Seminar
    Contact
    AbstractShow full text abstract about The basic motivation for our work is to understand how charg...»
    The basic motivation for our work is to understand how charge is transported on an atomic spatial and attosecond time scale. Strong-field ionization in the dipole approximation (i.e. tunnel ionization) is much faster than the group delay of the electron wavepacket (i.e. Wigner delay), whereas photoemission from atoms can typically be described by the Wigner delay - but not in all cases. For example autoionization resonances in the continuum can change the ionization delay. Moving to condensed matter we have investigated the escape time of photoemitted electrons from metal surfaces such as Ag, Au and Cu. We want to address the question about the correct escape velocity of the electons and their ability to “feel” the periodic crystal potential on a attosecond time and an atomic length scale. Our most recent experiment can confirm an upper limit of around 300 attosecond over a distance less than 2 atomic layers during which an electron can assume its effective mass. Furthermore femtosecond charge transport modulation driven by a transient electric field in the petahertz regime have been observed in diamond and can be explained by the dynamical Kranz Keldysh effect (DFKE). State-of-the-art numerical calculations reveal that only a small number of transitions give rise to the observed effects and that the more classical intra-band transitions dominate the response over inter-band transitions.
    Lecture
  • Date:02ThursdayMarch 2017

    The Impact of Ploidy on Adaptation

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    Time
    10:00
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    Botnar Auditorium
    Lecturer
    Dr. Anna Selmecki
    Assistant Professor Department of Medical Microbiology and Immunology Creighton University Medical School
    Organizer
    Department of Molecular Genetics
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    Lecture
  • Date:02ThursdayMarch 2017

    Nonlinear phononics: coherent control of the crystal lattice and of the collective properties of solids

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    Time
    11:15 - 12:30
    Location
    Edna and K.B. Weissman Building of Physical Sciences
    Auditorium
    Lecturer
    Andrea Cavaliery
    Max Planck Gesellschaft
    Organizer
    Faculty of Physics
    Contact
    DetailsShow full text description of 11:00 – coffee, tea, and more...»
    11:00 – coffee, tea, and more
    AbstractShow full text abstract about In this talk, I will discuss how coherent electromagnetic ra...»
    In this talk, I will discuss how coherent electromagnetic radiation at infrared and TeraHerz frequencies can be used to coherently rearrange atoms within the crystal lattice of a solid. The motion of atoms is large, and energy flows between different modes of the crystal. Such nonlinear phononics allows for the control of metal insulator transitions, magnetic phenomena, superconductivity and ferroelectricity.
    I will also discuss how femtosecond x-ray beams from free electron lasers are integral to these studies, and are used to image structures during these non-equilibrium processes.
    Colloquia
  • Date:02ThursdayMarch 2017

    Neuronal ensembles: emergent motifs of cortical function?

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    Time
    11:30
    Location
    Gerhard M.J. Schmidt Lecture Hall
    Lecturer
    Prof. Rafael Yuste
    Dept of Biological Sciences, Columbia University, NY
    Organizer
    Department of Brain Sciences
    Contact
    DetailsShow full text description of Host: Dr. Yaniv Ziv yaniv.ziv@weizmann.ac.il tel: 4275 For ...»
    Host: Dr. Yaniv Ziv yaniv.ziv@weizmann.ac.il tel: 4275
    For assistance with accessibility issues, please contact naomi.moses@weizmann.ac.il
    Lecture
  • Date:02ThursdayMarch 2017

    Cortical spike multiplexing using gamma frequency latencies

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    Time
    12:45
    Location
    Gerhard M.J. Schmidt Lecture Hall
    Lecturer
    Prof. Dana H. Ballard
    Dept of Computer Sciences, University of Texas at Austin
    Organizer
    Department of Brain Sciences
    Contact
    DetailsShow full text description of Host: Dr. Yaniv Ziv yaniv.ziv@weizmann.ac.il tel: 4275 For ...»
    Host: Dr. Yaniv Ziv yaniv.ziv@weizmann.ac.il tel: 4275
    For assistance with accessibility issues, please contact naomi.moses@weizmann.ac.il
    Lecture
  • Date:02ThursdayMarch 2017

    AMO Special Seminar

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    Time
    14:00 - 15:30
    Location
    Edna and K.B. Weissman Building of Physical Sciences
    Auditorium
    Lecturer
    Dr. Tracy Northup
    Universtität Innsbruck
    Organizer
    Department of Physics of Complex Systems
    Optics and Atomic Physics Seminar
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    Lecture
  • Date:05SundayMarch 2017

    FRISNO14

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    Time
    08:00 - 15:00
    Location
    David Lopatie Conference Centre
    Kimmel Auditorium
    Chairperson
    Dan Oron
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    Conference
  • Date:05SundayMarch 201707TuesdayMarch 2017

    Next Generation Data Analysis with R/Bioconductor

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    Time
    08:00 - 08:00
    Location
    The David Lopatie Hall of Graduate Studies
    Chairperson
    Dan Ben-Avraham
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    Conference
  • Date:05SundayMarch 2017

    Science and Clinical Orthopedics

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    Time
    08:30 - 12:00
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    Botnar Auditorium
    Lecturer
    Prof. Benjamin Alman,Keynote speaker
    Duke University
    Organizer
    Department of Molecular Genetics
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    Lecture
  • Date:05SundayMarch 2017

    Sandbox- a Playground for Genomic Research and Science Innovation

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    Time
    09:00 - 10:00
    Location
    Gerhard M.J. Schmidt Lecture Hall
    Lecturer
    Dr. Hadas Keren-Shaul
    Life Science Core Facilities
    Organizer
    Department of Life Sciences Core Facilities
    Seminar
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    Lecture
  • Date:05SundayMarch 2017

    Seeing methanogens through computer simulations

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    Time
    11:00
    Location
    Sussman Family Building for Environmental Sciences
    M. Magaritz Seminar Room
    Lecturer
    Qusheng Jin
    Department of Earth Sciences University of Oregon
    Organizer
    Department of Earth and Planetary Sciences
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    Lecture
  • Date:05SundayMarch 2017

    Chemical Physics Department Guest Seminar

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    Time
    11:00
    Title
    TEERs for DEERs - advanced spectroscopy of correlated spins in molecules using a single spin sensor‎
    Location
    Gerhard M.J. Schmidt Lecture Hall
    Lecturer
    Dr Amit Finkler
    University of Stuttgart
    Organizer
    Department of Chemical and Biological Physics
    Contact
    AbstractShow full text abstract about Defects in the solid state are potentially suitable candidat...»
    Defects in the solid state are potentially suitable candidates for nanoscale sensing and imaging. Among these, the nitrogen-vacancy (NV) center in diamond has gained wide publicity due to its long coherence time, stability and wide temperature and frequency ranges of operation. With recent reports on the sensing of electron and nuclear spins from single proteins, we attempt to go one step further to the realm of correlated spins. I will present measurements of electron spins in spin-labeled molecules both at room temperature and at low temperature. I will show that it is possible to detect the dipolar coupling between two spin labels in a doubly-labeled peptide using a scheme we call "triple electron-electron resonance". This is a necessary step towards sensing of spins in correlated-electrons
    systems. Together with quantum-assisted schemes and improvements in signal readout, I will offer methods with which we can tackle challenges in chemical physics, laying out a potential platform for a spin network.
    Lecture
  • Date:05SundayMarch 2017

    Molecular Neuroscience Forum Seminar

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    Time
    15:00 - 16:00
    Title
    Neurotrophic factor signaling in cerebellar development
    Location
    Wolfson Building for Biological Research
    Auditorium
    Lecturer
    Carlos Ibanez
    Weston Visiting Professor, Weizmann Institute of Science Department of Neuroscience Karolinska Institute Stockholm, Sweden
    Organizer
    Department of Biomolecular Sciences
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    Lecture
  • Date:05SundayMarch 2017

    Personalized medicine for type 2 diabetes: Are we there?

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    Time
    15:00 - 16:00
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    Botnar Auditorium
    Lecturer
    Prof. Hilla Knobler
    Institute of Diabetes, Endocrinology & Metabolism, Kaplan Medical Centre, Hebrew University School of Medicine
    Organizer
    Life Sciences
    Metabollic Research Forum
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    Lecture
  • Date:06MondayMarch 2017

    "Surface studies and matter wave optics experiments with neutral helium beams"

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    Time
    11:00 - 12:15
    Location
    Gerhard M.J. Schmidt Lecture Hall
    Lecturer
    Prof. Bodil Holst
    University of Bergen
    Organizer
    Faculty of Chemistry
    Contact
    Colloquia
  • Date:06MondayMarch 2017

    Metabolic regulation of normal and leukaemia stem cells: the role of reactive oxygen species, mitochondria transfer and nitric oxide

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    Time
    14:00 - 15:00
    Title
    Cancer Research Club
    Location
    Max and Lillian Candiotty Building
    Seminar Room
    Lecturer
    Prof. Tsvee Lapidot
    Dept. of Immunology, Weizmann Institute
    Organizer
    Department of Immunology and Regenerative Biology
    Contact
    AbstractShow full text abstract about Bone marrow (BM) retained blood forming stem cells are prote...»
    Bone marrow (BM) retained blood forming stem cells are protected from DNA damaging agents including chemotherapy to prevent lethal infections and hematology failure. Stem cell chemotherapy resistance, requires dynamic interactions with BM stromal and endothelial cells and involves metabolic regulation of ROS, mitochondria transfer, and inhibition of NO. Leukemic stem cells initiate and maintain the disease and are the major target for clinical chemotherapy treatment. These malignant stem cells also reside in the BM and their chemotherapy resistance can lead to lethal leukemia relapse. Metabolic regulation of normal and leukemic stem cells in the bone marrow will be discussed.
    Lecture
  • Date:06MondayMarch 2017

    Dira Lehaskir - Children's theater

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    Time
    17:30
    Location
    Michael and Anna Wix Auditorium
    Contact
    Cultural Events
  • Date:07TuesdayMarch 2017

    How did the first protein form(s) evolve?

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    Time
    10:00 - 10:30
    Location
    Wolfson Building for Biological Research
    Auditorium
    Lecturer
    Dr. Maria Luisa Romero Romero
    Member - Dept. of Biomolecular Sciences-WIS
    Organizer
    Department of Biomolecular Sciences
    Contact
    AbstractShow full text abstract about Short functional peptides are likely to have served as cruci...»
    Short functional peptides are likely to have served as crucial intermediates between a primordial RNA world and the extant protein world. Our working hypothesis is that relics of these ancestral peptides still exist in the form of key motifs in active sites of present-day proteins. One such motif, probably the most obvious one, is the P-loop (Walker A motif) that typically binds the transferred phosphate moiety of ATP. Overall, our results show that P-loop NTPases could have emerged from a relatively short P-loop containing peptide and that self-assembly played a key role in endowing biochemical function despite limited size and complexity.
    Lecture
  • Date:07TuesdayMarch 2017

    Designed by Nature: Reduced Protein Stability Prevents Promiscuous Protein Binding The Case of TEM1-β-Lactamase

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    Time
    10:30 - 11:00
    Location
    Wolfson Building for Biological Research
    Auditorium
    Lecturer
    Ruth Khait
    Member - Dept. of Biomolecular Sciences-WIS
    Organizer
    Department of Biomolecular Sciences
    Contact
    AbstractShow full text abstract about Protein-protein interactions play important roles in most ce...»
    Protein-protein interactions play important roles in most cellular processes. Proteins interact through chemical and structural complementarity of their mutual binding sites. Amino acids found in physical proximity form non-covalent interactions that stabilize the complex. Here we studied the evolution of PPI interfaces applying directed in vitro evolution on a random TEM library expressed on yeast surface. Our study focused on two specific questions: 1) How plastic is a well-defined PPI interface? For that purpose the TEM library was softly selected against its high affinity binder BLIP and analyzed by deep sequencing. 2) Is it possible to evolve new PPIs? Here the monomeric TEM library was selected against TEM-WT and other proteins to create new binders. Our results show that PPI interfaces are plastic and easily formed, hence evolution must actively act to prevent promiscuous protein binding. One mechanism which seems to be applied by nature for that purpose is keeping wild type proteins below their potential stability in a way that they are easily destabilized upon mutation.
    Lecture

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