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June 01-30, 2017

  • Date:01ThursdayJune 2017

    Through the looking glass: The red queens race and other tales of immunovirology

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    Time
    11:15
    Title
    Virology Club
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    Botnar Auditorium
    Lecturer
    Dr. Leslie Lobel
    Organizer
    Department of Molecular Genetics
    Contact
    Lecture
  • Date:04SundayJune 201705MondayJune 2017

    From Molecular beams to photosynthesis-Conference in honor of Ron Naaman

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    Time
    08:00 - 08:00
    Location
    David Lopatie Conference Centre
    Kimmel Auditorium
    Chairperson
    David Cahen
    Homepage
    Contact
    Conference
  • Date:04SundayJune 2017

    Metabolome analysis:Finding a Needle in a Haystack

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    Time
    09:00 - 10:00
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    Botnar Auditorium
    Lecturer
    Dr. Sergey Malitsky
    Organizer
    Department of Life Sciences Core Facilities
    Seminar
    Lecture
  • Date:04SundayJune 2017

    Deciphering the wastewater resistome and its potential impact on downstream environments

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    Time
    11:00
    Location
    Sussman Family Building for Environmental Sciences
    M. Magaritz Seminar Room
    Lecturer
    Eddie Cytryn, PhD
    Institute of Soil, Water and Environmental Sciences Volcani Center, Agricultural Research Organization
    Organizer
    Department of Earth and Planetary Sciences
    Contact
    AbstractShow full text abstract about Wastewater treatment plants consolidate high loads of fecal ...»
    Wastewater treatment plants consolidate high loads of fecal and environmental bacteria and residual concentrations of antibiotics and consequentially, effluents released from these facilities may contribute to antibiotic resistance in downstream ecosystems. This is especially relevant in arid and semi-arid environments, where treated wastewater (TWW) is used for irrigation. The goal of this study was to pinpoint key antibiotic resistance genes (ARGs) in wastewater effluents and to determine the impact of TWW irrigation on antibiotic resistance in terrestrial and food-associated microbiomes. The diversity and abundance of ARGs was evaluated in wastewater effluents, in TWW -irrigated soils and in crops irrigated with TWW using state of the art molecular, genomic and bioinformatic analyses. Three specific methods were applied: (A) a novel high-throughput amplicon sequencing methodology that specifically targeted ARGs associated with integron gene cassettes in effluents from 12 wastewater treatment facilities across Europe and in pristine vs. wastewater effluent-saturated soil; (B) quantitative PCR that assessed the abundance of selected ARGs along freshwater- and TWW-irrigated, water-soil-crop continuum; and (C) comparative in-silico-based analyses of human gut, wastewater and soil metagenomes to determine specific associations between wastewater and soil resistomes. Our results reveal that wastewater effluents contain a diverse array of ARGs, and that specific ARGs and class 1 integrons (mobile genetic elements that often harbor ARGs) are profuse and strongly associated with wastewater effluents. In contrast we found that other ARGs that are ubiquitous to soil regardless of TWW irrigation suggesting that these elements are common in environmental microbiomes. Collectively, the study indicates the distribution of ARGs in the environment is highly complex and is impacted by both natural and anthropogenic factors, and that while the impact of wastewater-derived ARGs in TWW-irrigated soils is limited, there is evidence that plasmid- and integron-associated ARGs are disseminated to soil microbiomes.

    Lecture
  • Date:04SundayJune 2017

    Aggregation of a bacterial extracellular matrix protein

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    Time
    11:00 - 12:00
    Location
    Perlman Chemical Sciences Building
    Room 404
    Lecturer
    Dr. Liraz Chai
    Institute of Chemistry, HUJI
    Organizer
    Department of Molecular Chemistry and Materials Science
    Soft Matter and Biomaterials
    DetailsShow full text description of Biofilms are groups of microbial cells that are encased in a...»
    Biofilms are groups of microbial cells that are encased in an extracellular matrix (ECM) composed mainly of proteins and polysaccharides. Biofilms can be beneficial, for example when protecting the roots of plants, but they are often detrimental to the host: their formation on medical devices and implants such as catheters, artificial hips, or contact lenses may lead to both acute and chronic infections. The ECM functions as an inter-cellular glue and it is also known to protect the cells from external toxins. The major proteinaceous component of the ECM forms fibrillar appendages that are ‘functional amyloids’. In contrast to amyloid proteins that are related with disease, functional amyloids are not considered harmful but rather, they have a functional role as they provide mechanical stability to biofilms. The formation of amyloid fibers has been extensively studied in the context of neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. However, very little is known about the mechanisms of functional - amyloid - fiber formation. We use the ECM of the soil bacterium B. subtilis as a model organism for biofilm formation. Specifically, we study the processes that lead to the aggregation of the ECM protein, TasA. Here we describe our aggregation experiments in solution and at the surface of membranes. Understanding the properties of the ECM and the mechanisms that underlie its assembly may lead the way for antibiofilm drugs that target the extracellular matrix.

    Lecture
  • Date:04SundayJune 2017

    To be announced

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    Time
    13:00
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    Botnar Auditorium
    Lecturer
    Inna Averbukh
    Naama Barkai's and Benny Shilo's groups, Dept. of Molecular Genetics, WIS
    Organizer
    Department of Molecular Genetics
    Lecture
  • Date:04SundayJune 2017

    RECYCLE THE BRAIN: Glutamine repeats (polyQ) shape cell recycling in health and neurodegeneration

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    Time
    14:00 - 15:00
    Location
    Max and Lillian Candiotty Building
    Seminar Room
    Lecturer
    Dr. Avraham Ashkenazi
    Cambridge Institute for Medical Research, University of Cambridge
    Organizer
    Department of Immunology and Regenerative Biology , Department of Biomolecular Sciences
    Contact
    Lecture
  • Date:04SundayJune 2017

    When Lithium Travels in Solid State Disorder

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    Time
    15:00 - 16:00
    Location
    Perlman Chemical Sciences Building
    Room 404
    Lecturer
    Prof. Jennifer Rupp
    Dept. Materials Science, MIT
    Organizer
    Department of Molecular Chemistry and Materials Science
    DetailsShow full text description of Next generation of energy storage and sensors may largely ...»

    Next generation of energy storage and sensors may largely benefit from fast Li+ ceramic electrolyte conductors to allow for safe and efficient batteries and real-time monitoring anthropogenic CO2. Recently, Li-solid state conductors based on Li-garnet structures received attention due to their fast transfer properties and safe operation over a wide temperature range. Through this presentation basic theory and history of Li-garnets will first be introduced and critically reflected towards new device opportunities. Central to our research is the fundamental investigation of the electro-chemo-mechanic characteristics and design of disordered to crystallizing Li-garnet strucure types and their description. Understanding the fundamental transport in solid state and asking the provokative question: how do Li-amorphous to crystalline structures conduct? As well, as how can we alter their charge-and mass transport properties for solid electrolytes and towards electrodes is discussed. Here, we firstly present new Li-garnet battery architectures for which we discuss lithium titanate and antimony electrodes in their making, electrochemistry and assembly to full battery architectures1-4. Secondly, new insights on degree of glassy to crystalline Li-garnet thin films are presented based on model experiments of the structure types. Here, the thermodynamic stability range of maximum Li-conduction, phase, nucleation and growth of nanostructure is discussed using high resolution TEM studies, near order Raman investigations on the Li-bands and electrochemical transport measurements. The insights provide novel aspects of material structure designs for both the Li-garnet structures (bulk to films) and their interfaces to electrodes, which we either functionalize to store energy for next generation solid state batteries or ... make new applications such as Li-operated CO2 sensor tracker chips.

    Lecture
  • Date:04SundayJune 2017

    A key role of c-Abl tyrosine kinase in metabolic physiology

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    Time
    15:00 - 16:00
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    Botnar Auditorium
    Lecturer
    Prof. Yosef Shaul
    Department of Molecular Genetics
    Organizer
    Life Sciences
    Metabollic Research Forum
    Contact
    Lecture
  • Date:05MondayJune 2017

    AMO Special Seminar

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    Time
    11:00
    Title
    Photon Processing in the Frequency Domain
    Location
    Edna and K.B. Weissman Building of Physical Sciences
    Drory Auditorium
    Lecturer
    Prof. Alexander Gaeta
    Columbia University
    Organizer
    Department of Physics of Complex Systems
    Contact
    AbstractShow full text abstract about Nonlinear optical processes play a central role in many quan...»
    Nonlinear optical processes play a central role in many quantum information devices. I will describe our recent work in which we explore the use of quantum frequency conversion based on four-wave mixing to process photons with high quantum efficiency without adding noise. I will describe how we use this conversion process to create a single-photon Ramsey interferometer, temporally magnify photon wavepackets, and perform frequency multiplexing to create a quasi-deterministic photon source.
    Lecture
  • Date:06TuesdayJune 2017

    "Mechanisms of bone surface sensing by osteoclasts"

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    Time
    09:00
    Location
    Helen and Milton A. Kimmelman Building
    Dov Elad Room
    Lecturer
    Michal Shemesh
    WIS Departments of Structural Biology and Molecular Cell Biology
    Organizer
    Department of Chemical and Structural Biology
    DetailsShow full text description of Ph.D. student of Prof. Lia Addadi and Prof. Benny Geiger...»
    Ph.D. student of Prof. Lia Addadi and Prof. Benny Geiger
    Lecture
  • Date:06TuesdayJune 2017

    Regulating the 20S proteasome degradation pathway

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    Time
    10:00 - 10:30
    Location
    Wolfson Building for Biological Research
    Auditorium
    Lecturer
    Dr. Maya Olshina
    Members - Dept. of Biomolecular Sciences-WIS
    Organizer
    Department of Biomolecular Sciences
    Contact
    AbstractShow full text abstract about The protein degradation machinery in cells plays a critical ...»
    The protein degradation machinery in cells plays a critical role in the maintenance of homeostasis, preventing the accumulation of damaged or misfolded proteins and controlling the levels of regulatory proteins. The predominant degradation pathway involves the ubiquitin-dependent 26S proteasome, however recent evidence has identified an alternate ubiquitin-independent pathway involving only the 20S core particle of the proteasome. The regulatory mechanisms controlling its function are poorly understood, and only a small number of regulators have been identified. Using a combination of bioinformatics, structural and in vivo analyses, as well as native mass spectrometry techniques, new 20S proteasome regulatory proteins were identified, hinting towards an as yet undescribed regulatory network of the 20S proteasome.
    Lecture
  • Date:06TuesdayJune 2017

    Andor Dragonfly - High speed confocal imaging Platform

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    Time
    10:30 - 11:30
    Location
    Max and Lillian Candiotty Building
    Seminar Room
    Lecturer
    Dr. Bruno Combettes
    Business Development Manager ANDOR Technology
    Organizer
    Department of Life Sciences Core Facilities
    Seminar
    Lecture
  • Date:06TuesdayJune 2017

    Computational Design of Novel Enzymes Guided By Evolutionary Data

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    Time
    10:30 - 10:00
    Location
    Wolfson Building for Biological Research
    Auditorium
    Lecturer
    Gideon Lapidoth
    Members - Dept. of Biomolecular Sciences-WIS
    Organizer
    Department of Biomolecular Sciences
    Contact
    AbstractShow full text abstract about The ability to computationally design efficient, specific ...»
    The ability to computationally design efficient,
    specific enzymes is a rigorous test of our understanding of the principles of catalysis and molecular recognition.
    Successful designs have to date shown several limitations:
    they only targeted simple reactions, involving two to three catalytic residues with low efficiencies and selectivities, and impaired stability. We developed a new algorithm using Rosetta to combine compatible backbone fragments from natural enzymes of the
    same enzyme superfamily to generate novel conformations. The designs’ sequences are then optimized, guided by sequence conservation data to improve stability and expressibility. We used the algorithm to design novel TIM barrel fold enzymes belonging to the
    GH10 family capable of hydrolyzing xylan, an abundant plant polysaccharide, with Kcat/Km values similar to those of natural xylanases. The designed enzyme conformations differ from one another and from any other known natural xylanase conformations and have
    different substrate specificities.
    The algorithm is completely automated and can be
    applied to other enzymes of modular fold to efficiently and broadly explore the potential selectivities of the superfamily.
    Lecture
  • Date:06TuesdayJune 2017

    Processing of Chemical Signals by Enzymatic and Organic Reactions

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    Time
    11:00 - 12:00
    Location
    Helen and Milton A. Kimmelman Building
    Dov Elad Room
    Lecturer
    Dr. Sergey Semenov
    Dept. of Chemistry and Chemical Biology Harvard University
    Organizer
    Department of Molecular Chemistry and Materials Science
    Lecture
  • Date:06TuesdayJune 2017

    Life Sciences Colloquium

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    Time
    11:00 - 12:00
    Title
    A chemo-evolutionary basis for polypharmacology
    Location
    Gerhard M.J. Schmidt Lecture Hall
    Lecturer
    Prof. Brian K. Shoichet
    UCSF
    Organizer
    Life Sciences
    Homepage
    Contact
    Colloquia
  • Date:06TuesdayJune 2017

    Utilizing nework analysis to identify functions: from deep time evolution of oxidoreductases to virulence mechanisms of plant pathogens

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    Time
    11:15
    Location
    Ullmann Building of Life Sciences
    Aharon Katzir Hall
    Lecturer
    Dr. Arik Harel
    Department of Vegetable and Crop Science, Institute of Plant Sciences, Agricultural Research Organization (ARO), Volcani Center, Rishon LeZion.
    Organizer
    Department of Plant and Environmental Sciences
    DetailsShow full text description of http://www.agri.gov.il/people/1127.aspx...»
    http://www.agri.gov.il/people/1127.aspx
    Lecture
  • Date:06TuesdayJune 2017

    MCB - Students seminar

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    Time
    12:15
    Title
    TBA
    Location
    Wolfson Building for Biological Research
    Auditorium
    Organizer
    Department of Molecular Cell Biology
    Lecture
  • Date:06TuesdayJune 2017

    Presynaptic dysfunction in Fragile X syndrome

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    Time
    12:30
    Location
    Gerhard M.J. Schmidt Lecture Hall
    Lecturer
    Prof. Vitaly Klyachko
    Dept of Biomedical Engineering, Dept of Cell Biology and Physiology Washington University School of Medicine
    Organizer
    Department of Brain Sciences
    DetailsShow full text description of Host: Dr. Ofer Yizhar ofer.yizhar@weizmann.ac.il tel: 6957 ...»
    Host: Dr. Ofer Yizhar ofer.yizhar@weizmann.ac.il tel: 6957
    For assistance with accessibility issues, please contact naomi.moses@weizmann.ac.il
    AbstractShow full text abstract about I will discuss our efforts towards understanding synaptic an...»
    I will discuss our efforts towards understanding synaptic and circuit dysfunction in Fragile X syndrome, the most common heritable cause of intellectual disability and the leading genetic cause of autism. I will describe our studies identifying major presynaptic defects in excitability and neurotransmitter release in Fragile X and the role of ion channel dysregulation in these deficits. Finally, I will present evidence for a direct link between presynaptic dysregulation and specific Fragile X phenotypes in a patient.
    Lecture
  • Date:06TuesdayJune 2017

    "New Structure-activity Paradigms for Amyloids from Pathogenic Microbes"

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    Time
    13:00
    Location
    Helen and Milton A. Kimmelman Building
    Dov Elad Room
    Lecturer
    Prof.Meytal Landau
    Technion
    Organizer
    Department of Chemical and Structural Biology
    Contact
    Lecture

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