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  • Date:29TuesdayMay 2018

    Defining the microglia contributions to lysosomal storage disorders

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    Time
    10:30 - 11:00
    Location
    Nella and Leon Benoziyo Building for Biological Sciences
    Auditorium
    Lecturer
    Dr. Soo-Min Cho
    Members - Dept. of Biomolecular Sciences-WIS
    Organizer
    Department of Biomolecular Sciences
    Contact
    AbstractShow full text abstract about Lysosomal storage disorders (LSD), such as Gaucher disease (...»
    Lysosomal storage disorders (LSD), such as Gaucher disease (GD) and Niemann–Pick type C (NPC) disease, display neuronal degeneration accompanied by neuroinflammation. In the brain, innate immunity is maintained by microglia, the major myeloid cell population in the CNS. FACS analysis of end stage LSD models showed minor monocyte infiltration indicating that CNS-resident microglia are the major myeloid player in these pathologies. I will further discuss the functional contribution of microglia to LSD pathophysiology based on RNAseq analysis of microglia from various LSD animal models.

    Lecture
  • Date:29TuesdayMay 2018

    Live demonstration of Redcap – a new system for working with secure clinical online questionnaires

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    Time
    11:00 - 12:00
    Location
    Max and Lillian Candiotty Building
    Auditorium
    Lecturer
    Dr. Ron Rotkopf
    Bioinformatics unit, Life Sciences Core Facilities
    Organizer
    Department of Life Sciences Core Facilities
    Contact
    AbstractShow full text abstract about Redcap – a new system for working with clinical online quest...»
    Redcap – a new system for working with clinical online questionnaires
    Hello all,
    We would like to bring to your attention that we have recently installed REDCap at
    the Weizmann Institute. REDCap is a secure web application for building and
    managing online surveys and databases, used by thousands of academic institutions
    and hospitals around the world.
    Using REDCap, you can easily create online questionnaires or surveys, and collect
    responses from your collaborators anywhere, or even from survey participants who
    are not logged in. This is particularly useful for clinical projects, but can be used for
    any project that requires collecting data from multiple collaborators.
    The REDCap interface is user-friendly, and no coding experience is needed to start a
    new project and create your own questionnaires.
    After the data is collected, it can be exported easily to Excel or any common statistical
    packages (e.g. SPSS, SAS, Stata, R).
    You can read more about REDCap at https://www.project-redcap.org/
    The Weizmann installation of REDCap is at https://redcap.weizmann.ac.il/
    If you just want to check it out without registering, a demo version is available (only
    from within the institute) at http://demohealth.weizmann.ac.il/.
    Do not enter any important/confidential data in the demo version!
    If you have any questions, or would like to register to REDCap, please contact
    Ron Rotkopf (ron.rotkopf@weizmann.ac.il) at the LSCF Bioinformatics unit.
    The demonstration will be held at Candiotty auditorium on Tuesday, May 29th, at 11:00.
    Registration is not required, but if you plan to come, please take a minute to answer this
    anonymous survey:
    http://j.mp/2rtn7a6
    The survey was created in Redcap, and we will use it as an example of creating a
    questionnaire and collecting data.
    Lecture
  • Date:29TuesdayMay 2018

    Algebraic Geometry and Representation Theory Seminar

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    Time
    11:15 - 12:30
    Title
    Branching laws for non-generic representations
    Location
    Jacob Ziskind Building
    Room 155
    Lecturer
    Max Gurevich
    Singapore
    Organizer
    Department of Computer Science and Applied Mathematics
    Faculty of Mathematical Sciences Seminar
    Contact
    Lecture
  • Date:29TuesdayMay 2018

    Enzyme rates in the omics era

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    Time
    11:30
    Title
    From global characterization to a pivotal case study
    Location
    Nella and Leon Benoziyo Building for Biological Sciences
    Auditorium
    Lecturer
    Dan Davidi
    Prof. Ron Milo’s lab., Dept. of Plant and Environmental Sciences, Weizmann Institute of Science
    Organizer
    Department of Plant and Environmental Sciences
    Contact
    AbstractShow full text abstract about Enzymes determine the rate of most biological processes. Dec...»
    Enzymes determine the rate of most biological processes. Decades of biochemistry have demonstrated how enzymes vary by orders of magnitude in their kinetic properties. Why are some enzymes faster than others and how are enzyme capacities related to physiological demands? I will talk about the interplay between enzyme kinetics and different evolutionary driving forces in an attempt to unravel which factors constrain and sculpt enzymatic rates. I will then move to examine the relevance of in-vitro kinetics to living systems, asking whether the rates of enzymes are similar between test-tubes and cells, and if not, why this is the case.
    Lastly, I will focus on one particular enzyme with lousy kinetics. This enzyme is called Rubisco - the key carboxylating enzyme on the planet, and therefore the gateway into the organic world.
    Instead of trying to improve Rubisco by directed evolution approaches, which have largely failed so far, I will describe our ongoing journey to find the best Rubisco Nature has to offer...
    Lecture
  • Date:29TuesdayMay 2018

    Synaptic and extrasynaptic neuron-glia interactions

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    Time
    12:30 - 13:30
    Location
    Gerhard M.J. Schmidt Lecture Hall
    Lecturer
    Prof. Alexey Semyanov
    Institute of Neuroscience University of Nizhny Novgorod, Russia
    Organizer
    Department of Neurobiology
    Contact
    DetailsShow full text description of Host: Prof. Menahem Segal Menahem.segal@weizmann.ac.il tel:...»
    Host: Prof. Menahem Segal Menahem.segal@weizmann.ac.il tel: 2553
    For assistance with accessibility issues, please contact naomi.moses@weizmann.ac.il
    AbstractShow full text abstract about Brain is often viewed as large neuronal connectome where the...»
    Brain is often viewed as large neuronal connectome where the information is encoded in the patterns of action potentials and stored in the changes of synaptic strength or appearance of new wiring routes. However, recent studies have demonstrated that astrocytes also possess complex patterns of calcium signals influenced by neuronal activity. Astrocytic calcium signals regulate various functions of these cells including release of gliotransmitters and morphological changes in the astrocytic processes (Tanaka et al., 2013). It has been tempting to suggest that information in astrocytes is encoded in the frequency of calcium events, similar to patters of neuronal action potentials. Synaptically released neurotransmitters thought to trigger new calcium events in perisynaptic astrocytic processes (PAPs) though activation of metabotropic glutamate receptors (mGluRs). In contrast, our recent findings suggest that PAPs are devoid of calcium stores that are required for mGluR-mediated calcium signaling (Patrushev et al., 2013). This makes unlikely any significant role of mGluRs in triggering calcium events in PAPs. Instead, we show that activation of ‘extrasynaptic’ astrocytic mGluRs increases proportion of spatially extended calcium events in the power-law based distribution of calcium event sizes (Wu et al., 2014). This effect takes place without any significant increase in the frequency of calcium events. These findings suggest that astrocytic response to surrounding neuronal activity is rather encoded in spatial characteristics of their calcium events and fundamentally different from temporal information coding in neurons (e.g. coincidence detection, action potentials sequences etc). Nevertheless, we cannot exclude local ionic changes in PAPs in response to synaptic activity. For example, potassium ions accumulate in the synaptic cleft of glutamatergic synapses during repetitive activity. We have demonstrated that the bulk of these ions is contributed by potassium efflux through postsynaptic NMDA receptors (Shih et al., 2013). Potassium mediated depolarization of presynaptic terminal increases glutamate release probability. Now we have found that accumulation of intracleft potassium during repetitive synaptic activity could also inhibit astrocytic glutamate uptake by depolarizing PAPs. This extends glutamate dwell-time in the synaptic cleft and boosts glutamate spillover effects.
    Lecture
  • Date:29TuesdayMay 2018

    Contrary to Dogma: Tau is not a stabilizer of microtubules in the axon

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    Time
    13:00
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    Botnar Auditorium
    Lecturer
    Prof. Peter W. Baas
    Professor, Department of Neurobiology and Anatomy Director, Graduate Program in Neuroscience Drexel University College of Medicine, Philadelphia, USA http://drexel.edu/medicine/About/Departments/Neurobiology-Anatomy/Research/Baas-Lab/
    Organizer
    Department of Molecular Genetics
    Contact
    Lecture
  • Date:29TuesdayMay 2018

    Molecular Neuroscience Forum Seminar

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    Time
    15:00 - 16:00
    Title
    Molecular mechanisms for synaptic control of gene transcription
    Location
    Nella and Leon Benoziyo Building for Biological Sciences
    Auditorium
    Lecturer
    Michael R. Kreutz
    Leibniz Institute for Neurobiology, Magdeburg and Center for Molecular Neurobiology, ZMNH, Hamburg
    Organizer
    Department of Biomolecular Sciences
    Homepage
    Contact
    Lecture
  • Date:30WednesdayMay 2018

    Nano safety and Education

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    Time
    11:00 - 12:00
    Location
    Perlman Chemical Sciences Building
    Room 404
    Lecturer
    Prof. Martin Himly
    Dept. Of Bio-sciences, University of Salzburg
    Organizer
    Department of Materials and Interfaces
    Contact
    AbstractShow full text abstract about Nanotechnology has reached every-day life. A high number o...»

    Nanotechnology has reached every-day life. A high number of all-day products either contain nanomaterials (NMs) or have been processed by nanotechnological work flows. New interactions with other all-day products, i.e. an every-growing number of modern lifestyle products (MLPs), become more and more likely. Moreover, the new generation has a high degree of creativity in using MLPs in different ways potentially resulting in not foreseen interactions of NMs with MLPs during the marketing process. Therefore, an interdisciplinary research project termed Nan-O-Style has been established investigating interactions between NMs in consumer products with substances from daily life with a special focus on MLPs used by adolescents. Furthermore, Nan-O-Style aims at the compilation of an education initiative about nanotechnology including teaching resources and international peer-teaching.
    In order to achieve a high variety of perspectives, students from different types of Austrian higher schools (technical/scientific vs. economic vs. artistic) work in close contact with scientists from academia. Due to the within Nan-O-Style acquired competences and the established network between academic scientists, students and educational institutions, the students develop new models for interdisciplinary teaching in mathematical/scientific/technical (MINT) subjects and apply them as best practice examples. We particularly focus on schools with an economic or fashion background which typically have a higher share of girls. A number of pre-scientific projects in nano-technological, nano-biological or nano-educational topics are carried out.
    This approach towards interdisciplinary MINT education thus strengthens the profile formation of the Paris Lodron University of Salzburg and further extends to the education of teachers. Previously, the educational EU framework projects www.NanoTOES.eu and www.NanoEIS.eu had been coordinated by Prof. Duschl and his group. Nan-O-Style is based on this background and therefore internationally connected to educational partners in Israel (ORT Moshinsky R&D Center, Tel Aviv, http://en.ort.org.il/), Spain (Nanoeduca, Barcelona, http://nanoeduca.cat/es/inicio/), and Germany (cc-NanoBioNet e.V, Saarbrücken, http://www.nanobionet.de/).
    The Duschl group furthermore conducts nanosafety research involving advanced in vitro models of the human lung barrier, including air-liquid interface cultures (1), addressing potential modulations of the immune response towards NMs (2, 3). As allergens may be inhaled simultaneously to nanoparticles they can become part of the protein corona. The group investigates whether this poses a risk for people with an existing allergic condition (4).

    Lecture
  • Date:31ThursdayMay 2018

    Annual Meeting of the Israeli Statistical Association

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    Time
    08:00 - 08:00
    Location
    David Lopatie Conference Centre
    Chairperson
    Boaz Nadler
    Homepage
    Contact
    Conference
  • Date:31ThursdayMay 2018

    Brain Cancer

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    Time
    11:00 - 13:00
    Title
    Clinical Oncology Course
    Location
    Max and Lillian Candiotty Building
    Auditorium
    Lecturer
    Prof. Uri Tabori
    Hospital for Sick Children, Toronto, Canada
    Organizer
    Department of Biological Regulation
    Contact
    Lecture
  • Date:31ThursdayMay 2018

    Physics Colloquium

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    Time
    11:15 - 12:30
    Location
    Edna and K.B. Weissman Building of Physical Sciences
    Auditorium
    Lecturer
    TBA
    Organizer
    Faculty of Physics
    Contact
    DetailsShow full text description of 11:00 Coffee, Tea and more...»
    11:00 Coffee, Tea and more
    AbstractShow full text abstract about TBA ...»
    TBA
    Colloquia
  • Date:31ThursdayMay 2018

    Lung cancer and HER family proteins

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    Time
    14:00 - 15:00
    Location
    Max and Lillian Candiotty Building
    Auditorium
    Lecturer
    Prof. Hovav Nechushtan
    Oncology Dept., Sharett Inst. Hadassah Hebrew University Medical Center
    Organizer
    Department of Biological Regulation
    Contact
    Lecture
  • Date:03SundayJune 2018

    TBA

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    Time
    11:00
    Location
    Sussman Family Building for Environmental Sciences
    M. Magaritz Seminar Room
    Lecturer
    Mark Thiemens
    UCSB
    Organizer
    Department of Earth and Planetary Sciences
    Contact
    Lecture
  • Date:03SundayJune 2018

    The multi-scale structure of chromatin in the nucleus

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    Time
    11:00 - 12:00
    Location
    Perlman Chemical Sciences Building
    Room 404
    Lecturer
    Prof. Yuval Garini
    Dept. Physics, BIU
    Organizer
    Department of Materials and Interfaces
    Soft Matter and Biomaterials
    Contact
    AbstractShow full text abstract about The DNA in a human cell which is ~3 meters long is packed ...»

    The DNA in a human cell which is ~3 meters long is packed in a tiny nucleus of ~10 μm radius. The DNA is surrounded by thousands of proteins, and it is highly dynamic while taking part in the process of protein expression and cell division. Nevertheless, it must stay organized to prevent chromosome entanglement. Studying this nanometer – micrometer scale structure is difficult, as it falls short of the optical resolution, while electron microscopy is limited due to the need to fixate the sample.
    We therefore adopted various methods for studying the organization of the genome in the nucleus, including live-cell imaging, time-resolved spectroscopy and single molecule methods such as AFM. It allowed us to identify that a protein, lamin A, forms chromatin loops thereby restricting the chromatin dynamics in the whole nucleus volume. Based on the results, we conclude that the organization of the DNA in the nucleus is based on a “DNA matrix”, a structure that we describe here for the first time. The experimental methods we use necessitate the use of biophysical modeling based on Smoluchowski equation, modified diffusion equations and polymer physics.
    I will describe the problem, the methods we use, the results and the conclusions as described above.
    Lecture
  • Date:04MondayJune 2018

    Foundations of Computer Science Seminar

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    Time
    14:30 - 16:00
    Title
    Quantum Tokens for Digital Signatures
    Location
    Jacob Ziskind Building
    Room 155
    Lecturer
    Or Sattath
    Ben-Gurion University
    Organizer
    Faculty of Mathematics and Computer Science
    Faculty of Mathematical Sciences Seminar, Department of Computer Science and Applied Mathematics
    Faculty of Mathematical Sciences Seminar, Department of Mathematics
    Faculty of Mathematical Sciences Seminar
    Contact
    Lecture
  • Date:05TuesdayJune 2018

    Students Seminar

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    Time
    11:15 - 12:30
    Location
    Wolfson Building for Biological Research
    Auditorium
    Lecturer
    Prof. Eran Segal's lab
    Organizer
    Department of Molecular Cell Biology
    Contact
    Lecture
  • Date:06WednesdayJune 2018

    Developmental Club Series 2017-2018

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    Time
    10:00 - 11:00
    Title
    “Transcriptional regulation of regulation of lysosome biogenesis shapes chondrocyte identity during bone growth”
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    Botnar Auditorium
    Lecturer
    Carmine Settembre, PhD
    Telethon Institute of Genetic and Medicine and Federico II University, Naples, Italy
    Organizer
    Department of Molecular Genetics
    Developmental Club
    Contact
    Lecture
  • Date:06WednesdayJune 2018

    Chemical and Biological Physics Guest Seminar

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    Time
    10:45
    Title
    Polarized Cell locomotion on surfaces and in soft tissue
    Location
    Gerhard M.J. Schmidt Lecture Hall
    Lecturer
    Prof. Erich Sackmann
    Dept. of Physics Technical University Munich
    Organizer
    Department of Chemical and Biological Physics
    Contact
    AbstractShow full text abstract about I discuss fundamental differences between the physical conce...»
    I discuss fundamental differences between the physical concepts of the globally coordinated and directed migration of cells on resilient tissue surfaces and in soft tissue, such as the brain. Cell locomotion on resilient surfaces is driven by solitary actin gelation pulses and myosin motors while microtubules and associated motors guide the global polarization of the cell
    The motion on surfaces is driven by protrusions forces generated by solitary actin gelation pulses that are emitted from adhesion domains, acting as biochemical reaction and force transmission centers. I describe the formation of functional membrane domains as a paradigm of the logistically controlled self-assembly of functional domains in membranes.
    In soft tissue of developing brains cell locomotion is driven by spreading of protrusions along long fibers protruding from glial cells followed by retraction of the nucleus which is powered by dynein motors.
    Lecture
  • Date:07ThursdayJune 2018

    “Mass Spectrometry Based Metabolic Profiling - tool for understanding comprehensive biological processes”

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    Time
    09:00 - 10:00
    Location
    Max and Lillian Candiotty Building
    Auditorium
    Lecturer
    Sergey Malitsky
    Metabolic Profiling Unit
    Organizer
    Department of Life Sciences Core Facilities
    Contact
    Lecture
  • Date:07ThursdayJune 2018

    Life Science Colloquium

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    Time
    11:00 - 12:00
    Title
    TBD
    Location
    Nella and Leon Benoziyo Building for Biological Sciences
    Auditorium
    Lecturer
    Prof. Christopher Walsh
    Howard Hughes Medical Institute
    Organizer
    Life Sciences
    Contact
    Colloquia

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