Chemical shift imaging is commonly used for spatial localization in the 3D spatial-1D spectral proton magnetic resonance spectroscopic imaging experiment despite suffering from intrinsic losses in signal-to-noise ratio and localization due to its sinc-shaped point-spread-function. These losses are exacerbated at low resolutions and cannot be corrected without cost.

In this talk I will describe an alternative spatial encoding method, three-dimensional transverse Hadamard spectroscopic imaging, that overcomes these limitations. I will show spectra from phantom and human brain experiments that were acquired with the new sequence and discuss the potential of the method for spectroscopic imaging at clinical (1.5, 3T) and ultra high (7T) fields.