March 29, 1994 - March 29, 2027

  • Date:19SundayNovember 2017

    Mapping a network of intrinsically-disordered proteins

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    Time
    11:00 - 12:00
    Location
    Perlman Chemical Sciences Building
    Room 404
    Lecturer
    Dr. Hagen Hofmann
    Dept. of Structural Biology, WIS
    Organizer
    Department of Molecular Chemistry and Materials Science
    Soft Matter and Biomaterials
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    AbstractShow full text abstract about Intrinsically disordered proteins (IDPs) are ubiquitously fo...»
    Intrinsically disordered proteins (IDPs) are ubiquitously found in eukaryotic systems. Their lack of a well-defined structure suggests that their broad conformational ensemble is functionally advantageous. Here, we use single-molecule fluorescence resonance energy transfer (smFRET) to investigate the link between the polymer properties of one important IDP network system and the process of coupled binding and folding that leads to functional complexes. Our results suggest that the properties of the disordered IDP ensemble and the stability of the functional complexes are strongly correlated.
    Lecture