מרץ 29, 1994 - מרץ 29, 2027

  • Date:26שלישיספטמבר 2017

    Shedding light on the dynamics of HIV-1 infection in humanized mouse model through virological and omics approaches

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    שעה
    10:00 - 11:00
    מיקום
    בניין לביוכימיה על שם נלה וליאון בנוזיו
    Auditorium
    מרצה
    Dr. Kei Sato
    Institute for Frontier Life and Medical Sciences,Kyoto University,Japan
    מארגן
    המחלקה למדעים ביומולקולריים
    צרו קשר
    תקצירShow full text abstract about To overcome the anti-viral effects mediated by type I interf...»
    To overcome the anti-viral effects mediated by type I interferon-induced restriction factors, HIV-1 have evolutionarily acquired viral antagonists. For instance, tetherin (also known as BST2), a well-known protein restricting HIV-1 replication, exerts anti-HIV-1 effect by anchoring released progeny virions on the cell surface, whereas viral protein U (Vpu), an HIV-1-encoding accessory protein, antagonizes the anti-viral action mediated by tetherin. However, its precise role in HIV-1 replication in vivo remains unclear. Here we use a hematopoietic stem cell-transplanted humanized mouse model and several vpu mutants specifically lacking its function and demonstrate that anti-tetherin ability of Vpu is a prerequisite for efficient viral spread during the initial phase of infection. Our results suggest that tetherin is an important intrinsic effector restricting HIV-1 replication in vivo, while Vpu is a key factor to ensure efficient viral spread during the initial phase of infection by antagonizing tetherin.
    Furthermore, by using HIV-1-infected humanized mouse model, we have recently launched a new approach to investigate the dynamics of HIV-1 infection through omics analyses. We would like to introduce our recent findings and discuss about them.
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