2018 research activities

Head Prof. Steffen Jung

Picture of Prof. Steffen Jung
Head

Prof. Steffen Jung

Office +972-8-934-2787

Overview

Research topics of our Department span the wide range from basic mechanisms in the development, recognition, inter-cellular communication, trafficking, and effector functions of the immune system to the role of these processes in autoimmune disorders, allergies and cancer. Special attention is given to the studies of immunomodulation and immunotherapy of these diseases leading to the development of specific vaccines to viruses, parasites, cancer and autoimmune diseases. Specific projects include production of specific antibodies for targeting of drugs and effector lymphocytes; raising of catalytic antibodies; studies of the repertoire and specificity of the T-cell receptor in autoimmune models for multiple sclerosis, diabetes, arthritis, and myasthenia gravis; definition of antigen recognition and mode of action of killer lymphocytes in allograft and tumor rejection; understanding the developmental process of leukemias and treating them; use of cytokines for immunotherapy of metastases and immunomodulation of lymphocyte migration; immune cell adhesion and migration; the control of inflammatory processes; development of hematopoietic stem cells and T-cells activity during aging as well as understanding antigen recognition mechanisms by their receptors and its coupling to cellular response in mast cells as a model.

ScientistsShow details

  • Picture of Dr. Jakub Abramson

    Dr. Jakub Abramson

    Understanding how breakdown of this process results in autoimmunity.
    Deciphering the molecular and cellular mechanisms that control the establishment of central immune tolerance.

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  • Picture of Prof. Ronen Alon

    Prof. Ronen Alon

    The role of talin1 and Kindlin-3 in integrin activation and lymphocyte adhesiveness to inflamed vessels under shear stress.
    Mice models for chronic obstructive pulmonary diseases (COPD) .
    Role of lymph node chemokines in lymphocyte scanning of dendritic cells.
    Effector lymphocyte trafficking to sites of inflammation.
    The functions of endothelial and myeloid ICAM-1 in adaptive and innate immunity.
    Endothelial stores of chemokines and their function in leukocyte extravasation.
    Chemokine activation of leukocyte integrins at endothelial contacts under shear stress.

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  • Picture of Prof. Ido Amit

    Prof. Ido Amit

    Genomics and Systems Biology of the Immune System.
    Decoding the mammalian transcriptional Regulatory Code in health and disease.

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  • Picture of Prof. Ruth Arnon

    Prof. Ruth Arnon

    Pathological mechanism in the CNS of various multiple sclerosis animal models.
    Neuroprotection, neurogenesis and remyelination – consequences of Glatiramer Acetate treatment in EAE.
    Mechanism of action of Copolymer 1 (Copaxone®), a therapeutic vaccine against multiple sclerosis.
    Collaboration with:  M. Sela
  • Picture of Prof. Avi Ben-Nun

    Prof. Avi Ben-Nun

    Neuroimmunology, pathogenic autoimmunity, myelin/neuronal repair, and treatment of autoimmune diseases in central nervous system (CNS):
    T-cell pathogenesis and regulation in autoimmune diseases of the CNS.
    Effects of functional epistasis between HLA class-II alleles on genetic predisposition to multiple sclerosis (MS) in “humanized” HLA-Tg mice and MS patients.
    Defining major pathogenic MS-related myelin/neuronal epitopes in HLA-transgenic (Tg) mice.
    Antigen-based immune-specific approaches to therapy (and mechanisms) of MS and other T-cell mediated autoimmune diseases.
    Myelin/neuronal repair by adult neural stem cells in mice with chronic MS-like disease.
  • Picture of Prof. Gideon Berke

    Prof. Gideon Berke

    Immunopathology in AIDS: Killing of HIV-infected CD4 T cells induced by Autologous CD8 T cells is Modulated by Nef expression
    Collaboration with:  Hassin D. and Sevilya Z.; Assuta Ashdod Medical Center.
  • Picture of Prof. Irun R. Cohen

    Prof. Irun R. Cohen

    Development and clinical applications of an antigen microarray device and informatics analyses aimed at diagnosis, prognosis, monitoring and management of autoimmune and other inflammatory diseases – the ImmunArray Ltd iCHIP (Israel and USA); now in clinical use.
    Treatment of inflammatory bowel disease, arthritis and other autoimmune conditions using DNA plasmids encoding human HSP90 or HSP70 – Alma Bio Therapeutics (France).
    Treatment of ALS using a synthetic peptide that inhibits apoptosis and fosters cell growth – Immunity Pharma Ltd. (Israel); entering clinical trials.

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  • Picture of Dr. Rony Dahan

    Dr. Rony Dahan

    Antibody response in cancer
    Anti-tumor mechanisms of immune checkpoint antibodies
    Therapeutic window of antibody-based immunotherapies

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  • Picture of Prof. Lea Eisenbach

    Prof. Lea Eisenbach

    Autoimmunity and immunotherapy
    Collaboration with:  Dr Ilan Volovitz, Prof. Irun Cohen
    Cancer Stem Cells and immunotherapy
    the role of small interferon induced genes in tumorigenicity and apoptosis
    cryoimmunotherapy
    tumor escape and tolerance
    T cell receptor evolution for immunotherapy
    Antigen presentation by engineered MHC molecules
    Collaboration with:  Dr Gideon Gross

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  • Picture of Prof. Zelig Eshhar

    Prof. Zelig Eshhar

    Development of universal vaccine for the control of allergic responses.
    Study of colorectal induced tumors in colitis.
    Redirecting regulatory T cells for adoptive cell therapy of autoimmune inflammation.
    Redirecting effector T cells for adoptive cell treatment of cancer.
  • Picture of Prof. Nir Friedman

    Prof. Nir Friedman

    Applications of TCR-seq: Autoimmunity, Neuroimmunology, Vaccination.
    Collaboration with:  R. Arnon, M. Schwartz, B. Chain - UCL
    Mapping T cell receptor repertoire using high-throughput sequencing (TCR-seq): developing methodologies and bioinformatic tools.
    Live cell imaging of T cell activation and differentiation using microfluidics devices.
    Studies of intercellular cytokine communication networks in T-cell development and differentiation.
    Studies of CD4 T cell differentiation combining experimental single cell approaches and mathematical modeling.

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  • Picture of Prof. Sara Fuchs

    Prof. Sara Fuchs

    The basis of D2 dopamine receptor diversity: Cloning, signal transduction, development, and correlation with disease.
    The nicotinic acetylcholine receptor: Structure, function, and regulation of gene expression.
    Myasthenia gravis: Regulatory mechanisms, epitopes, and immunodulation.
  • Picture of Prof. Steffen Jung

    Prof. Steffen Jung

    Microglia Functions in Functional Brain Maintenance and Neurological Disorders.
    Collaboration with:  Marco Prinz, University of Freiburg
    The role CX3C chemokine axis in intercellular communication.
    Contributions of Dendritic cell, Macrophages and Monocytes Contributions to Gut Health and Inflammatory Bowel Disease (IBD).
    Studying Molecular Cues guiding Mononuclear Phagocyte Differentiation
    Studying Interactions of Macrophages with Sympathetic Nerve System

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  • Picture of Prof. Tsvee Lapidot

    Prof. Tsvee Lapidot

    Metabolic regulation of Blood and Bone forming Stem Cells by Daily Light and Dark Cues (NE, TNF, Melatonin and PGE2).
    Regulation of Human and Murine Hematopoietic Stem Cell Migration and Development by Coagulation Cascades (both aPC/EPCR/Par1 anti inflammatory signals and Thrombin/PAR1 pro-inflammatory signals).
    Studying Molecular Cues guiding Human and murine Hematopoietic Stem Cells Homing and Bone Marrow (BM) recognition, retention and mobilization to the circulation.
    Metabolic regulation of BM Neutrophils activation and recruitment by Lactatae and GPR81 Signaling.
    Metabolic regulation of BM Neutrophils by Daily Light and Dark Cues.
    Energy sharing, Chemotherapy Resistance and Stress induced Mitochondira Transfer between Blood and Bone forming Stem Cells.
    AML AF9 Leukemic Stem Cells Metabolic interactions with BM Stromal Cells and Chemotherapy Resistance.
    Dynamic regulation of the Blood Bone Marrow Endothelial Barrier and Hematopoietic Stem Cell Niches.

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  • Picture of Prof. Edna Mozes

    Prof. Edna Mozes

    Systemic lupus erythematosus (SLE): Induction and development in various animal models.
    The role of various cell types (APC, T, B) and cytokines in the pathogenesis of autoimmune diseases.
    The status and role of T regulatory cells in autoimmune diseases.
    Specific immunomodulation of the autoimmune diseases, Systemic lupus erythematous and Sjogren Syndrome by a synthetic, tolerogenic peptide.
    Collaboration with:  Prof. Zev Sthoeger, Kaplan Medical Center.
    Elucidation of the mechanisms (effects on main pathways, cell types, cytokines and other pathogenic molecules) by which the tolerogenic peptide ameliorates autoimmune disease manifestations in animal models and in patients with SLE and Sjogren Syndrome.
    Development of the tolerogenic peptide as a novel specific drug for the treatment of SLE and Sjogren Syndrome.
  • Picture of Prof. Yair Reisner

    Prof. Yair Reisner

    Immature dendritic cells: investigating a novel granule mediated killing mechanism and the therapeutic potential for the prevention of Graft versus Host Disease.
    Crossing allogeneic and xenogeneic barriers by growing organs in-vivo from embryonic tissues : potential curative approaches for diabetes, hemophilia and lung diseases.
    Hematopoietic size control: A novel role for coagulation cascade factors in regulating the interplay between dynamic bone structure and long term survival and mobilization of hematopoietic stem cells.
    Developing a protocol for the production of human central memory CD8 T cells, to induce tolerance in allogeneic stem cell transplantation.
    Investigating the use of activated CD8 T cells as novel cell therapy for the treatment of autoimmune diseases.
    Role and mechanism of tolerance induction by activated CD8 T cells: A novel cell therapy for chimerism induction, stem cell transplant engraftment and enhanced Graft versus Lymphoma / Leukemia effect.

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  • Picture of Prof. Michael Sela

    Prof. Michael Sela

    Importance of negligible amounts of a partner in antibody combinations
    An aptamer strategy to target oncogenic signaling in ErbB2 carrying human tumors.
    Collaboration with:  G. Mahlknecht , Y. Yarden G. Mahlknecht
    Synergy of antibodies towards decreasing pancreatic cancer.
    Collaboration with:  R. Maron, B. Schechter, Y. Yarden
    Towards vaccination: Generation of peptide mimotopes specific for anti ErbB-2 monoclonal antibodies.
    Collaboration with:  E. Witsch, Y. Yarden
    Mechanism of action of Copolymer 1 (Copaxone), a therapeutic vaccine against multiple sclerosis.
    Collaboration with:  R. Arnon
    Effective synergism by anti ErbB-2 mAb combinations comprising one mAb against the dimerization site of ErbB-2.
    Collaboration with:  Y. Yarden
    Monoclonal antibodies (mAbs) to ErbB-1 and ErbB-2 receptors and their role in potential anti-tumor strategy.
    Collaboration with:  B. Schechter, Y. Yarden
    Synergistic effects of combinations of mAb against distinct epitopes on EGFR/ErbB-1 and ErbB-2 receptors: accelerated receptor aggregation, down regulation and inhibition of tumor growth.
    Collaboration with:  B. Schechter, Y. Yarden
  • Picture of Prof. Idit Shachar

    Prof. Idit Shachar

    Analyze the pathway regulateing the survival cascades in Chronic lymphocytic leukemia
    Collaboration with:  Dr Michal Haran, Kaplan Medical center
    Follow the mechanisms controlling homing of immune cells in health and disease.
    Determine the mechanisms regulating peripheral B cell maturation and survival in health and disease.

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  • Picture of Prof. Guy Shakhar

    Prof. Guy Shakhar

    Dendritic cell behavior:
    The dynamics of antigen sampling, chemokinesis, lymphatic migration
    Antigen presentation by dendritic cells as revealed by intravital imaging

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