2017 research activities

Head Prof. Idit Shachar

Picture of Prof. Idit Shachar
Head

Prof. Idit Shachar

Office +972-8-934-4257

Overview

Research topics of our Department span the wide range from basic mechanisms in the development, recognition, inter-cellular communication, trafficking, and effector functions of the immune system to the role of these processes in autoimmune disorders, allergies and cancer. Special attention is given to the studies of immunomodulation and immunotherapy of these diseases leading to the development of specific vaccines to viruses, parasites, cancer and autoimmune diseases. Specific projects include production of specific antibodies for targeting of drugs and effector lymphocytes; raising of catalytic antibodies; studies of the repertoire and specificity of the T-cell receptor in autoimmune models for multiple sclerosis, diabetes, arthritis, and myasthenia gravis; definition of antigen recognition and mode of action of killer lymphocytes in allograft and tumor rejection; understanding the developmental process of leukemias and treating them; use of cytokines for immunotherapy of metastases and immunomodulation of lymphocyte migration; immune cell adhesion and migration; the control of inflammatory processes; development of hematopoietic stem cells and T-cells activity during aging as well as understanding antigen recognition mechanisms by their receptors and its coupling to cellular response in mast cells as a model.

ScientistsShow details

  • Picture of Dr. Jakub Abramson

    Dr. Jakub Abramson

    Understanding how breakdown of this process results in autoimmunity.
    Deciphering the molecular and cellular mechanisms that control the establishment of central immune tolerance.

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  • Picture of Prof. Ronen Alon

    Prof. Ronen Alon

    The role of talin1 and Kindlin-3 in integrin activation and lymphocyte adhesiveness to inflamed vessels under shear stress.
    Mice models for chronic obstructive pulmonary diseases (COPD) .
    Role of lymph node chemokines in lymphocyte scanning of dendritic cells.
    Effector lymphocyte trafficking to sites of inflammation.
    The functions of endothelial and myeloid ICAM-1 in adaptive and innate immunity.
    Endothelial stores of chemokines and their function in leukocyte extravasation.
    Chemokine activation of leukocyte integrins at endothelial contacts under shear stress.

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  • Picture of Prof. Ido Amit

    Prof. Ido Amit

    Genomics and Systems Biology of the Immune System.
    Decoding the mammalian transcriptional Regulatory Code in health and disease.

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  • Picture of Prof. Ruth Arnon

    Prof. Ruth Arnon

    Pathological mechanism in the CNS of various multiple sclerosis animal models.
    Neuroprotection, neurogenesis and remyelination – consequences of Glatiramer Acetate treatment in EAE.
    Mechanism of action of Copolymer 1 (Copaxone®), a therapeutic vaccine against multiple sclerosis.
    Collaboration with:  M. Sela
  • Picture of Prof. Avi Ben-Nun

    Prof. Avi Ben-Nun

    Neuroimmunology, pathogenic autoimmunity, myelin/neuronal repair, and treatment of autoimmune diseases in central nervous system (CNS):
    T-cell pathogenesis and regulation in autoimmune diseases of the CNS.
    Effects of functional epistasis between HLA class-II alleles on genetic predisposition to multiple sclerosis (MS) in “humanized” HLA-Tg mice and MS patients.
    Defining major pathogenic MS-related myelin/neuronal epitopes in HLA-transgenic (Tg) mice.
    Antigen-based immune-specific approaches to therapy (and mechanisms) of MS and other T-cell mediated autoimmune diseases.
    Myelin/neuronal repair by adult neural stem cells in mice with chronic MS-like disease.
  • Picture of Prof. Gideon Berke

    Prof. Gideon Berke

    Cancer Immunity: a) Tetrameric MHC-peptide complexes in cancer detection and as cancer vaccines, b) Fas/Fas-L in tumor immunity c) Tumor escape mechanisms.
    Immunological memory in cancer.
    Apoptosis of the heart muscle.
  • Picture of Prof. Irun R. Cohen

    Prof. Irun R. Cohen

    Autoimmune T cells and tissue maintenance in the nervous system
    Collaboration with:  M. Schwartz
    Autoimmunity to hsp60 and the development of subunit vaccines against infectious diseases.
    Regulation of immune inflammation by small carbohydrate molecules
    Collaboration with:  O. Lider
    Autoimmunity to p53 and the development of systemic lupus erythematosus
    Collaboration with:  V. Rotter
    Autoimmune diabetes: Pathogenesis and immune therapy.

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  • Picture of Prof. Lea Eisenbach

    Prof. Lea Eisenbach

    Autoimmunity and immunotherapy
    Collaboration with:  Dr Ilan Volovitz, Prof. Irun Cohen
    Cancer Stem Cells and immunotherapy
    the role of small interferon induced genes in tumorigenicity and apoptosis
    cryoimmunotherapy
    tumor escape and tolerance
    T cell receptor evolution for immunotherapy
    Antigen presentation by engineered MHC molecules
    Collaboration with:  Dr Gideon Gross

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  • Picture of Prof. Zelig Eshhar

    Prof. Zelig Eshhar

    Development of universal vaccine for the control of allergic responses.
    Study of colorectal induced tumors in colitis.
    Redirecting regulatory T cells for adoptive cell therapy of autoimmune inflammation.
    Redirecting effector T cells for adoptive cell treatment of cancer.
  • Picture of Prof. Nir Friedman

    Prof. Nir Friedman

    Applications of TCR-seq: Autoimmunity, Neuroimmunology, Vaccination.
    Collaboration with:  R. Arnon, M. Schwartz, B. Chain - UCL
    Mapping T cell receptor repertoire using high-throughput sequencing (TCR-seq): developing methodologies and bioinformatic tools.
    Live cell imaging of T cell activation and differentiation using microfluidics devices.
    Studies of intercellular cytokine communication networks in T-cell development and differentiation.
    Studies of CD4 T cell differentiation combining experimental single cell approaches and mathematical modeling.

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  • Picture of Prof. Sara Fuchs

    Prof. Sara Fuchs

    The basis of D2 dopamine receptor diversity: Cloning, signal transduction, development, and correlation with disease.
    The nicotinic acetylcholine receptor: Structure, function, and regulation of gene expression.
    Myasthenia gravis: Regulatory mechanisms, epitopes, and immunodulation.
  • Picture of Prof. Steffen Jung

    Prof. Steffen Jung

    Microglia Functions in Functional Brain Maintenance and Neurological Disorders.
    The role CX3C chemokine axis in intercellular communication.
    Dendritic cell, Macrophage and Monocyte Contributions to the Maintenance of Intestinal Homeostasis and the Development of Inflammatory Bowel Disease (IBD).
    Molecular Cues guiding Mononuclear Phagocyte Differentiation focusing on the role of microRNAs.

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  • Picture of Prof. Edna Mozes

    Prof. Edna Mozes

    Systemic lupus erythematosus (SLE): Mechanisms for the induction and development and approaches for disease immunomodulation.
    T cell and cytokine dysregulation in autoimmune diseases.
    T cell epitopes of the human acetylcholine receptor and their analogs in myasthenia gravis.
    Autoimmunity in aging: The SLE experimental model.
  • Picture of Prof. Yair Reisner

    Prof. Yair Reisner

    Immature dendritic cells: investigating a novel granule mediated killing mechanism and the therapeutic potential for the prevention of Graft versus Host Disease.
    Crossing allogeneic and xenogeneic barriers by growing organs in-vivo from embryonic tissues : potential curative approaches for diabetes, hemophilia and lung diseases.
    Hematopoietic size control: A novel role for coagulation cascade factors in regulating the interplay between dynamic bone structure and long term survival and mobilization of hematopoietic stem cells.
    Developing a protocol for the production of human central memory CD8 T cells, to induce tolerance in allogeneic stem cell transplantation.
    Investigating the use of activated CD8 T cells as novel cell therapy for the treatment of autoimmune diseases.
    Role and mechanism of tolerance induction by activated CD8 T cells: A novel cell therapy for chimerism induction, stem cell transplant engraftment and enhanced Graft versus Lymphoma / Leukemia effect.
  • Picture of Prof. Michael Sela

    Prof. Michael Sela

    An aptamer strategy to target oncogenic signaling in ErbB2 carrying human tumors.
    Collaboration with:  G. Mahlknecht , Y. Yarden G. Mahlknecht
    Synergy of antibodies towards decreasing pancreatic cancer.
    Collaboration with:  R. Maron, B. Schechter, Y. Yarden
    Towards vaccination: Generation of peptide mimotopes specific for anti ErbB-2 monoclonal antibodies.
    Collaboration with:  E. Witsch, Y. Yarden
    Mechanism of action of Copolymer 1 (Copaxone), a therapeutic vaccine against multiple sclerosis.
    Collaboration with:  R. Arnon
    Effective synergism by anti ErbB-2 mAb combinations comprising one mAb against the dimerization site of ErbB-2.
    Collaboration with:  Y. Yarden
    Monoclonal antibodies (mAbs) to ErbB-1 and ErbB-2 receptors and their role in potential anti-tumor strategy.
    Collaboration with:  B. Schechter, Y. Yarden
    Synergistic effects of combinations of mAb against distinct epitopes on EGFR/ErbB-1 and ErbB-2 receptors: accelerated receptor aggregation, down regulation and inhibition of tumor growth.
    Collaboration with:  B. Schechter, Y. Yarden
  • Picture of Prof. Idit Shachar

    Prof. Idit Shachar

    Analyze the pathway regulateing the survival cascades in Chronic lymphocytic leukemia
    Collaboration with:  Dr Michal Haran, Kaplan Medical center
    Follow the mechanisms controlling homing of immune cells in health and disease.
    Determine the mechanisms regulating peripheral B cell maturation and survival in health and disease.

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  • Picture of Prof. Guy Shakhar

    Prof. Guy Shakhar

    Dendritic cell behavior:
    The dynamics of antigen sampling, chemokinesis, lymphatic migration
    Antigen presentation by dendritic cells as revealed by intravital imaging

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