Publications

2021

  • Kuhlisch, C., Schleyer, G., Shahaf, N., Vincent, F., Schatz, D. and Vardi, A. (2021) Viral infection of algal blooms leaves a unique metabolic footprint on the dissolved organic matter in the ocean. Sci. Adv.: EABF4680. doi: 10.1126/sciadv.abf4680
  • Schatz, D., Schleyer, G., Saltvedt, M.R., Sandaa R-A., Feldmesser, E. and Vardi, A. (2021) Ecological significance of extracellular vesicles in modulating host-virus interactions during algal blooms. ISME J. doi: https://doi.org/10.1038/s41396-021-01018-5
  • Gavish, A.R., Shapiro, O.H., Kramarsky-Winter, E. and Vardi, A. (2021) Microscale tracking of coral-vibrio interactions. ISME Comm. 1, article number: 18. doi: https://doi.org/10.1038/s43705-021-00016-0
  • Vincent, F., Sheyn, U., Porat, Z., Schatz, D. and Vardi, A. (2021) Visualizing active viral infection reveals diverse cell fates in synchronized algal bloom demise. Proc. Natl. Acad. Sci. USA, 118 (11) e2021586118; doi: 10.1073/pnas.2021586118
  • Carrara, F., Sengupta, A., Behrendt, L., Vardi, A. and  Stocker, R. (2021) Bistability in oxidative stress response determines the migration behavior of phytoplankton in turbulence. PNAS 118 (5) e2005944118. doi: https://doi.org/10.1073/pnas.2005944118

2020

  • Schleyer, G. and Vardi, A. (2020) Algal blooms. Current Biology. 30:R1116-R1118. doi: https://doi.org/10.1016/j.cub.2020.07.011
  • Trainic, M., Flores, J.M., Pinkas, I. Pedrotti, M.L., Lombard, F., Bourdin, G., Gorsky, G., Boss, E., Rudich, Y., Vardi, A. and Koren, I. (2020) Airborne microplastic particles detected in the remote marine atmosphere. Commun. Earth. Environ. 1, 64. doi:https://doi.org/10.1038/s43247-020-00061-y
  • Kyle M. J. Mayers, K.M.J. Poulton, A.J., Bidle, K., Thamatrakoln, K., Schieler, S., Giering, S.L.C., Wells, S.R., Tarran, G.A., Mayor, D., Johnson, M., Riebesell, U., Larsen, A., Vardi, A. and Harvey, E.L. (2020) The Possession of Coccoliths Fails to Deter Microzooplankton Grazers. Front. Mar. Sci. 7:569896. doi: 10.3389/fmars.2020.569896
  • Dror, T., Flores, J.M., Altaratz, O., Dagan, G., Levin, Z., Vardi, A. and Koren, I. (2020) Sensitivity of warm clouds to large particles in measured marine aerosol size distributions – a theoretical study. Atmos. Chem. Phys., 20, 15297–15306. doi: https://doi.org/10.5194/acp-20-15297-2020
  • Ku, C., Sheyn, U., Sebé-Pedrós, A., Ben-Dor, S., Schatz, D., Tanay, A., Rosenwasser, S. and Vardi, A. (2020) A single-cell view on alga-virus interactions reveals sequential transcriptional programs and infection states. Science Advances.  6:eaba4137. doi: 10.1126/sciadv.aba4137
  • Flores, J.M., Bourdin, G. Altaratz, O. Trainic, M. Lang-Yona, N. … Rudich, Y. Vardi, A. and Koren, I. (2020) Tara Pacific Expedition’s Atmospheric Measurements of Marine Aerosols across the Atlantic and Pacific Oceans: Overview and Preliminary Results. Bull. Amer. Meteor. Soc., 101, E536–E554 doi: https://doi.org/10.1175/BAMS-D-18-0224.1
  • Minina, EA., Staal, J., Alvarez, VE, Berges, J., … Vardi, A.…and Bozhkov PV (2020), Classification and nomenclature of metacaspases and paracaspases: No more confusion with caspases. Molecular Cell 77(5): 927-929. doi: https://doi.org/10.1016/j.molcel.2019.12.020.

2019

  • Gorsky, G …Flores, J. M… Koren, I… Trainic, M… Vardi, A. et al (2019) Expanding Tara Oceans Protocols for Underway, Ecosystemic Sampling of the Ocean-Atmosphere Interface During Tara Pacific Expedition (2016–2018). Front. Mar. Sci. 6:750. doi: 10.3389/fmars.2019.00750
  • Johnson, M. D., Edwards, B. R., Beaudoin, D. J., Van Mooy, B. A. S. and Vardi, A. (2019) Nitric oxide mediates oxylipin production and grazing defense in diatoms. Environmental Microbiology, doi: 10.1111/1462-2920.14879
  • Stock, F., Syrpas, M., Graff van Creveld, S, …, Kroth, PG, Vardi, A., Vyverman, W., Mangelinckx, S. (2019). N-Acyl Homoserine Lactone derived tetramic acids impair photosynthesis in Phaeodactylum tricornutum. ACS Chemical Biollogy , 14(2):198-203. doi: https://doi.org/10.1021/acschembio.8b01101
  • Mizrachi, A.,  Graff van Creveld, S., Shapiro, O.H., Rosenwasser, S. and Vardi, A (2019) Light-dependent single-cell heterogeneity in the chloroplast redox state regulates cell fate in a marine diatom. eLife 2019;8:e47732 doi: 10.7554/eLife.47732
  • Rosenwasser, S., Sheyn, U.,  Frada, M.J., Pilzer, D., Rotkopf, R. and Vardi, A. (2019) Unmasking cellular response of a bloom-forming alga to viral infection by resolving expression profiles at a single-cell level. PLOS Pathogens doi: https://doi.org/10.1371/journal.ppat.1007708
  • Schleyer, G., Shahaf, N., Ziv, C., Dong, Y., Meoded, R.A.,  Helfrich, E. J. N.,  Schatz, D., Rosenwasser, S., Rogachev, I., Aharoni, A., Piel, J and Vardi, A. (2019)  In plaque-mass spectrometry imaging of a bloom-forming alga during viral infection reveals a metabolic shift towards odd-chain fatty acid lipids. Nature Microbiology, doi: https://doi.org/10.1038/s41564-018-0336-y

     

2018

  • Ku, C., Barak-Gavish, N., Maienschein-Cline, M., Green, S. J. and Vardi, A. (2018) Complete Genome Sequence of Sulfitobacter sp. Strain D7, a Virulent Bacterium Isolated from an Emiliania huxleyi Algal Bloom in the North Atlantic. Microbiology Resource Announcement 7:e01379-18. https://doi.org/10.1128/MRA.01379-18.
  • Gibbin, E., Gavish, A., Krueger, T., Kramarsky-Winter, E., Shapiro, O., Guiet, R., Jensen, L., Vardi, A. and Meibom, A. (2018) Vibrio coralliilyticus infection triggers a behavioural response and perturbs nutritional exchange and tissue integrity in a symbiotic coral. The ISME Journal. doi:10.1038/s41396-018-0327-2
  • Gibbin, E., Gavish, A., Domart-Coulon, I., Kramarsky-Winter, E., Shapiro, O., Meibom, A. and Vardi, A. (2018) Using NanoSIMS coupled with microfluidics to visualize the early stages of coral infection by Vibrio coralliilyticus. BMC Microbiology, 18:39. https://doi.org/10.1186/s12866-018-1173-0
  • Barak-Gavish, N., Frada, M.J., Ku, C., Lee, P.A., DiTullio, G.R., Malitsky, S., Aharoni, A., Green, S.J., Rotkopf, R., Kartvelishvily, E., Sheyn, U., Schatz, D. and Vardi A. (2018) Bacterial virulence against an oceanic bloom-forming phytoplankter is mediated by algal DMSP. Science Advances 4(10), eaau5716, doi: 10.1126/sciadv.aau5716
  • Trainic, M., Koren, I., Sharoni, S., Frada, M., Segev, L., Rudich, Y. and Vardi, Assaf, (2018) Infection Dynamics of a Bloom-Forming Alga and Its Virus Determine Airborne Coccolith Emission from Seawater. iScience. doi: http://dx.doi.org/10.2139/ssrn.3188480
  • Shapiro, O. H., Kartvelishvily, E., Kramarsky-Winter, E. and Vardi, A (2018) Magnesium-Rich Nanometric Layer in the Skeleton of Pocillopora damicornis With Possible Involvement in Fibrous Aragonite Deposition. Frontiers in Marine Science. doi: https://doi.org/10.3389/fmars.2018.00246
  • Laber, C. P.,  Hunter, J. E., , Carvalho, F., Collins, J. R., Hunter, E. J., Schieler, B. M., Boss, E., More, K., Frada, M., Thamatrakoln, K., Brown, C. M., Haramaty, L., Ossolinski, J., Fredricks, H., Nissimov, J. I., Vandzura, R., Sheyn, U., Lehahn, Y.,  Chant, R. J., Martins, A. M., Coolen, M. J. L., Vardi, A., DiTullio, G. R., Van Mooy, B. A. S. & Bidle, K. D (2018) Coccolithovirus facilitation of carbon export in the North Atlantic Nature Microbiology  3:537-547. doi:10.1038/s41564-018-0128-4
  • Volpert, A., Graff van Creveld, S., Rosenwasser, S. and Vardi, A. (2018) Diurnal fluctuations in chloroplast GSH redox state regulate susceptibility to oxidative stress and cell fate in a bloom‐forming diatom. Journal of Phycology. doi: 10.1111/jpy.12638
  • Schatz, D. and Vardi, A. (2018) Extracellular Vesicles - new players in cell-cell communication in aquatic environments. Current Opinion in Microbiology. 43:148-154
  • Sheyn, U., Rosenwasser, S., Lehahn, Y., Barak-Gavish, N., Rotkopf, R., Bidle, K.D., Koren, I., Schatz, D. and Vardi, A. (2018) Expression profiling of host and virus during a coccolithophore bloom provides insights into the role of viral infection in promoting carbon export. ISME Journal. doi:10.1038/s41396-017-0004-x

2017

  • Frada MJ, Rosenwasser S, Ben-Dor S, Shemi A, Sabanay H. and Vardi, A. (2017) Morphological switch to a resistant subpopulation in response to viral infection in the bloom-forming coccolithophore Emiliania huxleyi  PLOS Pathogens 13(12): e1006775 doi.org/10.1371/journal.ppat.1006775
  • Schatz, D., Rosenwasser, S., Malitsky, S., Wolf, S.G., Feldmesser, E. and Vardi, A. (2017) Communication via extracellular vesicles enhances viral infection of a cosmopolitan alga. Nature Microbiology. doi:10.1038/s41564-017-0024-3
  • Lehahn, Y., Koren, I., Sharoni, S., d’Ovidio, F., Vardi, A. and Boss, E. (2017) Dispersion/dilution enhances phytoplankton blooms in low-nutrient waters. Nature Communications. doi: 10.1038/ncomms14868
  • Woehle, C., Dagan, T., Landan, G., Vardi, A. and Rosenwasser, S. (2017) Expansion of the redox-sensitive proteome coincides with the plastid endosymbiosis. Nature Plants, doi:10.1038/nplants.2017.66
  • Brodie, J., Ball, S.G., Bouget, F-Y., Chan, C.X., De Clerck, O., Cock, J.M., Gachon, C., Grossman, A.R., Mock, T., Raven, J.A., Saha, M., Smith, A.G., Vardi, A., Yoon, H.S. and Bhattacharya, D. (2017) Biotic interactions as drivers of algal origin and evolution. New Phytologist, doi:10.1111/nph.14760

2016

  • Alcolombri, U., Lei, L., Meltzer, D., Vardi, A. and Tawfik, D.S. (2016) Assigning the algal source of dimethylsulfide using a selective lyase inhibitor. ACS Chemical Biology. doi; 10.1021/acschembio.6b00844
  • Graff van Creveld, S., Rosenwasser, S., Levin, Y. and Vardi, A. (2016) Chronic iron limitation confers transient resistance to oxidative stress in marine diatoms. Plant Physiology, doi:10.1104/pp.16.00840
  • Rosenwasser, S., Ziv, C., Graff van Creveld, S. and Vardi, A. (2016) Virocell Metabolism: Metabolic Innovations During Host–Virus Interactions in the Ocean. Trends Microbiol. 24:821–832. 
  • Shemi, A., Schatz, D., Fredricks, H. F. Van Mooy, B. A. S., Porat, Z. and Vardi, A. (2016) Phosphorus starvation induces membrane remodeling and recycling in Emiliania huxleyi. New Phytologist, 211: 886–898.
  • Ziv, C., Malitsky, S., Othman, A., Ben-Dor, S., Wei, Y., Zheng. S., Aharoni, A., Hornemann, T. and Vardi, A. (2016) Viral serine palmitoyltransferase induces metabolic switch in sphingolipid biosynthesis and is required for infection of a marine alga. Proc. Natl. Acad. Sci. USA. doi: 10.1073/pnas.1523168113
  • Shapiro, O.H., Kramarsky-Winter, E., Gavish, A.G., Stocker, R. and Vardi, A. (2016) A coral-on-a-chip microfluidic platform enabling live-imaging microscopy of reef-building corals. Nature Communications 7:10860. doi:10.1038/ncomms10860
  • Malitsky, S., Ziv, C., Rosenwasser, S., Zheng, S., Schatz, D., Porat, Z., Ben-Dor, S., Aharoni, A. and Vardi, A. (2016) Viral infection of the marine alga Emiliania huxleyi triggers lipidome remodeling and induces the production of highly saturated triacylglycerol. New Phytologist. 210:88–96
  • Sheyn, U., Rosenwasser, S., Ben-Dor, S., Porat, Z. and Vardi, A (2016) Modulation of host ROS metabolism is essential for viral infection of a bloom-forming coccolithophore in the ocean. ISME Journal. doi: 10.1038/ismej.2015.228

2015

  • Sharoni, S., Trainic, M., Schatz, D., Lehahn, Y., Flores, M.J., Bidle, K.D., Ben-Dor, S., Rudich, Y., Koren, I. and Vardi, A. (2015)  Infection of phytoplankton by aerosolized marine viruses. Proc. Natl. Acad. Sci. USA. 112:6643–6647.
  • Shemi, A., Ben-Dor, S. and Vardi, A. (2015) Elucidating the composition and conservation of the autophagy pathway in photosynthetic eukaryotes. Autophagy 11:701-15
  • Alcolombri, U., Ben-Dor, S., Feldmesser, E., Levin, Y., Tawfik, D.S. and Vardi, A (2015). Identification of the algal dimethyl sulfide-releasing enzyme: a missing link in the marine sulfur cycle.  Science.348:1466-1469.
  • Graff Van Creveld, S., Rosenwasser, S., Schatz, D., Koren, I and Vardi, A (2015). Early perturbation in mitochondria redox homeostasis in response to environmental stress predicts cell fate in diatoms.  ISME Journal. 9:385-395.
  • Frada, M.J., Vardi, A. (2015). Algal viruses hitchhiking on zooplankton across phytoplankton blooms.  Communicative and Integrative Biology. 8:e1029210

2014

  • Frada, MJ., Schatz, D., Farstey, V., Ossolinski, J.E., Sabanay, H., Ben-Dor, S., Koren, I. and Vardi, A. (2014) Zooplankton may serve as transmission vectors for viruses infecting algal blooms in the ocean. Current Biology. 24:2592–2597.
  • Schatz, D., Shemi, A., Rosenwasser, S., Sabanay, H., Wolf, S.G., Ben-Dor, S. and Vardi, A. (2014) Hijacking of an autophagy-like process is critical for the life cycle of a DNA virus infecting oceanic algal blooms. New Phytologist. 204(4):854-63.
  • Shapiro, O.H., Fernandez, V.I., Garren, M., Guasto, J.S., Debaillon-Vesque, F.P., Kramarsky-Winter, E., Vardi A. and Stocker, R.  (2014) Vortical ciliary flows actively enhance mass transport in reef corals. Proc. Natl. Acad. Sci. USA. 111:13391–13396.
  • Rosenwasser, S., Mausz, M.A., Schatz, D., Sheyn, U., Weinstock, E., Pohnert, G. and Vardi, A. (2014) Rewiring host lipid metabolism by large viruses determines the fate of Emiliania huxleyi, a bloom-forming alga in the ocean. Plant Cell. 26: 2689-2707.
  • Alcolombri, U., Laurino, P., Lara-Astiaso, P., Vardi, A., Tawfik, D.S. (2014) DddD as a CoA-transferase/lyase producing dimethyl sulfide in the marine environment. Biochemistry, 53(34): 5473-5475
  • Lehahn, Y., Koren, I., Rudich, Y., Bidle, K.D., Trainic, M., Flores, M., Sharoni, S., Vardi, A. (2014) Decoupling oceanic and atmospheric factors affecting aerosol loading over a cluster of mesoscale North Atlantic eddies, Geophysical Research Letters 41(11): 4075–4081.
  • Lehahn, Y., Koren, I., Schatz, D., Frada, M., Sheyn, U., Boss, E., Efrati, S., Rudich, Y., Trainic, M., Sharoni, S., Laber, C., DiTullio, G.R., Coolen, M., Martins, A., Van Mooy, B.A.S., Bidle, K.D. and Vardi, A. (2014) Decoupling physical from biological processes to assess the impact of viruses on a mesoscale algal bloom. Current Biology 24(17):2041-2046.
  • Rosenwasser, S., Graff van Creveld, S. Schatz, D., Malitsky, S., Tzfadia, O., Aharoni, A., Levin,Y., Gabashvili, A., Feldmesser, E and Vardi A. (2014) Mapping the diatom redox-sensitive proteome provides insight into response to nitrogen stress in the marine environment. Proc. Natl. Acad. Sci. USA 111(7): 2740–2745.
  • Feldmesser, E., Rosenwasser, S., Vardi, A and Ben-Dor, S. (2014) Improving transcriptome construction in non-model organisms: integrating manual and automated gene definition in Emiliania huxleyi. BMC Genomics 15:148

2012

  • Vardi, A., Haramati, L., Van Mooy, B.A.S.,Fredericks, H.F., Kimmance, S.A., et al. (2012) Host-virus dynamics and subcellular controls of call fate in a natural coccolithophore population.  Proc. Natl. Acad. Sci. USA 109:19327-19322.

2011

2010

  • Bowler, C.P., Vardi, A. and Allen, A.E. (2010) Oceanographic and biogeochemical insights from diatom genomes. Annual Reviews in Marine Sciences. 2: 333-365.
  • Maheswari U., Jabbari K., Petit J.L., Porcel B.M., Allen A.E., Cadoret J.P., [...], Vardi A., Armbrust E.V., Weissenbach J., Katinka M. and Bowler C. (2010) Digital expression profiling of novel diatom transcripts provides insight into their biological functions. Genome Biology 11(8): R85

2009

  • Vardi, A., Van Mooy, B.A.S., Fredericks, H.F., Popendorf, K, Ossolinski, J, Haramaty, L. and Bidle, K.D. (2009) Viral glycosphingolipids induce lytic infection and cell death in marine phytoplankton. Science 326, 861 (2009).
  • Maumus, F., Allen, A., Mhiri, C., Hu, H., Jabbari, K., Vardi, A., Grandbastien, M.A. and Bowler, C. (2009) Potential impact of stress activated retrotransposons on genome evolution in a marine diatom. BMC Genomics. 10:624 doi:10.1186/1471-2164-10-624.

2008

  • Vardi, A, Thamatrakoln, K, Bidle, K.D. and Falkowski, P.G. (2008) Diatom genomes come of age. Genome Biology 9(12):245.
  • Vardi A (2008) Cell signaling in marine diatoms. Communicative & Integrative Biology 1(2): 134.
  • Bowler C., […], Vardi A., Grigoriev IV. (2008) The Phaeodactylum genome reveals the evolutionary history of diatom genomes. Nature. 456:239-244.
  • Andrianasolo EH, Haramaty L, Vardi A, White E, Lutz R and Falkowski PG. (2008) Apoptosis Inducer Galactolipids from a Cultured Marine Diatom Phaeodactylum tricornutum. Journal of Natural Products 71 (7):1197–1201.
  • Vardi A, Bidle KD, Kwityn C, Thompson SM, Callow JA, Falkowski PG, Bowler C (2008). A Diatom Gene Regulating Nitric Oxide Signaling and Susceptibility to Diatom-Derived Aldehydes. Current Biology 18(12):895-9.
  • Kahl, A.L., Vardi, A. and Schofield, O. (2008). The effect of phytoplankton physiology on export flux. Marine Ecology Progress Series (Feature Article) 354: 3-19.

2007

  • Vardi, A., Eisenstadt, D., Murik, O., Berman-Frank, I., Zohary, T., Kaplan, A., and Levine, A. (2007). Synchronization of cell death in a dinoflagellate population is mediated by an extracreted thiol protease. Environmental Microbiology 9 (2): 360–369.
  • Montsant, A., […],Vardi, A […], Bowler, B. (2007). Identification and comparative genomic analysis of signaling and regulatory components in the diatom Thalassiosira pseudonana. Journal of Phycology 43(3): 585-604.
  • Schatz, D., Keren, Y., Vardi, A., Sukenik, A., Carmeli, S., Börner, T., Dittmann E., and Kaplan, A. (2007). Towards clarification of the biological role of microcystins, a family of cyanobacterial toxins. Environmental Microbiology 9(4), 965–970.

2006

  • Vardi, A., Formiggini, F., Casotti, R., de Martino, A., Ribalet, F., Miralto, A., and  Bowler, C. (2006). A stress surveillance system based on calcium and nitric oxide in marine diatoms. PLoS Biology 4(3):e60.
  • Allen, A.E., Vardi, A., Bowler, C.P. (2006). An ecological and evolutionary context for integrated nitrogen metabolism and cell signaling pathways in marine diatoms. Current Opinion in Plant Biology 9 (3):264-273.

2004

  • Armbrust, E.V, […],Vardi, A., Wilkerson, F.P, and. Rokhsar D. S. (2004). The genome of the diatom Thalassiosira pseudonana: Ecology, evolution and metabolism. Science 306: 79-86.

2002

  • Vardi, A., Schatz, D., Beeri,K., Motro, U., Sukenik, A., Levine, A., Kaplan, A.. (2002) Dinoflagellate-cyanobacterium communication may determine the composition of phytoplankton assemblage in a mesotrophic lake. Current Biology. 12: 1767-1772.
  • Sukenik, A., Eshkol, R., Livne, A., Hadas, O., Rom, M., Tchernov, D., Vardi, A., Kaplan, A. (2002). Inhibition of growth and photosynthesis of the dinoflagellate Peridinium gatunense by Microcystis sp. (cyanobacteria): A novel allelopathic mechanism. Limnology and Oceanography 47(6): 1656–1663.

1999

  • Vardi, A., Berman-Frank, I., Rozenberg, T., Hadas, O., Kaplan, A., Levine, A. (1999) Programmed cell death of the bloom-forming dinoflagellate Peridinium gatunense is mediated by CO2 limitation and oxidative stress. Current Biology. 9: 1061-1064.
  • Hadas, O., Pinkas, R., Delphine, E., Vardi, A., Kaplan, A. Sukenik, A. (1999) Limnological and ecological aspects of Aphanizomenon ovalisporum bloom in Lake Kinneret, Israel. J. Plankton Research. 21: 1439-1453.