|Moross Repository||Mouse Lines at the FGMA||Other WIS Lines||Database Import Requests|
The Moross Repository for Genetically-Modified Mice contains strains of transgenic and gene-targeted mice that were produced or obtained by Weizmann Institute scientists, which are no longer in use, but might reasonably be needed by WIS scientists in the future. The repository maintains strains of mice either as small nuclei of breeding pairs or as stocks of frozen embryos. The aim of the Repository is to free Institute scientists from the need to maintain strains that are potentially useful but which they themselves no longer need. The repository houses mice relevant to any discipline of scientific research performed at the WIS.
The Repository is funded by the MD Moross Institute for Cancer Research and by the Weizmann Institute of Science.
The Moross Repository will also participate in financing import of new and potentially interesting strains of transgenic or gene-targeted mice that are relevant to cancer research (as defined in a rather broad way). For additional information see the Moross Repository Guidelines below.
Submitting mice to the Moross Repository
Scientists who wish to suggest strains of mice for inclusion in the Repository are requested to contact:
Prof. Ari Elson, Department of Molecular Genetics, Tel: 2331, 2209
or Dr. Rebecca Haffner, Department of Veterinary Resources, Tel: 2719.
Once approval for acceptance has been secured, scientists are required to fill out an order form via
Internal Services → Animal Breeding Services → Moross Cancer Bank.
Requesting Mice from the Moross Repository
IACUC approval must be obtained for all mice requested from the Moross Repository. Once IACUC approval has been secured, scientists are required to fill out an order form via Internal Services - Animal Breeding Services - Moross Cancer Bank.
Moross Repository Guidelines
- The Moross Repository of Genetically-Modified Mice aims to maintain living or frozen stocks of select strains of genetically-modified mice that are no longer in use but which may be of potential future use by WIS scientists. In so doing the Repository maintains availability of potentially-useful strains of mice while freeing WIS scientists from the burden of maintaining stains they no longer need.
- The Moross Repository accepts genetically-modified mice relevant to any discipline of scientific research performed at the WIS.
- A strain of mice will be considered for inclusion in the Repository providing that:
- The strain is not maintained in parallel by any researcher at the WIS.
- There are no frozen stocks of this strain at the WIS.
- There is reasonable expectation that the strain may be needed in the future by WIS scientists other than the scientist who donated the strain.
- The legal/IP limitations on the use of the strain are such that it can be used by scientists other than the WIS donor.
- Other issues (broad scientific interest, ease/difficulty to obtain the strain from other sources, ease/difficulty to maintain the strain, available resources) may also be considered.
- Strains are accepted into the collection and are maintained without cost to the donating scientist.
- The Moross Repository maintains strains as small live breeding stocks and cannot provide large amounts of mice. WIS scientists may receive breeding pairs from the Repository with which to establish breeding colonies should they need more than a few mice for their studies.
- Strains of mice not in frequent demand will be frozen and maintained as stocks of frozen embryos. In order to preserve resources the Repository will typically not freeze strains of mice that are maintained as living colonies in the Jackson Labs or other providers, since it takes about as much time to import these mice as it does to thaw and re-establish them from frozen stock locally.
- Freezing of strains will be done at no cost to the donating scientist. However, costs of thawing embryos will be borne by the WIS scientist that requests it.
- Any WIS scientist may request breeding stocks from the Repository providing:
- He/she obtains IACUC approval.
- The legal/IP commitments undertaken by the WIS scientist who originally obtained the strain will be respected.
- If the line is frozen, costs of thawing will be borne by the WIS scientist who requests it.
- WIS scientists are strongly encouraged to freeze down strains of mice they no longer need without the intervention of the Moross Repository. Such freezing is currently free, is carried out by the staff of the mouse facility, and involves little effort on the part of the scientific group. The Repository will therefore accept only strains of mice of potential future use to several WIS groups.
- In extreme cases, where a scientist wishes to freeze down a strain and cannot do so due to backlogs in the freezing process, the Repository may accept a small number of these mice to maintain the line until freezing becomes possible. This will be done at no cost to the scientist; however, the scientist will be responsible for genotyping these mice, if needed.
- The Moross Repository adheres to and respects all legal/IP limitations undertaken by the WIS scientist/s who originally obtained the strains. Therefore, WIS scientists requesting strains from the Repository may have to request permission to do so from the original non-WIS source and/or may be required to sign MTAs or undertake other commitments.