Selected Publications

Prickett T, Wei X, Teer J, Cherukuri P, Lin J, Molinolo A, Rosenberg S, Davies M, Gershenwald J, Stemke-Hale K, Margulies E, Samuels Y. Exon capture analysis of G-Protein Coupled Receptors reveals activating mutations in GRM3 in melanoma. Nature Genetics, 43:1119-1126. 2011. [PubMed]

Solomon D, Kim T, Diaz-Martinez L, Fair J, Elkahloun A, Harris B, Toretsky J, Baker S, Rosenberg S, Ladanyi M, Samuels Y, James D, Yu J, Kim J, Waldman T. Mutational inactivation of STAG2 causes aneuploidy in human cancer. Science, 333:1039-1043. 2011. [PubMed]

Wei X, Walia V, Lin JC, Teer JK, Prickett TD, Gartner J, Davis S, Stemke-Hale K, Davies MA, Gershenwald JE, Robinson W, Robinson S, Rosenberg SA, Samuels Y. Exome sequencing identifies GRIN2A as frequently mutated in melanoma. Nature Genetics, 43:442-446. 2011. [PubMed Central]

Prickett TD, Agrawal NS, Wei X, Yates KE, Lin JC, Wunderlich JR, Cronin JC, Cruz P, Rosenberg SA, Samuels Y: Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4. Nature Genetics, 41(10):1127-32. 2009. [PubMed]

Palavalli LH, Prickett TD, Wunderlich JR, Wei X, Burrell AS, Porter-Gill P, Davis S, Wang C, Cronin JC, Agrawal NS, Lin JC, Westbroek W, Hoogstraten-Miller S, Molinolo AA, Fetsch P, et al. Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma. Nature Genetics 41:518-520. 2009. [PubMed]

Bergamaschi D, Samuels Y, Sullivan A, Gasco M, Syed N, Zvelebil M, Breyssens H, Bisso A, Smith P, Del Sal G, Crook T, Lu X. iASPP preferentially binds the proline rich region of p53 and modulates the apoptotic function of codon 72 polymorphic p53. Nature Genetics, 38(10):1133-1141. 2006. [PubMed]

Samuels Y, Diaz LA, Jr., Schmidt-Kittler O, Cummins JM, Delong L, Cheong I, Rago C, Huso DL, Lengauer C, Kinzler KW, Vogelstein B, Velculescu VE. Mutant PIK3CA promotes cell growth and invasion of human cancer cells. Cancer Cell, 7:561-573. 2005. [PubMed]

Samuels Y, Wang Z, Bardelli A, Silliman N, Ptak J, Szabo S, Yan H, Gazdar A, Powell SM, Riggins GJ, Willson JK, Markowitz S, Kinzler KW, Vogelstein B, Velculescu VE. High frequency of mutations of the PIK3CA gene in human cancers. Science, 304:554. 2004. [PubMed]

Bergamaschi D, Samuels Y, O’Neil NJ, Trigiante G, Crook T, Hsieh JK, O’Connor DJ, Zhong S, Campargue I, Tomlinson ML, Kuwabara PE, and Lu X. iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human. Nature Genetics, 33:162-167. 2003. [PubMed]

Samuels-Lev Y, O’Connor DJ, Bergamaschi D., Trigiante G, Hsieh JK, Zhong S, Campargue I., Naumovski L., Crook T., and Lu X. ASPP proteins specifically stimulate the apoptotic function of p53. Molecular Cell, 8:781-94. 2001. [PubMed]