Publications

RECENT PUBLICATIONS 

  1. Sharivkin, R., Walker, M.D., Soen, Y. (2012) Proteomics-based dissection of human endoderm progenitors by high-throughput differential cell capture on antibody array. Mol. Cell.  Proteomics 11: 586-595.
  2. Bahar Halpern, K., Veprik, A., Rubins, N., Naaman, O., and Walker, M.D. (2012) GPR41 gene expression is mediated by internal ribosome entry site (IRES) -dependent translation of a bicistronic mRNA encoding GPR40 and GPR41 proteins.  J.Biol.Chem. 287: 20154-63.
  3. Kredo-Russo, S., Ness, A., Mandelbaum, A.D., Walker, M.D. and Hornstein, E., (2012) Regulation of pancreatic microRNA-7 expression. Exp. Diabetes Res. Epub 2012 May 17.
  4. Avnit-Sagi, T, Vana, T. and Walker, M.D. (2012) Transcriptional mechanisms controlling miR-375 gene expression in the pancreas. Exp. Diabetes Res. Epub 2012 Jun 20.
  5. Kebede,M., Ferdaoussi1, M., Mancini1, A., Alquier, T., Kulkarni, R.N., Walker, M.D., and Poitout, V. (2012)  Glucose activates GPR40 gene transcription via phosphatidylinositol-3-kinase-dependent OGlcNAcylation of pancreas-duodenum homeobox-1. Proc. Natl. Acad. Sci. (USA) 109: 2376-81.
  6. Biton, M., Levin, A., Slyper, M., Alkalay, I., Horwitz, E., Mor, H., Kredo-Russo, S., Avnit-Sagi, T., Cojocaru, G., Zreik, F., Bentwich, Z., Poy, M. N., Artis, D., Walker, M. D., Hornstein, E., Pikarsky, E., and Ben-Neriah, Y. (2011) Epithelial microRNAs regulate gut mucosal immunity via epithelium-T cell crosstalk. Nat Immunol 12: 239-246.
  7. Avnit-Sagi T, Kantorovich L, Kredo-Russo S, Hornstein E, and Walker MD (2009). The promoter of the pri-miR-375 gene directs expression selectively to the endocrine pancreas. PLoS One.;4:5033.
  8. Walker MD (2008) Role of MicroRNA in pancreatic beta-cells: where more is less  Diabetes 57:2567-2568.
  9. Ridner, G., Bartoov-Shifman, R., Zalogin, T., Avnit-Sagi, T., Bahar, K., and Walker, M.D., (2008) Regulation of the GPR40 locus – towards  a molecular understanding. Biochem.Soc.Trans 36:360-2.
  10. Bartoov-Shifman, R., Ridner, G., Bahar, K., Rubins, N. and Walker, M.D. (2007) Regulation of the gene encoding GPR40, a fatty acid receptor expressed selectively in pancreatic beta cells. J Biol Chem, 282, 23561-23571.
  11. Steneberg, P., Rubins, N., Bartoov-Shifman., R.,  Walker, M.D., and Edlund., H. (2005) The free fatty acid receptor GPR40 links hyperinsulinemia, hepatic steatosis and impaired glucose homeostasis  in mouse Cell Metabolism 1: 245-258.

 

SELECTED EARLIER PUBLICATIONS 

  1. Walker, M. D., Edlund, T., Boulet, A. M. and Rutter, W. J. (1983) Cell-specific expression controlled  by the 5′ flanking region of insulin and chymotrypsin genes. Nature. 306: 557-561.
  2. Edlund, T., Walker, M. D., Barr, P. J. and Rutter, W. J. (1985) Cell-specific expression of the rat insulin gene: Evidence for role of two distinct 5′ flanking elements. Science. 230: 912-916.
  3. Nir, U., Walker, M. D. and Rutter, W. J. (1986) Regulation of rat insulin I gene expression: evidence for negative regulation in non-pancreatic cells. Proc. Natl. Acad. Sci. (USA). 83: 3180-3184.
  4. Peterlin, B. M., Luciw, P. A., Barr, P. J. and Walker, M. D. (1986) Elevated levels of mRNA can account for the transactivation of human immunodeficiency virus. Proc. Natl. Acad. Sci. (USA). 83: 9734-9738.
  5. Karlsson, O., Edlund, T., Moss, J. B., Rutter, W. J. and Walker, M. D. (1987) A mutational analysis of the insulin gene transcription control region: Expression in beta cells is dependent on two related sequences in the enhancer. Proc. Natl. Acad. Sci. (USA). 84: 8819-8823.
  6. Karlsson, O., Walker, M. D., Rutter, W. J. and Edlund, T. (1989) Individual protein binding domains of the insulin gene enhancer positively activate beta-cell specific transcription. Molec. and Cell. Biol. 9: 823-827.
  7. Walker, M. D., Park, C. W., Rosen, A. and Aronheim, A. (1990) A cDNA clone from pancreatic beta cells encoding a putative transcription factor of the insulin gene. Nucleic Acids Res. 18: 1159-1166.
  8. Leshkowitz, D. and Walker, M.D. (1991) Extinction of insulin gene expression in hybrids between beta cells and fibroblasts involves loss of the putative b cell specific transcription factor IEF1.  Molec. and Cell. Biol. 11: 1547-1542.
  9. Aronheim, A., Ohlsson, H., Park, C. W., Edlund, T. and Walker, M. D. (1991). Distribution and characterization of helix-loop-helix enhancer-binding proteins from pancreatic beta cells and lymphocytes. Nucl. Acids. Res. 19: 3893-3899.
  10. Leshkowitz, D., Aronheim, A. and Walker, M. D. (1992). Insulin-producing cells contain a cell-specific repressor activity which functions through multiple E box sequences. DNA and Cell. Biol. 11: 549-558.
  11. Park, C.-W. and Walker, M. D. (1992). Subunit structure of cell-specific E box binding proteins analyzed by quantitation of electrophoretic mobility shift. J. Biol. Chem. 267: 15642-15649.
  12. Aronheim, A., Shiran, R., and Walker, M. D. (1993). The E2A gene product contains two separable and functionally distinct transcription activation domains. Proc. Natl. Acad. Sci (USA)   90: 8063-8067.
  13. Birk, O.S., Douek, D., Elias, D., Takacs, K., Dewchand, H., Walker, M.D., van der Zee, R., Cohen, I.R. and Altmann, D.M. (1996) The role of Hsp60 in autoimmune diabetes: analysis in a transgenic model Proc. Natl. Acad. Sci (USA)  93:1032-1037.
  14. Argenton, F., Arava, Y., Aronheim, A. and Walker, M.D. (1996) An activation domain of the transcription  factor E2A shows cell type preference in micro-injected zebrafish embryos Mol. Cell. Biol. 16: 1714-1721.
  15. Arava, Y., Adamsky, K., Belleli, A., Shaltiel, S. and Walker, M. D. (1998). Differential expression of the protein kinase A regulatory subunit (RIalpha) in pancreatic endocrine cells. FEBS Lett. 425 24-8.
  16. Arava, Y., Adamsky, K., Ezerzer, C., Ablamunits, V. and Walker, M. D. (1999). Specific gene expression in pancreatic beta cells: cloning and characterization of differentially expressed genes. Diabetes. 48, 552-556
  17. Arava, Y., Seger, R. and Walker, M. D. (1999). GRFbeta, a novel regulator of calcium signaling, is expressed in pancreatic beta cells and brain. J Biol Chem. 274, 24449-52.
  18. Bartoov-Shifman, R., Hertz, R., Wang, H., Wollheim, C. B., Bar-Tana, J., and Walker, M. D. (2002) Activation of the insulin gene promoter through a direct effect of hepatocyte nuclear factor 4 alpha J Biol Chem 277, 25914-9.
  19. Liberzon, A., Ridner, G., and Walker, M. D. (2004) Role of intrinsic DNA binding specificity in defining target genes of the mammalian transcription factor PDX1 Nucleic Acids Res 32: 54-64.