Ion flow through protein channels is one of the fundamental mechanisms of transmembrane signaling. Ion channels are involved in processes as diverse as development, hormone secretion, salt balance and memory. Abnormalities in channel function can result in a wide range of neural, muscular, cardiovascular and renal diseases. To understand the normal and pathological roles of channels, it is necessary to know how they regulate the flow of specific ions across the membrane and how other proteins affect this function. More specifically, we are interested in understanding how chemical transmission, via G protein coupled receptors (GPCRs), is converted into changes in electrical signaling, via the activation of G protein coupled potassium channels (GIRK) and voltage gated calcium channels. Other aspects of cellular physiology are also studied, mainly concentrating on the store operated calcium entry (SOCE) system that is responsible for maintaining appropriate calcium levels in both excitable and non excitable cells, as well as the mediation of various cellular functions.
The lab has the capability of addressing common questions using electrophysiological, molecular and advanced imaging techniques, both in cultured cells and in native tissues.