Selected publications
1) Liu, Y. F., Hershkowitz, A., Boura-Halfon, S., Ronen, D., Paz, K., LeRoith D., and Zick, Y. “Serine Phosphorylation Proximal to its PTB Domain Inhibits IRS-1 Function and Promotes Insulin Resistance”. Mol. Cell. Biol. 24, 9668-9681, 2004
2) Zick, Y. “Ser/Thr phosphorylation of IRS proteins: A molecular basis for insulin resistance”. Sci. STKE , pe4, 2005
3) Arbel-Goren, R., Levy, Y., Ronen, D., and Zick, Y. “Cyclin-Dependent Kinase Inhibitors and JNK Act as Molecular Switches, Regulating the Choice Between Growth Arrest and Apoptosis Induced by Galectin-8” J. Biol. Chem 280, 19105-19114, 2005
4) Levy, Y., Auslender, S., Eisenstein, M., Vidavski, R.R., Ronen, D., Bershadsky, A.D., and Zick, Y. “It Depends on the hinge: A structure-Functional Analysis of Galectin-8, a tandem-repeat type lectin” Glycobiology 16, 463-476, 2006
5) Herschkovitz, A. Liu, Y-F., Ilan, E. Ronen, D. Boura-Halfon, S., and Zick, Y. Common inhibitory serine sites phosphorylated by IRS-1 kinases, triggered by insulin and inducers of insulin resistance, J. Biol. Chem. 282, 18018-18027, 2007
6) Eshkar-Sebban, L., Ronen, D., Levartovsky, D., Elkayam, O., Caspi, D., Aamar, S., Howard A, Rubinow, A., Golan, I., Naor, D., Zick, Y., and Golan, I. The Involvement of CD44 and its Novel Ligand Galectin-8 in Apoptotic Regulation of Autoimmune Inflammation J. Immunol. 179. 1225-1235, 2007
7) Levkovitz, Y., Ben-shushan, G., Hershkovitz, A., Isaac, R., Gil-Ad, I., Shvartsman, D., Ronen, D., Weizman, A., and Zick, Y. Antidepressants Induce Cellular Insulin Resistance by Activation of IRS-1 Kinases. Mol. Cell. Neurosci. 36, 305-312, 2007
8) Shanik, M. H., Xu, Y., Skrha, J., Dankner, R., Zick, Y., and Roth, J. Insulin Resistance and Hyperinsulinemia: is hyperinsulinemia the cart or the horse? Diabetes Care, S262-S268, 2008
9) Boura-Halfon, S., and Zick, Y. Phosphorylation of IRS Proteins, Insulin Action and Insulin Resistance, Am. J. Physiol. 296:E581-E591, 2009
10) Boura-Halfon, S. and Zick, Y. Serine kinases of insulin receptor substrate proteins. in: Vitamins and hormones. 80:313-349, 2009 .
11) Gurevitch, D., Boura- Halfon, S., Isaac, R., Albersein, M., Ronen, D., Lewis, E., and Zick, Y. Eliminatation of Negative Feedback Control Mechanisms Along the Insulin Signalling Pathway Improves b Cell Function Under Stress. Diabetes 59(9):2188-2197, 2010
12) Boura-Halfon, S. Shuster-Meiseles, T., Beck, A., Petrovich, K., Gurevitch, D., Ronen, D., and Zick, Y. A Novel Domain Mediates Insulin Induced Proteasomal Degradation of Insulin Receptor Substrate 1 (IRS-1) Mol Endocrinol. 24(11):2179-2192, 2010
13) Beck, A., Lavelin, I., Hart, Y., Volberg, T., Geiger, B., and Zick, Y. An RNAi Screen Identifies TM7SF3, a Seven Transmembrane Orphan Receptor, as an Inhibitor of Cytokine-Induced Death of Pancreatic β-Cells Diabetologia, 54 (11) 2845-2855, 2011
14) Gurevitch D, Shuster-Meiseles T, Nov O, Zick Y, Rudich A, Rudich Y. TiO2 nanoparticles induce insulin resistance in liver-derived cells both directly and via macrophage activation. Nanotoxicology. 2011 (In Press)
15) Alberstein M, Zornitzki T, Zick Y, Knobler H. Hepatitis C core protein impairs insulin downstream signalling and regulatory role of IGFBP-1 expression. J Viral Hepat. 2012 19(1):65-71, 2012