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Angiogenesis in reproduction and development

Vicki plaks, Nava Dekel and Michal Neeman

Processes related to vascular development during pregnancy and embryonic development were non-invasively studied by magnetic resonance imaging
(MRI) in three different transgenic mouse models. Primarily, MRI was used to characterize angiogenesis during embryo implantation and then applied to study impaired fertility related to an implantation disorder:
MRI assisted in mapping subfertility  females to the point of implantation, and was further applied to characterize placental function in various knockout mice.

 

E5.5 mouse embryo implantation sites

 
 
 
 

2D-SE image of E13.5 embryos in utero.

 

E18.5 mouse placentas

 
 
 
 

Biotin-BSA-GdDTPA enhanced MIP of a 3D-GE data set of E18.5 mouse placentas.

 

E13.5 embryos in utero

 
 
 
 

Biotin-BSA-GdDTPA enhanced MIP of a 3D-GE data set of E5.5 mouse embryo implantation sites.