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Investigating the feto-maternal processing pattern of albumin in the placenta with DCE-MRI - Marina Lysenko

Murine placenta is a complex organ, consisting of different cell compartments that vastly influence its blood-flow pattern. In my study, we use high-MW, albumin-based macromolecular contrast agent that does not cross the placental barrier, but is actively internalized by trophoblast cells in the labyrinth in order to study placental perfusion and compartmental complexity . To interpret the observed data, we suggest a novel model for describing Feto-maternal processing of labeled- albumin in placental DCE-MRI experiments.Taken together, this model can be utilized to investigate the unexplored placental functionality in fetal recycling of maternal albumin at the different placental compartments.