We employ high throughput approaches to identify oscillations in metabolite levels and metabolic pathways. A current study in our lab quantified hundreds of lipids in mouse liver throughout the day and addressed their circadian clock and feeding time dependency. Another project examines the circadian accumulation of polyamines, essential positively charged amines, and their involvement in circadian rhythmicity (Adamovich et al., Cell Metabolism, 2014; Zwighaft et al., Cell Metabolism, 2015; Neufeld-Cohen et al., Proc. Natl. Acad. Sci. USA, 2016; Aviram et al., Molecular Cell, 2016).