Enzyme and metabolic engineering

We apply state-of-the art approaches towards the engineering of new enzymes, including computational design, ‘smart’ library designs and high-throughput selection strategies. We have engineered, for example, enzymes that can efficiently degrade and thus prevent intoxication by the most toxic nerve agent, VX. We are currently engineering enzymes for new applications in cell- and neuro-biology, and in engineering novel metabolic pathways for improving crop efficiency