Events
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Date:19
Tuesday
September 2023
Hour: 14:00 - 15:00,Location: Gerhard M.J. Schmidt Lecture HallEvent name: How did the protoribosomes form the first peptide bonds – chemical and structural studiesDr. Tanaya Bose, Yonath Lab, Dept. of Chemical and Structural Biology, Weizmann Institute
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Date:04
Monday
September 2023
Hour: 10:00 - 11:00,Location: Nella and Leon Benoziyo Building for Biological SciencesEvent name: High-speed atomic force microscopy captures a rare oligomeric state of an ion channelDr. Shifra Lansky, Cornell University, New York
Transient receptor potential (TRP) channels are a large, eukaryotic ion-channel superfamily that control diverse physiological functions. To date, more than 210 structures from over 20 TRP-channels have been determined, all are tetramers. Using high-speed atomic force microscopy (HS-AFM), a pioneering technique capable of “filming” single-molecule proteins, we discovered a rare and transient pentameric state for TRPV3, and determined the pentamer structure using single-particle cryo-EM. Our results suggest that the pentamer relates to the pore-dilated state, a structurally-elusive state characterized by increased conductance and permeability to small molecules. These findings lay the foundation for many new directions in ion-channel research, and demonstrate the strength of HS-AFM in discovering transient and rare states of proteins.
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Date:15
Tuesday
August 2023
Hour: 14:00 - 15:00,Location: Gerhard M.J. Schmidt Lecture HallEvent name: Intra-host evolution of HIV env after broadly-neutralizing antibody infusionDr. Frida Belinky, Virus Persistence and Dynamics Section Immunology Laboratory Vaccine Research Center National Institute of Allergy and Infectious Diseases National Institutes of Health
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Date:27
Tuesday
June 2023
Hour: 14:00 - 15:00,Location: Gerhard M.J. Schmidt Lecture HallEvent name: Functional studies of lysine ac(et)ylation using genetically encoded post-translational modificationsProf. Eyal Arbely, Department of Chemistry Ben Gurion University
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Date:22
Thursday
June 2023
Hour: 11:00 - 12:00,Location: Gerhard M.J. Schmidt Lecture HallEvent name: Quo Vadis Small Molecule Drug Discovery?Dr. Ingo Hartung, Head of Medicinal Chemistry & Drug Design Global Research & Development Merck Healthcare KGaA
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Date:13
Tuesday
June 2023
Hour: 14:00 - 15:00,Location: Gerhard M.J. Schmidt Lecture HallEvent name: Translational Chemical BiologyProf. Xiaoguang Lei, Peking University
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Date:06
Tuesday
June 2023
Hour: 14:00 - 15:00,Location: Gerhard M.J. Schmidt Lecture HallEvent name: Microbiome Metabolites: Syntheses and SurprisesProf. Karl Gademann, Department of Chemistry University of Zurich
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Date:30
Tuesday
May 2023
Hour: 14:00 - 15:00,Location: Gerhard M.J. Schmidt Lecture HallEvent name: Electrosome assembly: a first look at the structural principles underlying ion channel biogenesisProf. Daniel Minor, Departments of Biochemistry & Biophysics University of California San Francisco
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Date:23
Tuesday
May 2023
Hour: 14:00 - 15:00,Location: Gerhard M.J. Schmidt Lecture HallEvent name: Advances of Liquid Biopsy Diagnostics and Structural Models in the Development of Data-Driven AI in Future HospitalsDr. Milana Frenkel-Morgenstern, Azrieli Faculty of Medicine Bar-Ilan University
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Date:15
Monday
May 2023
Hour: 11:00 - 12:00,Location: Gerhard M.J. Schmidt Lecture HallEvent name: KENDREW LECTURE: Computational Structural Biology in the Era of Deep LearningProf. John Moult, Institute of Bioscience and Biotechnology Research Department of Cell Biology and Molecular Genetics University of Maryland
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Date:02
Tuesday
May 2023
Hour: 14:00 - 15:00,Location: Gerhard M.J. Schmidt Lecture HallEvent name: Conspiring with the Enemy: A Unique Mechanism in Class A JDPs Stabilizes Oncogenic p53 MutantsGuy Zoltsman, Dept. of Chemical & Structural Biology Weizmann Institute
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Date:18
Tuesday
April 2023
Hour: 14:00 - 15:00,Location: Gerhard M.J. Schmidt Lecture HallEvent name: Structural Biology Response to Biomedical ThreatsProf. Wladek Minor, Department of Molecular Physiology and Biological Physics University of Virginia
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Date:02
Sunday
April 2023
Hour: 11:00 - 12:00,Location: Gerhard M.J. Schmidt Lecture HallEvent name: Fluorescent nucleosides, nucleotides and oligonucleotidesProf. Yitzhak Tor, University of California San Diego
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Date:28
Tuesday
March 2023
Hour: 14:00 - 15:00,Location: Gerhard M.J. Schmidt Lecture HallEvent name: Intestinal mucin is a chaperone of multivalent copperNava Reznik, Fass Lab Dept. of Chemical & Structural Biology Weizmann Institute
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Date:15
Wednesday
March 2023
Hour: 11:00 - 12:00,Location: Gerhard M.J. Schmidt Lecture HallEvent name: Towards resolving dynamics of molecular machines using time-resolved cryo-EMProf. Rouslan Efremov, VIB-VUB Center for Structural Biology Belgium
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Date:14
Tuesday
March 2023
Hour: 14:00 - 15:00,Location: Gerhard M.J. Schmidt Lecture HallEvent name: Structure-based prediction of protein-protein and protein compound interactions on a proteome-wide scaleProf. Barry Honig, Columbia University
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Date:28
Tuesday
February 2023
Hour: 14:00 - 15:00,Location: Gerhard M.J. Schmidt Lecture HallEvent name: Fast and Processive Artificial Molecular Motors and Rotors Made of DNAProf. Eyal Nir, Department of Chemistry Ben-Gurion University
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Date:31
Tuesday
January 2023
Hour: 14:00 - 15:00,Location: Gerhard M.J. Schmidt Lecture HallEvent name: Chemical Evolution: From Origins of Life to BiotechnologyDr. Moran Frenkel-Pinter , Institute of Chemistry The Hebrew University of Jerusalem
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Date:24
Tuesday
January 2023
Hour: 14:00 - 15:00,Location: Gerhard M.J. Schmidt Lecture HallEvent name: Intrinsically disordered proteins can also exhibit millisecond conformational dynamicsDr. Eitan Lerner, The Alexander Silberman Institute of Life Sciences The Hebrew University
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Date:17
Tuesday
January 2023
Hour: 14:00 - 15:00,Location: Gerhard M.J. Schmidt Lecture HallEvent name: Rational discovery of selective chemical probes of the polyamine deacetylase HDAC10Dr. Aubry Miller, Cancer Drug Development German Cancer Research Center DKFZ, Germany
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Date:12
Thursday
January 2023
Hour: 14:00 - 15:00,Location: Gerhard M.J. Schmidt Lecture HallEvent name: GPCR structure and dynamics - Insights from RhodopsinProf. Oliver P. Ernst, University of Toronto Canada
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Date:03
Tuesday
January 2023
Hour: 14:00 - 15:00,Location: Gerhard M.J. Schmidt Lecture HallEvent name: The Simple QTY Code for Protein DesignProf. Shuguang Zhang, MIT Media Lab USA